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基本信息

 

 

 

张彦民

 

 医学博士,教授,博士研究生导师

教育部新世纪优秀人才

陕西省中青年科技创新领军人才

陕西省青年科技新星

陕西省三秦人才

西安交通大学首批青年拔尖人才入选者

医学部首批国家级人才后备人选(菁英人才)

陕西省天然药物研究与工程重点实验室副主任

西安交通大学药物研究所药物活性评价室主任

国家自然科学基金委员会通讯评审专家

 

研究领域

 

 *药物分析

(1)抗肿瘤中药药效物质筛选分析

  • (2药物作用过程分析 

  •  

    • *肿瘤药理

    (1)分子靶向抗肿瘤药物-酪氨酸激酶受体抑制剂研究

    (2)肿瘤细胞信号转导通路 

招生信息

博士后招聘:

        欢迎进入药学博士后流动站进行博士后研究。提供年薪18万,出站优秀者直接应聘副教授岗位。

其他启动费等详细情况请参照:http://pd.xjtu.edu.cn

 http://hrm.xjtu.edu.cn/info/1020/1075.htm

 

博士研究生招生

100704 药物分析学:

      03 药物作用过程分析; 

      12 血管生成抑制剂筛选研究

药理学:肿瘤药物调控机制

 

硕士研究生招生

100704 药物分析学:

      03 药物作用过程分析; 

      12 血管生成抑制剂筛选研究

 

考试科目

    参照西安交通大学招生目录

研究队伍

   西安交通大学医学部药物研究所分子药理学研究室为陕西省天然药物研究与工程重点实验室和生物与药理研究所依托研究室。

   目前共有研究人员28人,其中教师8人(教授1人,副教授2人、讲师4人,技术员1人),在读博士和硕士研究生、进修人员15人,本科毕业设计5人。

 

       研究室研究领域:

 

  • 抗肿瘤创新药物筛选研究;
  • 血管药物药效学和分子机制研究;
  • 肿瘤免疫治疗药物的筛选及药效学研究;
  • 肿瘤细胞生物传感分析
  • 膜蛋白受体与药物分子相互作用研究
  •  

 

联系方式

电话:029-82656264

传真:029-82655451
E-mail:
zhang2008@xjtu.edu.cn           

Web:http://gr.xjtu.edu.cn/web/zhang2008

           http://medgs.xjtu.edu.cn/tearch/t_index.php?id=1267

地址:西安交通大学医学校区54号信箱(西安市雁塔西路76号)
邮编:710061

 

Analog Clock 3
个人简介

 

张彦民   
 

       从事抗肿瘤药理、靶向血管药物分析、药物作用过程分析、中药药效物质基础分析等方面的研究工作。在“肿瘤血管生成抑制剂”药理模型建立和药效物质筛选方面开展了系列研究。自2009年至今在西安交通大学医学部药学院依次任讲师、硕士生导师、副教授、博士生导师、特聘研究员、教授。期间于2015年6月-2016年8月在美国Arizona State University(任职Assistant Research Scientist)进行访问学习。

   主持国家自然科学基金项目3项,国家“十二五”重大新药创制专项,教育部新世纪优秀人才支持计划项目,中央高校基本科研业务费专项资金-青年教师跟踪支持项目,陕西省自然科学基金,陕西省重点实验室青年学术骨干培植等项目16项;参加国家重大科研仪器设备研制专项、国家自然科学基金重点、面上项目、西安市重大科技计划等项目的研究工作。

  发表论文110余篇,其中在Pharmacol Therapeut, JACSCDDs, Org Lett, Chem Commun, SCI Reports,Can lett,JCMM 等杂志上发表SCI论文88篇,H=16; 申请国际和国家发明专利26项,授权13项。

       2012年获国家技术发明二等奖(第六),2010年获陕西省优秀博士学位论文,同年获中国药学会科学技术二等奖(第三)。

       

      主要学术任职

 

杂志编委:

Hepatoma Research 杂志,Editorial board member(EBM, 编委)

