基本信息

 

 

                                                                   

张彦民

 

医学博士、教授、博士研究生导师

陕西省天然药物研究与工程重点实验室 主任

陕西省中药绿色制造技术协调创新中心 副主任

西安交通大学药学院血管药物研究所 所长

西安交通大学药学院血管药物研究所支部 书记

 

教育部新世纪优秀人才

陕西省中青年科技创新领军人才

陕西省青年科技新星

陕西省三秦人才

西安交通大学青年拔尖人才(A类)

医学部首批国家级后备菁英人才

西安交通大学创新团队负责人

研究领域

    主要在分析药理学研究领域开展肿瘤相关的药物和生物学机理研究:

 *药物分析

(1)复杂体系药效物质筛选分析

(2)药物作用过程分析 

*肿瘤药理

(1)分子靶向抗肿瘤药物-酪氨酸激酶受体抑制剂研究

(2)肿瘤细胞信号转导通路 

招生信息

人才招聘(长期):热烈欢迎生物学、药理学、药物分析学、分析化学、纳米靶向材料及其相关专业加入课题组。


应聘职位
1. 青年拔尖人才:提供年薪45万(A类,直接聘任为教授、博导);30万(B类,直接聘任为特聘研究员、博导)。

2. 优秀青年人才:提供年薪30万。

以上人才均按照西安交通大学要求安排子女就读西安交通大学幼儿园、附属小学、附属中学等。

3. 博士研究生招生

100704 药物分析学:

      03 药物作用过程分析; 

      12 血管生成抑制剂筛选研究

药理学:肿瘤药物调控机制

硕士研究生招生

100704 药物分析学:

      03 药物作用过程分析; 

      12 血管生成抑制剂筛选研究

考试科目

    参照西安交通大学招生目录

Brief biography

Professor Yanmin Zhang:

 

Dr. Yanmin Zhang is a full professor of School of Pharmacy, Health Science Center, Xi'an Jiaotong University of China. Yanmin Zhang received his B.S. in chemistry and Ph.D. in Pharmacy. He is currently the director of molecular pharmacology program. He has holden more than 20 national and other projects, published 144 papers including Pharmacol Therapeut, Advanced Science, Semin Cancer Bio, Cell Death Dis, J Cell Mol Med, Cancer Lett, Chem Communet al. and holden 29 patents. 

 

Research field of Interest:

Tumor Pharmacology;

Screening and Activity Evaluation of Targeting-Drug

Analysis of drug action process

 

 

Editorial Experience:

Executive Editor of Journal of Pharmaceutical Analysis;

Editorial board member of Oncology Reports, Current Drug Therapy, Pharmaceutical Nanotechnology, Hepatoma Research, et al.

 

研究队伍

   西安交通大学医学部药物研究所分析药理学研究室为陕西省天然药物研究与工程重点实验室和生物与药理研究所依托研究室。

   目前共有研究人员31人,其中教师8人(教授1人,副教授4人、讲师1人,技术员2人),博士后2人,博士留学生3人,在读博士和硕士研究生15人。

       

研究室研究领域

* 抗肿瘤创新药物开发研究;

* 抗肿瘤创新药物生物学功能和作用机制; 

* 血管药物药效学和分子机制研究;

* 肿瘤免疫治疗药物的筛选及药效学研究;

* 肿瘤细胞生物传感分析;

* 膜蛋白受体与药物分子相互作用研究。

 

​​​​​

 

 

联系方式

E-mail:zhang2008@xjtu.edu.cn           

Web:http://gr.xjtu.edu.cn/web/zhang2008

           http://medgs.xjtu.edu.cn/tearch/t_index.php?id=1267

地址:陕西省西安市雁塔西路76号西安交通大学医学校区54号信箱
邮编:710061

 

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个人简介

张彦民 

      

从事抗肿瘤药理、靶向血管药物分析、药物作用过程分析、中药药效物质基础分析等方面的研究工作。在肿瘤血管生成抑制剂药理模型建立和药效物质筛选方面开展了系列研究。自2009年至今在西安交通大学医学部药学院依次任讲师、硕士生导师、副教授、博士生导师、特聘研究员、教授。期间于20156-20168月在美国Arizona State University(任职Assistant Research Scientist)进行访问学习。

        主持国家自然科学基金项目面上项目、青年项目,国家十二五重大新药创制专项,教育部新世纪优秀人才支持计划项目,中央高校基本科研业务费专项资金-青年教师跟踪支持项目,创新团队项目,陕西省自然科学基金,陕西省重点实验室青年学术骨干培植等项目20余项;参加国家重大科研仪器设备研制专项、国家自然科学基金重点、面上项目、西安市重大科技计划等项目的研究工作。

发表论文164篇,其中在Advanced Science, Biomaterials, Seminars in Cancer Biology, Cliniacl and Translational Medicine, Chemical Engineering Journal, Pharmacology & Therapeutics, Journal of the American Chemical SocietyCell Death & Disease, Chemical Communications, Cancer Letters, Pharmacological Research 等杂志上发表SCI论文137篇,总影响因子为731.24,H=26; 申请国际和国家发明专利30项,授权20项。

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       获奖情况

 

2021年获陕西省高等学校科学技术一等奖(R1

2018年获陕西省科学技术二等奖(R1

2012年获国家技术发明二等奖(R6

2020年获陕西省高等学校科学技术二等奖(R4

2010年中国药学会科学技术二等奖(R3

2010年获陕西省优秀博士学位论文

2009年获西安交通大学优秀博士学位论文 

2008年获陕西省高等学校科学技术奖一等奖

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        主要学术任职:

 

杂志编委:

Journal of Pharmaceutical Analysis杂志,Executive Editor 

​​​​​​​​​​​​​​Biosensors 杂志,编委

Oncology Reports 杂志,编委 

Molecular Medicine Reports 杂志编委 

Experimental and Therapeutic Medicine 杂志,编委

Current Drug Therapy 杂志,编委

Hepatoma Research 杂志, 编委

《药物生物技术》杂志,编委

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委员会:

中国抗癌协会抗癌药物专业委员会,常务委员

中国药理学会分析药理专业委员会,  委员

陕西省天然药物学会,  副理事长
​​​​​​​
陕西省性学会医药开发专业委员会, 主任委员

陕西省老年学与老年医学学会药学专业委员会,常务委员

世界中联中药鉴定专业委员会,理事

陕西省药学会药物分析专业委员会,委员

Asia-Pacific Association of Medical Research 会员

受邀担任Advanced Science, Cancer Letters, Journal of Medicinal Chemistry, Acta Pharmaceutica Sinica B, Journal of Experimental & Clinical Cancer Research, Vascular Pharmacology, Phytomedicine,  Biomedicine & Pharmacotherapy, Phytotherapy Research, Cell Proliferation, Analytical Methods, Biomedical Chromatography等国际SCI期刊特邀审稿人。

