基本信息

 

西安交通大学第二附属医院老年心血管科副主任（负责工作），副教授，研究员，博士生导师，西安交通大学青年拔尖人才，国家自然科学基金一审专家。

现任陕西省医师协会老年医师分会委员，西安医学会老年医学分会委员。

研究方向：1.心肌损伤与保护

                 2.心肌病与心衰的发病机制

联系方式

邮箱：dingmingge@xjtu.edu.cn

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工作教育经历

丁铭格，西安交通大学第二附属医院老年心血管内科副主任（负责工作），全科医学教研室副主任，研究员，博士生导师，副教授。擅长高血压，冠心病，心衰，心肌病等心内科疾病的诊疗工作。主持国家自然科学基金3项，陕西省重点研发计划2项，院校课题3项，主编专著3部，以第一/通讯作者发表SCI论文15篇，4篇论文入选ESI高被引论文。 2020年入选西安交通大学“青年拔尖人才支持计划”。

 

科研成果

    主持在研经费超过100万，主要项目如下：

  1. 国家自然科学基金面上项目，49万
  2. 国家自然科学基金面上项目，55万
  3. 国家自然科学基金青年项目，17.5万
  4. 陕西省重点研发计划一般项目，10万
  5. 西安交通大学基本科研业务费项目，15万
  6. 西安交通大学基础与临床融合项目，20万

    发表论文：

 

  1. Rui Shi , Zhenhua Liu , Huan Yue , Man Li , Simin Liu, Dema De， Runjing Li, Yunan Chen, Shuli Cheng , Xiaoming Gu, Min Jia, Jun Li, Juan Li, Shumiao Zhang , Na Feng , Rong Fan , Feng Fu , Yali Liu,  Mingge Ding，Jianming Pei. IP3R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin. Cell Mol Biol Lett. 2024 Feb 2;29(1):22(IF=9.2)

  2. Tian Gao , Rui Shi , Zhenhua Liu , Dema De , Runjing Li , Yunan Chen , Jianming Pei , Mingge Ding. Ischemia/reperfusion-induced MiD51 upregulation recruits Drp1 to mitochondria and contributes to myocardial injury. Biochem Biophys Res Commun. 2023 Jul 12:665:78-87(IF=3.3)

  3. Shi R, Fu F, Ding M. Letter by Shi et al regarding article, "Proteasomal degradation of TRAF2 mediates mitochondrial dysfunction in doxorubicin-cardiomyopathy". Circulation. 2023, doi: 10.1161/CIRCULATIONAHA.122.063010. (IF=37.8)

  4. De D, Fu F, Ding M. Letter by De et al regarding article, "MicroRNA-210 controls mitochondrial metabolism and protects heart function in myocardial infarction". Circulation. 2022, 146(12): e170. (IF=37.8)

  5. Ding M, Shi R, Fu F, Li M, De D, Du Y , Li Z.Paeonol protects against doxorubicin-induced cardiotoxicity by promoting Mfn2-mediated mitochondrial fusion through activating the PKCε-Stat3 pathway.J Adv Res. 2022 Jul 14.(IF 12.822，综合2区)

  6. Ding M, Shi R, Cheng S, Li M, De D, Liu C, Gu X, Li J, Zhang S, Jia M, Fan R, Pei J, Fu F.Mfn2-mediated mitochondrial fusion alleviates doxorubicin-induced cardiotoxicity with enhancing its anticancer activity through metabolic switch. Redox Biol. 2022; Jun;52:102311.(IF 10.78，生物1区)

  7. Liu C, Han Y, Gu X, Li M, Du Y, Feng N, Li J, Zhang S, Maslov LN, Wang G, Pei J, Fu F, Ding M. (*Corresponding author).Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2α-Stat3 pathway in diabetic cardiomyopathy. Redox Biol. 2021; Oct;46: 102098. (通讯作者，IF 11.799，生物1区)

  8. Fu F, Liu C, Shi R, Li M, Zhang M, Du Y, Wang Q, Li J, Wang G, Pei J*, Ding M*(*Corresponding author). Punicalagin protects against diabetic cardiomyopathy by promoting Opa1-mediated mitochondrial fusion via regulating PTP1B-Stat3 pathway. Antioxid Redox Signal. 2021 Apr 28. doi: 10.1089/ars.2020.8248. (IF 8.40，生物2区)

  9. Ding M, Liu C, Shi R, Yu M, Zeng K, Kang J, Fu F, Mi M. Mitochondrial fusion promoter restores mitochondrial dynamics balance and ameliorates diabetic cardiomyopathy in an optic atrophy 1-dependent way. Acta Physiol (Oxf). 2020; 229(1): e13428. (IF 5.54，生理学1区，ESI高被引论文)

  10. Hu L#, Ding M#(#co-first author), Tang D#, Gao E, Li C, Wang K, Qi B, Qiu J, Zhao H, Chang P, Fu F, Li Y. Targeting mitochondrial dynamics by regulating Mfn2 for therapeutic intervention in diabetic cardiomyopathy. Theranostics. 2019; 9(13): 3687-3706. (IF8.06，医学1区)

  11. Ding M, Hu L, Yang H, Gao C, Zeng K, Yu M, Feng J, Qiu J, Liu C, Fu F, Li Y. Reduction of SIRT1 blunts the protective effects of ischemic post-conditioning in diabetic mice by impairing the Akt signaling pathway. Biochim Biophys Acta Mol Basis Dis. 2019; 1865(6): 1677-1689. (IF 4.32，生物物理1区)

  12. Ding M, Feng N, Tang D, Feng J, Li Z, Jia M, Liu Z, Gu X, Wang Y, Fu F, Pei J. Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway. J Pineal Res. 2018; 65(2): e12491. (IF 11.61，医学1区，ESI高被引论文)

  13. Ding M, Ning J, Feng N, Li Z, Liu Z, Wang Y, Wang Y, Li X, Huo C, Jia X, Xu R, Fu F, Wang X, Pei J. Dynamin-related protein 1-mediated mitochondrial fission contributes to post-traumatic cardiac dysfunction in rats and the protective effect of melatonin. J Pineal Res. 2018; 64(1): e12447. (IF 11.61，医学1区，ESI高被引论文)

  14. Ding M, Dong Q, Liu Z, Liu Z, Qu Y, Li X, Huo C, Jia X, Fu F, Wang X. Inhibition of dynamin-related protein 1 protects against myocardial ischemia-reperfusion injury in diabetic mice. Cardiovasc Diabetol. 2017; 16(1): 19. (IF 4.75，医学2区)

  15. Ding M, Wang Y, Sun D, Liu Z, Wang J, Li X, Huo C, Jia X, Chen W, Fu F, Wang X. Punicalagin Pretreatment Attenuates Myocardial Ischemia-Reperfusion Injury via Activation of AMPK. Am J Chin Med. 2017; 45(1): 53-66. (IF 3.22，医学2区)

  16. Ding M, Lei J, Han H, Li W, Qu Y, Fu E, Fu F, Wang X. SIRT1 protects against myocardial ischemia-reperfusion injury via activating eNOS in diabetic rats. Cardiovasc Diabetol. 2015; 14: 143. (IF 4.01，医学2区)

  17. Ding M, Lei J, Qu Y, Zhang H, Xin W, Ma F, Liu S, Li Z, Jin F, Fu E. Calorie Restriction Attenuates Monocrotaline-induced Pulmonary Arterial Hypertension in Rats. J Cardiovasc Pharmacol. 2015; 65(6): 562-70. (IF 2.13，医学4区)