温玉荣 博士 研究员
博士研究生导师
西安交通大学医学部
Email: Yurong.Wen@xjtu.edu.cn
Yurong.Wen@hotmail.com
工作经历:
2019- 至今 西安交通大学医学部 教授、 研究员/博士生导师
2018-2019 加拿大阿尔伯塔大学 访问学者/博士后
2017-2019 西安交通大学生命学院 副教授/硕士生导师
2017 清华大学生命学院 访问学者
2014-2017 西安交通大学生命学院 讲师
学习经历:
2010-2014 比利时根特大学 生物化学与生物技术博士
2008-2010 西安交通大学医学部 生物化学与分子生物学硕士
2004-2008 西安交通大学生命学院 生物工程学士
Project number | Project name | Project origin | Start time | Roles | Project kind |
---|---|---|---|---|---|
2023-JC-JQ- 63 | 陕西省杰出青年科学基金 | 陕西省科技厅 | 2023-01~- | 负责人 | Vertical project |
22HWYZ0040 | 纳米抗体创新生物医药研发 | 西安市引进海外高层次人才智力项目 | 2022-01~- | 负责人 | Vertical project |
KSJRC202205 | 陕西省“特支计划”青年拔尖人才 | 陕西省委组织部 | 2022-01~- | 负责人 | Vertical project |
82072237 | 鲍曼不动杆菌转录调控元件毒力因子的作用机制研究 | 国家自然科学基金项目 | 2021-1~ | 负责人 | Vertical project |
1100011046 | 肠道微生物与宿主相互作用 | 其他 | 2020-1~ | 负责人 | Vertical project |
2020JQ-084 | 金黄色葡萄球菌ArlRS二元调控系统的分子机制研究 | 陕西省自然科学基金 | 2020-1~ | 负责人 | Vertical project |
xzd012020056 | 多重耐药细菌的感染和耐药分子机制研究 | 重大项目培育项目 | 2020-12~- | 负责人 | Vertical project |
31870132 | 多重耐药鲍曼不动杆菌RND家族药物外排泵的结构与调控机制研究 | 国家自然科学基金项目 | 2019-1~ | 负责人 | Vertical project |
81741088 | 二元调控系统介导新生儿严重细菌感染毒素分泌和多重耐药的分子机制研究 | 国家自然科学基金项目 | 2018-1~ | 负责人 | Vertical project |
81772745 | 基于PSMA和TIM3的双特异性纳米抗体在前列腺癌的应用研究 | 国家自然科学基金项目 | 2018-1~ | 骨干成员 | Vertical project |
31771557 | RAF小分子抑制剂在BRAF突变黑色素瘤细胞中诱导ERBB3转录表达的机制研究 | 国家自然科学基金项目 | 2018-1~ | 骨干成员 | Vertical project |
31500051 | 分子伴侣CsgE/CsgF调控Curli分泌和组装的结构和功能研究 | 国家自然科学基金项目 | 2016-1~2018-12 | 负责人 | Vertical project |
XJJ2015056 | 肿瘤调控中信号通路交互作用的分子机制及其在抗肿瘤药物研发中的应用研究 | 中央高校基本科研业务费 | 2016-1~2018-12 | 负责人 | Vertical project |
2017T100738 | 多重耐药鲍曼不动杆菌二元调控系统的结构和功能研究 | 中国博士后特别资助 | 2016-1~2017-12 | 负责人 | Vertical project |
留学回国08 | 以抗肿瘤药物研发为导向的β-Catenin和YAP在肿瘤调控信号通路交互作用中的分子机制研究 | 教育部留学回国基金 | 2015-1~2017-12 | 负责人 | Vertical project |
2015M572545 | β-Catenin和YAP在肿瘤调控信号通路交互作用的分子机制研究 | 中国博士后基金面上项目 | 2015-1~2017-10 | 负责人 | Vertical project |
2014046 | 抗感染和抗肿瘤的一体化结构生物学研究 | 西安交通大学新教师支持计划 | 2014-9~2017-10 | 负责人 | Vertical project |
(36) Ting Yu#, Fang Zheng#, Wenbo He, Serge Muyldermans, Yurong Wen*. (2024) Single Domain Antibody: Development and Application in Biotechnology and Biopharma. Immunological Reviews. DOI: 10.1111/imr.13381. (IF: 10.7, 通讯作者)
(35) Wenbo He #, Ke Wu #, Zhenlin Ouyang, Yixin Bai, Wen Luo, Di Wu, Hao An, Yucheng Guo, Min Jiao, Qian Qin, Jiaxin Zhang, Yi Wu, Junjun She, Peter M. Hwang, Fang Zheng, Li Zhu*, Yurong Wen*. (2023) Structure and Assembly of Type VI secretion system cargo delivery vehicle. Cell Reports. 42. 112781. (Cell 子刊,IF: 9.995, 通讯作者)