代表性文章

*2021年*

 

140. Xiaoqian Yu, Qi Su, Xiaowei Chang, Kun Chen, Pingyun Yuan, Tao Liu, Ran Tian, Yongkang Bai, Yanmin Zhang*, Xin Chen*. Multimodal obstruction of tumorigenic energy supply via bionic nanocarriers for effective tumor therapy. Biomaterials, 2021, 278: 121181. (IF=12.479)

 

139. Tianfeng Yang, Jian Huo, Rui Xu, Wenjuan Tang, Dongdong Zhang, Man Zhu, Yingzhuan Zhan, Bingling Dai*, Yanmin Zhang*. Selenium sulfide disrupts the PLAGL2/C-MET/STAT3-induced resistance against mitochondrial apoptosis in hepatocellular carcinoma. Clinical and Translational Medicine, 2021, 11:e536.  (IF=11.492)

 

138. Li Chen, Tianfeng Yang, Ran Tian, Tian Yin, Lin Weng, Yongkang Bai, Yanmin Zhang*, Xin Chen*. Near-Infrared and Tumor Environment Co-activated Nanoplatform for Precise Tumor Therapy in Multiple Models. Applied Materials Today, 2021, 24:101133.  (IF=10.041)

 

137. Jin Yan*, Wangxiao He*, Xiao Li, Weiming You, Xiaojing Liu, Shumei Lin, Jianghao Chen, Yunyu Zhao, Yanmin Zhang*, Fanpu Ji*. Carnosic acid-Induced Co-self-assembly of Metal-Peptide Complexes into a Nanocluster-Based Framework with Tumor-Specific Accumulation for Augmented Immunotherapy. Chemical Engineering Journal, 2021416:129141. (IF=13.273)

 

136. Tianfeng Yang, Rui Xu, Jian Huo, Bo Wang, Xia Du, Bingling Dai, Man Zhu, Yingzhuan Zhan, Dongdong Zhang, Yanmin Zhang*. WWOX activation by toosendanin suppresses hepatocellular carcinoma metastasis through JAK2/Stat3 and Wnt/β-catenin signaling.Cancer Letters, 2021, 513:50-62. (IF=8.679)

 

135. Asmat Ullah, Leong Sze Wei, Jingjing Wang, Qing Wu, Mohsin Ahmad Ghauri, Ammar Sarwar, Qi Su*, Yanmin Zhang*. Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1α interaction in lung cancer. Cell Death & Disease, 2021, 12:490.   (IF=8.469) 

 

134. Weina Ma, Liu Yang, Yanhong Liu, Panpan Lei, Yanmin Zhang*. β2-Adrenergic receptor affinity chromatography with interaction force analysis model: A method for efficient and rapid analysis of the active compounds targeting β2-Adrenergic receptor. Journal of Chromatography A, 2021, 1652:462371.   (IF=4.759)

 

133. Xiaoyan Guo, Man Zhu, Pingyun Yuan, Tao Liu, Ran Tian, Yongkang Bai, Yanmin Zhang*, Xin Chen*. Facile formation of hierarchical mesoporous silica nanocarriers for tumor selective multi-model theranostics. Biomaterials Science, 2021, 9:5237-5246.  (IF=6.843) 

 

132. Qi Su, Jingjing Wang, Qing Wu, Asmat Ullah, Mohsin Ahmad Ghauri, Yanmin Zhang*. Sanguinarine combats hypoxia-induced activation of EphB4 and HIF-1α pathways in breast cancer. Phytomedicine, 2021, 84:153503. (IF=5.340)

 

131. Man Zhu, Xiaoyu Tang, Zhengyan Gong, Wenjuan Tang, Yanmin Zhang*. TAD1822-7 induces ROS-mediated apoptosis of HER2 positive breast cancer by decreasing E-cadherin in an EphB4 dependent manner. Life Science, 2021, 285:119954 (IF=5.037)​​​​​​​​​​​​​​

 

130. Tianfeng Yang, Jian Huo, Rui Xu, Yanmin Zhang*. Synergistic effect of toosendanin and regorafenib against cell proliferation and migration by regulating WWOX signaling pathway in hepatocellular carcinoma. Phytotherapy Research, 2021, 35:4567-4578. (IF=5.878)

 

129. Mohsin Ahmad Ghauri, Qi Su, Asmat Ullah, Jingjing Wang, Ammar Sarwar, Qing Wu, Yanmin Zhang*. Sanguinarine impedes metastasis and causes inversion of epithelial to mesenchymal transition in breast cancer. Phytomedicine, 2021, 84:153500. (IF=5.340)

 

128. Ammar Sarwar, Bo Wang, Qi Su, Yanmin Zhang*. MiRNAs directly targeting the key intermediates of biological pathways in pancreatic cancer. Biochemical Pharmacology, 2021, 189, 11114357.(IF=5.858) 

 

* ~~2020年*

 

127. Pingyun Yuan, Tianfeng Yang, Tao Liu, Xiaoqian Yu, Yongkang Bai, Yanmin Zhang*, Xin Chen*. Nanocomposite Hydrogel with NIR/Magnet/Enzyme Multiple Responsiveness to Accurately Manipulate Local Drugs for On-Demand Tumor Therapy. Biomaterials, 2020, 262:120357. (IF=12.479)

 

126. Man Zhu, Zhengyan Gong, Qing Wu, Xianpeng Shi, Qi Su, Yanmin Zhang*. Sanguinarine suppresses migration and metastasis in colorectal carcinoma associated with the inversion of EMT through the Wnt/β-catenin signaling. Clinical and Translational Medicine2020, 10:1-12. (IF=11.492)   

 

125. Man Zhu, Zhengyan Gong, Qing Wu, Qi Su, Tianfeng Yang, Runze Yu, Rui Xu, Yanmin Zhang*. Homoharringtonine suppresses tumor proliferation and migration by regulating EphB4-mediated β-catenin loss in hepatocellular carcinoma. Cell Death & Disease, 2020, 11:632.  (IF=8.469) 

 

124. Man Zhu, Xianpeng Shi, Zhengyan Gong, Runze Yu, Bo Wang, Qi Su, Tianfeng Yang, Yanmin Zhang*. Cantharidin treatment restrains hepatocellular carcinoma development by regulating the JAK2/STAT3 and PI3K/Akt pathways in an EphB4-dependent manner. Pharmacological Research, 2020, 158:104868. (IF=7.658)  

  

