基本信息

 

 

张  伊, PhD

教授, 博士生导师

西安交通大学医学部基础医学院

生理学与病理生理学系

联系方式

陕西省西安市沣西新城交大创新港科创基地21号楼4136

email: zhangyixjtu（a）xjtu.edu.cn

站点计数器

研究领域

 心血管病理生理学：（1）鞘磷脂信号影响心肌免疫应答、心脏组织纤维化的分子机制；（2）内皮通透性及冠状动脉斑块形成的机制；（3）心肌钙离子信号调控在心律失常中的作用机制。

 

 Our research aims to exploring the role of : ①Sphingolipids signaling on hypertension, cardiac fibrosis and coronary plaque formation;   ②Revealed the mechanistic role of stretch in altered calcium homeostasis and arrhythmia.

教育及工作经历

  • 2024 至 今，  西安交通大学医学部基础医学院生理学与病理生理学系，教授
  • 2017~2023，  西安交通大学医学部基础医学院生理学与病理生理学系，副教授
  • 2012~2017，美国康奈尔大学威尔医学院，博士后（合作导师：Annarita Di Lorenzo 教授）
  • 2007~2012，北京大学分子医学研究所，理学博士（导师：中国科学院院士程和平教授）
  • 2003~2007，中国农业大学动物科学与技术学院，动物科学专业获得学士学位

主持基金项目

  1. 2022.01-2025.12，心肌细胞Nogo-A在心肌病中应激上调的作用与机制研究，国家自然科学基金面上项目
  2. 2019.01-2022.12，内皮细胞Nogo-B在高血压诱发冠状动脉粥样硬化过程中的作用与机制，国家自然科学基金面上项目
  3. 2019.01-2020.12，冠状动脉内皮细胞中S1P-S1PR1在心脏重构中的作用与机制，陕西省自然科学基金青年项目
  4. 2019.09-2024.09，西安交通大学医学部“攀登人才”支持计划
  5. 2019.01-2021.12，Nogo-A调控线粒体钙转运及其对心肌肥大的影响研究，中国博士后科学基金特别资助项目
  6. 2019.01-2021.12，Nogo-B调控鞘磷脂代谢在高血压诱发冠状动脉粥样硬化中的作用，陕西省博士后基金项目
  7. 2018.01-2020.12，S1PR1在压力超负荷致心力衰竭中的作用与机制，中国博士后科学基金面上项目
  8. 2018.01-2020.12，S1PR1在RyR2磷酸化及心衰中的作用与机制研究，西安交通大学基本科研业务费​​​​​​​
  9. 2018.01-2020.12，冠状动脉内皮细胞S1PR1 在压力超负荷所致心力衰竭中的作用与机制，西安交通大学新教师科研支持计划

