基本信息

      李冬民 博士/教授/博士生导师

   西安交通大学基础医学院院长助理、生物化学与分子生物系主任；西安交通大学本科生院医学生物学系副主任；西安交通大学教学后备名师；西安交通大学医学部名师。西安市免疫相关疾病基础与转化重点实验室副主任。高等学校国家级实验教学示范中心联席会首届高等学校基础医学创新创业协同育人工作组副组长；中国生物化学与分子生物学教学专业委员会委员；陕西省生物化学与分子生物学会常务理事；中国生物物理学会代谢生物学分会会员；《西安交通大学学报（医学版）》 第二届责任编委；国家及多个省市自然科学基金函评专家。2010～2011年在美国辛辛那提大学医学院代谢性疾病研究所公派留学。2016年10月，被选派加州大学伯克利分校参加“Berkeley Faculty Development Program for XJTU”项目研修。承担医学各专业本科生生物化学和分子生物学，硕士、博士研究生医学分子生物学，以及留学生本科生“Biochemistry”和留学生硕士、博士研究生“Molecular Biology”课程的教学工作。

学术成绩：主持国家自然科学4项、省部级科研项目9项（重点2项）；参与7项；在Hepatology、J. Am. Chem. Soc.、Cellular and Molecular Gastroenterology and Hepatology、Molecular Therapy-Nucleic Acids、Free Radical Biology & Medicine等国际著名期刊发表SCI收录论文43篇，其中第一或（共同）通讯作者20篇；2020年荣获陕西省第十四届自然科学优秀学术论文奖-二等奖1项。主持国家级虚拟仿真实验一流课程1门；主持国家级2021年实验教学百门应用示范课程1门；主持部、省、校级课程建设及教学改革项目23项；主编、副主编、参编规划教材12部。指导国家级、省级及校级大学生创新训练项目20项，指导开放实验项目12项。指导大学生获第十四届全国挑战杯二等奖1项，陕西省挑战杯一等奖1项，西安交通大学腾飞杯特等奖1项、二等奖2项、三等奖2项；个人荣获“优秀指导教师”称号。指导大学生荣获第七届全国大学生基础医学创新研究暨实验设计论坛分区赛（西部赛区）一等奖1项、总决赛铜奖1项。

联系方式

手机：13379091389

Email：lidongm@mail.xjtu.edu.cn

个人主页：http://gr.xjtu.edu.cn/web/lidongm

 

