Basic Information

 

         Dr. Yurong Wen,  Professor

           Xi'an Jiaotong University

Contact

 

Email:

          Yurong.Wen@xjtu.edu.cn

          Yurong.Wen@hotmail.com

Work Experience

2019/11-present: Professor, Health Science Center, Xi’an Jiaotong University, China

2018/06-2019/06: Visiting Scholar/Postdoctoral fellow, University of Alberta, Canada

2017/09-2019/12: Associate professor, Xi’an Jiaotong University, China

2017/09-2017/12: Visiting Scholar, Tsinghua University, China

2014/09-2017/9: Lecturer/Assistant professor, Xi’an Jiaotong University, China

 

Education

2010/03-2014/03: Ph.D. in Biochemistry and Biotechnology, Ghent University, Belgium.

Supervisor: Prof. Savvas N. Savvides and Prof. Bart Devreese

2008/09-2010/02: Master in Biochemistry, Xi’an Jiaotong University

2004/09-2008/07: B.Sc. in Bioengineering, Xi’an Jiaotong University

Publications

       * Corresponding author

 

(22) Zhenlin Ouyang#, Fang Zheng#, Li Zhu#, Jan Felix, Di Wu, Ke Wu, Irina Gutsche, Yi Wu, Peter M Hwang, Junjun She*, Yurong Wen*.(2021)Proteolysis and multimerization regulate signaling along the two-component regulatory system AdeRS. iScience. DOI: https://doi.org/10.1016/j.isci.2021.102476 

(21) Fang Zheng, Jinhong Zhou, Zhenlin Ouyang, Jiaxin Zhang, Xinyi Wang, Serge Muyldermans, Jo Van Ginderachter, Nick Devoogdt, Yurong Wen*, Steve Schoonooghe* and Geert Raes*. (2021) Development and characterization of nanobodies targeting the Kupffer cell. Frontiers in Immunology 12 : 641819. (IF:6.5)

(20) Yibo Ren, Zhenlin Ouyang, Zhanwu Hou, Yuwei Yan, Zhe Zhi, Mengjin Shi, Mengtao Du, Huadong Liu, Yurong Wen*, Yongping Shao*. (2020) CIC is a mediator of the ERK1/2-DUSP6 negative feedback loop. iScience. 23(11): 101635. https://doi.org/10.1016/j.isci.2020.101635

(19) Yufeng Zhao, Yi Shen, Yurong Wen*, and R.E. Campbell*. (2020) High performance intensiometric direct- and inverse-response genetically encoded biosensors for citrate. ACS Central Science. 6. 1441-1450. (IF: 12.685)

(18) Zhenlin Ouyang#, Fang Zheng#, Yingmei Pei, Jinhong Zhou, Keqing Wen, Miao Han, Peter M. Hwang, M. Joanne Lemieux, Yurong Wen*. (2019) Deciphering the activation and recognition mechanisms of Staphylococcus aureus response regulator ArlR. Nucleic Acids Research. 47(21):11418-11429.IF: 11.56

(17)   Zhenlin Ouyang, Jan Felix, Jinhong Zhou, Yingmei Pei, Peter M Hwang, M Joanne Lemieux, Irina Gutsche, Fang Zheng, Yurong Wen*. (2020) Trimeric structure of Kupffer cell C-type lectin receptor Clec4f. FEBS Letters. 594 (1):189-198IF: 3.1

(16) Qingye Xu, Xiaoting Hua, Jintao He, Di Zhang, Qiong Chen, Linghong Zhang, Belinda Loh, Sebastian Leptihn, Yurong Wen, Higgins Paul G., Yunsong Yu, Zhihui Zhou*. (2020) The distribution of mutations and hotspots in transcription regulators of resistance-nodulation-cell division efflux pumps in tigecycline non-susceptible Acinetobacter baumannii in China. International Journal of Medical Microbiology. 310 (8): 151464. (IF: 3.4)

(15)   Yurong Wen#,*, Zhenlin Ouyang#, Yue Yu, Xiaorong Zhou, Yingmei Pei, Bart Devreese, Paul G Higgins, Fang Zheng* (2017). Mechanistic insight into how multidrug resistance Acinetobacter baumannii response regulator AdeR recognize its promoter DNA. Nucleic Acids Research.45(16): 9773-9787. (IF: 11.56)

(14)   Yurong Wen, Ester Behiels, Jan Felix, Jonathan Elegheert, Bjorn Vergauwen, Bart Devreese*, Savvas Savvides*. (2014). The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistenceNucleic Acids Research. 42(15): 10134-47.(IF: 11.56)

