(1.)Basic Information

 

                                                                                          CURRICULUM VITAE

                   

     Daocheng Wu was born in Zhenjiang City, China, in 1962. He received his M.S. degree in Applied Chemistry from the Changsha Institute of Technology in 1989, and received his Ph.D degree in Biomedical Engineering from the Xi’an Jiaotong University in 2003. P. R. China. From 1999-2004, he worked as associate professor in the Department of Pharmacy, the Fourth Military Medical University, Xi’an, P. R. China. He joined the Xi’an Jiaotong university as a professor in 2005.

 

Currently he’s research is focused on the areas of biomaterials, bionanotechnology, and related topics that include drug delivery system, nanoparticles for diagnosis and therapy, as well as functional nanoparticles and their applications in the biomedical field. In recent 10 years, he has published over 120 papers in many peer-review journals. 


 

Work Address
School of Life Science and Technology, Xi’an Jiaotong University, P.R.China.
28 West Changle Road, Xi’an 710049.
Tel: 86-29-82663941    Fax: 86-29-82663941 
e-mail: wudaocheng@mail.xjtu.edu.cn
Home Address:    5 Jinhua Road, Xi’an  710048, Tel: 86-29-82310823

 

 Research Grants:

1. Bifunctional drug delivery micro-system with the characteristics of ultrasound- triggered release and ultrasound tracking
(National Natural Science Foundation of China, 30570494)
Role: Principal Investigator
  
2.Systemic pre-clinic research of adriamycin liposomes
(Major Program of science and technology of Guizhou Province of China, 97003)
Role: Principal Investigator
 
3. The preparation and characteristics of Intelligence release nanogel
(National Natural Science Foundation of China, 30170171)
Role: Principal Investigator
 
4. Nanosized particles for medical diagnosis and therapy
( National Medical Science and Technique Foundation during the 10th Five-Year Plan Period, No. 2001AA-218031).
Role: Principal Investigator
 
5.Novel nanosized drug delivery system and their industrialization
(National High Technology Research and Development Program of China, 2001BA310A7 -7) (863 Program ).
Role: Principal Investigator
 
6. The preparation and anti-tumor mechanism of (-) gossypol micro-system with the characteristics of ultrasonic controlled release and tumor targeting
( National Natural Science Foundation of China, 30772658).
Role: Principal Investigator
 
7. Bcl-2/Mcl-1 protein inhibitor with the characteristics of ultrasonic controlled release and tumor targeting.
(Projects of International Cooperation and Exchanges NSFC, 30710403089)
Role: Principal Investigator
 
8. Study on the Chiral microemulsion and related hydrogel and their characteristics of lipase catalyse.
(Key Laboratory Project on Key Laboratory of Colloid Interface Chemistry, Ministry of Education)
Role: Principal Investigator

9.Multi-functional core-shell immunomagnetic bead for the research of cancer stem cells.
( National Natural Science Foundation of China, 30970712).
Role: Principal Investigator

10 . Extract process of Gossypol acetic acid from cottonseed soapstock and  (-) Gossypol   separation  
(Shaanxi province science and technology innovation project , 2011KTCL03-07)
 Role: Principal Investigator
 
11.Dual- targeting of Bcl-2 proteins inhibitor delivery system to the tumor cells and their mitochondrions ( National Natural Science Foundation of China,  81271686).
Role: Principal Investigator
 
12．Gossypol/MicroDNAs antitumor system with the characteristics of tumorcells and their nucleus dual-targeting（Overseas, Hong Kong & Macao Scholars Collaborated Researching Fund of National Natural Science Foundation of China.81228011）.
Role: Co-Principal Investigator
 
13.Multi-functional mulberry like AQ4N∕thiotepa nanocarrier with the characteristics of hypoxia phosphorescence indication for drug release,hyaluronic acid tumor targeting, AQ4N hypoxia-selective reduction and combined therapy,
Natural Science Foundation of China,  81471771).
Role: Principal Investigator
 
