发布时间：2021-10-01

文章标题：【学术成果】一篇通讯作者文章在国际学术期刊 AIP Advances上发表

内容：

我们从流体动力学角度对两种人工心脏瓣膜进行了实验对比，提出了一套瓣膜测试的流体动力学程序~

Dynamics of transcatheter heart valves with an in vitro experiment incorporating particle image velocimetry, AIP Advances 11, 105301 (2021)

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The malfunctioning heart valve will compromise the cardiovascular circulation of the human body. Given that artificial valves can be used to replace a disabled one, a feasible in vitro evaluation system is important before any possible implantation. In this study, two types of transcatheter heart valves, namely, V-A (diameter: 23 mm) and V-B (diameter: 25 mm), are tested and compared by an in vitro experiment that incorporates a circulation system and a particle image velocimetry measuring module. Three dynamical indices, namely, the time-averaged wall shear stress, oscillatory shear index, and relative residence time, are applied for the evaluation. The results show that compared with V-B, V-A leads to lower probabilities of vessel wall damage and thrombosis formation, especially when the flow rate is close to that of the human body (4 L/min). Meanwhile, an independent analysis, which mainly concerns the mean pressure difference and regurgitation volume across the two ends of the valve, demonstrates that V-A has a better performance than V-B, thus verifying the above-mentioned analysis from the perspective of fluid dynamics. Therefore, the present in vitro measuring system is considered effective in evaluating the valve functionality.