1. 肿瘤放疗的免疫学机制；

2. 肿瘤发生和转移的免疫学机制；

3. 肿瘤免疫治疗。

1. Chen Chen, Liahong Shi, Yutiantian Lei Qian Wang, Peihai Cao, Dairu Hou, Mengdi Huang, Ruiying Wang, Qiuyu Mu, Tingting Lv, Rui Jia, Mingjun Si, Dingge Jiang, Lei Li, Zhixuan Cai, Yakun Huang, liahao Sun, Lianying Jiao, Zhengtao Xiao, Yuhan Li, Binxian Wang, Shan Huang. Wengian Du, Lu Bai, Linlu Ma, Suxia Han, Baojun Zhang, Chen Lin, Hui Guo, Xiangjiao Meng & Yuzhu Hou*. Pregnancy promotes tumor metastasis through adenosine-induced immunosuppressive neutrophils in pre-metastatic microenvironment. Nature Communications, 2026 Aug 4;(17):9394. (IF: 18.1)

2. Chen Chen, Jiahong Shi, Peihai Cao, Juan Bai, Yutiantian Lei, Mengdi Huang, Mingjun Si, Ruiying Wang, Tingting Lv, Rui Jia, Qiuyu Mu, Dingge Jiang, Yuzhu Hou*, Shan Huang*. Tumor-cell HMGB1 restrains CD8+ T-cell immunity during conventional fractionated radiotherapy. Cancer Letters, 2026 Sep 19:660:218843. (IF: 11.8)

3. Yutiantian Lei, Rui Ji, Chen Chen, Peihai Cao, Jiahong Shi, Mengdi Huang, Qiuyu Mu, Yixin Wang, Dairu Hou, Mingjun Si, Ruishan Guo, Jiahao Sun, Dingge Jiang, Yihan Wang, Tingting Lv, Ruiying Wang, Junyi Zhang, Liuyi Yang, Renyi Ding, Wenhua Li, Haiyan Liu, Anjun Jiao, Linyun Hui, Chen Lin, Jinlu Ma*, Suxia Han*, Yuzhu Hou*. CXCR5⁺ monocyte emigration impairs the radiation-induced antitumor immune response. Nature Communications,2026 Mar;17(1):4258. (IF: 18.1)

4. Shirong Zhang, Mengjie Liu, Deli Tan, Kejia Lv, Wenyuan Li, Xubo Huang, Jia Hou, Yaru Yang, Chen Chen, Jinteng Feng, Wenjuan Wang, Lili Jiang, Min Jiao, Zhiping Ruan, Ying Zan, Yuzhu Hou*, Hui Guo*. p57 increases immunotherapy efficacy by promoting cGAS-STING-mediated innate sensing in hepatocellular carcinoma. Cell Reports, 2026 Jan; 45(1):116769. (IF: 6.9)

5. Yufei Cao, Moujiang Zheng, Jiahong Shi, Jiale Si, Guopu Huang, Yuanyuan Ji, Yuzhu Hou*, Zhishen Ge*. X-ray-Triggered Activation of Polyprodrugs for Synergistic Radiochemotherapy. Biomacromolecules, 2025 Jan 13;26(1):579-590. doi: 10.1021/acs.biomac.4c01373 (IF: 5.5)

6. Jun-Rui Feng, Xue Li, Cong Han, Yue Chang, Yu Fu, Gong-Chang Feng, Yutiantian Lei, Hai-Yun Li, Patrick Ming-Kuen Tang, Shang-Rong Ji, Yuzhu Hou*, Yi Wu*. C-Reactive Protein Induces Immunosuppression by Activating FcγR2B in Pulmonary Macrophages to Promote Lung Metastasis. Cancer Research, 2024 Dec 16;84(24):4184-4198. doi: 10.1158/0008-5472.CAN-24-0253 (IF: 12.5)

7. Ke-Jia Lv, Si-Zhe Yu, Yu Wang, Shi-Rong Zhang, Wen-Yuan Li, Jia Hou, De-Li Tan, Hui Guo, Yuzhu Hou*.Cancer-associated fibroblasts promote the progression and chemoresistance of HCC by inducing IGF-1. Cellular Signalling, 2024 Dec:124:111378. doi: 10.1016/j.cellsig.2024.111378 (IF: 4.4)

