| 论文标题 |
A monocrystal graphene domain biosensor array with differential output for real-time monitoring of glucose and normal saline |
| 作者 |
Junjie Shi, Xin Li,Chen,Gao,Song, Guo,Li,Fang,Liu,Liu,Xiaoli Wang |
| 发表/完成日期 |
2015-07-20 |
| 期刊名称 |
Nanoscale(SCI) |
| 期卷 |
2015, 7, 7867 |
| 相关文章 |
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| 论文简介 |
A monocrystal graphene domain biosensor array with differential output for real-time monitoring of glucose and normal saline
A biosensor array with differential output based on a monocrystal graphene domain is proposed to realize
high resolution measurements. The differential output structure can eliminate the noise that comes from
graphene crystal orientation and grain boundary, as well as the fluctuation that comes from the contact
resistance and experiment process, so as to improve resolution in the lower concentration. We have fabri-
cated a high quality monocrystal graphene domain that has millimeter size by the chemical vapor depo-
sition method. Two identical graphene ribbons that are cut from the same domain are used as field effect
transistor source-to-drain channels for the reference and the test of differential output, respectively. The
experimental results show that the source-to-drain current has a fast response shorter than 0.5 second in
glucose, normal saline and pH buffer solutions of different concentrations. Sensitivity increases exponen-
tially with the increase of concentration of the tested liquid and the high resolution range is 0.01–2 wt%
in glucose and 0.0009–0.018 wt% in saline, and the highest resolutions of glucose and saline are 0.01 wt%
and 0.0009 wt%, respectively. We have fabricated a 1 × 4 array structure with differential outputs that pave
the way for rapidly detecting ultra-low concentration of analytes. |
(创新港)