123. Xingchen Wang, Qi Su, Zeyuan Zhang, Yang Jin, Yanming Zhang*, Mingming Zhang*. Biotinylated platinum(II) metallacage towards targeted cancer theranostics. Chemical communications, 2020, 56, 8460-8463.  (IF=6.222)

 

122. Lingzhi Ma, Tianfeng Yang, Shuya Li, Zeyuan Zhang, Shuai Lu, Ponmani Jeyakkumar, Zhongxiao Song, Xiaopeng Li, Guocan Yu, Dake Chu*, Hang Liu*, Yanmin Zhang* Mingming Zhang*. Fluorescent Metallacycle-Cored Amphiphilic Nanoparticles Formed by β-Cyclodextrin-Based Host-Guest Interactions towards Cancer Theranostics. Chemistry - A European Journal, 2020, 26:13031-13038.  (IF=5.236)   

 

121. Yinnan Chen, Hongmei Zhang*, Yanmin Zhang*. Target receptor tyrosine kinase EphB4 in cancer therapy. Seminars in Cancer Biology, 2019, 56:37-46. (IF=15.707)   

 

120. Qi Su, Mengying Fan, Jingjing Wang, Asmatullah, Mohsin Ahmad Ghauri, Bingling Dai, Yingzhuan Zhan, Dongdong Zhang,  Yanmin Zhang*. Sanguinarine inhibits epithelial-mesenchymal transition via targeting HIF-1α/TGF-β feed-forward loop in hepatocellular carcinoma. Cell Death and Disease, 2019, 10:939.  (IF=8.469) 

  

119. Yinnan Chen, Yanmin Zhang*. Application of the CRISP/CAS9 system to drug resistance in breast cancer. Advanced Science, 2018, 5:1700964.    (IF=16.806) 

 

118. Yinnan Chen, Yanmin Zhang*. Functional and mechanistic analysis of telomerase: an anti-tumor drug target. Pharmacology & Therapeutics, 2016, 163:24-47. (IF=12.310) 

 

117. Arnaud Chevalier, Yanmin Zhang, Omar M. Khdour, Justin Kaye and Sidney M. Hecht. Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting. Journal of the American Chemical Society, 2016, 138:12009-12012. (IF=15.419) 

 

116. Qi Su, Jingjing Wang, Mengying Fan, Mohsin Ahmad Ghauri, Asmat Ullah, Bo Wang, Bingling Dai, Yingzhuan Zhan, Dongdong Zhang, Yanmin zhang*. Sanguinarine disrupts the colocalization and interaction of HIF-1α with tyrosine and serine phosphorylated-STAT3 in breast cancerJournal of Cellular and Molecular Medicine, 2020, 24:3756-3761. (IF=5.310) 

 

115. Yanmin Zhang, Shuoxing Jiang, Dongdong Zhang, Xiaoguang Bai, Sidney M. Hecht, Shengxi Chen. DNA-Affibody Nanoparticles for Inhibiting Breast Cancer Cells overexpressing HER2. Chemical communications, 2017, 53:573-576. (IF=6.222) 

 

114. Dongdong Zhang, Xia Chen, Weina Ma, Tianfeng Yang, Bingling Dai, Yanmin Zhang*. Direct electrochemistry of glucose oxidase based on one step electrodeposition of reduced graphene oxide incorporating polymerized L-lysine and its application in glucose sensing. Materials Science & Engineering C, 2019, 104:109880. (IF=7.328) 

 

113. Tianfeng Yang, Guowen Du, Yuxin Cui, Runze Yu, Chen Hua, Wei Tian*, Yanmin Zhang*. pH-sensitive doxorubicin-loaded polymeric nanocomplex based on β-cyclodextrin for liver cancer-targeted therapy. International Journal of Nanomedicine2019,14,1997-2010. (IF=6.400) 

 

112. Man Zhu, Yuxin Cui, Liu Yang, Tianfeng Yang, Hongying Wang, Dongdong Zhang, Weina Ma*, Yanmin Zhang*. Ephrin type-B receptor 4 affinity chromatography: an effective and rapid method studying the active compounds targeting Ephrin type-B receptor 4. Journal of Chromatography A, 2019, 1586: 82-90. (IF=4.759) 

 

111. Daibingling, Tianfeng Yang, Yujiao Ma, Nan Ma, Xianpeng Shi, Jie Zhang, Dongdong Zhang, Jie Zhang, Yanmin zhang*. HMQ-T- F2 exert antitumor effects by upregulation of Axin in human cervical HeLa cells. Journal of Cellular and Molecular Medicine, 2018, 22:2955-2959. (IF=5.310) 

 

110. Bingling Dai, Wenjie Wang, Yujiao Ma, Junpeng Qi, Yingzhuan Zhan, Dongdong Zhang, Rui Liu, Yanmin Zhang* Dihydroberberine exhibits synergistic effects with suntinib on NSCLC NCI-H460 cells by repressing MAPK pathway and inflammatory mediators. Journal of Cellular and Molecular Medicine, 2017, 21:2573-2585.  (IF=5.310) 

 

109. Dongdong Zhang, Lingzhi Li, Weina Ma, Juanjuan Zhang, Yanmin Zhang*Electrodeposited reduced graphene oxide incorporating polymerization of L-lysine on electrode surface and its application in simultaneous electrochemical determination of ascorbic acid, dopamine and uric acid. Materials Science & Engineering C, 2017, 70:241-249.  (IF=7.328) 

 

108. Zhang Dongdong, Zhang Yanmim, Lei Zheng, He Langchong. Graphene oxide/poly-L-lysine assembled layer for adhesion and electrochemical impedance detection of leukemia K562 cancer cells. Biosensors & Bioelectronics, 2013, 42:112-118. (IF=10.618)

 

107. Yanmin Zhang, Bingling Dai, Lei Zheng, Yingzhuan Zhan, Jie Zhang, Wanli W. Smith, Xiaoli Wang, Yinnan Chen, Langchong He. A novel angiogenesis inhibitor impairs lovo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation. Cell Death and Disease, 2012, 3:e406. (IF=8.469) 

 

106. Wenjuan Luo, Xiaoli Wang, Lei Zheng, Yingzhuan Zhan, Dongdong Zhang, Jie Zhang, Yanmin Zhang*Brucine suppresses colon cancer cells growth via mediating KDR signaling pathway. Journal of Cellular and Molecular Medicine, 2013, 17:1316-1324. (IF=5.310) 

 

105. Yanmin Zhang, Langchong He, Liang Meng, Wenjuan Luo, Xuemei Xu. Suppression of tumor-induced angiogenesis by taspine isolated from Radix et Rhizoma Leonticis and its mechanism of action in vitro. Cancer Letters, 2008, 262:103-113. (IF=8.679) 