(34) Min Jiao, Wenbo He, Zhenlin Ouyang, Qian Qin, Yucheng Guo, Jiaxin Zhang, Yixin Bai, Xiaolong Guo, Qinyue Yu, Junjun She, Peter M. Hwang, Fang Zheng, Yurong Wen*. (2023) Mechanistic and Structural insights into the bifunctional enzyme PaaY from Acinetobacter baumannii. Structure. 31. 935-947. (Cell 子刊,通讯作者)
(33) Yi Shen*, Yurong Wen, Silvia Sposini, Anjali Amrapali Vishwanath, Ahmed S. Abdelfattah, Eric R. Schreiter, M. Joanne Lemieux, Jaime de Juan-Sanz, David Perrais, Robert E. Campbell*. (2023). Rational Engineering of an Improved Genetically Encoded pH Sensor Based on Superecliptic pHluorin. ACS Sensors. 8. 3014-3022. (IF: 8.9)
(32) Yucheng Guo†, Zhenlin Ouyang†, Wenbo He, Jiaxin Zhang, Qian Qin, Min Jiao, Serge Muyldermans, Fang Zheng*, Yurong Wen*. (2023) Screening and Epitope Characterization of Diagnostic Nanobody against Total and Activated Bacteroides fragilis Toxin. Frontiers in Immunology. 14: 1065274. (IF: 8.786, 通讯作者)
(31) Sheng-Yi Wu, Yurong Wen, Nelson B. C. Serre, Cathrine Charlotte Heiede Laursen, Andrea Grostøl Dietz, Brian R. Taylor, Mikhail Drobizhev, Rosana S. Molina, Abhi Aggarwal, Vladimir Rancic, Michael Becker, Klaus Ballanyi, Kaspar Podgorski, Hajime Hirase, Maiken Nedergaard, Matya´sˇ Fendrych, M. Joanne Lemieux, Daniel F. Eberl1, Alan R. Kay, Robert E. Campbell*, Yi Shen*. (2022) A sensitive and specific genetically encoded potassium ion biosensor for in vivo applications across the tree of life. Plos Biology. 20(9):e3001772. (IF: 9.65)
(30) Qian Qin, Hao Liu, Wenbo He, Yucheng Guo, Jiaxin Zhang, Junjun She, Fang Zheng, Sicai Zhang, Serge Muyldermans, Yurong Wen*. (2022) Single Domain Antibody application in Bacterial Infection Diagnosis and Neutralization. Front. Immunol. 13:1014377. (IF: 8.786, 通讯作者)
(29) Min Jiao, Wenbo He, Zhenlin Ouyang, Qindong Shi and Yurong Wen *. (2022) Progress in structural and functional study of the bacterial phenylacetic acid catabolic pathway, its role in pathogenicity and antibiotic resistance. Frontiers in Microbiology. 13:964019. (IF: 6.1, 通讯作者)
(28) Lei Han, Yiyuan Gao, Yuqing Liu, Siyu Yao, Shuyan Zhong, Sirui Zhang, Jingdan Wang, Peng Mi, Yurong Wen, Zhenlin Ouyang, Jing Zhang, Mona Mohamed Al-Shamiri, Pu Li, Shaoshan Han. (2022) An Outer Membrane Protein YiaD Contributes to Adaptive Resistance of Meropenem in Acinetobacter baumannii. Microbiology Spectrum. 10 (2): e00173-22. (IF: 9.3)
(27) Yunhua Peng, Jing Liu, Zhen Wang, Chunping Cui, Tiantian Zhang, Shuangxi Zhang, Peipei Gao, Zhanwu Hou, Huadong Liu, Jianping Gao, Jinfang Zhang, Yurong Wen, Wenyi Wei, Lingqiang Zhang, Jiankang Liu, Jiangang Long. (2022) Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc. Cell Death & Differentiation.29:1730-1743. (IF: 15.8)
