孙瑞芳，西安交通大学医学部病理学系副教授，硕士生导师。
2002-2007年就读于西安交通大学，获医学/法学双学士学位。2013年于西安交通大学获医学博士学位。2011-2012年在美国哈佛大学医学院公派留学。2013年起在西安交通大学医学部病理学系工作。
工作至今一直承担医学基础课程《病理学》的教学工作，参编教材三本。
主要从事基因表达调控、肿瘤分子病理、精神压力与消化道疾病等研究工作。主持国家自然科学基金1项、陕西省重点研发计划项目1项、陕西省自然科学基金1项、国家博士后基金2项、陕西省博士后基金1项、西安交通大学科研基金2项。在《New England Journal of Medicine》、《Journal of the National Cancer Institute》、《Cell Death & Disease》、《The FASEB Journal》、《Acta Biomaterialia》、《Materials Today Bio》等学术期刊发表学术论文30余篇。获陕西高等学校科学技术研究优秀成果奖特等奖1项。指导大学生创新创业训练项目1项。
2002.09-2007.07，西安交通大学，医学/法学双学士
2007.09-2013.06，西安交通大学，医学博士（直博）
2011.10-2012.10 哈佛大学医学院，访问学者
1、基因表达调控
2、肿瘤分子病理
3、精神压力与消化道疾病
| 项目编号 | 项目名称 | 项目来源 | 起讫时间 | 承担角色 | 项目类别 |
|---|---|---|---|---|---|
| 2023-YBSF-447 | 结肠癌细胞分泌DEFA6蛋白通过YAP1/TEAD4下调siglec-6靶向激活MAPK促进肥大细胞增殖的机制研究 | 陕西省重点研发计划项目 | 2023-01~2024-12 | 负责人 | 横向项目 |
| 2022041 | 结肠癌细胞外泌防御素α6 通过 YAP1/TEAD4/siglec-6促进肥大细胞增殖的机制研究 | 西安交通大学医学“基础-临床”融合创新项目 | 2022-09~2024-09 | 负责人 | 横向项目 |
| 81802788 | TRIM24-FOXI1-AE2轴调控细胞内酸碱平衡影响胃癌细胞增殖的研究 | 国家自然科学基金项目 | 2019-01~2021-12 | 负责人 | 纵向项目 |
| 2018JM7028 | FOXI1调控BRD7抑制胃癌细胞侵袭迁移的作用及机制 | 陕西省自然科学基金项目 | 2018-01~2020-12 | 负责人 | 横向项目 |
| 2019T120918 | FOXI1异常甲基化通过CAMTA1影响胃癌迁移侵袭 | 中国博士后科学基金会 | 2017-09~2019-07 | 负责人 | 横向项目 |
| 2018BSHEDZZ91 | FOXI1通过BRD7抑制胃癌干细胞自我更新及迁移侵袭的机制研究 | 陕西省博士后基金会 | 2017-09~2019-07 | 负责人 | 横向项目 |
| 2017M620458 | FOXI1调控胃癌干细胞自我更新及侵袭转移的分子机制 | 中国中国博士后科学基金会 | 2017-09~2019-07 | 负责人 | 横向项目 |
| 论文标题 | 作者 | 发表/完成日期 | 期刊名称 |
|---|---|---|---|
| Rno_circRNA_008646 regulates formaldehyde induced lung injury through Rno-miR-224 mediated FOXI1/CFTR axis | Yang Yan-Qi, Ge Pan, Lv Mo-Qi, Yu Peng-Fei, Liu Zhi-Gang, Zhang Jian, Zhao Wen-Bao, Han Shui-Ping, Sun Rui-Fang*, Zhou Dang-Xia* | 2023-09-15 | Ecotoxicol Environ Saf |
| Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression | Sun Ruifang#, Yang Yang#, Lü Weidong#, Yang Yanqi, Li Yulong, Liu Zhigang, Diao Dongmei, Wang Yang, Chang Su'e, Lu Mengnan, Jiang Qiuyu, Dai Bingling, Ma Xiaobin, Zhao Chang'an, Lü Moqi, Zhang Juan, Ding Caixia, Li Na, Zhang Jian, Xiao Zhengtao #, Zhou Da | 2023-03-21 | Cell Biosci |
| Comprehensive analysis of alfa defensin expression and prognosis in human colorectal cancer | Zhao Xinliang#, Lu Mengnan#, Liu Zhigang#, Zhang Mingming, Yuan Hongmei, Dan Zhaoqiang, Wang Daihua, Ma Bingbing, Yang Yanqi, Yang Funing, Sun Ruifang*, Li Lin*, Dang Chengxue* | 2023-01-10 | Front Oncol |
| MBD1/HDAC3-miR-5701-FGFR2 axis promotes the development of gastric cancer | Changan Zhao, Jiyu Miao, Ruifang Sun, Rui Liang, Wenhu Chen, Yi Gao, Xiaofei Wang, Shuiping Han, Wenbao Zhao, Ting Lei, Chen Huang | 2022-07-22 | Aging (Albany NY) |
