| 论文标题 |
Hybrid biointerface engineering nanoplatform for dual-targeted tumor hypoxia relief and enhanced photodynamic therapy |
| 作者 |
Xueyan Zhen, Lanlan Jia, Qingyu Tang, Ying Zhao, Peishan Li, Jing Li, Xiaoyu Xie*, Sicen Wang* |
| 发表/完成日期 |
2023-07-02 |
| 期刊名称 |
JOURNAL OF COLLOID AND INTERFACE SCIENCE |
| 期卷 |
647 |
| 相关文章 |
|
| 论文简介 |
The clinical application of photodynamic therapy (PDT) is limited by the lack of tumor selectivity of photo-sensitizer (PS) and the hypoxic tumor microenvironment (TME). To address these limitations of PDT, we developed a hybrid engineered biointerface nanoplatform that integrated anti-epidermal growth factor receptor (EGFR)-aptamer (EApt)-modified liposomes with tumor cell membranes (TMs) to create M/L-EApt. M/L-EApt exhibited enhanced stability and significant dual-targeting ability, enabling selectively accumulate in hypoxic |
(创新港)