(26) Yusuke Nasu, Ciaran Murphy-Royal, Yurong Wen, Jordan Haidey, Anne Schohl, Marion R. Van Horn, M. Rosana S. Molina, Abhi Aggarwal, Shuce Zhang, Yuki Kamijo, Kaspar Podgorski, Mikhail Drobizhev, Edward S. Ruthazer, Jaideep S. Bains, M. Joanne Lemieux, Grant R. Gordon, Robert E. Campbell*. (2021) A genetically encoded fluorescent biosensor for extracellular L-lactate. Nature Communications. 12: 7058. (IF: 14.9, Nature 子刊)
(25) Zhe Zhi, Zhenlin Ouyang, Yibo Ren, Ying Cheng, Peijun Liu , Yurong Wen and Yongping Shao. (2022) Non-canonical phosphorylation of Bmf by p38 MAPK promotes its apoptotic activity in anoikis. Cell Death & Differentiation. 29: 323-336. (IF: 15.8)
(24) Xiaocen Lu, Yurong Wen#, Shuce Zhang#, Wei Zhang, Yilun Chen, Yi Shen, M. Joanne Lemieux, Robert E. Campbell. (2021) Photocleavable Proteins that Undergo Fast and Efficient Dissociation. Chemical Science.12: 9658-9672. (IF: 9.825, # Contributed Equally, Chemical Science HOT article)
(23) Zhenlin Ouyang#, Fang Zheng#, Li Zhu#, Jan Felix, Di Wu, Ke Wu, Irina Gutsche, Yi Wu, Peter M Hwang, Junjun She*, Yurong Wen*.(2021)Proteolysis and multimerization regulate signaling along the two-component regulatory system AdeRS. iScience. 24(5): 102476. (Cell子刊, IF: 5.5, 通讯作者)
(22) Fang Zheng, Jinhong Zhou, Zhenlin Ouyang, Jiaxin Zhang, Xinyi Wang, Serge Muyldermans, Jo Van Ginderachter, Nick Devoogdt, Yurong Wen*, Steve Schoonooghe* and Geert Raes*. (2021) Development and characterization of nanobodies targeting the Kupffer cell. Frontiers in Immunology 12 : 641819. (IF:7.56, 通讯作者)
(21) Kai Lucaßen, K. Xanthopoulou, J. Wille, T. Wille, Yurong Wen, Xiaoting Hua, H. Seifert, Paul G. Higgins*. (2021) Characterization of amino acid substitutions in the two-component regulatory systemAdeRS identified in multi-drug resistant Acinetobacter baumannii. mSphere. 6(6). e00709-21. (IF: 4.4)
(20) Yufeng Zhao, Yi Shen, Yurong Wen*, and R.E. Campbell*. (2020) High performance intensiometric direct- and inverse-response genetically encoded biosensors for citrate. ACS Central Science. 6. 1441-1450. (IF: 12.685, 通讯作者)
(19) Yibo Ren, Zhenlin Ouyang, Zhanwu Hou, Yuwei Yan, Zhe Zhi, Mengjin Shi, Mengtao Du, Huadong Liu, Yurong Wen*, Yongping Shao*. (2020) CIC is a mediator of the ERK1/2-DUSP6 negative feedback loop. iScience. 23(11): 101635. https://doi.org/10.1016/j.isci.2020.101635 (Cell 子刊, IF: 5.5, 通讯作者)
(18) Zhenlin Ouyang#, Fang Zheng#, Yingmei Pei, Jinhong Zhou, Keqing Wen, Miao Han, Peter M. Hwang, M. Joanne Lemieux, Yurong Wen*. (2019) Deciphering the activation and recognition mechanisms of Staphylococcus aureus response regulator ArlR. Nucleic Acids Research. 47(21):11418-11429.(IF: 16.96, 通讯作者)