American Journal of Pharmacology and Toxicology杂志,编委

Clinics in Oncology 杂志,编委

Advances in Modern Oncology Research 杂志,编委

Advances in Oncology Research and Treatments 杂志,编委

Med One 杂志,编委

Current Pharmacogenomics and Personalized Medicine, 编委

Reactive Oxygen Species 杂志,编委

Journal of Biochemistry and Molecular Biology Research杂志,编委

Insights in Breast Cancer杂志,编委

Journal of Pharmacology and Therapeutic Research杂志,编委

Journal of Radiology and Oncology杂志,编委

Journal of Cancer Research Forecast杂志,编委

《药物生物技术》杂志,编委

 -------------------------------------------------------------------------------------------------------

委员会:

世界中联中药鉴定专业委员会,理事

陕西省药学会药物分析专业委员会,委员

中国药学会, 高级会员

Asia-Pacific Association of Medical Research, 会员

 

     受邀担任JACS, Oncotarget, Scientific reports, Gene, Phytomedicine, International Journal of Oncology, Tumor Biology, International Journal of Molecular Sciences, Molecules, Phytotherapy Research, International Journal of Pharmacology, Food & Function, Analytical Methods, Natural Product Research, Anti-Cancer Agents in Medicinal Chemistry, Biomedical Chromatography, Letters in drug design & discovery, Pharmaceutical Biology, Journal of Cancer Biology & Treatment等国际SCI期刊特邀审稿人。

 

 

主要文章

 

91. Yinnan Chen, Yanmin Zhang (通讯). Functional and mechanistic analysis of telomerase: an anti-tumor drug target. Pharmacology and Therapeutics, 2016, 163:24-47. (IF=11.137)
 
90. Arnaud Chevalier, Yanmin Zhang, Omar M. Khdour, Justin Kaye and Sidney M. Hecht. A Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting. Journal of the American Chemical Society, 2016, 138:12009-12012. (IF=13.858)
 
89. Yanmin Zhang, Shuoxing Jiang, Dongdong Zhang, Xiaoguang Bai, Sidney M. Hecht, Shengxi Chen. DNA-Affibody Nanoparticles for Inhibiting Breast Cancer Cells overexpressing HER2. Chemical communications, 2017, 53:573-576. (IF=6.319)
 
88. Bingling Dai, Wenjie Wang, Yujiao Ma, Junpeng Qi, Yingzhuan Zhan, Dongdong Zhang, Rui Liu, Yanmin Zhang (通讯). A natural product dihydroberberine increases the sensitivity of lung carcinoma to sunitinib by mediating MAPK pathway and inflammatory mediators. Journal of Cellular and Molecular Medicine, 2017, Doi: 10.1111/jcmm.13178. (IF=4.499)
 
87. Arnaud Chevalier, Yanmin Zhang, Omar M. Khdour and Sidney M. Hecht*. Selective Functionalization of Antimycin A Through an N-Transacylation Reaction. Organic Letters, 2016, 18:2395-2398. (IF=6.579)
 
86. Yanmin Zhang, Yingzhuan Zhan, Dongdong Zhang, Bingling Dai, Weina Ma, Junpeng Qi, Rui liu, Langchong He. Eupolyphaga sinensis Walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling. Scientific Reports, 2014, 4:5518. (IF=4.529)
 
85. Zhang Dongdong, Zhang Yanmim, Lei Zheng, He Langchong. Graphene oxide/poly-L-lysine assembled layer for adhesion and electrochemical impedance detection of leukemia K562 cancer cells. Biosensors and Bioelectronics, 2013, 42:112-118. (IF=7.780)
 
84. Yanmin Zhang, Bingling Dai, Lei Zheng, Yingzhuan Zhan, Jie Zhang, Wanli W. Smith, Xiaoli Wang, Yinnan Chen, Langchong He. A novel angiogenesis inhibitor impairs lovo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation. Cell Death and Disease, 2012, 3:e406. (IF=5.965)
 
83. Wenjuan Luo, Xiaoli Wang, Lei Zheng, Yingzhuan Zhan, Dongdong Zhang, Jie Zhang, Yanmin Zhang (通讯). Brucine suppresses colon cancer cells growth via mediating KDR signaling pathway. Journal of Cellular and Molecular Medicine, 2013, 17:1316-1324. (IF=4.499)
 
82. Yanmin Zhang, Langchong He, Liang Meng, Wenjuan Luo, Xuemei Xu. Suppression of tumor-induced angiogenesis by taspine isolated from Radix et Rhizoma Leonticis and its mechanism of action in vitro. Cancer Letters, 2008, 262:103-113. (IF=6.375)
 
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81. Yanmin Zhang, Arnaud Chevalier, Omar M. Khdour, Larisa Morales Soto, Sidney M. Hecht*. Inhibition of Human Cancer Cell Growth by Analogues of Antimycin A. Plant Medica, 2017, DOI: 10.1055/s-0043-112343.
 
