教育及工作经历

2020.11至今          西安交通大学，药学院，副教授

2018.07-2020.10     西安交通大学，药学院，助理研究员

2012.09-2018.06     西安交通大学，药物分析学，医学博士

2007.09-2011.07     西安交通大学，制药工程，工学学士

科研项目

[1]   国家自然科学基金青年科学基金项目, 81903573, 基于肥大细胞MrgX2的异欧前胡素衍生物抗类过敏活性筛选研究, 2020-01至2022-12, 21万元, 在研, 主持

[2]   中国博士后科学基金面上项目, 2018M643682, 呋喃香豆素类抗过敏化合物的合成与活性研究, 2019-01至2020-12, 5万元, 结题, 主持

[3]   陕西省自然科学基础研究计划青年项目，2020JQ-089, IIMP-9的抗类过敏活性及与MrgX2关系研究, 2020-01至2021-12, 3万元, 在研, 主持

已发表论文

[1]  Cheng Wang, Tian Hu, Jiayu Lu, Yuexin Lv, Shuai Ge, Yajing Hou, Huaizhen He*. Convenient Diaryl ureas as promising anti-pseudo-allergic agents. Journal of Medicinal Chemistry, 2022, 65(15): 10626-10637.

[2]  Cheng Wang, Yajing Hou, Shuai Ge, Jiayu Lu, Xiangjun Wang, Yuexin Lv, Nan Wang, Huaizhen He*. Synthetic imperatorin derivatives alleviate allergic reactions via mast cells. Biomedicine & Pharmacotherapy, 2022, 150: 112982.

[3]  Jiayu Lu, Xiangjun Wang, Shuai Ge, Yajing Hou, Yuexin Lv, Huaizhen He, Cheng Wang*. Synthesis and evaluation of new potential anti-pseudo-allergic agents. Bioorganic & Medicinal Chemistry Letters, 2022, 59: 128575.

[4]  Yajing Hou, Jiayu Lu, Di Wei, Yuexin Lv, Huaizhen He, Cheng Wang*, Langchong He. Establishment of substance P modified affinity chromatography for specific detection and enrichment of Mas-related G protein–coupled receptor X2. Journal of Chromatography A, 2021, 1659: 462633.

[5]  Jiayu Lu, Yajing Hou, Shuai Ge, Xiangjun Wang, Jue Wang, Tian Hu, Yuexin Lv, Huaizhen He, Cheng Wang*. Screened antipsychotic drugs inhibit SARS-CoV-2 binding with ACE2 in vitro, Life Sciences, 2021, 266: 118889.

[6]  Cheng Wang, Zhenru Liu, Tian Hu, Youjia Li, Rui Liu, Junjie Zhang, huaizhen He*. Potential neurotoxicity of 5-hydroxymethylfurfural and its oligomers: widespread substances in carbohydrate-containing foods, Food & Function, 2020, 11(5): 4216-4223.

[7]  Tian Hu, Yajing Hou, Jiayu Lu, Xiangjun Wang, Di Wei, Cheng Wang*. Dextromethorphan-A widely-used cough suppressant-induces local anaphylaxis via MRGPRX2 on mast cells, Chemico-Biological Interactions, 2020, 330: 109248.

[8]  Yitong Xie#, Di Wei#, Tian Hu, Yajing Hou, Yuanyuan Lin, Huaizhen He*, Cheng Wang*. Anti-pseudo-allergic capacity of alkaloids screened from Uncaria rhynchophylla, New Journal of Chemistry, 2020, 43: 38-45.

[9]  Cheng Wang, Youjia Li, Ting Zhang, Di Wei, Yajing Hou, Huaizhen He*. 5-Phenylcoumarin derivatives: design, synthesis, and vasodilatory activity. Chemistry & Biodiversity, 2018, 15(11): e1800255.

[10] Cheng Wang, Yajing Hou, Yuanyuan Lin, Yitong Xie, Di Wei, Nan Zhou, Huaizhen He*. Rapid determination and conversion study of 5-hydroxymethylfurfural and its derivatives in glucose injection, New Journal of Chemistry, 2018, 42: 17725-17731.

[11] Cheng Wang, Limin Huang, Yuanyuan Lin, Youjia Li, Yajing Hou, Liu Yang, Meng Sun, Huaizhen He*. Functionalization of silica gel with 5-hydroxymethylfurfural: preparation, characterization and preliminary verification. New Journal of Chemistry, 2017, 41(12): 4738-4742.

[12] Cheng Wang, Tao Wang, Limin Huang, Yajing Hou, Wen Lu, Huaizhen He*. Facile synthetic approach for 5-aryl-9-hydroxypyrano [3,2-f] indol-2(8H)-one. Arabian Journal of Chemistry, 2016, 9(6): 882-890.

[13] Cheng Wang#, Huaizhen He#, Yuanyuan Lin, Limin Huang, Meng Sun, Tao Zhang, Langchong He*. Preparation and preliminary application of 5-HMF@SiO2 micro-particles. RSC Advances, 2016, 6(74): 70586-70591.

[14] Cheng Wang, Tao Wang, Limin Huang, Wen Lu, Jie Zhang, Huaizhen He*. Synthesis and fluorescent study of 5-phenyl furocoumarin derivatives as vasodilatory agents. Bioorganic & Medicinal Chemistry Letters, 2016, 26(2): 640-644.

研究领域      

细胞膜色谱分析；

药物安全性评价；

抗过敏药物筛选研究。