 

104. Xianpeng Shi, Man Zhu, Zhengyan Gong, Tianfeng Yang, Runze Yu, Jingjing Wang, Yanmin Zhang*. Homoharringtonine suppresses the growth of LoVo cells through targeting EphB4 and inhibiting the PI3K/AKT and MAPK/EKR1/2 signaling pathways. Food and Chemical Toxicology, 2020, 136:110960. (IF=6.023) 

 

103. Bingling Dai, Mengying Fan, Runze Yu, Qi Su, Bo Wang, Tianfeng Yang, Feng Liu, Yanmin Zhang*Novel Diphenyl urea derivative serves as an inhibitor on human lung cancer cell migration by disrupting EMT via Wnt/β-catenin and PI3K/Akt signaling. Toxicology in Vitro, 2020, 69:105000. (IF=3.500) 

 

102. Tianfeng Yang, Rui Xu, Qi Su, Hongying Wang, Feng Liu, Bo Wang*, Yanmin Zhang*. Chelerythrine hydrochloride inhibits proliferation and induces mitochondrial apoptosis in cervical cancer cells via PI3K/BAD signaling pathway. Toxicology in Vitro, 2020, 68, 104965. (IF=3.500) 

 

101. Zhenqiu Huang, Yinnan Chen, Yanmin Zhang*. Mitochondrial reactive oxygen species causing major oxidative mitochondrial DNA damages and the repairing pathways. Journal of Bioscience, 2020, 45:84. 

 

100. Qi Su, Jingjing Wang, Feng Liu, Yanmin Zhang*. Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis. Toxicology in Vitro, 2020, 66:104840. (IF=3.500) 

 

99Bingling Dai, Yujiao Ma, Tianfeng Yang, Mengying Fan, Runze Yu, Qi Su, Hongying Wang, Feng Liu, Changhua Yang, Yanmin Zhang*. Synergistic effect of berberine and HMQ1611 impairs cell migration by regulating Wnt signal pathway in hepatocellular carcinoma. Phytotherapy Research, 2019, 33:745-755 (IF=5.878) 

  

98. Hao Yao, Tianfeng Yang, Jia He, Guowen Du, Xin Song, Yanmin Zhang*, Wei Tian*. Ultrasound and Redox-Triggered Morphology Transitions of Supramolecular Self-assemblies with pH Responsiveness for Triple-Controlled Release. Langmuir, 2019, 35: 8045-8051.  (IF=3.882) 

 

97. Lingzhi Ma, Tianfeng Yang, Zeyuan Zhang, Siping Yin, Zhongxiao Song, Wen Shi, Dake Chu*, Yanming Zhang*, Mingming Zhang*. Cyanostilbene-based near-infrared emissive platinum(II) metallacycles for cancer theranostics. Chinese Chemical Letters, 2019, 30:1942-1946.  (IF=6.779) 

 

96. Bingling Dai, Runze Yu, Mengying Fan, Tianfeng Yang, Bo Wang, Yanmin Zhang*. HMQ-T-F2 suppresses migration of human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway. Oncology Reports, 2019, 42:1451-1458.   (IF=3.906) 

 

95. Bingling Dai, Tianfeng Yang, Xianpeng Shi, Nan Ma, Yuan Kang, Jie Zhang, Yanmin Zhang*. HMQ-T-F5 (1-(4-(2-aminoquinazolin-7-yl)phenyl)-3-(2-bromo-5- (trifluoromethoxy)phenyl) thiourea) suppress proliferation and migration of human cervical HeLa cells via inhibiting Wnt/β-catenin signaling pathway. Phytomedicine, 2018, 51:48-57.  (IF=5.340) 

 

94. Tianfeng Yang, Xianpeng Shi, Yuan Kang, Man Zhu, Mengying Fan, Dongdong Zhang*, Yanmin Zhang*. Novel compounds TAD-1822-7-F2 and F5 inhibited HeLa cells growth through the JAK/Stat signaling pathway. Biomedicine & Pharmacotherapy, 2018, 103:118-126.  (IF=6.529) 

 

93. Xianpeng Shi, Man Zhu, Yuan Kang, Tianfeng Yang, Xia Chen, Yanmin Zhang*. Wnt/β-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells. Phytomedicine, 2018, 46:85-92. (IF=5.340) 

  

92. Weina Ma, Man Zhu, Tianfeng Yang. Yanmin Zhang*. Synergistic Effect of TPD7 and Berberine against Leukemia Jurkat Cell Growth through Regulating Ephrin-B2 Signaling. Phytotherapy research, 2017, 31:1392-1399. (IF=5.878) 

 

91. Bingling Dai, Yujiao Ma, Tianfeng Yang, Wenjie Wang, Yanmin Zhang*Taspine derivative 12k suppressed A549 cell migration through the Wnt/β-catenin and EphrinB2 signaling pathway. Biomedicine & Pharmacotherapy, 2017, 87:102-109. (IF=6.529) 

 

90. Weina Ma, Man Zhu, Dongdong Zhang, Liu Yang, Tianfeng Yang, Xin Li, Yanmin Zhang*Berberine Inhibits Proliferation and Migration in Breast Cancer ZR-75-30 Cells through Targeting Ephrin-B2. Phytomedcine, 2017, 25:45-51. (IF=5.340) 

 

89.  Rui Liu, Runze Yu, Yuxin Cui, Mengying Fan, Bo Wang, Yanmin Zhang*. Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppressing EphrinB2 and related signaling pathways. Acta Pharmaceutica, 2019, 69:423-431. 

 

88. Feng Liu, Xia Du, Rui Su, Yuhong Sun, Yanmin Zhang*Screening and analysis of key active constituents in GuanxinShutong capsule by using mass spectrum and integrative network pharmacology. Chinese Journal of Natural Medicine, 2018, 16:302-312. 

 

87Yanmin Zhang, Arnaud Chevalier, Omar M. Khdour, Larisa Morales Soto, Sidney M. Hecht*. Inhibition of Human Cancer Cell Growth by Analogues of Antimycin A. Plant Medica, 2017, 83:1377-1383. 

 

86. Man zhu, Yanmin Zhang*Function of Mcl-1 and its regulative relations with hepatocellular carcinoma. Hepatoma Research, 2017, 3:129-140. 

 

85. Dongdong Zhang, Xiaoyan Ouyang, Lingzhi Li, Bingling Dai, Yanmin Zhang*Real-time amperometric monitoring of cellular hydrogen peroxide based on electrodeposited reduced graphene oxide incorporating adsorption of electroactive methylene blue hybrid composites. Journal of Electroanalytical Chemistry, 2016, 780:60-67. 

