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何晓聪

副教授 硕士生导师

西安交通大学生命科学与技术学院

招收具有生物医学工程/医学/能源动力/机械/力学/电子信息类/物理等相关背景的推免/考研硕士生，欢迎有志青年咨询报考！

Email: xiaoconghe@xjtu.edu.cn

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2020-今， 西安交通大学，生命科学与技术学院，副教授

2017-2020，西安交通大学，生命科学与技术学院，讲师

2015-2016，美国明尼苏达大学，机械学院，访问学者

2011-2017，西安交通大学，能源与动力工程学院，博士

2007-2011，中国矿业大学，机电学院，学士

研究方向

1. 肿瘤力学微环境：纳米药物输运机理、调控策略研究
2. 即时检测：微流控芯片、柔性可穿戴器件与设备研发

    所开展的工作对疾病的临床早期诊断、成像及治疗具有重要指导意义。目前已在PNAS，ACS Sensors，Drug Discov Today，Int J Heat Mass Tran 等国际权威期刊发表SCI学术论文30余篇，5篇入选期刊封面，作为亮点介绍；授权国家发明专利3项。

承担科研项目

承担科技部十四五国家重点研发计划（子课题负责人）、中央军委科技委员会重大基础研究（子课题负责人）、主持国家自然科学基金青年项目、陕西省自然科学基金、国家“博士后创新人才支持计划”、国家博士后科研基金、陕西省博士后科研基金、西安交通大学科研基金、企业横向等项目。

获奖

获得2017年“博士后创新人才支持计划”