代表性论文

  1. Yu Zhang#, Jing-Jing Li#, Rui Xu, Xin-Pei Wang, Xin-Yi Zhao, Yuan Fang, Yu-Peng Chen, Shan Ma, Xiao-Hui Di, Wei Wu, Gang She, Zheng-Da Pang, Yi-Dong Wang, Xing Zhang, Wenjun Xie, Xiu-Ling Deng, Xiao-Jun Du, Yi Zhang*(corresponding author). Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts. Redox Biol. 2023 Oct; 68:102944. (IF=11.4)
  2. Jing-Jing Li#, Xin-Yi Zhao#, Yan Wang#, Rui Xu, Xiao-Hui Di, Yu Zhang, Hongyan Yang, Meng-Zhuan Han, Ru-Yue Bai, Lin Xie, Zheng-Da Pang, Xing Zhang, Jianbao Zhang, Xiao-Jun Du, Xiu-Ling Deng*, Yi Zhang*(corresponding author), Wenjun Xie*. Endothelial KCa3.1 and KCa2.3 Mediate S1P (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure Homeostasis. Arterioscler Thromb Vasc Biol. 2023 May; 43(5):726-738. (IF=10.514)
  3. Yi Zhang#, Xiao-Zhen Ma#, Xin-Yi Zhao, Jing-Jing Li, Shan Ma, Zheng-Da Pang, Jing Xu, Xiao-Jun Du, Xiu-Ling Deng*, Jun-Hong Wang*. AGEs-RAGE-KCa3.1 pathway mediates palmitic acid-induced migration of PBMCs from patients with type 2 diabetes. Heliyon. 2023 Mar 24;9(4):e14823. (IF=4.0)
  4. Linda Sasset#, Onorina Laura Manzo#, Yi Zhang# (co-first author), Alice Marino, Luisa Rubinelli, Maria Antonietta Riemma, Madhavi Latha S Chalasani, Dragos C Dasoveanu, Fiorentina Roviezzo, Stanislovas S Jankauskas, Gaetano Santulli, Maria Rosaria Bucci, Theresa T Lu, Annarita Di Lonrenzo*. Nogo-A reduces ceramide de novo biosynthesis to protect from heart failure. Cardiovasc Res. 2023 Mar 31;119(2):506-519. (IF=14.239)
  5. Zheng-Da Pang#, Xia Sun#, Ru-Yue Bai, Meng-Zhuan Han, Yong-Jian Zhang, Wei Wu, Yu Zhang, Bao-Chang Lai, Yi Zhang, Yan Wang, Xiao-Jun Du, Xiu-Ling Deng*. YAP-galectin-3 signaling mediates endothelial dysfunction in angiotensin II-induced hypertension in mice. Cell Mol Life Sci. 2023 Jan 11;80(2):38. (IF=9.207)
  6. Gang She, Jin-Chan Du, Wei Wu, Tian-Tian Pu, Yu Zhang, Ru-Yue Bai, Yi Zhang, Zheng-Da Pang, Hui-Fang Wang, Yu-Jie Ren, Junichi Sadoshima, Xiu-Ling Deng, Xiao-Jun Du*. Hippo pathway activation mediates chemotherapy-induced anti-cancer effect and cardiomyopathy through causing mitochondrial damage and dysfunction. Theranostics. 2023 Jan 1;13(2):560-577. (IF=11.600)
  7. 戚瑛, 赵芯仪, 姚佳辉, 谢文俊, 张伊*. IP3R和RyR对新生大鼠心肌细胞钙振荡的调控研究. 西安交通大学学报(医学版).Ying Qi, Xinyi Zhao, Jiahui Yao, Wenjun Xie, Yi Zhang*(corresponding author). Regulation of calcium oscillations by IP3R and RyR in neonatal rat cardiomyocytes.  J Xi’an Jiaotong Univ Med Sci. 2022; 43(6):801-806.
  8. Wei Wu, Mark Ziemann, Kevin Huynh, Gang She, Zheng-Da Pang, Yi Zhang, Thy Duong, Helen Kiriazis, Tian-Tian Pu, Ru-Yue Bai, Jing-Jing Li, Yu Zhang, Ming-Xia Chen, Junichi Sadoshima, Xiu-Ling Deng, Peter J Meikle, Xiao-Jun Du*. Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice. Theranostics. 2021 Aug 21; 11(18):8993-9008. (IF=11.600)
  9. Zheng-Da Pang, Yang Wang, Zheng Song, Gang She, Xiao-Zhen Ma, Xia Sun Wei Wu, Bao-Chang Lai, Jiao Zhang, Yi Zhang, Xiao-Jun Du, John Y J Shyy*, Xiu-Ling Deng*. AMPK upregulates KCa2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice. Biochem Pharmacol. 2021 Jan; 183:114337. (IF=6.100)
  10. Yi Zhang#, Ying Qi#, Jingjing Li#, Xiaohang Gao, Yu Zhang, Xia Sun, Wenjin He, Jie Tong, Jianbao Zhang, Xiu-Ling Deng, Xiao-Jun Du, Wenjun Xie*. Stretch-induced sarcoplasmic reticulum calcium leak is causitively associated with atrial fibrillation in pressure-overloaded hearts. Cardiovasc Res. 2021 Apr; 117(4):1091-1102. (IF=14.239, ESI highly cited paper)
  11. Ying Qi#, Jing-Jing Li#, Xiao-Hui Di#, Yu Zhang#, Jie-Long Chen, Zi-Xuan Wu, Zi-Yue Man, Ru-Yue Bai, Fujian Lu, Jie Tong, Xue-Liang Liu, Xiu-Ling Deng, Jianbao Zhang, Xing Zhang, Yi Zhang*(corresponding author), and Wenjun Xie*. Excess sarcoplasmic reticulum-mitochondria calcium transport induced by sphingosine-1-phosphate contributes to cardiomyocyte hypertrophy. Biochim Biophys Acta Mol Cell Res. 2021 Apr; 1868(5):118970. (IF:5.011)