 

84. Yingzhuan Zhan, Rui Liu, Wenjie Wang, Jing Li, Xiaoyan Ou Yang, Yanmin Zhang*Total saponins isolated from Radix et Rhizoma Leonticis suppresses tumor cells growth by regulation of PI3K/Akt/mTOR and p38 MAPK pathways. Environmental Toxicology and Pharmacology2016, 41: 39-44. 

 

83. Bingling Dai, Wenjie Wang, Yujiao Ma, Rui Liu, Yanmin Zhang*A taspine derivative supresses Caco-2 cell growth by competitively targeting EphrinB2 and regulating its pathway. Oncology reports, 2016, 36: 1526-1534. 

 

82. Dongdong Zhang, Xiaoyan Ouyang, Jing Ma, Lingzhi Li, Yanmin Zhang*Electrochemical behavior and voltammetric determination of curcumin at electrochemically reduced graphene oxide modified glassy carbon electrode. Electroanalysis, 2016, 28, 749-756. 

 

81. Yingzhuan Zhan, Han Zhang, Rui Liu, Wenjie Wang, Junpeng Qi, Yanmin Zhang*Eupolyphaga sinensis Walker ethanol extract suppresses cell growth and invasion in human breast cancer cells. Integrative Cancer Therapies2016, 15(1) 102-112. 

 

80. Dongdong Zhang, Xiaoyan Ouyang, Weina Ma, Lingzhi Li, Yanmin Zhang*Voltammetric determination of folic acid using adsorption of methylene blue onto electrodeposited of reduced graphene oxide film modified glassy carbon electrode. Electroanalysis, 2016, 28:312-319. 

 

79. Yinnan Chen, Yanmin Zhang*Human telomerase disease mutants and its relation with hepatocarcinoma. Hepatoma Research, 2016, 2:109-113. 

 

78. Dongdong Zhang, Junpeng Qi, Rui Liu, Bingling Dai, Weina Ma, Yingzhuan Zhan, Yanmin Zhang*c-Myc plays a key role in TADs-induced apoptosis and cell cycle arrest in human hepatocellular carcinoma cells. American Journal of Cancer Research, 2015, 5:1076-1088. 

 

77. Bingling Dai, Wenjie Wang, Rui Liu, Hongying Wang, Yanmin Zhang*Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma. Biomedicine & Pharmacotherapy, 2015, 70:227-233. 

 

76. Weina Ma, Dongdong Zhang, Lei Zheng, Yingzhuan Zhan, Yanmin Zhang*Potential roles of Centipede Scolopendra extracts as a strategy against EGFR-dependent cancers. American Journal of Translational Research, 2015, 7:39-52. 

 

75. Rui Liu, Junpeng Qi, Bingling Dai, Wenjie Wang, Yanmin Zhang*Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma. Molecular Medicine Reports, 2015, 12: 7735-7741. 

 

74. Weina Ma, Dongdong Zhang, Jing Li, Delu Che, Rui Liu, Jie Zhang, Yanmin Zhang*Interactions between histamine H-1 receptor and its antagonists by using cell membrane chromatography method. Journal of pharmy and pharmacology, 2015, 67, 1567-1574. 

 

73. Yanmin Zhang, Yingzhuan Zhan, Dongdong Zhang, Bingling Dai, Weina Ma, Junpeng Qi, Rui liu, Langchong He. Eupolyphaga sinensis Walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling. Scientific Reports, 2014, 4:5518. 

 

72. Bingling Dai1Yanmin Zhang1Yingzhuan Zhan, Dongdong Zhang, Nan Wang, Langchong He. A novel tissue model for angiogenesis: evaluation of inhibitors or promoters in tissue level. Scientific Reports, 2014, 4:3693. 

 

71. Bingling Dai, Junpeng Qi, Rui Liu, Jie Zhang, Yingzhuan Zhan, Yanmin Zhang*A novel compound T7 (N-{4'-[(1E)-N-hydroxyethanimidoyl] -3',5,6-trimethoxybiphenyl-3-yl}-N'-[4-(3-morpholin-4-ylpropoxy)phenyl]urea) screened by tissue angiogenesis model and its activity evaluation on anti-angiogenesis. Phytomedicine, 2014, 21:1675-1683. 

 

70. Weina Ma, Rui liu, Junpeng Qi, Yanmin Zhang*Extracts of Centipede Scolopendra induced cell cycle arrest and apoptosis in human melanoma A375 Cells. Oncology letters, 2014, 8:414-420. 

 

69. Bingling Dai, Yingzhuan Zhan, Junpeng Qi, Yanmin Zhang*Eupolyphaga sinensis Walker inhibits human chronic myeloid leukemia cell K562 growth by inducing G2-M phase cell cycle arrest and targeting EGFR signaling pathway and in S180 tumor-bearing mice. Environmental Toxicology and Pharmacology, 2014, 37:1177-1185. 

 

68. Bingling Dai, Junpeng Qi, Rui liu, Yanmin Zhang*Eupolyphaga sinensis Walker demonstrates angiogenic activity and inhibits A549 cell growth bytargeting the KDR signaling pathway. Molecular Medicine Reports, 2014, 10:1590-1596. 

 

67. Yanjun Cao, Feng Liu, Zhuangzhuang Huang, Yanmin Zhang*Protective effects of Guanxin Shutong Capsule drug-containing serum on TNF-alpha-induced endothelial dysfunction through NADPH oxidase and NO pathway. Experimental and Therapeutic Medicine, 2014, 8: 998-1004. 

 

66. Yuanji Wang, Nan Wang, Lei Wu, Wen Lu, Yanmin Zhang*Simultaneous determination of four components in Baige capsule by HPLC: Application to pharmacokinetics and tissue distribution of normal and middle cerebral artery occlusion rats. Biomedical Chromatography, 2014, 28:541-547.

 

65. Yanjun Cao, Xu He, Feng Liu, Zhuangzhuang Huang, Yanmin Zhang*Chinese medicinal formula Guanxin Shutong Capsule protects the heart against oxidative stress and apoptosis induced by ischemic myocardial injury in rats. Experimental and Therapeutic Medicine, 2014, 7: 1033-1039. 

 

64. Yingzhuan Zhan, Yinnan Chen, Han Zhang, Yanmin Zhang*Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling. Archives of Pharmacal Research, 2014, 37:1086-1095. 

 

63. Bingling Dai, Junpeng Qi, Yanmin Zhang*Eupolyphaga sinensis Walker screened by cell membrane chromatography and its inhibition on Hek293/EGFR cells by modulating the EGFR signaling pathway. Abstracts/ European Journal of Integrative Medicine, 2014, 6: 741. 