80. Feng Liu, Xia Du, Rui Su, Yuhong Sun, Yanmin Zhang (通讯). Screening and analysis of key active constituents in GuanxinShutong capsule by using mass spectrum and integrative network pharmacology. Chinese Journal of Natural Medicine, 2016, Accepted.
 
79. Man zhu, Yanmin Zhang (通讯). Function of Mcl-1 and its regulative relations with hepatocellular carcinoma. Hepatoma Research, 2017, 3:129-140.
 
78. Weina Ma, Man Zhu, Tianfeng Yang. Yanmin Zhang (通讯). Synergistic Effect of TPD7 and Berberine against Leukemia Jurkat Cell Growth through Regulating Ephrin-B2 Signaling. Phytotherapy research, 2017, DOI: 10.1002/ptr.5866.
 
77. Bingling Dai, Yujiao Ma, Tianfeng Yang, Wenjie Wang, Yanmin Zhang(通讯). Taspine derivative 12k suppressed A549 cell migration through the Wnt/β-catenin and EphrinB2 signaling pathway. Biomedicine & Pharmacotherapy, 2017, 87:102-109.
 
76. Weina Ma, Man Zhu, Dongdong Zhang, Liu Yang, Tianfeng Yang, Xin Li, Yanmin Zhang(通讯). Berberine Inhibits Proliferation and Migration in Breast Cancer ZR-75-30 Cells through Targeting Ephrin-B2. Phytomedcine, 2017, 25:45-51.
 
75. Dongdong Zhang, Lingzhi Li, Weina Ma, Juanjuan Zhang, Yanmin Zhang(通讯). Electrodeposited reduced graphene oxide incorporating polymerization of L-lysine on electrode surface and its application in simultaneous electrochemical determination of ascorbic acid, dopamine and uric acid. Materials Science & Engineering C, 2017, 70:241-249.
 
74. Dongdong Zhang, Xiaoyan Ouyang, Lingzhi Li, Bingling Dai, Yanmin Zhang(通讯). Real-time amperometric monitoring of cellular hydrogen peroxide based on electrodeposited reduced graphene oxide incorporating adsorption of electroactive methylene blue hybrid composites. Journal of Electroanalytical Chemistry, 2016, 780:60-67.
 
73. Yingzhuan Zhan, Rui Liu, Wenjie Wang, Jing Li, Xiaoyan Ou Yang, Yanmin Zhang(通讯). Total saponins isolated from Radix et Rhizoma Leonticis suppresses tumor cells growth by regulation of PI3K/Akt/mTOR and p38 MAPK pathways. Environmental Toxicology and Pharmacology2016, 41: 39-44.
 
72. Bingling Dai, Wenjie Wang, Yujiao Ma, Rui Liu, Yanmin Zhang(通讯). A taspine derivative supresses Caco-2 cell growth by competitively targeting EphrinB2 and regulating its pathway. Oncology reports, 2016, 36: 1526-1534.
 
71. Dongdong Zhang, Xiaoyan Ouyang, Jing Ma, Lingzhi Li, Yanmin Zhang(通讯). Electrochemical behavior and voltammetric determination of curcumin at electrochemically reduced graphene oxide modified glassy carbon electrode. Electroanalysis, 2016, 28, 749-756.
 
70. Yingzhuan Zhan, Han Zhang, Rui Liu, Wenjie Wang, Junpeng Qi, Yanmin Zhang(通讯). Eupolyphaga sinensis Walker ethanol extract suppresses cell growth and invasion in human breast cancer cells. Integrative Cancer Therapies2016, 15(1) 102-112 .
 
69. Dongdong Zhang, Xiaoyan Ouyang, Weina Ma, Lingzhi Li, Yanmin Zhang(通讯). Voltammetric determination of folic acid using adsorption of methylene blue onto electrodeposited of reduced graphene oxide film modified glassy carbon electrode. Electroanalysis, 2016, 28:312-319.
 