| FOCAD/miR-491-5p, downregulated by EGR1, function as tumor suppressor by inhibiting the proliferation and migration of gastric cancer cells | Ruifang Sun#, Zhigang Liu#*, Yun Lv#, Yanqi Yang#, Yang Yang, Yu Xiang, Qiuyu Jiang, Chang'an Zhao, Moqi Lv, Jian Zhang, Juan Zhang, Caixia Ding, Dangxia Zhou* | 2022-07-03 | Progress in Biophysics and Molecular Biology |
| FLG Is a Potential Biomarker of Prognosis and Immunotherapy in Skin Cutaneous Melanoma | Shaobo Wu#, Yuxia Liang, Qijuan Zang, Zixuan Xing, Pan Yin, Ruifang Sun*, Bingling Dai* | 2022-05-14 | Applied Bionics and Biomechanics |
| Effect of naturally derived surgical hemostatic materials on the proliferation of A549 human lung adenocarcinoma cells | Wei-Dong Lü#*, Yi-Zhi Liu#, Yan-Qi Yang, Zhi-Gang Liu, Kun Zhao, Jian-Rong Lu, Guang-Yan Lei, Yi-Yu Wang, Lin Cai, Rui-Fang Sun* | 2022-03-04 | Mater Today Bio |
| FOXI1 inhibits gastric cancer cell proliferation by activating miR-590/ATF3 axis via integrating ChIP-seq and RNA-seq data | Ruifang Sun#, Weidong Lü#, Zhigang Liu#, Yang Yang, Xiaofei Wang, Xinliang Zhao, Shufeng Fu, Wei Dai, Chen Huang*, Dongmei Diao* | 2021-02-18 | Progress in Biophysics and Molecular Biology |
| miR-491 inhibits BGC-823 cell migration via targeting HMGA2 | Zhigang Liu#, Yun Lü#, Qiuyu Jiang, Yang Yang, Chengxue Dang*, Ruifang Sun* | 2019-10-31 | Int J Biol Markers |
| miR-22 and miR-214 targeting BCL9L inhibit proliferation, metastasis, and epithelial-mesenchymal transition by down-regulating Wnt signaling in colon cancer | Ruifang Sun#, Zhigang Liu#, Lin Han#, Yang Yang, Fei Wu, Qiuyu Jiang, Huahua Zhang, Ruili Ma, Jiyu Miao, Kang He, Xiaofei Wang, Dangxia Zhou*, Chen Huang* | 2019-01-30 | The FASEB Journal |
| Photooxidatively crosslinked acellular tumor extracellular matrices as potential tumor engineering scaffolds | Wei-Dong Lü#*, Rui-Fang Sun#, Ye-Rong Hu*, Jan-Rong Lu, Lu Gu, Zhi-Gang Liu, Guang-Yan Lei, Zhun Qiang, Lin Cai | 2018-03-17 | Acta Biomaterialia |
| Prognostic value of MRP, LRP and P-gp in patients with non-small cell lung cancer | Zhigang Liu#, Ruifang Sun#, Juan Zhang, Caixia Ding, Gang Ma, Xinliang Zhao, Weidong Lü, Xiang Wang, Chengxue Dang* | 2017-06-15 | Int J Clin Exp Pathol |
| miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/β-catenin signaling in the development of gastric cancer | Ruifang Sun#, Zhigang Liu#, Dongdong Tong, Yang Yang, Bo Guo, Xiaofei Wang, Lingyu Zhao, Chen Huang* | 2017-03-30 | Cell Death and Disease |