 

62. Nan Wang, Lei Wu, Yanjun Cao, Yuanji Wang, Yanmin Zhang*The protective activity of imperatorin in cultured neural cells exposed to hypoxia re-oxygenation injury via anti-apoptosis. Fitoterapia, 2013, 90:38-43. 

 

61. Nan Wang, Lei Zheng, Yingzhuan Zhan, Yanmin Zhang*A novel taspine derivative suppresses human liver tumor growth and invasion in vitro and in vivo. Oncology letters, 2013, 6:855-859. 

 

60. Lei Zheng, Xiaoli Wang, Wenjuan Luo, Yingzhuan Zhan, Yanmin Zhang*Brucine, an effective natural compound derived from nux-vomica, induces G1 phase arrest and apoptosis in LoVo cells. Food and Chemical Toxicology, 2013, 58: 332-339. 

 

59.  Wen Lu, Bingling Dai, Weina Ma, Yanmin Zhang*A novel taspine analogue, HMQ1611, inhibits growth of non-small cell lung cancer by inhibiting angiogenesis. Oncology letters, 2012, 4:1109-1113.

  

58. Lei Zheng, Xu He, Weina Ma, Bingling Dai, Yingzhuan Zhan, Yanmin Zhang*Ta1722, an anti-angiogenesis inhibitor targeted on VEGFR-2 against human hepatoma. Biomedicine & Pharmacotherapy, 2012, 66: 499-505. 

 

57. Huaizhen He, Nan Wang, Yinnan Chen, Lei Zheng, Yanmin Zhang*Tas13D inhibits growth of SMMC-7721 cell through suppressing VEGF and EGF expression. Asian Pacific Journal of Cancer Prevention, 2012,13:2009-2014.

  

56. Yingzhuan Zhan, Meng Sun, Yinnan Chen, Yanmin Zhang*Determination of Taspine Using HPLC-MS and its Effect on EGFR in A431 and HEK293/EGFR Cells in Vitro. Chromatographia, 2011,74:383-389. 

 

55. Yanmin Zhang, Lei Zheng, Jie Zhang, Bingling Dai, Nan Wang, Yinnan Chen, Langchong He. Anti-tumor activity of taspine by modulating EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo. Planta Medica, 2011, 77: 1774-1781. 

 

54. Yanmin Zhang, Qiao Jiang, Nan Wang, Bingling Dai, Yinnan Chen, Langchong He. Effects of taspine on proliferation and apoptosis by regulating caspase-3 expression and the ratio of Bax/Bcl-2 in A431 cells. Phytotherapy research, 2011, 25: 357-364. 

 

53. Yanmin Zhang, Jie Zhang, Bingling Dai, Nan Wang, Langchong He. Anti-proliferative and apoptotic effects of the novel taspine derivative tas41 in the Caco-2 cell line. Environmental toxicology and pharmacology, 2011, 31:406-415. 

 

52. Yanmin Zhang, Youle Qu, Jie Zhang. Ardipusilloside I purified from Ardisia pusilla competitively binds VEGFR and induces apoptosis in NCI-H460 cells. Phytomedicine, 2010, 17:519-526. 

 

51. Yanmin Zhang, Xu Li, Xuemei Xu, Wenjuan Luo. Construction of a high-EGFR expression cell line and its biological properties comparing with A431 cell. African Journal of Biotechnology, 2010, 9:4674-4680. 

 

50. Yali Zhou, Wenjuan Luo, Lei Zheng, Miao Li, Yanmin Zhang*. Construction of recombinant FGFR1 containing full-length gene and its potential application. Plasmid, 2010, 64:60-67. 

 

49. Yanmin Zhang, Langchong He, Yali Zhou. Taspine isolated from Radix et Rhizoma Leonticis inhibits growth of human umbilical vein endothelial cell by inducing its apoptosis. Phytomedicine, 2008, 15:112-119. 

 

48. Yanmin Zhang, Langchong He, Liang Meng, Wenjuan Luo. Taspine isolated from Radix et Rhizoma Leonticis inhibits proliferation and migration of endothelial cells as well as chicken chorioallantoic membrane neovascularisation. Vascular Pharmacology, 2008, 48:129-137.   

 

47. Dandan Li, Mei Liu, Yingzhuan Zhan, Qi Su, Yanmin Zhang, Dongdong Zhang. Electrodeposited poly(3,4-ethylenedioxythiophene) doped with graphene oxide for the simultaneous determination of ascorbic acid, dopamine and uric acid". Microchimica Acta, 2020, 187:94. 

 

46. Yan Wang, Peipei Zhang, Shangchen Yao, Wenbo Zou, Yanmin Zhang, Erwin Adams, Changqin Hu*. Integrative strategy to determine residual proteins in cefaclor produced by immobilized penicillin G acylase. Journal of Pharmaceutical and Biomedical Analysis, 2020, 185:113229. 

 

45. Man Zhu, Liu Yang, Xianpeng Shi, Zhengyan Gong, Runze Yu, Dongdong Zhang, Yanmin Zhang, Weina Ma. TPD7 inhibits the growth of cutaneous T cell lymphoma H9 cell through regulating IL-2R signaling pathway. Journal of Cellular and Molecular Medicine, 2020, 24:984-995. 

 

44. Xia Chen, Dandan Li, Weina Ma, Tianfeng Yang, Yanmin Zhang, Dongdong Zhang. Preparation of a glassy carbon electrode modified with reduced graphene oxide and overoxidized electropolymerized polypyrrole, and its application to the determination of dopamine in the presence of ascorbic acid and uric acid. Microchimica Acta, 2019, 186: 407. 

 

43. Ying Song, Huijing Sun, Jie Xiao, Fan Wang, Yi Ding, Jinyi Zhao, Juan Bai, Lianghua Cheng, Kai Gao, Meiyou Liu, Qiyan Guo, Yanmin Zhang, Wei Gao, Yanyan Jia, Aidong Wen. Development of a liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for simultaneous determination of epigallocatechin-3-gallate, silibinin, and curcumin in plasma and different tissues after oral dosing of Protandim in rats and its application in pharmacokinetic and tissue distribution studies. Journal of Pharmaceutical and Biomedical Analysis, 2019, 170: 54-62. 

 

42. Le Wang, Yanmin Zhang, Xia Du, Teng Ding, Weiling Gong, Feng Liu. Review of Antidepressants in Clinic and Active Ingredients of Traditional Chinese Medicine Targeting 5-HT1A Receptors. Biomedicine & Pharmacotherapy, 2019,120:109408. 

