| 论文简介 |
Cavidine is an isoquinoline alkaloid which is isolated from Corydalis impatiens. In tra-
ditional Tibetan herb, C. impatiens has been widely used for treatment of skin injuries, hepatitis, chol-
ecystitis, and scabies. The present study aimed to evaluate its anti-inflammatory effect and investigate
the mechanisms underlying this anti-inflammatory action. We used different inflammation model
animals and lipopolysaccharide (LPS)-induced murine peritoneal macrophages to examine the anti-
inflammatory function of cavidine. Results indicated pretreatment with cavidine (i.p.) decreased xylene-
induced ear edema, formaldehyde-induced paw edema, leukocyte number, and the level of nitric oxide
(NO), prostaglandin E
2
(PGE
2
), and tumor necrosis factor-alpha (TNF-α) in acetic acid-induced
peritonitis in mice. The data also demonstrated that cavidine significantly inhibited LPS-induced
TNF-α, interleukin-6 (IL-6), and NO production in peritoneal macrophages. Moreover, cavidine
regulated the expression of cyclooxygenase-2 (COX-2) instead of cyclooxygenase-1 (COX-1) at protein
levels. These results suggested that cavidine is a selective COX-2 inhibitor which possesses an anti-
inflammatory activity. |
(创新港)
