Penems as the latest generation β- Lactam antibiotics are known as "the last barrier for humans to resist bacterial infections.". Meropenem is widely used in clinical practice as the most important type of penem drugs. In the chemical synthesis step of meropenem, it is necessary to use noble metal Pd/AC catalysts for hydrogenation to remove protective groups. However, the poisoning of the Pd/AC catalyst by residual mercaptans from the substrate in the one-pot process results in low target product yields, poor solid-liquid separation efficiency, and high palladium content in the catalyst. In this paper, using N/S co doping process modified activated carbon as a support, sulfur resistant 4% Pd/AC catalyst suitable for the one pot synthesis of meropenem has been successfully developed and implemented for industrial application. The palladium content of the catalyst is reduced by 20% compared to the Pd/AC catalyst in the two-step synthesis process of meropenem, effectively saving precious metal resources.

The first author of the paper is Yuefeng Li (PhD student), and the corresponding author is Professor Xinli Jing and Associate Professor Yu Li.

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培南类药物作为最新一代β-内酰胺类抗生素，被誉为“人类抵抗细菌感染的最后一道屏障”。美罗培南作为培南类药物最重要的品种被临床广泛使用。在美罗培南化学合成步骤需要使用贵金属Pd/AC催化剂来氢化脱除保护基，然而一锅法工艺中底物残留的硫醇对Pd/AC催化剂的毒化导致该工艺存在目标产物收率低、固液分离效率差、催化剂钯含量高等问题。本文以N/S共掺杂工艺改性活性炭为载体，成功开发出适用于一锅法合成美罗培南工艺的4% 的抗硫毒性Pd/AC催化剂并实现工业应用，该催化剂的钯含量相对美罗培南两步法合成工艺中的Pd/AC催化剂降低了20%，有效节约了贵金属资源。

论文的第一作者为博士研究生李岳锋，通讯作者为井新利教授和李瑜副教授。