基本信息

      辛静    博士，副教授，硕导

主要在智能精准光学诊断和治疗研究领域，围绕癌症等影响人民生命健康的重大疾病,针对难以实现早期诊断，缺乏有效的治疗方法等瓶颈问题，基于光学分子影像，光热光动力微创治疗方法以及人工智能算法，研究疾病的发生发展治疗机制，探究智能化精准光学诊疗方法，开发智能化光学诊疗量化评估方法，以期实现重大疾病的精准早期诊断和高效特异性治疗。主持国家自然科学基金青年基金和面上基金各一项，博士后基金面上资助和特别资助三项，陕西省科学基金一般项目一项，在Cancer Letters, Bioconjugate chemistry, International journal of nanomedicine，ACS Applied Materials & Interfaces等权威期刊发表SCI论文多篇，获得授权专利2项。

工作经历

2015.1-2018.7    西安交通大学    生命科学技术学院     博士后

2018.7-2022.7    西安交通大学    生命科学技术学院     助理教授

2019.9-2020.9    达特茅斯学院    Thayer school of Engineering 访问学者

2022.7-至今        西安交通大学    生命科学技术学院      副教授

联系方式

电话 ：+86 - 13759934879

邮箱 ：xinjing@mail.xjtu.edu.cn

研究领域

智能化精准光学诊疗方法

智能化光学诊疗量化评估

在研项目

(1) 国家自然科学基金委员会, 面上项目, 61975160, 高光谱成像引导下的精准“光动力/乏氧靶向”多模
诊疗方法在转移性胃癌中的应用研究, 2020-01-01 至 2023-12-31, 63万元, 在研, 主持
(2) 国家自然科学基金委员会, 面上项目, 61875159, 空气微生物快速采样-实时检测一体化技术研究, 20
19-01-01 至 2022-12-31, 63万元, 在研, 参与
(3) 国家自然科学基金委员会, 国家重大科研仪器研制项目, 61727823, 基于波前整形的高光谱成像引导
的肿瘤光热/光动力双模治疗手术系统, 2018-01-01 至 2022-12-31, 780万元, 在研, 参与

 

研究成果

Jing Xin, Lei Fu, Jing Wang, Sijia Wang, Luwei Zhang, Zhenxi Zhang, Cuiping Yao; Influence of Parameters on the Death Pathway of Gastric Cells Induced by Gold Nanosphere Mediated Phototherapy,Nanomaterials, 2022, 12,646.

Jing Xin, Sijia Wang, Jing Wang, Lei Fu, Zhenxi Zhang, Cuiping Yao; A Nucleus-Targeted Nanosystem Integrated with Photodynamic Therapy and Chemotherapy, Journal of Biomedical Nanotechnology, 2022, 18,1-12.

Liu Huifang; Yao Cuiping; Zhang Luwei; Xin Jing; Zhang Zhenxi; Wang Sijia; Nanoliposomes co-encapsulating Ce6 and SB3CT against the proliferation and metastasis of melanoma with the integration of photodynamic therapy and NKG2D-related immunotherapy on A375 cells, Nanotechnology, 2021, 32(45): 0-455102.

Wang Sijia; Liu Huifan; Xin Jing; Rahmanzadeh Ramtin; Wang Jing; Yao Cuiping; Zhang Zhenxi ; Chlorin-Based Photoactivable Galectin-3-Inhibitor Nanoliposome for Enhanced Photodynamic Therapy and NK Cell-Related Immunity in Melanoma, ACS Applied Materials & Interfaces, 2019, 11(45): 41829-41841.

Xin Jing; Wang Sijia; Wang Bing; Wang Jiazhuang; Wang Jing; Zhang Luwei; Xin Bo; Shen Lijian; Zhang Zhenxi; Yao Cuiping ; AlPcS4-PDT for gastric cancer therapy using gold nanorod, cationic liposome, and Pluronic®F127 nanomicellar drug carriers, International journal of nanomedicine,2018, 13: 2017-2036.
Xin Jing; Wang Senhao; Zhang Luwei; Xin Bo; He Yulu; Wang Jing; Wang Sijia; Shen Lijian; Zhang Zhenxi; Yao Cuiping ; Comparison of the synergistic anticancer activity of AlPcS4 photodynamic therapy in combination with different low dose chemotherapeutic agents on gastric cancer cells., Oncology Reports, 2018, 40(1): 165-178.
Xin Jing; Wang Sijia; Wang Jing; Wang Jiazhuang; Fu Lei; Zhang Luwei; Shen, Lijian Zhang, Zhenxi; Yao Cuiping ; Nanosystem Integrated with Photosensitizer and Novel Targeting Chemotherapy Agent for Gastric Cancer Chemo-Photodynamic Combined Therapy, Journal of Biomedical Nanotechnology, 2018, 14(8D): 1430-1447.

Sijia Wang, Jing Xin, Luwei Zhang, Yicheng Zhou, Cuiping Yao, Bing Wang, Jing Wang, Zhenxi Zhang，Cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells，International Journal of Nanomedicine(13)2143-2160，2018-04-10.

Zhang L, Xia L, Zhao L, Chen Z, Shang X, Xin J, Liu M, Guo X, Wu K, Pan Y, Fan D*. Activating of PAX3-MET pathways due to miR-206 loss promotes gastric cancer metsstasis. Carcinogenesis 2015;36(3):390-399.
Wang J，Cai X，Xia L，Zhou J，Xin J，Liu M，Shang X，Liu J，Li X，Chen Z, Nie Y, Fan D*. Decreased expression of FOXJ1 is a potential prognositic predictor for progression and poor survival of gastric cancer. Ann Surg Oncol 2015;22(2):685-692.

He YL,Wang S, Zhang L, Xin J, Yao C, Zhang Z*, Yang CC. Sensitized TiO2 nanocomposities through HMME linkage for photodynamic effects. J Biomed Opt 2016;21(12):128001.
Yao C, Zhang L, Wang J, He Y, Xin J, Wang S, Xu H, and Zhenxi Zhang*. Gold Nanoparticle Mediated Phototherapy for Cancer. Journal of Nanomaterials Volume 2016 (2016), Article ID 5497136, 29 pages

Xin J, Zhang X, Liang J, Xia L, Yin J, Nie Y, Wu K, Tian J*, In vivo gastric cancer targeting and imaging using novel symmetric cyanine dye-conjugated GX1 peptide probes, Bioconjugate chem 2013;24(7):1134-1143.
Xin J, Zhan Y, Liu M, Hu H, Xia L, Nie Y, Wu K, Liang J, and Tian J*. ApoG2 induces ER stress-dependent apoptosis in gastric cancer cells in vitro and its real-time evaluation by bioluminescence imaging in vivo. Cancer Lett 2013;336(2):260-269.
Xin J, Zhan Y, Xia L, Zhu H, Nie Y, Liang J, and Tian J*. ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells. Biomed Pharmacother 2013;67(1):88-95.

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