68. Yinnan Chen, Yanmin Zhang(通讯). Human telomerase disease mutants and its relation with hepatocarcinoma. Hepatoma Research, 2016, 2:109-113.
 
67. Dongdong Zhang, Junpeng Qi, Rui Liu, Bingling Dai, Weina Ma, Yingzhuan Zhan, Yanmin Zhang(通讯). c-Myc plays a key role in TADs-induced apoptosis and cell cycle arrest in human hepatocellular carcinoma cells. American Journal of Cancer Research, 2015, 5:1076-1088.
 
66. Bingling Dai, Wenjie Wang, Rui Liu, Hongying Wang, Yanmin Zhang(通讯). Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma. Biomedicine & Pharmacotherapy, 2015, 70:227-233.
 
65. Weina Ma, Dongdong Zhang, Lei Zheng, Yingzhuan Zhan, Yanmin Zhang(通讯). Potential roles of Centipede Scolopendra extracts as a strategy against EGFR-dependent cancers. American Journal of Translational Research, 2015, 7:39-52.
 
64. Rui Liu, Junpeng Qi, Bingling Dai, Wenjie Wang, Yanmin Zhang(通讯). Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma. Molecular Medicine Reports, 2015, 12: 7735-7741.
 
63. Weina Ma, Dongdong Zhang, Jing Li, Delu Che, Rui Liu, Jie Zhang, Yanmin Zhang(通讯). Interactions between histamine H-1 receptor and its antagonists by using cell membrane chromatography method. Journal of pharmy and pharmacology, 2015, 67, 1567-1574.
 
62. Yanmin Zhang, Yingzhuan Zhan, Dongdong Zhang, Bingling Dai, Weina Ma, Junpeng Qi, Rui liu, Langchong He. Eupolyphaga sinensis Walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling. Scientific Reports, 2014, 4:5518
 
61. Bingling Dai1, Yanmin Zhang1(共同第1, Yingzhuan Zhan, Dongdong Zhang, Nan Wang, Langchong He. A novel tissue model for angiogenesis: evaluation of inhibitors or promoters in tissue level. Scientific Reports, 2014, 4:3693
 
60. Bingling Dai, Junpeng Qi, Rui Liu, Jie Zhang, Yingzhuan Zhan, Yanmin Zhang(通讯). A novel compound T7 (N-{4'-[(1E)-N-hydroxyethanimidoyl] -3',5,6-trimethoxybiphenyl-3-yl}-N'-[4-(3-morpholin-4-ylpropoxy)phenyl]urea) screened by tissue angiogenesis model and its activity evaluation on anti-angiogenesis. Phytomedicine, 2014, 21:1675-1683.
 
59. Weina Ma, Rui liu, Junpeng Qi, Yanmin Zhang(通讯). Extracts of Centipede Scolopendra induced cell cycle arrest and apoptosis in human melanoma A375 Cells. Oncology letters, 2014, 8:414-420.
 
58. Bingling Dai, Yingzhuan Zhan, Junpeng Qi, Yanmin Zhang(通讯). Eupolyphaga sinensis Walker inhibits human chronic myeloid leukemia cell K562 growth by inducing G2-M phase cell cycle arrest and targeting EGFR signaling pathway and in S180 tumor-bearing mice. Environmental Toxicology and Pharmacology, 2014, 37:1177-1185.
 
57. Bingling Dai, Junpeng Qi, Rui liu, Yanmin Zhang(通讯). Eupolyphaga sinensis Walker demonstrates angiogenic activity and inhibits A549 cell growth bytargeting the KDR signaling pathway. Molecular Medicine Reports, 2014, 10:1590-1596.
 
56. Yanjun Cao, Feng Liu, Zhuangzhuang Huang, Yanmin Zhang(通讯). Protective effects of Guanxin Shutong Capsule drug-containing serum on TNF-alpha-induced endothelial dysfunction through NADPH oxidase and NO pathway. Experimental and Therapeutic Medicine, 2014, 8: 998-1004.
 
55. Yuanji Wang, Nan Wang, Lei Wu, Wen Lu, Yanmin Zhang(通讯). Simultaneous determination of four components in Baige capsule by HPLC: Application to pharmacokinetics and tissue distribution of normal and middle cerebral artery occlusion rats. Biomedical Chromatography, 2014, 28:541-547.
 
