个人简介

 

黄荣,研究员,博士生导师

西安交通大学”青年拔尖人才”

 

邮箱:huangrong(at)xjtu.edu.cn   请手动将(at)替换为@

 

研究领域

主要研究方向:

1. 突触传递新理论-CiVDS的分子机制和生理功能研究;

2. 慢性疼痛的致病机理和临床新靶点研究;

3. 支持学生探索感兴趣且有潜力的好方向;

 

理解大脑的运转机制是人类与科学面临的最伟大挑战之一。神经系统钙活动和囊泡分泌活动是大脑与神经元最基本的生命活动之一,是维持大脑正常生理功能的基础,其调控机制一直都是本领域最基础、最重要的关键科学问题。申请人结合电生理、电化学、高分辨TIRFM成像、药理学等手段在神经分泌的触发与调控机制、胞吐-胞吞的偶联与平衡机制、自发钙活动与慢性疼痛等病理机制方面取得一系列突破性进展:揭示钙离子非依赖性分泌-CiVDS”的调控新机制,证明CiVDS在交感系统广泛分布并调控心脏功能,阐明CiVDS参与中枢突触传递,对分泌领域最基本的核心理论“Katz假说进行重要修订;首次揭示胞吞过程的双向调控油门与刹车机制,发现胞吐-胞吞的偶联与平衡新机制;并在上述由外部刺激触发的神经活动基础上,进一步揭示了自发水平钙活动在慢性疼痛等相关疾病的病理过程中的调控功能。上述原创性发现均在国内完成,是我国近年在神经分泌领域的重大原始创新和关键贡献。

教育经历

2014.09-2020.01  北京大学,前沿交叉学科研究院,整合生命科学,博士          

2010.09-2014.07  四川大学,轻工科学与工程学院,轻工生物技术,学士

工作经历

2023.01-2028.12  西安交通大学,生命学院,研究员,博士生导师

2020.07-2022.12  北京大学,未来技术学院,博士后,助理研究员,师从海内外著名神经生物学家周专教授

科研项目

1. 陕西省面上项目,2024JC-YBMS-1415万,2024.01-2025.12,在研,主持;

2. 西安交通大学青年拔尖人才计划,100万,2023.01-2028.12,在研,主持;

3. 北京大学博雅博士后项目,2020.07-2022.06,结题,主持;

4. 中国博士后科学基金,第14批特别资助(站中)2021T14001418万,2021.01-2022.12,结题,主持;

5. 中国博士后科学基金,第68批面上资助,2020M6802118万,2021.01-2022.12,结题,主持;

6. 国家自然科学基金,重点项目,31930061303万,2020.01-2024.12,在研,参与。

人才称号及获奖

2024 中国神经学会突触可塑性分会委员

2023 Biophysics Reports期刊青年编委

2023 西安市地区优秀人才

2022 西安交通大学青年拔尖人才

2020 北京大学博雅博士后

 

2020 北京市优秀毕业生

2020 北京大学优秀毕业生

2014 四川省优秀大学毕业生

2014 四川大学优秀毕业生干部

2013 国家奖学金

2011 国家奖学金

2015 中国生物物理学会“Best Poster Award”

2018 北京大学三好学生

2017 北京大学五四奖学金

2011 四川大学优秀团员干部

2010 四川大学党校优秀学员

期刊论文

代表性论文(通讯*,一作#)

Zhuoyu Zhang, Rong Huang*. Stronger stimulus triggers synaptic transmission faster through earlier started action potential. Cell Communication and Signaling. 2024, DOI: 10.1186/s12964-024-01483-3 (期刊论文,IF8.4)

 

Yang Chen, Shaoqin Hu, Xuanang Wu, Zhenli Xie, Yuan Wang, Bianbian Wang, Xiaopeng Li, Yingmei Pei, Yuhao Gu, Kai Huang, Jingxiao Huo, Anqi Wei, Cheng Bi, Zhe Lu, Qian Song, Huadong Xu, Xinjiang Kang, Shuli Shao, Jiangang Long, Jiankang Liu, Zhuan Zhou, Rong Huang*, Zuying Chai*, and Changhe Wang*. Synaptotagmin-1 is a bidirectional Ca2+ sensor for neuronal endocytosis. PNAS. 2022, DOI: 10.1073/pnas.2111051119 (期刊论文,IF12.8)

 

Yuan Wang#, Rong Huang#, Zuying Chai#, Changhe Wang#, Xingyu Du, Yuqi Hang, Yongxin Xu, Jie Li, Xiaohan Jiang, Xi Wu, Zhongjun Qiao, Yinglin Li, Bing Liu, Xianying Zhang, Peng Cao, Feipeng Zhu, Zhuan Zhou. Ca2+-independent transmission at the central synapse formed between dorsal root ganglion and dorsal horn neurons. EMBO Reports. 2022, DOI: 10.15252/embr.202154507 (期刊论文,IF9.1)

