发布时间：

2025-04-30

论文名称：

Gold Nanoparticles Modify the Photophysical and Photochemical Properties of 6-Thioguanine: Preventing DNA Oxidative Damage

发表刊物：

The Journal of Physical Chemistry C

摘要：

For the widely used anticancer, antiinflammatory, and immunosuppressant drug 6-thioguanine (6-TG), its unique photochemistry of absorbing UVA, generating singlet oxygen (1O2), and inducing oxidative DNA damage can cause
severe phototoxicity side effects in biomedical applications. Here we raise a new strategy of loading 6-TG onto gold
nanoparticles (AuNPs) and demonstrate from systematic ultraviolet irradiation experiments that the 6-TG photochemistry can be successfully modulated by binding with AuNPs and the phototoxicity under UVA irradiation are effectively removed, not only for single base 6-TG but also for 6-TG embedded in DNA. In conjunction with excited state ab initio calculations, the molecular mechanisms are further unveiled, accounting for the protection effects of AuNPs in prohibiting the 6-TG photoactivation and 1O2 oxidation. These findings point to tremendous possibilities of using AuNPs as inert carrier to modify excited state photochemistry and prevent unwanted phototoxicity effects of the adsorbed drug molecules.

合写作者：

Wang, R.; Yue, L.; Yu, Y.; Zou, X.; Song, D.; Liu, K.; Liu, Y.; Su, H.

卷号：

120(26)

页面范围：

14410-14415

是否译文：

否

发表时间：

2016-06-13