(17) Zhenlin Ouyang, Jan Felix, Jinhong Zhou, Yingmei Pei, Peter M Hwang, M Joanne Lemieux, Irina Gutsche, Fang Zheng, Yurong Wen*. (2020) Trimeric structure of Kupffer cell C-type lectin receptor Clec4f. FEBS Letters. 594 (1):189-198(IF: 3.1, 通讯作者)
(16) Qingye Xu, Xiaoting Hua, Jintao He, Di Zhang, Qiong Chen, Linghong Zhang, Belinda Loh, Sebastian Leptihn, Yurong Wen, Higgins Paul G., Yunsong Yu, Zhihui Zhou*. (2020) The distribution of mutations and hotspots in transcription regulators of resistance-nodulation-cell division efflux pumps in tigecycline non-susceptible Acinetobacter baumannii in China. International Journal of Medical Microbiology. 310 (8): 151464. (IF: 3.4)
(15) Yurong Wen#,*, Zhenlin Ouyang#, Yue Yu, Xiaorong Zhou, Yingmei Pei, Bart Devreese, Paul G Higgins, Fang Zheng* (2017). Mechanistic insight into how multidrug resistance Acinetobacter baumannii response regulator AdeR recognize its promoter DNA. Nucleic Acids Research.45(16): 9773-9787. (IF: 16.96, 第一兼通讯作者)
(14) Yurong Wen, Ester Behiels, Jan Felix, Jonathan Elegheert, Bjorn Vergauwen, Bart Devreese*, Savvas Savvides*. (2014). The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence. Nucleic Acids Research. 42(15): 10134-47.(IF: 16.96,第一作者)
(13) Fang Zheng, Siyu Luo, Zhenlin Ouyang, Jinhong Zhou, Huanye Mo, Steve Schoonooghe, Serge Muyldermans, Patrick De Baetselier, Geert Raes*, and Yurong Wen*. (2019) NIRF-Molecular Imaging with Synovial Macrophages-Targeting Vsig4 Nanobody for Disease Monitoring in a Mouse Model of Arthritis. International Journal of Molecular Sciences. 20(13), 3347. (IF: 4.6, 通讯作者)
(12) Yurong Wen#,*, Zhenlin Ouyang#, Bart Devreese, Wangxiao He, Yongping Shao, Wuyuan Lu, Fang Zheng* (2017). Crystal structure of master biofilm regulator CsgD regulatory domain reveals an atypical receiver domain. Protein Science. 26: 2073-2082. (IF: 3.8,第一兼通讯作者)
(11) Yurong Wen*, Zhenlin Ouyang*, Steve Schoonooghe, Siyu Luo, Patrick De Baetselier, Wuyuan Lu, Serge Muyldermans, Geert Raes, Fang Zheng. (2017). Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity. Immunobiology. 222(6): 807-813. (IF: 3.1, 第一作者)
(10) Yurong Wen, Frank Sobott, Bart Devreese. (2016). ATP and autophosphorylation driven conformational changes of HipA kinase revealed by ion mobility and crosslinking mass spectrometry. Analytical and Bioanalytical Chemistry. 408:5925–5933. (IF: 3.4, 第一作者)
(9) Yurong Wen, Ester Behiels, Bart Devreese. (2014). Toxin-Antitoxin systems: their role in persistence, biofilm formation and pathogenicity. Pathogens and Disease. 70(3), 240-249.(IF: 2.5, 第一作者)
