科学研究 - 吴 莹
Paper Name | Astrocyte and ions metabolism during epileptogenesis: A review for modeling studies |
Author | Meng-Meng Du(独盟盟), Jia-Jia Li(李佳佳), Zhi-Xuan Yuan(袁治轩), Yong-Chen Fan(范永晨), Ying |
Publication/Completion Time | 2020-01-09 |
Magazine Name | Chin. Phys. B |
Vol | |
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Paper description | As a large group of cells in a central nervous system, astrocytes have a great influence on ion and energy metabolism in a nervous system. Disorders of neuronal ion and energy metabolism caused by impaired astrocytes play a key role in the pathogenesis of epilepsy. This paper reviews the existing computational models of epileptogenesis resulting from im- paired astrocytes and presents several open perspectives with regard to ion and energy metabolism-induced epileptogenesis in a neuron-astrocyte-capillary coupled model. |