8. Yuzhu Hou, Kaiting Yang, Liangliang Wang, Jiaai Wang, Xiaona Huang, András Piffkó, Sean Z Luo, Xinshuang Yu, Enyu Rao, Carlos Martinez, Jason Bugno, Matthias Mack, Everett E Vokes, Sean P Pitroda, Steven J Chmura, Ralph R Weichselbaum*, Hua Laura Liang*. Radiotherapy Enhances Metastasis Through Immune Suppression by inducing PD-L1 and MDSC in distal sites. Clinical Cancer Research, 2024; 30(9): 1945-1958 (IF: 11.1)

9. Yuanyuan Zhang, Yujie Zhang, Yonghong Li, Yuhan Fu, Yuanru Zhao, Wei Zhao, Runqing Li, Yao Xian, Kangsheng Tu, Feng Wu, Cheng Li*, Yuzhu Hou*, Mingzhen Zhang*. Harnessing Ag2S quantum dots with immune adjuvant for NIR-II fluorescence imaging-guided sonodynamic immunotherapy of colon cancer. Chemical Engineering Journal, 2023; 474. doi: 10.1016/j.cej.2023.145685 (IF: 15.1)

10. Liangliang Xu#, Chang Zou#, Shanshan Zhang#, Timothy Shun Man Chu, Yan Zhang, Weiwei Chen, Caining Zhao, Li Yang, Zhiyuan Xu, Shaowei Dong, Hao Yu, Bo Li, Xinyuan Guan, Yuzhu Hou*, Feng-Ming Kong*. Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors. Journal of Hematology and Oncology, 2022; 15(1):87. doi: 10.1186/s13045- 022-01307-2 (IF: 23.1)

11. Yuzhu Hou#*, Hua L Liang#, Xinshuang Yu, Zhida Liu, Xuezhi Cao, Enyu Rao, Xiaona Huang, Liangliang Wang, Lei Li, Jason Bugno, Yanbin Fu, Steven J Chmura, Wenjun Wu, Sean Z Luo, Wenxin Zheng, Ainhoa Arina, Jessica Jutzy, Anne R McCall, Everett E Vokes, Sean P Pitroda, Yang-Xin Fu*, Ralph R Weichselbaum*. Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity. Science Translational Medicine, 2021; 13(528):eabb0130. doi: 10.1126/scitranslmed.abb0130 (IF: 19.3)

12. Enyu Rao#, Yuzhu Hou#, Xiaona Huang, Liangliang Wang, Jiaai Wang, Wenxin Zheng, Hengjin Yang, Xinshuang Yu, Kaiting Yang, Jason Bugno, Xingchen Ding, Everett Vokes, Yang-Xin Fu, Ralph R Weichselbaum*, Hua L Liang*. All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages. Science Immunology, 2021; 6(60):eaba8426. doi: 10.1126/sciimmunol.aba8426 (IF: 30.6)

13. Yuzhu Hou, Hua Liang, Enyu Rao, Wenxin Zheng, Xiaona Huang, Liufu Deng, Yuan Zhang, Xinshuang Yu, Meng Xu, Helena Mauceri, Ainhoa Arina, Ralph R Weichselbaum*, Yang-Xin Fu*. Non-canonical NF-κB antagonizes STING sensor-mediated DNA sensing in radiotherapy. Immunity, 2018; 49(3): 490-503. (IF: 22.5)

14. Yuzhu Hou#, Linnan Zhu#, Hongling Tian, Haixi Sun, Lianfeng Zhang, Ruoyu Wang, Yong Zhao*. IL-23-induced macrophage polarization and its pathological roles in mice withimiquimod-induced psoriasis. Protein Cell. 2018; doi: 10.1007/s13238-018-0505-z(IF: 10.1)

15. Yuzhu Hou#, Haijiang Lin#, Linnan Zhu, Zhaoting Liu, Fanlei Hu, Jianfeng Shi, Tao Yang, Xiaoyun Shi, Huifang Guo, Lianfeng Zhang, Qiang Wang, Zhanguo Li, Yong Zhao*. The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis. Journal of Immunology, 2014;193(1):130-8(IF: 4.8)

16. Yuzhu Hou#, Haijiang Lin#, Linnan Zhu, Zhaoting Liu, Fanlei Hu, Jianfeng Shi, Tao Yang, Xiaoyun Shi, Mingzhao Zhu, Bernard F Godley, Qiang Wang, Zhanguo Li, Yong Zhao*. LPS increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA1 expression. Arthritis & Rheumatism. 2013; 65(11): 2835-46. (IF: 9.5)

    授权发明专利：

    “过表达CXCR5基因的靶向B7H3的CAR-T细胞及其应用”