 

41. Yingzhuan Zhan, Han Zhang, Bingling Dai, Yanmin Zhang, Jie Zhang, Langchong He. A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer. Oncology Reports, 2018, 40: 1064-1072. 

 

40. Ying Song, Weihai Liu , Yi Ding , Yanyan Jia , Jinyi Zhao , Fan Wang , Juan Bai, Lianghua Cheng , Kai Gao , Meiyou Liu, Minna Yao , Liang Li ,Yanmin Zhang, Aidong Wen, Langchong He. Salvianolic acid A ameliorates renal ischemia/reperfusion injury by activating Akt/mTOR/4EBP1 signaling pathway. 2018, American Journal of Physiology-Renal Physiology, 2018, 315:F254-262. 

 

39. Bingling Dai, Xianpeng Shi, Nan Ma, Weina Ma, Yanmin Zhang, Tianfeng Yang, Jie Zhang, Langchong He*. HMQ-T-B10 induces human liver cell apoptosis by competitively targeting EphrinB2 and regulating its pathway. Journal of cellular and molecular medicine, 2018, 22: 5231-5243. 

 

38. Weina ma, Liu Yang, Yanmi Lv, Jia Fu, Yanmin Zhang, Langchong He. Determine equilibrium dissociation constant of drug-membrane receptor affinity using the cell membrane chromatogarphy relative standard method. Journal of Chromatography A, 2017, 1503:12-20. 

 

37. Cuicui Liu, Yanmin Zhang, Bingling Dai, Yujiao Ma, Yi Wang, Qian Zhang, Hao Yang. Chlorogenic acid prevents interleukin--induced inflammation in human SW-1353 chondrocytes, a model for osteoarthritis. Molecular Medicine Reports, 2017, 16:1369-1375. 

 

36. Arnaud Chevalier, Yanmin Zhang, Omar M. Khdour and Sidney M. Hecht*. Selective Functionalization of Antimycin A Through an N-Transacylation Reaction. Organic Letters, 2016, 18:2395-2398.  

 

35. Huiling Jing, Wenyan Sun, Jinghua Fan, Yanmin Zhang, Jiao Yang, Jinjing Jia, Jichang Li, Jiaqi Guo, Suju Luo, Yan Zheng*. Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways. Molecular Medicine Reports, 2016, 13: 3009-3016. 

 

34. Yingzhuan Zhan, Han Zhang, Jing Li, Yanmin Zhang, Jie Zhang, Langchong He*. A novel biphenyl urea derivate inhibits the invasion of breast cancer through the modulation of CXCR4. Journal of cellular and molecular medicine, 2015, 19:1614-1623. 

 

33. Yanjun Cao, Yanmin zhang, Junpeng Qi, Rui Liu, Han Zhang, Langchong He. Ferulic acid inhibits H2O2-induced oxidative stress and inflammation in rat vascular smooth muscle cells via inhibition of the NADPH oxidase and NF-kappa B pathway. International Immunopharmacology, 2015, 28:1018-1025. 

 

32. Yuanji Wang, Yanmin Zhang, Weina Ma, Xiaoyan Pan, Nan Zhou, Bingling Dai, Langchong He. The Vasodilatation Effects of Four Active Components in Baige Capsule and the Potential Mechanism of Them with the NMDA Receptor. Current Pharmaceutical analysis, 2015, 11, 173-179. 

 

31. Lei Zheng, Yanmin Zhang, Yanping Liu, Xiaoyan Ouyang, Yingzhuan Zhan. Momordica cochinchinensis Spreng. seed extract suppresses breast cancer growth by inducing cell cycle arrest and apoptosis. Molecular medicine reports, 2015, 12: 6300-6310. 

 

30. Gao, Hongping, Su, Ping, Shi, Yaling, Shen, Xiuxiu, Zhang, Yanmin, Dong, Jinyun, Zhang, Jie*. Discovery of novel VEGFR-2 inhibitors. Part II: Biphenyl urea incorporated with salicylaldoxime. European Journal of Medicinal Chemistry, 2015, 90:232-240. 

 

29. Weina Ma, Yanmin Zhang, Jing Li, Rui Liu, Delu Che, Langchong He. Analysis of drug interactions with dopamine receptor by frontal analysis and cell membrane chromatography. Chromatographia, 2015, 78:649-654. 

 

28. Nan Wang, Yanmin Zhang, Lei Wu, Yuanji Wang, Yanjun Cao, Langchong He, Xia Li, Jianjun Zhao. Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition. Neuropharmacology, 2014, 79:282-289. 

 

27. Xiaoyan Pan, Jinyun Dong, Hongping Gao, Fang Wang, Yanmin Zhang, Sicen Wang, Jie Zhang*. Design, synthesis and biological evaluation of pyridin-3-yl pyrimidines as potent Bcr-Abl inhibitors. Chemical Biology & Drug Design, 2014, 83: 592-599. 

 

26. Yanjun Cao, Yanmin Zhang, Nan Wang, Langchong He. Antioxidant effect of imperatorin from Angelica Dahurica in hypertension via inhibiting NADPH oxidase activation and MAPK pathway. Journal of the American Society of Hypertension, 2014 8:527-36. 

 

25. Lei Zheng, Yan-min Zhang, Ying-Zhuan Zhan, Chang-xiao Liu. Momordica cochinchinensis Seed Extracts Suppress Migration and Invasion of Human Breast Cancer ZR-75-30 Cells Via Down-regulating MMP-2 and MMP-9. Asian Pacific Journal of Cancer Prevention, 2014, 15:1105-1110. 

 

24. Chen Wang, Hongping Gao, Jinyun Dong, Yanmin Zhang, Ping Su, Yaling Shi, Jie Zhang. Biphenyl derivatives incorporating urea unit as novel VEGFR-2 inhibitors: Design, synthesis and biological evaluation. Bioorganic & Medicinal Chemistry, 2014, 22:277-284. 

 

23. Xiaofang Hou, Sicen Wang, Tao Zhang, Jing Ma, Jie Zhang, Yanmin Zhang, Wen Lu, Huaizhen He, Langchong He. Recent advances in cell membrane chromatography for traditional Chinese medicines analysis. Journal of Pharmaceutical and Biomedical Analysis, 2014, 101: 141-150. 

 

22. Li Weifeng, Huang Huimin, Zhang Yanmin, Fan Ting, Liu Xia, Xing Wei, Niu Xiaofeng. Anti-inflammatory effect of tetrahydrocoptisine from Corydalis impatiens is a function of possible inhibition of TNF-alpha, IL-6 and NO production in lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-kappa B activation and MAPK pathway. European Journal of Pharmacology, 2013, 715: 62-71. 

