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Currently he’s research is focused on the areas of biomaterials, bionanotechnology, and related topics that include drug delivery system, nanoparticles for diagnosis and therapy, as well as functional nanoparticles and their applications in the biomedical field. In recent 10 years, he has published over 120 papers in many peer-review journals. He has published more than 70 research papers in advanced functional materials (IF 15.7), biomaterials (IF 10.3), J material Chem a (IF10.4), nanoscale (IF7.3), autophagy (IF11.3), ACS appl. Material. Inter (IF8.1) and other famous SCI journals. His cittation is more than 7500 times in total and H factor 24. Among them, there are more than 60 articles written by the first and corresponding authors. He has published more than 100 articles in core journals in China. More than 30 doctoral and master degree students have been trained.
Research fields:
1.Antitumor effects of gossypol and its derivatives
A lot of studies have been carried out on the separation and purification of gossypol and its derivatives as well as the anti-cancer research of its derivatives. For the first time, gossypol derivatives have been found to have the mechanism of autophagy of tumor cells, and the synergistic effect of gossypol derivatives and adriamycin on tumors has been found. They are assembled into mulberry-like double-drug targeting self-assembly. In the assembled nano-drug carrier system, only 1/5 dosage of the drug can achieve 1.5 times the original therapeutic effect, and the toxicity and side effects are greatly reduced. The synergistic effect of gossypol derivatives with other drugs was also found. More than 20 papers hace been published in Adv Funct Mater, Biomaterials, Cancer Biology and Treatment Cancer, J Mater Chem B, J Control Release and other international well-known journals ,
2. Ultrasound Drug Controlled Release System and Equipment
A gelatin ionized nanogel with reversible ultrasound triggered intelligent drug release was designed and prepared. The response time and recovery time of the gelatin ionized nanogel were 1-2 min and 3-4 min， respectively. The average particle size of the gelatin ionized nanogel was increased to 2-3 micron after reversible ultrasound triggered, which greatly increased the drug load of the system. A high photothermal conversion efficiency system of polydopamine and near infrared dye IR-780 was designed to modify perfluorocarbon nanodroplets with sensitive photothermal phase transition ability. Under the action of near infrared laser, the temperature of the system has been greatly increased from room temperature to above 60 C, which is enough to realize the hyperthermia of tumor cells and tissues. In addition, perfluorocarbon nanodroplets undergo obvious phase transition (from liquid to gaseous). The perfluorocarbon gas after phase transition can enhance the contrast effect of ultrasound, visualize the tumor site of photothermal therapy, and the intensity of ultrasound signal also indicates the temperature change process and degree of hyperthermia. In this study, perfluorocarbon nanodroplets were used to achieve in vivo treatment of animals and real-time monitoring of treatment status. More than 10 papers have been published in ACS Applied Materials & Interfaces, Current Medicinal Chemistry, Nanoscale, J Mater Chem B, C and other well-known international journals. A number of invention patents have been also granted.
3 Nanothermometer for biomedical applications
A new method for the formation of fluorescent nanothermometer by encapsulating water-soluble rhodamine F-127 fluorescent dye and Rhodamine B (reference) in melamine nanoparticles at the same time was studied. The temperature sensitivity of the fluorescent nanothermometer is high (7.6%C-1). It can measure temperature in a wide temperature range from -20 C to 150 C. It has been successfully applied to microwave heating of cells measurement. The fluorescence resonance energy transfer (FRET) of random curl size Rg of single stranded DNA molecule was used to measure the microenvironment temperature. A colorimetric fluorescent nanometric thermometer based on single stranded DNA has been developed. It has high sensitivity (7.04% degree C-1) and wide temperature range (0-100 degrees C). It has a stable thermo sensitive property and successfully applied to the quantitative measurement of gel and intracellular temperature. More than 10 papers have been published in ACS Applied Materials & Interfaces, J Mater Chem B, C and other well-known international journals.
Research Grants: