||At present, it is difficult to remove the ultra-high concentration of chloride ions (about 20,000 mg/L) in desulfurization wastewater by traditional methods. The aim of this work was to evaluate the removal of chloride ions from desulfurization wastewater by electro-catalysis progress using Ti/SnO2–Sb2O3/PbO2 electrodes. Response surface methodology (Box–Behnken design (BBD)) was employed to investigate the effects of current density , pH value, and electrolysis time on the removal of chloride ions. Three factors-three levels (BBD) was used for the optimization of process parameters. The predicted value in the established model agreed well with the actual value. The chloride ion removal reached 68.7% with an operating cost of 10.68 $/m3 wastewater under the optimum conditions of the current density of 690 A/m2, pH value of 8, and electrolysis time of 90 min.