Publications:
Over 120 papers have been published in: Biomaterials, Clinic Chem, J Phy Chem, J Pharm Pharmaceut Sci ,  J Mater Chem, Nanoscale， IEEE Transactions on NanoBioscienc, Sensors & Actuators:B.Chemical, American Institute of Chemical Engineers Journal, Chem. Commun, Cancer  Immunol Immunother, J Biotechnol，and so on.  
Some of them are shown as following:
 1. Daocheng Wu*, Mingxi Wan，Yongfeng Du   Enhancing the Antitumor Effect of Adriamycin Nanoparticle Lipiodol Emulsion by Pretreating Liver Cancer with Diethyldithiocarbamate.    International  Journal of  Nonlinear and  Numerical simulation  2002,3(3-4):181-184 .
 2 .Wu Daocheng*, Wan Mingxi，Mo Jian ,Wu Hong. Enhancing the Antitumor Effect of Adriamycin nanoparticle by pretreating liver Cancer with Diethyldithiocarbamate.   J  Chin Pharm Sci 2002, 11(3):24-29
 3.  H. WU, Z. X. ZHANG, H. P. ZHAO, D. C. Wu, B. L. Wuz  Preparation of sodium fluoride-loaded gelatin microspheres, characterization and cariostatic studies. Journal of Microencapsulation 2004,21(8): 889-903.
 4.Guo-Ping Wang, Er-Qun Song,a Hai-Yan Xie,Zhi-Ling Zhang, Zhi-Quan Tian, Chao Zuo,Dai-Wen Pang, Dao-Cheng Wu and Yun-Bo Shi. Biofunctionalization of fluorescent- magnetic-bifunctional nanospheres and their applications. Chem. Commun. 2005, 4276–4278
 5. Ge W, Sui YF, Wu DC, Y.J. Sun Guang-Sheng Chen,Zeng-Shan Li ,Shao-Yan Si,Pei-Zhen Hu ,Yang  Huang,Xiu-Min Zhang.MAGE-1/Heat shock protein 70/MAGE-3 fusion protein vaccine innanoemulsion enhances cellular and humoral immune responses to MAGE-1 or MAGE-3 in vivo. Cancer  Immunol Immunother，2005,55（7）：841-849 
 6.Shi R, Hong L, Wu D, Ning X, Chen Y, Lin T, Fan D, Wu K.Enhanced Immune Response to GastricCancer Specific Antigen Peptide by Co-encapsulation with CpOligodeoxynucleotides  Nanoemulsion .  Cancer biological and therapy 2005, 4(2): 218-224 
 7. Hong Wu, Zhenxi Zhang, Daocheng Wu , Hongping Zhao, Kaitao Yu, Zhenqing Hou. Preparation and   drug release characteristics of Pingyangmicin-loaded dextran cross-linked gelatin microspheresfor embolization therapy. Journal of Biomedical Materials Research part B: Applied Biomaterials 2006,78 (1):56-62.
 8. Lan J, Huang X, Hu M, Li Y, Qu Y, Gao P,Wu DC . High efficient degradation of dyes with lignin peroxidase coupled with glucose oxidase. J Biotechnol. 2006,123(4):483-90
 9.Er-Qun Song, Guo-Ping Wang, Dao-Cheng Wu, Dai-Wen Pang. Visual Recognition and Efficient  Isolation of Apoptotic Cells with Fluorescent- Magnetic- Biotargeting Multifunctional Nanospheres. Clin. Chem. 2007,53(12):2177-2185.
 10. Wu Daocheng*, Wan Mingxi.  A Novel Fluoride Anion Modified Gelatin Nanogel System for Ultrasound-Triggered Drug Release. J Pharm Pharmaceut Sci 2008；11 (4): 32-45,
 11. Shuqiang M, Kunzheng W, Xiaoqiang D, Wei W, Mingyu Z, Daocheng W. Osteogenic growth peptide incorporated into PLGA scaffolds accelerates healing of segmental long bone defects in rabbits. J Plast Reconstr Aesthet Surg. 2008 ;61(12):1558-1560.
 12.Fei Z, Hu Y, Wu D, Wu H, Lu R, Bai J, Song H. Preparation and property of a novel bone graft composite consisting of rhBMP-2 loaded PLGA microspheres and calcium phosphate cement. J Mater Sci Mater Med. 2008,19(3):1109-1116
 13. Na Guo, Daocheng Wu*, Xinghua Pan, Maolin Lu Magnetic Polymer Microspheres with AzidocarbonylGroups: Synthesis, Characterization and Application in Protein Immobilization.  Journal of Applied Polymer Science 2009,112(4);2383-2390
