研究领域/方向
临床医学、肿瘤学(报考学科代码100214):
1. 新型PROTAC靶向蛋白降解药物研发
2. 肿瘤代谢及肿瘤免疫
教育及工作经历
2023.4-至今,西安交通大学第一附属医院,青年拔尖人才(A类),教授
2018-2023,美国哈佛大学医学院贝斯以色列女执事医疗中心,博士后
2017-2018,西安交通大学,生命学院,讲师
2014-2016,美国哈佛医学院,肿瘤学,联合培养博士生
2010-2016,西安交通大学,生命学院,生物学,博士
2006-2010,西安交通大学,生命科学人才基地班,生物医学工程,本科
学术及科研成果
长期致力于肿瘤及蛋白质翻译后修饰相关研究,针对肿瘤靶向治疗及免疫治疗开展了系统性工作,以第一/通讯作者在Science Advances(ESI高被引),Nature Communications(2篇),Cell Research(3篇),Journal of the American Chemical Society(4篇),Trends in Cell Biology及Seminar in Cancer Biology(2篇)等杂志发表论文16篇,他引2000余次,H因子29。研究成果被Nature Review Cancer,Nature Review Drug Discovery及Trends in Cell Biology等引用。
代表性论文
(*共同第一作者, #通讯作者)
- J Wang*, Z Wang*, H Inuzuka, W Wei, J Liu#. PRMT1 methylates METTL14 to modulate its oncogenic function. Neoplasia, 2023, 42, 100912
- Liu J*, Bu, X*, Chu, C. Dai X, Asara J. et al. PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity. Nature Communications. 2023, 14, 2806.
- Wang Z*, Liu J*, Chen H, Qiu X, Xie L, et al. Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins, Journal of the American Chemical Society. 2023, 17;145(19):10872-10879.
- Liu J*, Yu X*, Chen H, Kaniskan H, Xie L, et al. TF-DUBTACs stabilize tumor suppressor transcription factors. Journal of the American Chemical Society. 2022, 144 (28), 12934-12941.
- Liu J*, Peng Y*, Wei W#. Cell cycle on the crossroad of tumorigenesis and cancer therapy. Trends in Cell Biology. 2022, 32(1): 30-44.
- Liu J*, Peng Y*, Inuzuka H, Wei W#. Targeting micro-environmental pathways by PROTACs as a therapeutic strategy. Seminars in Cancer Biology. 2022, 86(2): 269-279.
- Liu J*, Peng Y*, Shi L*, Wan L, Inuzuka H, et al. Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle. Cell Research. 2021, 31(1): 80-93.
- Liu J*, Tokheim C*, Lee JD, Gan W, North BJ, et al. Genetic fusions favor tumorigenesis through degron loss in oncogenes. Nature Communications. 2021, 12(1): 6704.
- Liu J*, Chen H*, Kaniskan H, Xie L, Chen X, et al. TF-PROTACs enable targeted degradation of transcription factors. Journal of the American Chemical Society. 2021, 143(23): 8902-8910.
- Liu J*, Chen H*, Liu Y, Shen Y, Meng F, et al. Cancer selective target degradation by folate-caged PROTACs. Journal of the American Chemical Society. 2021, 143(19): 7380-7387.
- Liu J*, Ma J *, Liu Y *, Xia J, Li Y, et al. PROTACs: A novel strategy for cancer therapy. Seminars in Cancer Biology. 2020, 67, 171-179.
- Liu J*, Chen H*, Ma L, He Z, Wang D, et al. Light-induced control of protein destruction by opto-PROTAC. Science advances. 2020, 6 (8), eaay5154
联系方式
电子邮箱:jingliu@xjtu.edu.cn