| 论文简介 |
The brain requires diverse segregated and integrated processing to perform normal functions in terms of
anatomical structure and self-organized dynamics with critical features, but the fundamental relationships
between the complex structural connectome, critical state, and functional diversity remain unknown.
Herein, we extend the eigenmode analysis to investigate the joint contribution of hierarchical modular
structural organization and critical state to brain functional diversity. We show that the structural modes
inherent to the hierarchical modular structural connectome allow a nested functional segregation and
integration across multiple spatiotemporal scales. The real brain hierarchical modular organization
provides large structural capacity for diverse functional interactions, which are generated by sequentially
activating and recruiting the hierarchical connectome modes, and the critical state can best explore the
capacity to maximize the functional diversity. Our results reveal structural and dynamical mechanisms that
jointly support a balanced segregated and integrated brain processing with diverse functional interactions,
and they also shed light on dysfunctional segregation and integration in neurodegenerative diseases and
neuropsychiatric disorders. |
(创新港)