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研究领域

主要研究方向：

（1）肥胖、非酒精性脂肪肝等代谢性疾病的发病机制及靶向治疗；

（2）糖脂代谢的表观遗传调控；

（3）肠道菌群、免疫代谢与非酒精性脂肪肝病。 

代表性论文（#共同第一作者；*通讯作者）： 

  • Lu K#, He L#, Guo Z#, Li M, Cheng X, Liu S, Zhang T, Chen Q, Zhao R, Yang L, Wu X, Cheng K, Cao P, Wu L, Shahzad M, Zheng M, Jiao L, Wu Y, and Dongmin Li*. PDCD4 deficiency in hepatocytes exacerbates nonalcoholic steatohepatitis through enhanced MHC class II transactivator expression. Metabolism. 2024 Sep 27;161:156036. doi: 10.1016/j.metabol.2024.156036（SCI, IF= 10.8; JCR=Q1)
  • Zhao R#, Guo Z#, Lu K, Chen Q, Riaz F, Zhou Y, Yang L, Cheng X, Wu L, Cheng K, Feng L, Liu S, Wu X, Zheng M, Yin C, Dongmin Li*. Hepatocyte-specific NR5A2 deficiency induces pyroptosis and exacerbates non-alcoholic steatohepatitis by downregulating ALDH1B1 expression. Cell Death Dis. 2024 Oct 23;15(10):770. doi: 10.1038/s41419-024-07151-1.（SCI, IF=8.1; JCR=Q1)
  • Lin Cao, Yue Zhou, Shuai Lin, Chunyan Yang, Zixuan Guan, Xiaofan Li, Shujie Yang, Tong Gao, Jiazhen Zhao, Ning Fan, Yanan Song, Dongmin Li, Xiang Li, Zhuo Li, Feng Guan*, and Zengqi Tan*. The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis. J Extracell Vesicles. 2024 Sep;13(9):e12499. doi: 10.1002/jev2.12499 （SCI, IF=15.5; JCR=Q1)
  • Lu K, Cheng X, He L, Li M, Chen Q, Qian C, Zhao R, Yang L, Liu F, Liu S, Zhang T, Feng L, Wu L, Wu X, Xu N, Li Y, Wang J, Han Y, Yuan H, Liu T*, Zheng M*, Lu S*, Li D*. LNCHC directly binds and regulates YBX1 stability to ameliorate metabolic dysfunction-associated steatotic liver disease progression. Liver Int. 2024 Jun 7. doi: 10.1111/liv.15975. Epub ahead of print. PMID: 38847599.（SCI, IF= 6.0; JCR=Q1)
  • Lu K#, Zhou Y#, He L, Li Y, Shahzad M, Li D*. Coprococcus protects against high-fat diet-induced nonalcoholic fatty liver disease in mice. J Appl Microbiol. 2024 Jun 3;135(6):lxae125. doi: 10.1093/jambio/lxae125. PMID: 38830802.（SCI, IF= 3.2; JCR=Q2)
  • Lina Feng, Farooq Riaz, Kaikai Lu, Xiaona Cheng, Yanping Chen , Rong Zhao, Litao Wu, Shemin Lu and Dongmin Li*. Leucine Aminopeptidase 3:a Promising Serum Biomarker Candidate for Nonalcoholic Steatohepatitis Diagnosis. Int Immunopharmacol. 2023 Apr 12;119:110152. doi: 10.1016/j.intimp.2023.110152. （SCI, IF= 5.714; JCR= Q1)
  • Zhong Y, Xiao Y, Gao J, Zheng Z, Zhang Z, Yao L*, Li D*. Curcumin improves insulin sensitivity in high-fat diet-fed mice through gut microbiota. Nutr Metab (Lond). 2022 Nov 8;19(1):76. doi: 10.1186/s12986-022-00712-1. PMID: 36348361. （Published：08 November 2022）（SCI, IF= 4.127; JCR=Q3)
  • Qian Chen#, Jing Yi#, Fangtong Liu, Jing Li, Kaikai Lu, Xuan Wang, Fujun Zhang, Ya Li, Litao Wu, Xudong Yang, Shemin Lu and Dongmin Li*. TGF-β1 contributes to the hepatic inflammation in animal models with nonalcoholic steatohepatitis by Smad3/TLR2 signaling pathway. Mol Immunol. 2022 Dec;152:129-139. doi: 10.1016/j.molimm.2022.10.014. Epub 2022 Nov 2. （SCI, IF= 4.363; JCR=Q3)