 14. Xinghua Pan, Maolin Lu, Daocheng Wu*, Lili Gai. Synthesis and Characterization of Double-layer Quantum Dots- Tagged Microspheres.  IEEE Transactions on NanoBioscience, 2009 ,8(1);13-19
 15. Maolin Lu, Daocheng Wu*， Na Guo.  Novel functionalized ternary copolymer fluorescent nanopart- icles: synthesis, fluorescent characteristics and protein immobilization. J Mater Sci: Mater Med 2009, 20(2); 563.-572
 16. Lili Gai，Daocheng Wu*.A Novel Reversible pH-Triggered Release Immobilized Enzyme System.  Appl Biochem Biotechnol 2009,158(3):747-760 (2008 On Line , DOI 10.1007/s12010-008-8373-2).
  17. Guangfeng Jia, Daocheng Wu*, Yang Meng and Liang Xu. An Improved Ultrasound-Assisted Extraction Process of Gossypol Acetic Acid from Cottonseed Soapstock. American Institute of Chemical Engineers Journal 2009,55,(3) :797-897
 18.YonghuaZhan ,GuangfengJia , Daocheng Wu*, YiqingXu ,and LiangXu. Designand Synthesis of a Gossypol Derivative with Improved AntitumorActivities. Arch.Pharm.Chem.Life Sci.2009,342,223–229.
 19. Sun  F, Wu D., Qiu, Z., Li, J., Development of real-time PCR systems based on SYBR Green for the specific detection and quantification of Klebsiella pneumoniae in infant formula, Food Control , 2010, 21 (5):487-491.
 20.Daocheng  Wu* , Mingxi Wan, Hong Wu . Ultrasonic triggered release drug delivery   system of Pluronic micelle. Nanoscience, 2006,11(3):210-218
  21.Xian-Qing Zhang, Xiao-Feng Huang, Shi-Jie Mu, Qun-Xing An, Ai-Jun Xia, Rui Chen, Dao-Cheng Wu*  Inhibition of proliferation of prostate cancer cell line, PC-3,in vitro and in vivo using (–)-gossypol.     Asian Journal of Andrology 2010,12:390-399.
 22.Wu D*, Wan M. Preparation of the core-shell structure adriamycin lipiodol microemulsions and their  synergistic anti-tumor effects with diethyldithiocarbamate in vivo. Biomedicine & Pharmacotherapy 2010, 64(9):615-23.
  23.Xian-Qing Zhang,  Xiao-Feng Huang, Xing-Bin Hu, Yong-Hua Zhan, Qun-Xing An, Shi-Ming Yang, Ai- Jun Xia,Jing Yi, Rui Chen, Shi-Jie Mu, Dao-Cheng Wu*. Apogossypolone, a novel inhibitor of   antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro.    Asian Journal of Andrology. 2010;12:697-708.
 24.Xinghua Pan, Jianhui Ju, Yonghua Zhan, and Daocheng Wu*. Preparation and Fluorescence Characteristics of Amido- functionalized Dual-fluorescent Microspheres with Core-shell Structure   Micromolecular Chemistry  & Physics . 2010, 221 (21) ;2347-2355 .
  25.Xinghua Pan , Rachel Thompson , Xiaojie Meng , Daocheng Wu , Liang Xu. Tumor-targeted RNA-interference: functional non-viral nanovectors. Am J Cancer Res 2011;1(1):32-49(invited Review)
  26.Xinghua Pan, Jianhui Ju, Jianjun Li and Daocheng Wu*. Poly(styrene-acrylamide- acrylic acid) copolymer fluorescent microspheres with improved hydrophilicity: preparation and influence on protein immobilization. High Performance Polymers 2011，22（3）；255-262
  27.Liu T, Wu D. Simultaneous determination of some ultraviolet-absorbing chemicals in sunscreen cosmetics using a high-performance liquid chromatography method. Int J Cosmet Sci. 2011, 33, 408–415.
  28.Zhenhai Gan, Jianhui Ju, Ting Zhang, and Daocheng Wu*. Preparation of Rhodamine B Fluorescent Poly(methacrylic acid) Coated Gelatin Nanoparticles. J Nanomaterials 2011, Article ID 753705, 8 pages doi:10.1155/2011/753705.