 

21. Chen Wang, Jinyun Dong, Yanmin Zhang, Fang Wang, Hongping Gao, Pengfei Li, Sicen Wang and Jie Zhang. Design, synthesis and biological evaluation of biphenyl urea derivatives as novel VEGFR-2 inhibitors. MedChemComm. 2013, 4: 1434-1438. 

 

20. Zhang Dongdong, Zhang Yanmin, He Langhcong. Sensitive voltammetric determination of baicalein at thermally reduced graphene oxide modified glassy carbon electrode. Electroanalysis, 2013, 25:2136-2144. 

 

19. Xiaoyan Pan, Fang Wang, Yanmin Zhang, Hongping Gao, Zhigang Hu, Sicen Wang, Jie Zhang. Design, synthesis and biological activities of Nilotinib derivates as antitumor agents. Bioorganic & Medicinal Chemistry, 2013, 21:2527-2534. 

 

18. Weifeng Li, Ting Fan, Yanmin Zhang, Te Fan, Ping Zhou, Xiaofeng Niu*, Langchong He. Houttuynia cordata Thunb. Volatile Oil Exhibited Anti-inflammatory Effects In Vivo and Inhibited Nitric Oxide and Tumor Necrosis Factor-a Production in LPS-stimulated Mouse Peritoneal Macrophages In Vitro. Phytotherapy Research, 2013, 27:1629-39. 

 

17. Xiaofeng Niu, Ting Fan, Weifeng Li, Huimin Huang, Yanmin Zhang, Wei Xing. Protective effect of sanguinarine against acetic acid-induced ulcerative colitis in mice. Toxicology and Applied Pharmacology, 2013, 267:256-265. 

 

16. Zhang J, Zhang YM, Pan XY, Wang C, Hu ZG, Wang SC, He LC. Facile synthesis and biological evaluation of novel symmetrical biphenyls as antitumor agents. Medicinal Chemistry, 2012, 8:145-150. 

 

15. Huaizhen He, Yingzhuan Zhan, Yanmin Zhang, Jie Zhang, Langchong He. Synthesis of novel taspine diphenyl derivatives as fluorescence probes and inhibitors of breast cancer cell proliferation. Luminescence: The Journal of Biological and Chemical Luminescence. 2012, 27:310-314.

  

14. Weifeng Li, Ting Fan, Yanmin Zhang, Xiaofeng Niu, and Wei Xing. Effect of Chelerythrine Against Endotoxic Shock in Mice and Its Modulation of Inflammatory Mediators in Peritoneal Macrophages Through the Modulation of Mitogen-Activated Protein Kinase (MAPK) Pathway. Inflammation, 2012, 35:1814-1824. 

 

13. Yingzhuan Zhan, Yanmin Zhang, Cuicui Liu, Jie Zhang, Wanli W. Smith, Nan Wang, Yinnan Chen, Lei Zheng, Langchong He. A Novel Taspine Derivative, HMQ1611, Inhibits Breast Cancer Cell Growth via Estrogen Receptor and EGF Receptor Signaling Pathways. Cancer Prevention Research, 2012, 5:864-873. 

 

12. Yingzhuan Zhan, Yanmin Zhang, Yinnan Chen, Nan Wang, Lei Zheng, Langchong He. Activity of taspine isolated from Radix et Rhizoma Leonticis against estrogen-receptor-positive breast cancer. Fitoterapia, 2011, 82:896-902. 

 

11. Jie Zhang, Yanmin Zhang, Xiaoyan Pan, Sicen Wang, Langchong He. Synthesis and Cytotoxic Evaluation of Novel Symmetrical Taspine Derivatives as Anticancer Agents. Medicinal Chemistry, 2011, 7, 286-294. 

 

10. Weifeng li, Ping Zhou, Yanmin zhang, Langchong He. Houttuynia cordata, a novel and selective COX-2 inhibitor with anti-inflammatory activity. Journal of Ethnopharmacology, 2011, 133:922-927. 

 

9. Sun Meng, Zhang Yan-min, Zhang Jie, Wang Si-cen, He Lang-chong, A high expression EGFR/cell membrane chromatography and online high performance liquid chromatography/mass spectrometry method for screening EGFR antagonists from Rhizoma Polygoni Cuspidati. Acta Pharmaceutical Sinica B, 2011;1:115–120. 

 

8. Sicen Wang, Sun Meng, Yanming Zhang, Hui Du, Langchong He. A New A431/Cell Membrane Chromatography–online–high performance liquid chromatography /mass spectrometry Method for Screening Anti-EGFR Antagonists from Radix Sophorae Flavescentis. Journal of Chromatography A, 2010, 1217:5246-5252. 

 

7. Sicen Wang, Meng Sun, Yanmin Zhang, Jie Zhang, Langchong He. EGFR/Cell Membrane Chromatography–online–high performance liquid chromatography/mass spectrometry method for screening EGFR Antagonists from Radix Angelicae Pubescentis. Science China-Chemistry, 2010, 53:2357-2362. 

 

6. Miao Li, Sicen Wang, Yanmin Zhang, Langchong He. An online coupled cell membrane chromatography with LC/MS method for screening compounds from Aconitum carmichaeli Debx. acting on VEGFR-2. Journal of Pharmaceutical and Biomedical Analysis, 2010, 53:1063-1069. 

 

5. Jie Zhang, Yanmin Zhang, Yuanyuan Shan, Na Li, Wei Ma, Langchong He. Synthesis and preliminary biological evaluation of novel taspine derivatives as anticancer agents. European Journal of Medicinal Chemistry, 2010, 45:2798-2805. 

 

4. Jie Zhang, Yanmin Zhang, Sanqi Zhang,et al. Discovery of novel taspine derivatives as antiangiogenic agents. Bioorganic & Medicinal Chemistry Letters, 2010, 20:718-721. 

 

3. Meng Sun, Jing Ren, Hui Du, Yanmin Zhang, Jie Zhang, Sicen Wang, Langchong He. A combined A431 cell membrane chromatography and online high performance liquid chromatography/mass spectrometry method for screening compounds from total alkaloid of Radix Caulophylli acting on the human EGFR. Journal of Chromatography B, 2010, 878:2712-2718. 

 

2. Jiafang Lian, Sanqi Zhang, Jingwen Wang, Kunquan Fang, Yanmin Zhang, Yong Hao. Novel galactosylated SLN for hepatocyte-selective targeting of floxuridinyl diacetate. Journal of Drug Targeting, 2008, 16:250-256. 

 

1. Langchong He, Sicen Wang, Guangde Yang, Yanmin Zhang, Changhe Wang, Bingxiang Yang, Xiaofang Hou. Progress in the cell membrane chromatography. Drug Discoveries & Therapeutics, 2007, 1:104-107.