(13)   Fang Zheng, Siyu Luo, Zhenlin Ouyang, Jinhong Zhou, Huanye Mo, Steve Schoonooghe, Serge Muyldermans, Patrick De Baetselier, Geert Raes*, and Yurong Wen*. (2019) NIRF-Molecular Imaging with Synovial Macrophages-Targeting Vsig4 Nanobody for Disease Monitoring in a Mouse Model of Arthritis. International Journal of Molecular Sciences. 20(13), 3347. (IF: 4.6)

(12)   Yurong Wen#,*, Zhenlin Ouyang#, Bart Devreese, Wangxiao He, Yongping Shao, Wuyuan Lu, Fang Zheng* (2017). Crystal structure of master biofilm regulator CsgD regulatory domain reveals an atypical receiver domain. Protein Science. 26: 2073-2082. (IF: 3.8)

(11)   Yurong Wen*, Zhenlin Ouyang*, Steve Schoonooghe, Siyu Luo, Patrick De Baetselier, Wuyuan Lu, Serge Muyldermans, Geert Raes, Fang Zheng. (2017). Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity. Immunobiology. 222(6): 807-813. (IF: 3.1)

(10)   Yurong Wen, Frank Sobott, Bart Devreese. (2016). ATP and autophosphorylation driven conformational changes of HipA kinase revealed by ion mobility and crosslinking mass spectrometry. Analytical and Bioanalytical Chemistry. 408:5925–5933. (IF: 3.4)

(9)   Yurong Wen, Ester Behiels, Bart Devreese. (2014). Toxin-Antitoxin systems: their role in persistence, biofilm formation and pathogenicity. Pathogens and Disease. 70(3), 240-249.(IF: 2.5)

(8)    Bohan Ma, Fan Niu, Xiaoyan Qu, Wangxiao He, Chao Feng, Simeng Wang,Zhenlin Ouyang, Jin Yan, Yurong Wen, Dan Xu, Yongping Shao, Peter X. Ma,Wuyuan Lu. (2019) A tetrameric protein scaffold as a nano-carrier of antitumor peptides for cancer therapy. Biomaterials. 204, 1-12. (IF: 10.3)

(7)   Gerson Stefanie; Nowak Jennifer; Zander Esther; Ertel Julia; Wen Yurong; Krut Oleg; Seifert Harald; Higgins Paul. (2018) Diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with tigecycline resistance in Acinetobacter baumannii. Journal of Antimicrobial Chemotherapy. 73(6): 1501-1508. (IF: 5.2)

(6)   Fan Fan; Lei Lei Wang; Zhenlin Ouyang; Yurong Wen; Xiao Yun Lu. (2018) Development and optimization of a tumour targeting system based on microbial synthesized PHA biopolymers and PhaP mediated functional modification. Applied Microbiology and Biotechnology. 102(7): 3229-3241. (. IF: 3.4)

(5)    Monica X. Li, Shorena Gelozia, Gaddafi I. Danmaliki, Yurong Wen, Philip B. Liu, M. Joanne Lemieux, Frederick G. West, Brian D. Sykes, and Peter M. Hwang*. (2018) The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C. Biochemistry and Biophysics Report. 16: 145-151.

(4)    Fang Zheng , Harris Perlman , Patrick Matthys,Yurong Wen, Tony Lahoutte, Serge Muyldermans , Shemin Lu , Patrick De Baetselier, Steve Schoonooghe, Nick Devoogdt, Geert Raes. (2016). Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies. Scientific Reports. 6:35966  (IF: 5.2)

(3)   Johan Desmet#, Kenneth Verstraete#, Yehudi Bloch, Eric Lorent, Yurong Wen, Bart Devreese, Karen Vandenbroucke, Stefan Loverix, Thore Hettmann, Sabrina Deroo, Klaartje Somers, Paula Henderikx, Ignace Lasters*, Savvas Savvides*. (2014) Structural basis of IL-23 antagonism by an AlphabodyTMprotein scaffold. Nature Communications. 5: 5237. (IF: 12.4)

(2)    Ruben Van der Meeren, Yurong Wen, Patrick Van Gelder, Jan Tommassen, Bart Devreese, and Savvas N Savvides. (2013).New insights into the assembly of bacterial secretins: structural studies of the periplasmic domain of XcpQ from Pseudomonas aeruginosaJournal of Biological Chemistry, 288(2): 1214–25. (IF: 4.6)

(1)     Jan Felix, Jonathan Elegheert, Irina Gutsche, Alexander V Shkumatov, Yurong Wen, Nathalie Bracke, Erwin Pannecoucke, Isabel Vandenberghe, Bart Devreese, Dmitri I Svergun, Ewald Pauwels, Bjorn Vergauwen, Savvas N Savvides. (2013). Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor. Structure, 21, 528–539. (IF: 5.2)