| 论文标题 |
Reduced corrosion of Zn alloy by HA nanorods for enhancing early bone regeneration |
| 作者 |
Mengting Mao, Jun Chen, Fuwei Liu, Liang Kong, Yong Han*, Lan Zhang* |
| 发表/完成日期 |
2023-12-26 |
| 期刊名称 |
Biomaterials Science |
| 期卷 |
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| 相关文章 |
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| 论文简介 |
Zinc alloys have been emerging as promising materials for bone regeneration due to their moderate biodegradation rates. However, blast release of Zn2+ from Zn alloy substrates affect cell behaviors and the followed osseointegration quality, retarding their early service performance. To address this issue, an extracellular matrix like hydroxyapatite (HA) nanorods were prepared on Zn-1Ca (ZN) by a combined hydrothermal treatment (HT). HA nanoclusters nucleate on the presetting ZnO layer and grow into nanorods with the prolonged HT. HA nanorods protect the ZN substrate from serious corrosion and the corrosion rate is reduced by dozens of times compared with the bare ZN, resulting in significantly decreased release of Zn2+ ions. The synergistic effect of HA nanorods and appropriate Zn2+ endow ZN implants with obviously improved behaviors of osteoblasts and endothelial cells (e.g. adhesion, proliferation and differentiation) in vitro and new bone formation in vivo. Our work opens up a promising avenue for Zn-based alloys to improve bone regeneration in clinic. |
(创新港)