54. Yanjun Cao, Xu He, Feng Liu, Zhuangzhuang Huang, Yanmin Zhang(通讯). Chinese medicinal formula Guanxin Shutong Capsule protects the heart against oxidative stress and apoptosis induced by ischemic myocardial injury in rats. Experimental and Therapeutic Medicine, 2014, 7: 1033-1039.
 
53. Yingzhuan Zhan, Yinnan Chen, Han Zhang, Yanmin Zhang(通讯). Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling. Archives of Pharmacal Research, 2014, 37:1086-1095.
 
52. Bingling Dai, Junpeng Qi, Yanmin Zhang(通讯). Eupolyphaga sinensis Walker screened by cell membrane chromatography and its inhibition on Hek293/EGFR cells by modulating the EGFR signaling pathway. Abstracts/ European Journal of Integrative Medicine, 2014, 6: 741.
 
51. Nan Wang, Lei Wu, Yanjun Cao, Yuanji Wang, Yanmin Zhang(通讯). The protective activity of imperatorin in cultured neural cells exposed to hypoxia re-oxygenation injury via anti-apoptosis. Fitoterapia, 2013, 90:38-43.
 
50. Nan Wang, Lei Zheng, Yingzhuan Zhan, Yanmin Zhang(通讯). A novel taspine derivative suppresses human liver tumor growth and invasion in vitro and in vivo. Oncology letters, 2013, 6:855-859.
 
49. Lei Zheng, Xiaoli Wang, Wenjuan Luo, Yingzhuan Zhan, Yanmin Zhang(通讯). Brucine, an effective natural compound derived from nux-vomica, induces G1 phase arrest and apoptosis in LoVo cells. Food and Chemical Toxicology, 2013, 58: 332-339.
 
48.  Wen Lu, Bingling Dai, Weina Ma, Yanmin Zhang(通讯). A novel taspine analogue, HMQ1611, inhibits growth of non-small cell lung cancer by inhibiting angiogenesis. Oncology letters, 2012, 4:1109-1113.
 
47. Lei Zheng, Xu He, Weina Ma, Bingling Dai, Yingzhuan Zhan, Yanmin Zhang(通讯). Ta1722, an anti-angiogenesis inhibitor targeted on VEGFR-2 against human hepatoma. Biomedicine & Pharmacotherapy, 2012, 66: 499-505.
 
46. Huaizhen He, Nan Wang, Yinnan Chen, Lei Zheng, Yanmin Zhang(通讯). Tas13D inhibits growth of SMMC-7721 cell through suppressing VEGF and EGF expression. Asian Pacific Journal of Cancer Prevention, 2012,13:2009-2014.
 
45. Yingzhuan Zhan, Meng Sun, Yinnan Chen, Yanmin Zhang(通讯). Determination of Taspine Using HPLC-MS and its Effect on EGFR in A431 and HEK293/EGFR Cells in Vitro. Chromatographia, 2011,74:383-389
 
44. Yanmin Zhang, Lei Zheng, Jie Zhang, Bingling Dai, Nan Wang, Yinnan Chen, Langchong He. Anti-tumor activity of taspine by modulating EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo. Planta Medica, 2011, 77: 1774-1781.
 
43. Yanmin Zhang, Qiao Jiang, Nan Wang, Bingling Dai, Yinnan Chen, Langchong He. Effects of taspine on proliferation and apoptosis by regulating caspase-3 expression and the ratio of Bax/Bcl-2 in A431 cells. Phytotherapy research, 2011, 25: 357-364.
 
42. Yanmin Zhang, Jie Zhang, Bingling Dai, Nan Wang, Langchong He. Anti-proliferative and apoptotic effects of the novel taspine derivative tas41 in the Caco-2 cell line. Environmental toxicology and pharmacology, 2011, 31:406-415.
 
41. Yanmin Zhang, Youle Qu, Jie Zhang. Ardipusilloside I purified from Ardisia pusilla competitively binds VEGFR and induces apoptosis in NCI-H460 cells. Phytomedicine, 2010, 17:519-526.
 