  12. Yi Zhang#, Meng-Chen Hou#, Jingjing Li,Ying Qi, Yu Zhang, Gang She,Yu-Jie Ren, Wei Wu, Zheng-Da Pang, Wenjun Xie, Xiu-Ling Deng*, Xiao-Jun Du*. Cardiac β-adrenoceptor activation mediates diverse and cell type-dependent changes in the expression and distribution of connexin 43. J Cell Mol Med. 2020 Aug; 24(15):8505-8517. (IF=5.310)
  13. Gang She, Meng-Chen Hou, Yu Zhang, Yi Zhang, Yan Wang, Hui-Fang Wang, Bao-Chang Lai, Wei-Bo Zhao, Xiao-Jun Du, Xiu-Ling Deng*.Gal-3 (Galectin-3) and KCa3.1 Mediate Heterogeneous Cell Coupling and Myocardial Fibrogenesis Driven by βAR (β-Adrenoceptor) Activation. Hypertension. 2020 Feb;75(2):393-404. (IF=10.190)
  14. Alice Marino, Yi Zhang, Luisa Rubinelli, Maria Antonietta Riemma, James E. Ip, Annarita Di Lorenzo*. Pressure overload leads to coronary plaque formation, progression and myocardial events in ApoE-/- mice. JCI Insight. 2019;4(9):e128220. (IF=6.014)
  15. Gregory Farber, Matthew M. Parks, Nicole Lustgarten Guahmich, Yi Zhang, Sébastien Monette, Scott C. Blanchard, Annarita Di Lorenzo, Carl P. Blobe*, ADAM10 controls the differentiation of the coronary arterial endothelium, Angiogenesis. 2018. doi: 10.1007/s10456-018-9653-2. (IF=5.759)
  16. Ren Xu, Alisha Yallowitz, An Qin, Zhuhao Wu, Dong Yeon Shin, Jung-Min Kim, Shawon Debnath, Gang Ji, Mathias P. Bostrom, Xu Yang, Chao Zhang, Han Dong, Pouneh Kermani, Sarfaraz Lalani, Na Li, Yifang Liu, Michael G. Poulos, Amanda Wach, Yi Zhang, Kazuki Inoue, Annarita Di Lorenzo, Baohong Zhao, Jason M. Butler, Jae-Hyuck Shim, Laurie H. Glimcher*, Matthew B. Greenblatt*, Targeting skeletal endothelium to ameliorate bone loss, Nat Med. 2018, 24(6): 823–833.(IF=30.641)
  17. Swendeman Steven L, Xiong Yuquan, Cantalupo Anna, Yuan Hui, Burg Nathalie, Hisano Yu, Cartier Andreane, Liu Catherine H, Engelbrecht Eric, Blaho Victoria, Yi Zhang, Yanagida Keisuke, Galvani Sylvain, Obinata Hideru, Salmon Jane E, Sanchez Teresa, Di Lorenzo Annarita, Hla Timothy*, An engineered S1P chaperone attenuates hypertension and ischemic injury, Sci Signal. 2017, 10(492):1-30 (IF=6.481)
  18. Anna Cantalupo, Antonella Gargiulo, Elona Dautaj, Catherine Liu, Yi Zhang, Timothy Hla, and Annarita Di Lorenzo, S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure. Hypertension. 2017 Jun 12; 70(2): 426~434 (IF=7.017)
  19. Linda Sasset#, Yi Zhang# (co-first author), Teresa M. Dunn, and Annarita Di Lorenzo*. Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis. Trends Endocrinol Metab. 2016 Nov;27(11):807-819. pii:S1043-2760(16)30088-1. (IF=10.983)
  20. Yi Zhang, Yan Huang, Anna Cantalupo, Paula S. Azevedo, Mauro Siragusa, Jacek Bielawski, Frank J. Giordano, and Annarita Di Lorenzo*. Endothelial Nogo-B regulates sphingolipid biosynthesis to promote the transition from hypertrophy to heart failure during chronic pressure overload. JCI Insight. 2016 Apr 21; 1(5): e85484. (IF=6.014)
  21. Anna Cantalupo#, Yi Zhang# (co-first author), Milankumar Kothiya, Sylvain Galvani, Hideru Obinata, Mariarosaria Bucci, Frank J. G。iordano, Xian-Cheng Jiang, Timothy Hla, and Annarita Di Lorenzo*. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. Nat Med. 2015 Sep; 21(9):1028-37. (IF=30.641)
  22. Xianhua Wang*#, Wenjun Xie#, Yi Zhang# (co-first author), Peihui Lin, Liang Han, Peidong Han, YanruWang, Zheng Chen, Guangju Ji, Ming Zheng, Noah Weisleder, Rui-Ping Xiao, Hiroshi Takeshima, Jianjie Ma*, and Heping Cheng. Cardioprotection of ischemia-reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circ Res. 2010 Jul 9; 107(1):76-83. (IF=15.862)
  23. Chun-Mei Cao, Yan Zhang, Noah Weisleder, Christopher Ferrante, XianhuaWang, Fengxiang Lv, Yi Zhang, Ruisheng Song, Moonsun Hwang, Li Jin, Jiaojiao Guo, Wei Peng, Geng Li, Miyuki Nishi, Hiroshi Takeshima, Jianjie Ma, and Rui-Ping Xiao*. MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation. 2010 Jun 15; 121(23):2565-74. (IF= 23.054)