(8) Bohan Ma, Fan Niu, Xiaoyan Qu, Wangxiao He, Chao Feng, Simeng Wang,Zhenlin Ouyang, Jin Yan, Yurong Wen, Dan Xu, Yongping Shao, Peter X. Ma,Wuyuan Lu. (2019) A tetrameric protein scaffold as a nano-carrier of antitumor peptides for cancer therapy. Biomaterials. 204, 1-12. (IF: 10.3)
(7) Gerson Stefanie; Nowak Jennifer; Zander Esther; Ertel Julia; Wen Yurong; Krut Oleg; Seifert Harald; Higgins Paul. (2018) Diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with tigecycline resistance in Acinetobacter baumannii. Journal of Antimicrobial Chemotherapy. 73(6): 1501-1508. (IF: 5.2)
(6) Fan Fan; Lei Lei Wang; Zhenlin Ouyang; Yurong Wen; Xiao Yun Lu. (2018) Development and optimization of a tumour targeting system based on microbial synthesized PHA biopolymers and PhaP mediated functional modification. Applied Microbiology and Biotechnology. 102(7): 3229-3241. (. IF: 3.4)
(5) Monica X. Li, Shorena Gelozia, Gaddafi I. Danmaliki, Yurong Wen, Philip B. Liu, M. Joanne Lemieux, Frederick G. West, Brian D. Sykes, and Peter M. Hwang*. (2018) The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C. Biochemistry and Biophysics Report. 16: 145-151.
(4) Fang Zheng , Harris Perlman , Patrick Matthys,Yurong Wen, Tony Lahoutte, Serge Muyldermans , Shemin Lu , Patrick De Baetselier, Steve Schoonooghe, Nick Devoogdt, Geert Raes. (2016). Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies. Scientific Reports. 6:35966 (IF: 5.2)
(3) Johan Desmet#, Kenneth Verstraete#, Yehudi Bloch, Eric Lorent, Yurong Wen, Bart Devreese, Karen Vandenbroucke, Stefan Loverix, Thore Hettmann, Sabrina Deroo, Klaartje Somers, Paula Henderikx, Ignace Lasters*, Savvas Savvides*. (2014) Structural basis of IL-23 antagonism by an AlphabodyTMprotein scaffold. Nature Communications. 5: 5237. (IF: 12.4)
(2) Ruben Van der Meeren, Yurong Wen, Patrick Van Gelder, Jan Tommassen, Bart Devreese, and Savvas N Savvides. (2013).New insights into the assembly of bacterial secretins: structural studies of the periplasmic domain of XcpQ from Pseudomonas aeruginosa. Journal of Biological Chemistry, 288(2): 1214–25. (IF: 4.6)
(1) Jan Felix, Jonathan Elegheert, Irina Gutsche, Alexander V Shkumatov, Yurong Wen, Nathalie Bracke, Erwin Pannecoucke, Isabel Vandenberghe, Bart Devreese, Dmitri I Svergun, Ewald Pauwels, Bjorn Vergauwen, Savvas N Savvides. (2013). Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor. Structure, 21, 528–539. (IF: 5.2)
Patent Name | Application Number | xjtu.gr.patent.type | Application Date |
---|---|---|---|
一种Clec4F纳米抗体及其应用 | ZL201611047459.2 | Invention | 2016.11.23 |
一种Vsig4纳米抗体及其抗原表位鉴定方法和应用 | ZL201610601325.4 | Invention | 2016.07.27 |