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Galanthamine, Plicamine, and Secoplicamine Alkaloids from Zephyranthes candida and Their Anti-acetylcholinesterase and Antiinflammatory Activities
发布时间：2025-04-30
- 论文名称：
- Galanthamine, Plicamine, and Secoplicamine Alkaloids from Zephyranthes candida and Their Anti-acetylcholinesterase and Antiinflammatory Activities
- 发表刊物：
- Journal of Natrual Products
- 摘要：
- Abstract:
Sixteen new alkaloids belonging to the galanthamine (1−6), plicamine (7−14), and secoplicamine (15 and 16) classes, together with eight known analogues (17−24), were isolated from Zephyranthes candida. The structures of 1−16 were determined by extensive spectroscopic analyses, and the absolute configurations of 1, 2, 7, 8, and 17 were confirmed by singlecrystal X-ray diffraction analysis. The orientation of 3-OCH3 in N-methyl-5,6-dihydroplicane (22) was revised. Alkaloids 3, 12−14, and 18−21 exhibited anti-acetylcholinesterase activities with IC50 values ranging from 0.48 to 168.7 μM. Compounds 10−12, 14, and 16 showed in vitro anti-inflammatory activities with IC50 values ranging from 7.50 to 23.55 μM.
- 合写作者：
- Guanqun Zhan, Junfei Zhou, Guangmin Yao, et. al.
- 卷号：
- 79
- 页面范围：
- 760
- 是否译文：
- 否
- 发表时间：
- 2016-02-25