40. Yanmin Zhang, Xu Li, Xuemei Xu, Wenjuan Luo. Construction of a high-EGFR expression cell line and its biological properties comparing with A431 cell. African Journal of Biotechnology, 2010, 9:4674-4680.
 
39. Yali Zhou, Wenjuan Luo, Lei Zheng, Miao Li, Yanmin Zhang (通讯). Construction of recombinant FGFR1 containing full-length gene and its potential application. Plasmid, 2010, 64:60-67.
 
38. Yanmin Zhang, Langchong He, Yali Zhou. Taspine isolated from Radix et Rhizoma Leonticis inhibits growth of human umbilical vein endothelial cell by inducing its apoptosis. Phytomedicine, 2008, 15:112-119.
 
37. Yanmin Zhang, Langchong He, Liang Meng, Wenjuan Luo. Taspine isolated from Radix et Rhizoma Leonticis inhibits proliferation and migration of endothelial cells as well as chicken chorioallantoic membrane neovascularisation. Vascular Pharmacology, 2008, 48:129-137.
 
36. Cuicui Liu, Yanmin Zhang, Bingling Dai, Yujiao Ma, Yi Wang, Qian Zhang, Hao Yang. Chlorogenic acid prevents interleukin-1beta-induced inflammation in human SW-1353 chondrocytes, a model for osteoarthritis. Molecular Medicine Reports, 2016, Accepted.
 
35. Huiling Jing, Wenyan Sun, Jinghua Fan, Yanmin Zhang, Jiao Yang, Jinjing Jia, Jichang Li, Jiaqi Guo, Suju Luo, Yan Zheng*. Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways. Molecular Medicine Reports, 2016, 13: 3009-3016.
 
34. Yingzhuan Zhan, Han Zhang, Jing Li, Yanmin Zhang, Jie Zhang, Langchong He*. A novel biphenyl urea derivate inhibits the invasion of breast cancer through the modulation of CXCR4. Journal of cellular and molecular medicine, 2015, 19:1614-1623.
 
33. Yanjun Cao, Yanmin zhang, Junpeng Qi, Rui Liu, Han Zhang, Langchong He. Ferulic acid inhibits H2O2-induced oxidative stress and inflammation in rat vascular smooth muscle cells via inhibition of the NADPH oxidase and NF-kappa B pathway. International Immunopharmacology, 2015, 28:1018-1025
 
32. Yuanji Wang, Yanmin Zhang, Weina Ma, Xiaoyan Pan, Nan Zhou, Bingling Dai, Langchong He. The Vasodilatation Effects of Four Active Components in Baige Capsule and the Potential Mechanism of Them with the NMDA Receptor. Current Pharmaceutical analysis, 2015, 11, 173-179.
 
31. Lei Zheng, Yanmin Zhang, Yanping Liu, Xiaoyan Ouyang, Yingzhuan Zhan. Momordica cochinchinensis Spreng. seed extract suppresses breast cancer growth by inducing cell cycle arrest and apoptosis. Molecular medicine reports, 2015, 12: 6300-6310.
 
30. Gao, Hongping, Su, Ping, Shi, Yaling, Shen, Xiuxiu, Zhang, Yanmin, Dong, Jinyun, Zhang, Jie*. Discovery of novel VEGFR-2 inhibitors. Part II: Biphenyl urea incorporated with salicylaldoxime. European Journal of Medicinal Chemistry, 2015, 90:232-240
 
29. Weina Ma, Yanmin Zhang, Jing Li, Rui Liu, Delu Che, Langchong He. Analysis of drug interactions with dopamine receptor by frontal analysis and cell membrane chromatography. Chromatographia, 2015, 78:649-654.
 
28. Nan Wang, Yanmin Zhang, Lei Wu, Yuanji Wang, Yanjun Cao, Langchong He, Xia Li, Jianjun Zhao. Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition. Neuropharmacology, 2014, 79:282-289.
 
27. Xiaoyan Pan, Jinyun Dong, Hongping Gao, Fang Wang, Yanmin Zhang, Sicen Wang, Jie Zhang*. Design, synthesis and biological evaluation of pyridin-3-yl pyrimidines as potent Bcr-Abl inhibitors. Chemical Biology & Drug Design, 2014, 83: 592-599
 
26. Yanjun Cao, Yanmin Zhang, Nan Wang, Langchong He. Antioxidant effect of imperatorin from Angelica Dahurica in hypertension via inhibiting NADPH oxidase activation and MAPK pathway. Journal of the American Society of Hypertension, 2014 8:527-36.
 