  29.Wei Gao, Baoyong Sha, Wei Zou, Xuan Liang, Xiangzhong Meng, Hao Xu, Jun Tang, Daocheng  Wu,*   Lixian Xu, Hui Zhang. Cationic Amylose-Encapsulated Bovine Hemoglobin as a Nanosized Oxygen Carrier. Biomaterials 2011,32:9425-9433.
  30.Chen L, Kong X, Liang Z, Ye F, Yu K, Dai W, Wu D*, Luo C*, Jiang H. Theoretical Study of the Mechanism of Proton Transfer in the Esterase Estb from Burkholderia Gladioli. Journal of Physical Chemistry B. 2011, 115 (44):13019–13025.
  31.Lu XY, Wu DC, Li ZJ, Chen GQ. Polymer nanoparticles.  Prog Mol Biol Transl Sci. 2011;104:299-323.
  32. Ruifen Xu, Xuyang Feng, Xin Xie, Jin Zhang, Daocheng Wu*, Lixian Xu*.  HIV-1 Tat protein increase the permeability of brain endothelial cells by both inhibiting Occludin expression and cleaving occludin via matrix metalloproteinase-9. Brain Research 2012,1436:13-19.
  33.Wu Daocheng*, Wan Mingxi. Methylene diphosphonate-conjugated adriamycin    liposomes: Preparation, characteristics, and targeted therapy for osteosarcomas in vitro and in vivo. Biomedical Microdevices 2012,14:497-510
  34.Haseeb Zubair, Husain Y Khan, M.F. Ullah, Aamir Ahmad, Daocheng Wu, S.M.Hadi. Apogossypolone, derivative of gossypol, mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage. European Journal of Pharmaceutical Sciences, 2012 ,47:280-286.  
  35. Liu T, Wu D* High-performance liquid chromatographic determination of triclosan and triclocarban in cosmetic products. Int J Cosmet Sci. 2012 ,34:489-494
  36. Gan Z, Zhang T, Liu Y, Wu D*. Temperature-Triggered Enzyme Immobilization and Release Based on Cross-Linked Gelatin Nanoparticles. PLoSONE. 2012, 7(10): e47154. doi:10.1371/journal.pone.0047154 .
  37.Youshen Wu, Yan Li, Lei Qin, Feilong Yang and Daocheng Wu*. Monodispersed or narrow-dispersed melamine–formaldehyde resin polymer colloidal spheres: Preparation, size-control, modification, bioconjugation, and particle formation mechanism. Journal of Materials.Chemistry. 2013,1:204-212 (doi 10.1039/C2TB00043A).
  38.Chen Zhao, Daocheng Wu*  Rapid detection assay for the molecular imprinting of gossypol using a two-layer PMAA/SiO2 bulk structure with a piezoelectric imprinting sensor，Sensors & Actuators:B.Chemical, 2013,181；104-113.
  39.P Cheng, Z Ni, X Dai, B Wang, W Ding, A Rae Smith, L Xu, D Wu, F He and J Lian. The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular cells.Cell Death and Disease, 2013；4, e489;doi:10.1038/cddis.2013.17    
 40. Yan Li,Youshen Wu, Cheng Luo, Feilong Yang, Lei Qin, Tao Fu, Guangquan Wei, XiaoweiKang,Daocheng Wu*  Preparation and characterization of narrow-dispersed magnetic colloidal nanoparticle cluster/silica microspheres with controlled sizes, high saturation magnetization and MRI enhancement effect. Journal of Materials. Chemistry. B, 2013,1:4644-465  .  
 41.Yun zeng, Shaojuan Zhang,Menghui Jia, Yang Liu, Jin Shang,Youmin Guo,Jianghua Xu and Daocheng Wu*Hypoxia-sensitive Bis(2-(2-Benzothienyl)-pyridinato-N,C3') Iridium[poly(n-butylcyanoacrylate]/Chitosan nanoparticles and Their Phosphoresence Tumor Imageing In vitro and in vivo. Nanoscale 2013,5,12633 —12644   
42.Xuefan Gu, Youshen Wu, Lingze Zhang，Yongchun Liu, Yan Li, Yongli Yan and Daocheng Wu* Hybrid magnetic nanoparticle/nanogold cluster and its distance-dependent metal-enhanced fluorescence effect via DNA hybridization, Nanoscale, 2014，6，8681-8693.

43.Youshen Wu, Yan Li, Jianhua Xu and Daocheng Wu*.Incorporating Fluorescent Dyes into Monodisperse
Melamine-Formaldehyde Resin Microspheres via Organic Sol-Gel Process: Pre-polymer Doping Strategy.J. Mater. Chem. B, 2014, 2（35），5837-5846 . 

44.Hao Liu, Ke Li, Lan Lan, Jingwen Ma, Yun Zeng, Liang Xu*and Daocheng Wu*.Double-layered hyaluronic acid/stearic acidmodified polyethyleneimine nanoparticles encapsulating (-)-gossypol: a nanocarrier for chiral anticancer drugs.J. Mater. Chem. B, 2014 2,5238-5248.

45.Ke Li , Hao Liu , Wei Gao , Mu Chen, Yun Zeng , Jiajun Liu, Liang Xu ,Daocheng Wu*,Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy. Biomaterials 2015,39,131-144 
46.Hao Liu , Ke Li, Liang Xu, Daocheng Wu*, Bilayered near-infrared fluorescent nanoparticles
based on low molecular weight PEI for tumor-targeted in vivo imaging.  Journal Nanopart Research    2014, 16: 2784     
47. Xuehui Zhang, Xiaoli Xi, Zhongguo Song, Supin Wang, Mingxi Wan, and Daocheng Wu*. Performance Analysis of Spread Spectrum Through Wall Radar   IEEE TRANSACTIONS ON MAGNETICS  2014,50(11):5102004                           
48.Yun Zeng, Yang Liu, Jin Shang, Jingwen Ma, Rong Wang, Lei Deng, Youmin Guo,Fan Zhong, Mingfeng Bai, Shaojuan Zhang, Daocheng Wu*.   Phosphorescence Monitoring of Hypoxic Microenvironment in Solid-Tumors to Evaluate Chemotherapeutic Effects Using the Hypoxia-Sensitive Iridium (III) Coordination Compound. PLoS ONE. 2015,10(3): e0121293. doi:10.1371/ journal.pone.0121293
 49.   Gao wei, Sha Baoyong,
The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin



Read More: http://informahealthcare.com/doi/abs/10.3109/21691401.2015.1011807
Liu Yongchun, Daocheng Wu, Xin Shen,Guixia Jing.   
The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin



Read More: http://informahealthcare.com/doi/abs/10.3109/21691401.2015.1011807
The effect of cationic starch on  hemoglobin, and the primary attempt to capsulate  hemoglobin.  
The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin



Read More: http://informahealthcare.com/doi/abs/10.3109/21691401.2015.1011807
The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin



Read More: http://informahealthcare.com/doi/abs/10.3109/21691401.2015.1011807
The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin



Read More: http://informahealthcare.com/doi/abs/10.3109/21691401.2015.1011807
Artificial Cells, Nanomedicine, and Biotechnology 2015,43(3):196-202
  50.Yan Li,  Youshen Wu,Cheng Luo , Bo Wang and Daocheng Wu*. Rewritable megnetic fluorescence-encodeed  microspheres:preparation, characterization, and recycling. J. Mater. Chem C.  2015,3:8262-8271.
  51.Jinwen Ma, Youshen Wu, Yun Zeng,Yan Li and Daocheng Wu*. Thermo-stable hollow megnetic microspheres:preparation, characteristics and recycable catalytic applications. J. Mater. Chem A.  2015,3:16762-16773.
52. Daocheng Wu*,  Mingxi Wan.  A novel ultrasonic-triggered drug release and tracked drug
delivery system based on gas-filled BSA microbubbles and gelatin nanogels. Journal of Controlled release 2015,213;e24 (doi:10.1016/j.jconrel.2015.05.036)
 

53.Yiao Yu, Youshen Wu ,  Jiajun Liu, Yonghua  Zhan , Daocheng Wu*  Ultrasmall dopamine-coated  nanogolds: preparation, characteristics, and CT imaging  Journal of Experimental Nanoscience  2016,11(Sup1):S1-S11 (DOI:10.1080/ 17458080. 2015.1102343) 

54.Yao Yu, Youshen Wu, Jiajun Liu, Ke Li, Daocheng Wu*    Metabolizable dopamine-coated gold nanoparticles aggregates: Preparation, characteristics, computed tomography imaging, acute toxicity, and metabolism in vivo      Journal of Materials Chemistry B, 2016, 4,1090-1099(DOI: 10.1039/C5TB02497H )

55. Zhang X, Xi X, Li M , Wu D*. Comparison of Impulse Radar and Spread-Spectrum Radar in Through-Wall Imaging   IEEE Transactions on Microwave Theory and Techniques , 2016 ,64(3):699-706(DOI:10.1109/TMTT.2015.2508791).

  56.Hao Liu and Daocheng Wu*. In vivo near-infrared fluorescence tumor imaging using DiR-loaded nanocarriers.Current Drug Delivery  2016,13(1):40-48 (DOI: 10.2174/1567201812666150703114908. )

 57. Yun Zeng, Jingwen Ma, Shaojuan Zhang, and Daocheng Wu,*  Imaging Agents in Targeting Tumor Hypoxia. Current Medicinal Chemistry, 2016(17), 23, 1775-1800. 

 58..Yongxing Dua,Lingze Zhang,Lulu Sangeand Daocheng Wu,* Temperature field simulation and phantom validation of a Two-armed Spiral Antenna for microwave thermotherapy.Technology and Health Care  2016,24 S675–S682.  

 59.Youshen Wu, Jiajun Liu, Jingwen Ma, Yongchun Liu, Ya Wang, and Daocheng Wu*.Ratiometric  Nanothermometer Based on Rhodamine Dye-Incorporated F127-Melamine-Formaldehyde Polymer Nanoparticle:Preparation, Characterization, Wide-Range Temperature Sensing,and Precise Intracellular Thermometry.ACS Appl. Mater. Inter 2016,8(23):14396-14405.

60.Wei Gao , Yongchun Liu , Guixia Jing , Ke Li , Yuan Zhao , Baoyong Sha  Qiang Wang *,Daocheng Wu *. Rapid and efficient crossing blood-brain barrier: Hydrophobic drugdelivery system based on propionylated amylose helix nanoclusters.Biomaterials 2017;113 :133-144 (DOI : 10.1016/ j.biomaterials.2016.10.045

61.Jingwen Ma, Yun Zeng, Yongchun Liu and Daocheng Wu*.Thermostable polymeric        nanomicelles of iridium(III) complexes with aggregation-induced phosphorescence emission    characteristics and  their recyclable double-strand DNA monitoring.  J. Mater. Chem B. 2017,5,123-133.

62. Youshen Wu,Liu Jiajun, Ya Wang, Ke Li , Jianhua Xu , Daocheng Wu*. Novel ratiomatric flourescence nanothermometers based on flouropores-labeled short single-stranded DNA. ACS Appl. Mater. Inter 2017,9(12):11073-11081( doi .10.1021/acsami7b01554).

(*correspondence author)