1. He XC#, Yang YY#, Han YL#, Cao CY, Zhang ZB, Li LX, Xiao CL, Guo H, Wang L, Han LC, Qu ZG, Liu N∗, Han S∗, Xu F∗, Extracellular matrix physical properties govern the diffusion of nanoparticles in tumor microenvironment, Proceedings of the National Academy of Sciences, 2023, 120(1): e2209260120.
2. Ying Fu, Wenjun Dang, Xiaocong He#, Feng Xu#, Haishui Huang#, Biomolecular Pathways of Cryoinjuries in Low-Temperature Storage for Mammalian Specimens, Bioengineering, 2022, 9(10): 545
3. Lingxiao Li, Yuanyuan Yang, Lin Wang, Feng Xu, Yuan Li#, Xiaocong He#, The Effects of Serum Albumin Pre-Adsorption of Nanoparticles on Protein Corona and Membrane Interaction: A Molecular Simulation Study, Journal of Molecular Biology, 2022: 167771
4. Yupeng Yang, Haijuan Jia, Zhi Liu, Nan Bai, Xiaolai Zhang, Tong Cao, Jie Zhang, Pengbing Zhao, Xiaocong He，Overall and local effects of operating parameters on water management and performance of open-cathode PEM fuel cells, Applied Energy, 2022, 315: 118978
5. He XC, Yang Y, Li L, Dong Z, Qu ZG∗, Xu F∗, Tailoring patchy nanoparticles design to modulate serum albumin sdsorption and membrane interaction, Soft Matter, 2021, 17: 2071-2080.
6. XC He, Z Gu, W Lin, Z Qu∗, F Xu*; Coarse-grained molecular dynamics simulation of dendrimer transmembrane transport with temperature-dependent membrane phase states; International Journal of Heat and Mass Transfer，2020,155,119797.
7. XC He, YY Yang, LX Li, PH Zhang, H Guo, N Liu, XF Yang, Xu F; Engineering Extracellular Matrix to Improve Drug Delivery for Cancer Therapy; Drug discovery today, 2020, 25(9): 1727-1734.
8. 李玲潇，何晓聪*，刘智，屈治国，徐峰, 疏水障碍提高侧流试纸检测性能的模拟研究, 工程热物理学报，2020,41（6）：1524-1528。
9. He XC ; Liu Z; Yang YY; Li LX; Wang L; Li A; Qu ZG; Xu F; Sensitivity Enhancement of Nucleic Acid Lateral Flow Assays through a Physical−Chemical Coupling Method: Dissoluble Saline Barriers, ACS SENSORS, 2019, 4(6):1691-1700. 封面文章
10. Liu Z#, He XC#, Qu ZG, Xu F. A two-dimensional numerical study for analyzing effects of capture probe properties on the performance of lateral flow assays. ANALYST, 2019, 144(18): 5394-5403. 封面文章
11. Liu Z#, He XC#, Han JX, Zhang XH, Li F, Li A, Qu ZG, Xu F. Liquid wicking behavior in paper-like materials: mathematical models and their emerging biomedical applications. Microfluidics and Nanofluidics, 2018, 22(11): 132. 
12. 李玲潇，何晓聪*，刘智，屈治国，徐峰, 疏水障碍提高侧流试纸检测性能的模拟研究, 2018工程热物理学会传热传质年会，2018.10.12-10.15，哈尔滨
13. He XC, Qu ZG, Xu F. Simulation study of interaction mechanism between peptide and asymmetric membrane [J]. Molecular simulation, 2017, 43(1):1-8.
14. He XC, Lin M, Guo J, Qu ZG, Xu F. Experimental and simulation studies of polyarginines across the membrane of giant unilamellar vesicles [J]. RSC Advances, 2016, 6(36): 30454-30459. 
15. He XC, Lin M, Li F, Sha BY, Xu F, Qu ZG, Wang L. Advances in studies on nanoparticle-biomembrane interactions [J]. Nanomedicine, 2015, 10(1): 121-141. 
16. He XC, Lin M, Lu TJ, Qu ZG, Xu F. Molecular analysis of interactions between PAMAM dendrimer-paclitaxel conjugate and biomembrane [J]. Physical Chemistry Chemical Physics, 2015, 17(44): 29507-29517. 封面文章 
17. He XC, Lin M, Sha BY, Feng SS, Shi XH, Qu ZG, Xu F. Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension [J]. Scientific Reports, 2015, 5: 12808. 
18. He XC, Qu ZG, Xu F. Molecular analysis of interactions between peptide and asymmetric membrane; 2015 Asian Symposium on Computational Heat Transfer and Fluid Flow (ASCHT2015); Busan, Korea, November 22-25, 2015.
19. He XC, Qu ZG, Xu F, Lin M, Wang JL, Shi XH, Lu TJ. Molecular analysis of interactions between dendrimers and asymmetric membranes at different transport stages [J]. Soft Matter, 2014, 10(1): 139-148.
20. 何晓聪，屈治国. 渗透压调节巨型单层囊泡缩胀实验研究. 中国工程热物理学会传热传质分会，西安，10.31-11.2，2014。
21. He XC, Qu ZG, Xu F. Coarse-grained molecular simulations of the processes of nanoparticles penetrating an asymmetric lipid bilayer. 13th International Conference on Fracture (ICF13); Beijing, China, June 16-21, 2013.
22. S Sun, S Feng, C Ji, M Shi, XC He, F Xu, T Lu; Microstructural effects on permeability of Nitrocellulose membranes for biomedical applications，Journal of Membrane Science，595 (2020) 117502.
23. Tang RH, Liu LN, Zhang SF, He XC, Li XJ, Xu F, Ni YH, Li F (2019). A review on advances in methods for modification of paper supports for use in point-of-care testing. Microchimica Acta, 186(8),521.
24. Zhang SF, Liu LN, Tang RH, Liu Z, He XC, Qu ZG, Li F (2019). Sensitivity enhancement of lateral flow assay by embedding cotton threads in paper. Cellulose, 26(13-14), 8087-8099.
25. ZD Li, H Liu, XC He, F Xu, F Li, Pen-on-paper strategies for point-of-care testing of human health, TrAC - Trends in Analytical Chemistry, 2018,108:50-64. 封面文章
26. Liu Z, Qu ZG, Tang RH, He XC, Yang H, Bai D, Xu F. An improved detection limit and working range of lateral flow assays based on a mathematical model. Analyst, 2018,143, 2775-2783. 封面文章
27. Song FH , Ju DP, Gu FW, Liu Y, Ji Y, Ren YL, He XC, Sha BY, Li BQ, and Yang QZ. Parametric Study on Electric Field-Induced Micro-/Nanopatterns in Thin Polymer Films. Langmuir, 2018,34:(14) 4188-4198.
28. Zhang XH, Qu ZG, He XC, Lu DL. Experimental study on the sound absorption characteristics of continuously graded phononic crystals [J]. AIP Advances, 2016, 6(10): 105205.
29. Qu ZG, He XC, Lin M, Sha BY, Shi XH, Lu TJ, Xu F. Advances in the understanding of nanomaterial-biomembrane interactions and numerical modeling [J]. Nanomedicine, 2013, 8(6)：995-1011.
30. 何晓聪，徐峰，杨媛媛，刘智，屈治国.核酸检测试纸、制备方法和检测方法 [P]. 中国, 专利号：ZL201811252140.2, 2020.8.25.
31. 屈治国，刘智，何晓聪，徐峰. 三维侧流试纸检测仪、制备方法及检测方法 [P]. 中国，专利号：201810413748.2, 2020.3.31.
32. 屈治国，刘智，任秦龙，何晓聪，徐峰. 侧流试纸检测装置及其制备方法 [P]. 中国，专利号：201810591801.8, 2019.7.12.