25. Lei Zheng, Yan-min Zhang, Ying-Zhuan Zhan, Chang-xiao Liu. Momordica cochinchinensis Seed Extracts Suppress Migration and Invasion of Human Breast Cancer ZR-75-30 Cells Via Down-regulating MMP-2 and MMP-9. Asian Pacific Journal of Cancer Prevention, 2014, 15:1105-1110.
 
24. Chen Wang, Hongping Gao, Jinyun Dong, Yanmin Zhang, Ping Su, Yaling Shi, Jie Zhang. Biphenyl derivatives incorporating urea unit as novel VEGFR-2 inhibitors: Design, synthesis and biological evaluation. Bioorganic & Medicinal Chemistry, 2014, 22:277-284
 
23. Xiaofang Hou, Sicen Wang, Tao Zhang, Jing Ma, Jie Zhang, Yanmin Zhang, Wen Lu, Huaizhen He, Langchong He. Recent advances in cell membrane chromatography for traditional Chinese medicines analysis. Journal of Pharmaceutical and Biomedical Analysis, 2014, 101: 141-150.
 
22. Li Weifeng, Huang Huimin, Zhang Yanmin, Fan Ting, Liu Xia, Xing Wei, Niu Xiaofeng. Anti-inflammatory effect of tetrahydrocoptisine from Corydalis impatiens is a function of possible inhibition of TNF-alpha, IL-6 and NO production in lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-kappa B activation and MAPK pathway. European Journal of Pharmacology, 2013, 715: 62-71.
 
21. Chen Wang, Jinyun Dong, Yanmin Zhang, Fang Wang, Hongping Gao, Pengfei Li, Sicen Wang and Jie Zhang. Design, synthesis and biological evaluation of biphenyl urea derivatives as novel VEGFR-2 inhibitors. MedChemComm. 2013, 4: 1434-1438.
 
20. Zhang Dongdong, Zhang Yanmin, He Langhcong. Sensitive voltammetric determination of baicalein at thermally reduced graphene oxide modified glassy carbon electrode. Electroanalysis, 2013, 25:2136-2144.
 
19. Xiaoyan Pan, Fang Wang, Yanmin Zhang, Hongping Gao, Zhigang Hu, Sicen Wang, Jie Zhang. Design, synthesis and biological activities of Nilotinib derivates as antitumor agents. Bioorganic & Medicinal Chemistry, 2013, 21:2527-2534.
 
18. Weifeng Li, Ting Fan, Yanmin Zhang, Te Fan, Ping Zhou, Xiaofeng Niu*, Langchong He. Houttuynia cordata Thunb. Volatile Oil Exhibited Anti-inflammatory Effects In Vivo and Inhibited Nitric Oxide and Tumor Necrosis Factor-a Production in LPS-stimulated Mouse Peritoneal Macrophages In Vitro. Phytotherapy Research, 2013, 27:1629-39.
 
17. Xiaofeng Niu, Ting Fan, Weifeng Li, Huimin Huang, Yanmin Zhang, Wei Xing. Protective effect of sanguinarine against acetic acid-induced ulcerative colitis in mice. Toxicology and Applied Pharmacology, 2013, 267:256-265.
 
16. Zhang J, Zhang YM, Pan XY, Wang C, Hu ZG, Wang SC, He LC. Facile synthesis and biological evaluation of novel symmetrical biphenyls as antitumor agents. Medicinal Chemistry, 2012, 8:145-150.
 
15. Huaizhen He, Yingzhuan Zhan, Yanmin Zhang, Jie Zhang, Langchong He. Synthesis of novel taspine diphenyl derivatives as fluorescence probes and inhibitors of breast cancer cell proliferation. Luminescence: The Journal of Biological and Chemical Luminescence. 2012, 27:310-314.
 
14. Weifeng Li, Ting Fan, Yanmin Zhang, Xiaofeng Niu, and Wei Xing. Effect of Chelerythrine Against Endotoxic Shock in Mice and Its Modulation of Inammatory Mediators in Peritoneal Macrophages Through the Modulation of Mitogen-Activated Protein Kinase (MAPK) Pathway. Inflammation, 2012, 35:1814-1824.
 
