ISDTool: a computational model for predicting immunosuppressive domain of HERVs
发布时间：2025-04-30
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- 发布时间：
- 2025-04-30
- 论文名称：
- ISDTool: a computational model for predicting immunosuppressive domain of HERVs
- 发表刊物：
- Computational Biology and Chemistry
- 摘要：
- Human endogenous retroviruses (HERVs) have been found to act as etiological cofactors in several chronic diseases, including cancer, autoimmunity and neurological dysfunction. Immunosuppressive domain (ISD) is a conserved region of transmembrane protein (TM) in envelope gene (env) of retroviruses. In vitro and vivo, evidence has shown that retroviral TM is highly immunosuppressive and a synthetic peptide (CKS-17) that shows homology to ISD inhibits immune function. ISD is probably a potential pathogenic element in HERVs. However, only less than one hundred ISDs of HERVs have been annotated by researchers so far, and universal software for domain prediction could not achieve sufficient accuracy for specific ISD. In this paper, a computational model is proposed to identify ISD in HERVs based on genome sequences only. It has a classification accuracy of 97.9% using Jack-knife test. 117 HERVs families were scanned with the model, 1002 new putative ISDs have been predicted and annotated in the human chromosomes. This model is also applicable to search for ISDs in human T-lymphotropic virus (HTLV), simian T-lymphotropic virus (STLV) and murine leukemia virus (MLV) because of the evolutionary relationship between endogenous and exogenous retroviruses. Furthermore, software named ISDTool has been developed to facilitate the application of the model. Datasets and the software involved in the paper are all available at https://sourceforge.net/projects/isdtool/files/ISDTool-1.0.
- 合写作者：
- Lyu Hongqiang, Han Jiuqiang
- 是否译文：
- 否
- 发表时间：
- 2014-04-01