  • Jun Wang, Xinrong Sun, Lianying Jiao, Zhengtao Xiao,Farooq Riaz, Yufeng Zhang, Pengfei Xu, Ruiqing Liu,Tiantian Tang, Meiqi Liu and Dongmin Li*.  Clinical Characteristics and Variant Analyses of Transient Infantile Hypertriglyceridemia Related to GPD1 gene. Front Genet. 2022 Aug 16;13:916672. （SCI, IF=4.772; JCR= Q1）
  • Lina Feng#, Yanping Chen#, Ke Xu, Yingchao Li, Farooq Riaz, Kaikai Lu, Qian Chen, Xiaojuan Du, Litao Wu, Dan Cao, Chunyan Li, Shemin Lu, Dongmin Li*. Cholesterol-induced leucine aminopeptidase 3 (LAP3) upregulation inhibits cell autophagy in pathogenesis of NAFLD. Aging (Albany NY). 2022 Apr 11;14(7):3259-3275. （SCI, IF= 5.955; JCR=Q1)
  • Zeyu Dong, Fangzhou He, Xiaosong Yan, Yuanming Xing, Yuyang Lei, Jie Gao, Ming He, Dongmin Li, Liang Bai, Zuyi Yuan, John Y-J. Shyy. Hepatic Reduction in Cholesterol 25-Hydroxylase Aggravates Diet-induced Steatosis. Cellular and Molecular Gastroenterology and Hepatology. 2022 Jan 3, 13(4):1161-1179. （SCI, IF= 9.225, JCR=Q1)
  • Farooq Riaz, Qian Chen, Kaikai Lu, Ezra Kombo Osoro, Litao Wu, Lina Feng, Rong Zhao, Luyun Yang, Yimeng Zhou, Yingli He, Li Zhu, Xiaojuan Du, Muhammad Sadiq,  Xudong Yang and Dongmin Li*. Inhibition of miR-188-5p alleviates Hepatic Fibrosis by significantly reducing the activation and proliferation of HSCs through PTEN/PI3K/AKT pathway. Journal of Cellular and Molecular Medicine(JCMM), 2021, doi.org/10.1111/jcmm.16376（SCI, IF= 5.310; JCR=Q2)
  • Jing Li#, Qian Chen#, Jing Yi, Xi Lan, Kaikai Lu, Xiaojuan Du, Zizhen Guo, Yuanxu Guo, Manman Geng, Dongmin Li*and Shemin Lu*. IFN-γ Contributes to the Hepatic Inflammation in HFD-Induced Nonalcoholic Steatohepatitis by STAT1β/TLR2 Signaling Pathway. Mol Immunol. 2021Jun; 134:118-128. （SCI, IF= 4.407; JCR=Q3)
  • Kaikai Lu, Qian Chen, Mengda Li，Lei He，Farooq Riaz，Tianyun Zhang and Dongmin Li*. Programmed Cell Death Factor 4 (PDCD4), a Novel Therapy Target for Metabolic Diseases besides Cancer. Free Radic Biol Med. 2020 Nov 1;159:150-163.（SCI, IF=7.376; JCR=Q1 )
  • Kaiting Ning#, Kaikai Lu#, Qian Chen, Zizhen Guo, Xiaojuan Du, Farooq Riaz, Lina Feng, Yuping Fu, Chunyan Yin, Fujun Zhang, Litao Wu and Dongmin Li*.  Epigallocatechin Gallate Protects Mice against Methionine-Choline-Deficient-Diet induced Non-alcoholic Steatohepatitis by Improving Gut Microbiota to Attenuate Hepatic Injury and Regulate Metabolism. ACS Omega 2020, 5, 33, 20800–20809（SCI, IF= 3.512; JCR=Q2)
  • Litao Wu, Juan Sun, Li Liu, Xiaojuan Du, Yan Liu, Xiaofei Yan, Ezra Kombo Osoro, Fujun Zhang, Lina Feng, Dong Liang, Yazhao Li, Qian Chen, Sha Sun, Lei Zhang, Xi Lan*, Dongmin Li* and Shemin Lu. Anti-toll-like receptor 2 antibody ameliorates hepatic injury, inflammation, fibrosis and steatosis in obesity-related metabolic disorder rats via regulating MAPK and NF-κB pathways. Int Immunopharmacol. 2020 Mar 6;82:106368. （SCI, IF= 5.714; JCR=Q1)
  • Xi Lan*, Nan Wu, Litao Wu, Kai Qu, Ezra Kombo Osoro, Dongxian Guan, Xiaojuan Du, Bo Wang, Sifan Chen, Ji Miao, Juan Ren, Li Liu, Haiyun Li, Qilan Ning, Dongmin Li and Shemin Lu*. The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p, Molecular Therapy-Nucleic Acids, 2020, 20: 468-479. Mol Ther Nucleic Acids. 2020 Jun 5;20:468-479.（SCI, IF= 8.886; JCR=Q1)
