基本信息

 Jing Xin    Associate Professor

    辛静博士，西安交通大学生命科学技术学院副教授，硕士生导师。主要在智能精准光学诊断和治疗研究领域，围绕癌症等影响人民生命健康的重大疾病难以实现早期诊断，缺乏有效的治疗方法等瓶颈问题，基于光学分子影像和光热光动力微创治疗方法，研究疾病的发生发展治疗机制，以期实现重大疾病的精准早期诊断和高效特异性治疗。主持国家自然科学基金青年基金和面上基金三项，博士后基金面上资助和特别资助三项，陕西省科学基金一般项目一项，以第一作者在Cancer Letters, Bioconjugate chemistry, International journal of nanomedicine等国际期刊发表SCI论文10余篇，以共同作者在ACS Applied Materials & Interfaces等权威期刊发表SCI论文多篇，获得授权专利2项。担任中国医学学会生物医学光子学专业委员会青年委员。

Jing Xin is Associate Professor at the Institute of Biomedical Photonics and Sensors, Xi’an Jiaotong University. She was a visiting scientist at the University of Dartmouth, U.S.A. in 2019-2020 with collaboration of Prof. Dr. Brian W. Pogue. She has been awarded three the National Natural Science Foundation of China (NSFC) funded research programs and published more than 12 papers in the area. Currently, her research interests are nanomaterials mediated photodynamic therapy  and precise optical imaging for disease diagnosis and therapy.

 

工作经历

2015.1-2018.7    Xi'an Jiaotong University    School of Life Science and Technology     post-doctor

2018.7-2022.7    Xi'an Jiaotong University    School of Life Science and Technology     Assistant professor

2019.9-2020.9    The University of Dartmouth    Thayer school of Engineering          visiting scientist

2022.7-up date   Xi'an Jiaotong University    School of Life Science and Technology     Associate Professor

联系方式

Phone：+86 - 13759934879

Email：xinjing@mail.xjtu.edu.cn

研究领域

Pattern Recognition and Intelligent System

 

Precise optical imaging for disease diagnosis and therapy

 

Nanomaterials mediated photodynamic therapy  

 

 

在研项目

     Application of precise synergistic therapy of “Targeted gas photodynamic therapy" guided by hyperspectral and photoacoustic laparoscope in advanced gastric cancer, National Natural Science Foundation of China, 2025/01/01-2028/01/01, No.62475213;

 

研究成果

Jing Xin, Lei Fu, Jing Wang, Sijia Wang, Luwei Zhang, Zhenxi Zhang, Cuiping Yao; Influence of Parameters on the Death Pathway of Gastric Cells Induced by Gold Nanosphere Mediated Phototherapy,Nanomaterials, 2022, 12,646.

Jing Xin, Sijia Wang, Jing Wang, Lei Fu, Zhenxi Zhang, Cuiping Yao; A Nucleus-Targeted Nanosystem Integrated with Photodynamic Therapy and Chemotherapy, Journal of Biomedical Nanotechnology, 2022, 18,1-12.

Liu Huifang; Yao Cuiping; Zhang Luwei; Xin Jing; Zhang Zhenxi; Wang Sijia; Nanoliposomes co-encapsulating Ce6 and SB3CT against the proliferation and metastasis of melanoma with the integration of photodynamic therapy and NKG2D-related immunotherapy on A375 cells, Nanotechnology, 2021, 32(45): 0-455102.

Wang Sijia; Liu Huifan; Xin Jing; Rahmanzadeh Ramtin; Wang Jing; Yao Cuiping; Zhang Zhenxi ; Chlorin-Based Photoactivable Galectin-3-Inhibitor Nanoliposome for Enhanced Photodynamic Therapy and NK Cell-Related Immunity in Melanoma, ACS Applied Materials & Interfaces, 2019, 11(45): 41829-41841.

Xin Jing; Wang Sijia; Wang Bing; Wang Jiazhuang; Wang Jing; Zhang Luwei; Xin Bo; Shen Lijian; Zhang Zhenxi; Yao Cuiping ; AlPcS4-PDT for gastric cancer therapy using gold nanorod, cationic liposome, and Pluronic®F127 nanomicellar drug carriers, International journal of nanomedicine,2018, 13: 2017-2036.
Xin Jing; Wang Senhao; Zhang Luwei; Xin Bo; He Yulu; Wang Jing; Wang Sijia; Shen Lijian; Zhang Zhenxi; Yao Cuiping ; Comparison of the synergistic anticancer activity of AlPcS4 photodynamic therapy in combination with different low dose chemotherapeutic agents on gastric cancer cells., Oncology Reports, 2018, 40(1): 165-178.
Xin Jing; Wang Sijia; Wang Jing; Wang Jiazhuang; Fu Lei; Zhang Luwei; Shen, Lijian Zhang, Zhenxi; Yao Cuiping ; Nanosystem Integrated with Photosensitizer and Novel Targeting Chemotherapy Agent for Gastric Cancer Chemo-Photodynamic Combined Therapy, Journal of Biomedical Nanotechnology, 2018, 14(8D): 1430-1447.

Sijia Wang, Jing Xin, Luwei Zhang, Yicheng Zhou, Cuiping Yao, Bing Wang, Jing Wang, Zhenxi Zhang，Cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells，International Journal of Nanomedicine(13)2143-2160，2018-04-10.

Zhang L, Xia L, Zhao L, Chen Z, Shang X, Xin J, Liu M, Guo X, Wu K, Pan Y, Fan D*. Activating of PAX3-MET pathways due to miR-206 loss promotes gastric cancer metsstasis. Carcinogenesis 2015;36(3):390-399.
Wang J，Cai X，Xia L，Zhou J，Xin J，Liu M，Shang X，Liu J，Li X，Chen Z, Nie Y, Fan D*. Decreased expression of FOXJ1 is a potential prognositic predictor for progression and poor survival of gastric cancer. Ann Surg Oncol 2015;22(2):685-692.

He YL,Wang S, Zhang L, Xin J, Yao C, Zhang Z*, Yang CC. Sensitized TiO2 nanocomposities through HMME linkage for photodynamic effects. J Biomed Opt 2016;21(12):128001.
Yao C, Zhang L, Wang J, He Y, Xin J, Wang S, Xu H, and Zhenxi Zhang*. Gold Nanoparticle Mediated Phototherapy for Cancer. Journal of Nanomaterials Volume 2016 (2016), Article ID 5497136, 29 pages

Xin J, Zhang X, Liang J, Xia L, Yin J, Nie Y, Wu K, Tian J*, In vivo gastric cancer targeting and imaging using novel symmetric cyanine dye-conjugated GX1 peptide probes, Bioconjugate chem 2013;24(7):1134-1143.
Xin J, Zhan Y, Liu M, Hu H, Xia L, Nie Y, Wu K, Liang J, and Tian J*. ApoG2 induces ER stress-dependent apoptosis in gastric cancer cells in vitro and its real-time evaluation by bioluminescence imaging in vivo. Cancer Lett 2013;336(2):260-269.
Xin J, Zhan Y, Xia L, Zhu H, Nie Y, Liang J, and Tian J*. ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells. Biomed Pharmacother 2013;67(1):88-95.

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