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Peraksine derivatives with potential anti-inflammatory activities from the stems of Rauvolfia vomitoria
发布时间：2025-04-30
- 论文名称：
- Peraksine derivatives with potential anti-inflammatory activities from the stems of Rauvolfia vomitoria
- 发表刊物：
- Fitoterapia
- 摘要：
- Abstract:
Five new peraksine derivatives rauvomine C–G (1–5) along with four known analogues (6–9) were isolated from the stems of Rauvolfia vomitoria Afzel. (Apocynaceae). Structural determinations of the new monoterpene indole alkaloids were elucidated via comprehensive spectroscopic analyses and ECD calculations. Rauvomine C (1) with an unprecedented framework type represents the first example of C18 peraksine-type nor-monoterpene indole alkaloid featuring a chlorine atom at C-16 and its plausible biosynthetic pathway was also proposed. All the isolates were evaluated for their anti-inflammatory, cytotoxic, and acetylcholinesterase inhibitory activities. Among them, the new framework alkaloid rauvomine C (1) showed significant anti-inflammatory activities on NO production in LPS-induced RAW264.7 mouse macrophages with IC50 value of 10.76 μM. Additionally, peraksine-type alkaloids featuring pyran ring (5, 8, and 9) exhibited potential anti-inflammatory activities with IC50 values ranging from 17.52 to 20.99 μM.
- 合写作者：
- Guanqun Zhan, Rongkun Miao, Zengjun Guo, et al.
- 卷号：
- 146
- 页面范围：
- 104704
- 是否译文：
- 否
- 发表时间：
- 2020-08-19
