主要研究方向为多巴胺系统生理功能与相关疾病阶段的病理机制研究。揭示了社交决策的神经编码机制，建立多巴胺偏向性突触传递新理论，阐明慢性痛与负性情绪交互调控的核心机制及其渐进性进展的中枢机制，提出多巴胺分泌稳态调控新假说，证明其稳态失衡是介导精神分裂症和帕金森病的关键机制，为其临床诊治提供新靶点和新策略，以第一作者（含共同）在Science，Nat Neurosci, Nat Commun和 Cell Commun Signal等期刊发表高水平论文，研究成果获Science、Nat Rev Neurosci、Nat Neurosci亮点评述和特别推荐，入选2024年中国疼痛领域十大进展。

2019/09-2024/06      西安交通大学，         博士

2017/09-2019/07      里尔中央理工学院， 工程师

2015/09-2019/07      西安交通大学，         学士

张香桐神经科学优秀论文一等奖

西安交通大学“十大学术新人”

法国“埃菲尔优秀奖学金”

代表性论文 (# Equal Contribution)

1. Wei, A.#, Zhao, A. #, Zheng, C. #, Dong, N. #, Cheng, X., Duan, X., Zhong, S., Liu, X., Jian, J., Qin, Y., Yang, Y., Gu, Y., Wang, B., Gooya, N., Huo, J., Yao, J., Li, W., Huang, K., Liu, H., Mao, F., … Wang, C. (2025). Sexually dimorphic dopaminergic circuits determine sex preference. Science (New York, N.Y.), 387(6730), eadq7001.  https://doi.org/10.1126/science.adq7001

           Free-access reprint link: https://www.science.org/stoken/author-tokens/ST-2350/full  

          Recommended by Science (Circuits for switching social preference) 

         Highlighted in Science (Bitna Joo1 and Kay Tye, Stress drives a switch in sex preference, Science, 2025, 387(6730), 138-9).

2. Song, Q. #, Wei, A. #, Xu, H. #, Gu, Y. #, Jiang, Y., Dong, N., Zheng, C., Wang, Q., Gao, M., Sun, S., Duan, X., Chen, Y., Wang, B., Huo, J., Yao, J., Wu, H., Li, H., Wu, X., Jing, Z., Liu, X., … Wang, C. (2024). An ACC-VTA-ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences. Nature neuroscience, 27(2), 272–285. https://doi.org/10.1038/s41593-023-01519-w

           Featured article in Nature Neuroscience. Web of Science高被引论文，被中国生物物理学会推荐2024年度“中国生命科学十大进展

4. Chen, Y. #, Gu, Y. #, Wang, B. #, Wei, A. #, Dong, N., Jiang, Y., Liu, X., Zhu, L., Zhu, F., Tan, T., Jing, Z., Mao, F., Zhang, Y., Yao, J., Yang, Y., Wang, H., Wu, H., Li, H., Zheng, C., Duan, X., … Wang, C. (2024). Synaptotagmin-11 deficiency mediates schizophrenia-like behaviors in mice via dopamine over-transmission. Nature communications, 15(1), 10571. https://doi.org/10.1038/s41467-024-54604-4
5. Dong, N. #, Xie, Z. #, Wei, A. #, Yang, Y., Deng, Y., Cheng, X., Wang, B., Chen, Y., Gu, Y., Yao, J., Qin, Y., Zheng, C., Zhang, X., Zhang, Y., Kang, X., Chen, G., Qu, Q., Wang, C., & Xu, H. (2025). Compensatory synaptotagmin-11 expression conceals parkinson's disease-like phenotypes in parkin knockout mice. Cell communication and signaling : CCS, 23(1), 61. https://doi.org/10.1186/s12964-025-02037-x
6. Chen, Y., Hu, S., Wu, X., Xie, Z., Wang, Y., Wang, B., Li, X., Pei, Y., Gu, Y., Huang, K., Huo, J., Wei, A., Bi, C., Lu, Z., Song, Q., Xu, H., Kang, X., Shao, S., Long, J., Liu, J., … Wang, C. (2022). Synaptotagmin-1 is a bidirectional Ca²⁺ sensor for neuronal endocytosis. Proceedings of the National Academy of Sciences of the United States of America, 119(20), e2111051119. https://doi.org/10.1073/pnas.2111051119
7. Zhang, X., Li, N., Zhang, J., Zhang, Y., Yang, X., Luo, Y., Zhang, B., Xu, Z., Zhu, Z., Yang, X., Yan, Y., Lin, B., Wang, S., Chen, D., Ye, C., Ding, Y., Lou, M., Wu, Q., Hou, Z., Zhang, K., Liang, Z., Wei, A., Wang, B., Jiang, N., Zhang, W., Xiao, G., Ma, C., Ren, Y., Qi, X., Han, W., Wang, C., Rao, F. (2021). 5-IP₇ is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis. Nature metabolism, 3(10), 1400–1414. https://doi.org/10.1038/s42255-021-00468-7
8. Hu, S., Xie, Z., Wang, B., Chen, Y., Jing, Z., Hao, Y., Yao, J., Wu, X., Huo, J., Wei, A., Qin, Y., Dong, N., Zheng, C., Song, Q., Long, J., Kang, X., Wang, C., & Xu, H. (2024). STED Imaging of Vesicular Endocytosis in the Synapse. Neuroscience bulletin, 40(9), 1379–1395. https://doi.org/10.1007/s12264-024-01254-7