| Prognostic value of neuroendocrine markers for predicting survival in patients with small cell lung cancer | Ruifang Sun#*, Zhigang Liu#, Gang Ma, Caixia Ding, Weidong Lü, Juan Zhang, Xiang Wang, Dangxia Zhou | 2016-06-15 | Int J Clin Exp Pathol |
| Overexpression of stathmin is resistant to paclitaxel treatment in patients with non-small cell lung cancer | Ruifang Sun#*, Zhigang Liu#, Lumin Wang, Weidong Lv, Jia Liu, Caixia Ding, Yong Yuan, Guangyan Lei, Changfu Xu | 2015-04-18 | Tumor Biol |
| Associations of deregulation of mir-365 and its target mRNA TTF-1 and survival in patients with NSCLC | Ruifang Sun#*, Zhigang Liu#, Gang Ma, Weidong Lv, Xinliang Zhao, Guangyan Lei, Changfu Xu | 2015-03-15 | Int J Clin Exp Pathol |
| Aspirin and Colorectal Cancer Incidence and Mortality by CTNNB1 Expression: A Molecular Pathological Epidemiology (MPE) Study | Sun R#, Nishihara R, Qian ZR, Chan AT, and Ogino S* | 2013-03-11 | Cancer Epidemiol Biomarkers Prev |
| Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival | Xiaoyun Liao#, Paul Lochhead#, Reiko Nishihara#, Teppei Morikawa, Aya Kuchiba, Mai Yamauchi, Yu Imamura, Zhi Rong Qian, Yoshifumi Baba, Kaori Shima, Ruifang Sun, Katsuhiko Nosho, Jeffrey A Meyerhardt, Edward Giovannucci, Charles S Fuchs*, et al | 2012-10-25 | N Engl J Med |
| Prospective Study of Family History and colorectal cancer risk by tumor line-1 Methylation_level | Shuji Ogino#, Reiko Nishihara#, Paul Lochhead#, Yu Imamura, Aya Kuchiba, Teppei Morikawa, Mai Yamauchi, Xiaoyun Liao, Zhi Rong Qian, Ruifang Sun, Kaori Sato, Gregory J Kirkner, Molin Wang, Donna Spiegelman, Jeffrey A Meyerhardt, Eva S Schernhammer, et al | 2012-10-18 | J Natl Cancer Inst |
| The -938A/A genotype of BCL2 gene is associated with esophageal cancer | Zhigang Liu#, Ruifang Sun#, Weidong Lü, Chengxue Dang, Yangrong Song, Cheng Wang, Xi Zhang, Le Han, Hao Cheng, Wei Gao, Jia Liu, Guangyan Lei* | 2011-12-21 | Med Oncol |
| Genetic polymorphisms of 10 X-STR among four ethnic populations in northwest of China | Ruifang Sun#, Yongsheng Zhu, Feng Zhu, Wenjian Kuang, Jiali Feng, Zhao Tian, Zhaoqin Chai, Yao Liu, Shengbin Li* | 2011-08-02 | Mol Biol Rep |
| Polymorphisms of three new microsatellite sites of the dystrophin gene | R F Sun#, Y S Zhu, J L Feng, Z Tian, W J Kuang, Y Liu, H B Zhang*, S B Li* | 2011-04-26 | Genet Mol Res |
| The G-712A polymorphism of brain-derived neurotrophic factor is associated with major depression but not schizophrenia | R F Sun#, Y S Zhu, W J Kuang, Y Liu, S B Li* | 2010-12-01 | Neurosci Lett |
电子邮箱: ruifang_sun@xjtu.edu.cn
个人主页：https://gr.xjtu.edu.cn/web/ruifang_sun
联系地址: 西安市雁塔西路76号/中国西部科技创新港21号楼
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