 

Rong Huang#, Yuan Wang#, Jie Li#, Xiaohan Jiang#, Yinglin Li, Bing Liu, Xi Wu, Xingyu Du, Yuqi Hang, Mu Jin, Feipeng Zhu, Changhe Wang, Zuying Chai, and Zhuan Zhou. Ca2+-independent but voltage-dependent quantal catecholamine secretion (CiVDS) in the mammalian sympathetic nervous system. PNAS. 2019, DOI: 10.1073/pnas.1902444116 (期刊论文,IF12.8)

 

Zuying Chai#, Changhe Wang#, Rong Huang#, Yuan Wang#, Xiaoyu Zhang, Qihui Wu, Yeshi Wang, Xi Wu, Lianghong Zheng, Chen Zhang, Wei Guo, Wei Xiong, Jiuping Ding, Feipeng Zhu, Zhuan Zhou. CaV2.2 Gates Calcium-Independent but Voltage-Dependent Secretion in Mammalian Sensory Neurons. Neuron. 2017, DOI: 10.1016/j.neuron.2017.10.028 (期刊论文,IF18.7)

Highlighted in Nature Reviews Neuroscience (Natasha Bray, A discrete form of secretion, 2017, 19(1):6. doi: 10.1038/nrn.2017.162).

Recommended by the Faculty of 1000 (F1000Prime recommendations by Ronald W Holz, Yang Yang and William Colmers).

 

其它论文:

Quanfeng Zhang#, Bing Liu#, Yinglin Li#, Lili Yin, Muhammad Younus, Xiaohan Jiang, Zhaohan Lin, Xiaoxuan Sun, Rong Huang, Bin Liu, Qihui Wu, Feipeng Zhu, and Zhuan Zhou. Regulating quantal size of neurotransmitter release through a GPCR voltage sensor. PNAS. 2020, DOI: 10.1073/pnas.2005274117 (期刊论文,IF12.8)

 

Changhe Wang#, Xinjiang Kang#, Li Zhou#, Zuying Chai, Qihui Wu, Rong Huang, Huadong Xu, Meiqin Hu, Xiaoxuan Sun, Suhua Sun, Jie Li, Ruiying Jiao, Panli Zuo, Lianghong Zheng, Zhenyu Yue, Zhuan Zhou. Synaptotagmin-11 is a critical mediator of parkin-linked Parkinson’s disease. Nature Communications. 2017, DOI: 10.1038/s41467-017-02593-y (期刊论文,IF17.7)

Highlighted in Movement Disorders (Moghaddam HS and Arabi MH, Synaptotagmin-11 is a novel hotspot in the pathogenesis of parkin-linked Parkinson’s disease: new implications for clinical targeting, 2018, 33(4):582).

 

Yeshi Wang#, Qihui Wu#, Meiqin Hu, Bin Liu, Zuying Chai, Rong Huang, Yuan Wang, Zhou Li, Huadong Xu, Changhe Wang, and Zhuan Zhou. Ligand- and voltage-gated Ca2+ channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neurons. Science Signaling. 2017, DOI: 10.1126/scisignal.aal1683 (期刊论文,IF9.5)

Highlighted in Science (Ferrarelli LK, 2017, Kiss-and-run or a full commitment? 356(6344):1243-1245. doi: 10.1126/science.356.6344.1243-p).

 

Changhe Wang#, Yeshi Wang#, Meiqin Hu#, Zuying Chai, Qihui Wu, Rong Huang, Weiping Han, ClaireXi Zhang, Zhuan Zhou. Synaptotagmin 11 inhibits clathrin-mediated and bulk endocytosis. EMBO Reports. 2016, DOI: 10.15252/embr.201540689 (期刊论文,IF9.1)

 

Shujiang Shang#, Feipeng Zhu#, Bin Liu#, Zuying Chai, Qihui Wu, Meiqin Hu, Yuan Wang, Rong Huang, Xiaoyu Zhang, Xi Wu, Lei Sun, Yeshi Wang, Li Wang, Huadong Xu, Sasa Teng, Bing Liu, Lianghong Zheng, Chen Zhang, Fukang Zhang, Xinghua Feng, Desheng Zhu, Changhe Wang, Tao Liu, Michael Xi Zhu, Zhuan Zhou. Intracellular TRPA1 Mediates Ca2+ Release from   lysosomes in dorsal root ganglion neurons. Journal of Cell Biology. 2016, DOI: 10.1083/jcb.201603081 (期刊论文,IF8.1)

Highlighted in Journal of Cell Biology (Mingxue Gu and Haoxing Xu, A painful TR(i)P to lysosomes, 2016, 215(3):309-312).