  • Lan X, Wu L, Wu N, Chen Q, Li Y, Du X, Wei C, Feng L, Li Y, Osoro EK, Sun M, Ning Q, Yan X, Yang X, Li D, Lu S. Long Noncoding RNA lnc-HC Regulates PPARγ-Mediated Hepatic Lipid Metabolism through miR-130b-3p. Mol Ther-Nucleic Acids. 2019 Oct 25;18:954-965.（SCI, IF= 7.032; JCR=Q1)
  • Riaz F, Li D*. Non-coding RNA associated Competitive Endogenous RNA Regulatory Network: Novel Therapeutic Approach in Liver Fibrosis. Curr Gene Ther. 2019 Nov 6. 2019;19(5):305-317. （SCI, IF= 4.391; JCR=Q3)
  • Sha Sun*，Yuxuan Yang，Dongmin Li，Jin Zhu. Large Chiral Nanotubes Self-Assembled by DNA Bricks. J. Am. Chem. Soc. 2019, 141, 50, 19524–19528（SCI, IF= 14.695; JCR=Q1)
  • Yao Y#, Mao J#, Xu S, Zhao L, Long L, Chen L, Li D*, Lu S*. Rosmarinic acid inhibits nicotine-induced C-reactive protein generation by inhibiting NLRP3 inflammasome activation in smooth muscle cells. J Cell Physiol. 2019 Feb; 234(2):1758-1767. （SCI, IF= 5.546; JCR=Q1)
  • Lan X, Yan J, Ren J, Zhong B, Li J, Li Y, Liu L, Yi J, Sun Q, Yang X, Sun J, Meng L, Zhu W, Holmdahl R, Li D*, Lu S*. A Novel Long Non-coding RNA Lnc-HC Binds hnRNPA2B1 to Regulate Expressions of Cyp7a1 and Abca1 in Hepatocytic Cholesterol Metabolism. Hepatology 2016; 64(1):58-72.（SCI, IF= 14.679; JCR=Q1)
  • Xuan Wang#, Meichen Wang#, Hongmin Li, Xi Lan, Li Liu, Jiaxi Li, Yue Li, Jing   Li, Jing Yi, Xiaojuan, Jidong Yan, Yan Han, Fujun Zhang, Min Liu, Shemin Lu, Dongmin Li*.Upregulation of miR-497 induces hepatic insulin resistance in E3 rats with HFD-MetS by targeting insulin receptor［J］. Mol Cell Endocrinol. 2015 Nov 15;416:57-69. (SCI, IF=4.405; JCR=Q2)
  • Dongmin Li#, Xuan Wang#, Xi Lan, Yue Li, Li Liu, Jing Yi, Jing Li, Qingzhu Sun, Yili Wang, Hongmin Li, Nannan Zhong, Rikard Holmdahl and Shemin Lu*. Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats［J］. Mol Cell Endocrinol. 2015, 402(C):1-12. (SCI, IF=4.405; JCR=Q2)
  • Ren J, Li D, Li Y, Lan X, Zheng J, Wang X, Ma J, Lu S. HDAC3 interacts with sumoylated C/EBPα to negatively regulate the LXRα expression in rat hepatocytes. Mol Cell Endocrinol. 2013; 374(1-2): 35-45. (SCI, IF=4.405; JCR=Q2)
  • Dongmin Li#, Xuan Wang#, Wuchao Ren, Juan Ren, Xi Lan, Feimiao Wang, Hongmin Li, Fujun Zhang, Yan Han, Tianbao Song, Rikard Holmdahl, Shemin Lu, High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-γ and LXR-α-pathways in E3 rats［J］. Mol Cell Endocrinol. 2011; 344(1-2):69-80. (SCI, IF=4.405; JCR=Q2)
  • Jie Ma#, Dong-Min Li#, Rui Zhang, Xu-Dong Yang, Cheng-Ge Gao, She-Min Lu, Sheng-Nan Wu, and Lei Wang. Genetic analysis of glutamate cysteine ligase modifier (GCLM) gene and schizophrenia in Han Chinese［J］Schizophr Res. 2010 Jun;119(1-3):273-4.（SCI, IF: 4.458; JCR=Q1)
  • Dongmin Li, Wuchao Ren, Xuan Wang, Feimiao Wang, Yu Gao, Qilan Ning, Yan Han, Tianbao Song, Shemin Lu. A Modified Method using TRIzol® Reagent and Liquid Nitrogen Produces High-Quality RNA from Rat Pancreas［J］. Appl Biochem Biotechnol,  2009，158:253-261（SCI, IF= 3.1; JCR=Q2)