工作经历：
2022~至今 西安交通大学基础医学院 教授
2019~2021 清华大学 细胞生物学 博士后、“水木学者”
教育经历：
2013~2019 清华大学 细胞生物学 博士
2009~2013 厦门大学 生物技术专业 学士
主要研究方向：
1）迁移体的形成机制、功能及应用。
2）细胞膜损伤修复的机制研究及其功能应用的探索。
3）以Tetraspanins蛋白质为代表的多次跨膜蛋白质的结构、功能及核转运现象的研究。
详细内容请参阅“研究内容”页面。
2022.1~2028.1 西安交通大学“青年拔尖人才”A类
2025.11~2030.11 中华人民共和国科学技术部 重点研发计划，142万元，项目骨干，在研
2024.1~2027.12 国家自然科学基金委 面上项目，50万元，主持，在研
2021.1~2023.12 国家自然科学基金委 面上项目，58万元，主持，在研
2018.1~2022.12 国家自然科学基金委 重大项目， 445万元，参与，在研
2017.5~2020.5 清华大学结构生物学高精尖创新中心，120万元，学术带头人，已结题
2016.7~2021.6 中华人民共和国科学技术部 重点研发计划，113.5万元，参与，已结题
Publications:
1. Wang SN, Wang WS, Qiao JM, Ali S, Jiang Z, Jiang D, Ma JJ, Huang YW*. Palmitoylation of Tspan4 is essential for migrasome formation. J Cell Biol. 2026.
2. Huang YW, Yu L*. Seeing is believing: observation of migrasomes, Biophs Rep, 2024. (Cover story)
3. Huang YW, Zhang X, Wang HW, Yu L*. Assembly of Tetraspanin-enriched macrodomains contains membrane damage to facilitate repair, Nature Cell Biology, 2022.
4. Huang YW, Yu L*. Tetraspanin-enriched microdomains: The building blocks of migrasomes. Cell Insight, 2022. (Cover story)
5. Huang YW, Li J, Du W, Li S, Li Y, Qu H, Xv J, Yu L, Zhu R, Wang H*. Nuclear translocation of the 4-pass transmembrane protein Tspan8. Cell Res. 2021 Jun.
6. Huang YW#, Zucker B#, Zhang SJ#, Elias S, Zhu Y, Chen H, Ding TL, Li Y, Sun Y, Lou J, Kozlov MM*, Yu L*. Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains. Nat Cell Biol. 2019. (Cover story)(Co-first author)
7. Dharan R# , Huang YW#, Cheppali S , Goren S , Shendrik P ,Wang W, Qiao J, Kozlov MM, Yu L, Sorkin R*.Tetraspanin 4 stabilizes membrane swellings and facilitates their maturation into migrasomes. Nat Commun. 2023. (Co-first author)
8. 王维丝, 黄雨薇*. 迁移体生物发生的时空图谱, 中国细胞生物学学报, 2024.
9. Wang MR, Shu MM, Yan JJ, Liu C, Fu XD, Zhang JX, Lin YC, Zhao H, Huang YW, Ma DB, Ge YF, Hao HW, Zhao TY, Liang YS, Wang SW, Lei M*.Structured illumination microscopy for high SNR 3D imaging from millimeter thick tissues to cellular dynamics, The Innovation, 2026.
10. Wang FX, Graham ET, Naowarojna N, Shi ZN, Wang YQ, Xie GL, Zhou LL, Salmon W, Jia JM, Wang X, Huang YW, Schreiber SL, Zou YL. PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ, Cell Chemical Biology, 2022.
11. Lu XQ, An LW, Fan GJ, Zang LJ, Huang WY, Li JJ, Liu J, Ge WY, Huang YW, Xu JX, Du SQ, Cao Y, Zhou, Tian H, Yin HJ,Yu L, Jiao S,Wang HX. EGFR signaling promotes nuclear translocation of plasma membrane protein TSPAN8 to enhance tumor progression via STAT3-mediated transcription, Cell Res, 2022.
12. Jiang D#, Jiang Z#, Lu D, Wang X, Liang H, Zhang J, Meng Y, Li Y, Wu D, Huang YW, Chen Y, Deng H, Wu Q, Xiong J, Meng AM*, Yu L*. Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Nat Cell Biol. 2019.
13. Ma M#, Liu JJ#, Li Y#, Huang YW, Ta N, Chen Y, Fu H, Ye MD, Ding Y, Huang W, Wang J, Dong MQ, Yu L*, Wang HW*. Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and -C2. Cell Res. 2017.
14. Yi C#, Tong J#, Lu P, Wang Y, Zhang J, Sun C, Yuan K, Xue R, Zou B, Li N, Xiao S, Dai C, Huang YW, Xu L, Li L, Chen S, Miao D, Deng H, Li H, Yu L*. Formation of a Snf1-Mec1-Atg1 Module on Mitochondria Governs Energy Deprivation-Induced Autophagy by Regulating Mitochondrial Respiration. Dev Cell. 2017.