13. Yingzhuan Zhan, Yanmin Zhang, Cuicui Liu, Jie Zhang, Wanli W. Smith, Nan Wang, Yinnan Chen, Lei Zheng, Langchong He. A Novel Taspine Derivative, HMQ1611, Inhibits Breast Cancer Cell Growth via Estrogen Receptor and EGF Receptor Signaling Pathways. Cancer Prevention Research, 2012, 5:864-873.
 
12. Yingzhuan Zhan, Yanmin Zhang, Yinnan Chen, Nan Wang, Lei Zheng, Langchong He. Activity of taspine isolated from Radix et Rhizoma Leonticis against estrogen-receptor-positive breast cancer. Fitoterapia, 2011, 82:896-902.
 
11. Jie Zhang, Yanmin Zhang, Xiaoyan Pan, Sicen Wang, Langchong He. Synthesis and Cytotoxic Evaluation of Novel Symmetrical Taspine Derivatives as Anticancer Agents. Medicinal Chemistry, 2011, 7, 286-294.
 
10. Weifeng li, Ping Zhou, Yanmin zhang, Langchong He. Houttuynia cordata, a novel and selective COX-2 inhibitor with anti-inflammatory activity. Journal of Ethnopharmacology. 2011, 133:922-927.
 
9. Sun Meng, Zhang Yan-min, Zhang Jie, Wang Si-cen, He Lang-chong, A high expression EGFR/cell membrane chromatography and online high performance liquid chromatography/mass spectrometry method for screening EGFR antagonists from Rhizoma Polygoni Cuspidati. Acta Pharmaceutical Sinica B, 2011;1:115–120.
 
8. Sicen Wang, Sun Meng, Yanming Zhang, Hui Du, Langchong He. A New A431/Cell Membrane Chromatography–online–high performance liquid chromatography /mass spectrometry Method for Screening Anti-EGFR Antagonists from Radix Sophorae Flavescentis. Journal of Chromatography A, 2010, 1217:5246-5252.
 
7. Sicen Wang, Meng Sun, Yanmin Zhang, Jie Zhang, Langchong He. EGFR/Cell Membrane Chromatography–online–high performance liquid chromatography/mass spectrometry method for screening EGFR Antagonists from Radix Angelicae Pubescentis. Science China-Chemistry, 2010, 53:2357-2362.
 
6. Miao Li, Sicen Wang, Yanmin Zhang, Langchong He. An online coupled cell membrane chromatography with LC/MS method for screening compounds from Aconitum carmichaeli Debx. acting on VEGFR-2. Journal of Pharmaceutical and Biomedical Analysis, 2010, 53:1063-1069.
 
5. Jie Zhang, Yanmin Zhang, Yuanyuan Shan, Na Li, Wei Ma, Langchong He. Synthesis and preliminary biological evaluation of novel taspine derivatives as anticancer agents. European Journal of Medicinal Chemistry, 2010, 45:2798-2805.
 
4. Jie Zhang, Yanmin Zhang, Sanqi Zhang,et al. Discovery of novel taspine derivatives as antiangiogenic agents. Bioorganic & Medicinal Chemistry Letters, 2010, 20:718-721.
 
3. Meng Sun, Jing Ren, Hui Du, Yanmin Zhang, Jie Zhang, Sicen Wang, Langchong He. A combined A431 cell membrane chromatography and online high performance liquid chromatography/mass spectrometry method for screening compounds from total alkaloid of Radix Caulophylli acting on the human EGFR. Journal of Chromatography B, 2010, 878:2712-2718.
 
2. Jiafang Lian, Sanqi Zhang, Jingwen Wang, Kunquan Fang, Yanmin Zhang, Yong Hao. Novel galactosylated SLN for hepatocyte-selective targeting of floxuridinyl diacetate. Journal of Drug Targeting, 2008, 16:250-256.
 
1. Langchong He, Sicen Wang, Guangde Yang, Yanmin Zhang, Changhe Wang, Bingxiang Yang, Xiaofang Hou. Progress in the cell membrane chromatography. Drug Discoveries & Therapeutics, 2007, 1:104-107.

 

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