教育及工作经历：

  (1) 2025-12 至今, 陕西省国资委陕西医药控股集团医疗科技有限公司副总经理（挂职）

  (2) 2020-04 至今, 西安交通大学, 第二附属医院, 教授、博导

(3) 2016-01 至 2020-03, 厦门大学，生物医学，博士后

(4) 2010-09 至 2015-12, 厦门大学，微生物学，理学博士

(5) 2009-09 至 2010-07, 北京邮电大学，研究生预科，其他

(6) 2007-09 至 2009-07, 武汉轻工大学，生物工程，学士

(7) 2004-09 至 2007-07, 武汉生物工程大学，生物工程

研究领域：

感染和炎症与固有免疫调节

神经免疫调节与认知障碍

肿瘤免疫治疗机制

免疫缺陷病与感染性和非感染性炎症

获批项目：

1）国家自然科学基金委员会，面上项目，32671174，2027-01-01 至 2031-12-31, 50万元，在研，主持

2）ECMO 支持下肺修复的分子机制及机械通气策略优化，四大慢病国家重大专项子课题，2026ZD0555504，2026-03-01至2029-2-28，425.82万元，在研，主持

3）陕西基础科学（化学、生物学）研究院基础研究计划，23JHQ060青年项目，2024-01-01 至 2025-12-31, 5万元，结题，主持

4）陕西省自然科学基础研究计划重点项目（特别支持），2024JC-TBZC-23，2024-01-01 至 2026-12-31, 20万元，在研，主持

5）西安市项目医学研究一般项目, 24YXYJ0173, 2024-01-01 至 2026-12-31, 5万元，结题，主持

6）国家自然科学基金委员会，面上项目，32370922，2024-01-01 至 2027-12-31, 50万元，在研，主持

7）陕西省高层次人才项目，YJ0866，2021-01 至 2023-12，140万元，结题，主持

8）西安市科技局，国际科技合作基地，SXSKXJST-2021-004962，细胞应激与疾病诊疗国际科技合作基地，2021-01至今，50万元，主持

9）国家自然科学基金委员会，面上项目，32070891， 2021-01-01至2024-12-31，58万元，结题，主持

10）中华人民共和国科学技术部，人干细胞向调节型和效应型免疫细胞的分化与功能优化研究，国家重点研发计划，2021YFA1100702，2021-12 至 2026-06，30/2600万元，在研，参与

11）中央高校基本科研业务费，免疫分子功能/固有免疫应答，2020年1月  至  2022年12月，30万，结题，主持

12）中国科学技术协会，青年人才托举工程，YESS20170159，2017-01至2019-12，45万元，结题，主持

13）国家自然科学基金委员会，青年科学基金项目，31600698，2017-01-01至2019-12-31，20万元，结题，主持

14）中国博士后基金会，特别资助项目，2017T100470，2017-01至2018-12，15万元，结题，主持

15）中国博士后基金会，面上项目，2016-01至2017-12，5万元，结题，主持

代表性研究成果(*Corresponding author, #co-first author)

（1）Zhang S, Zang L, Li Y, Zhang Y, Chen X, Xin Y, He G, Zhou Z, Halalmeh I, Liang Y, Li W, Yang J, Geng J*, Xiong X*. Numb attenuates LPS-induced neuroinflammation via autophagic regulation of Ifi204 in microglia. Neurobiol Dis. 2026 Jun 1;223:107386. doi: 10.1016/j.nbd.2026.107386. Epub 2026 Apr 8.

（2）Xin Y#, Xiong X#, Zhang Y, Zhang S, Zhang S, Yang Y, Liang Y, Zang L, Chen X, Li W, Halalmeh I, Zhou R, Li Z, Liu H, Geng J. Calhm6 Governs Macrophage Polarization Through Chp1-Camk4-Creb1 Axis and Ectosomal Delivery in Inflammatory Responses. Adv Sci. 2025 Sep 26:e02395. doi: 10.1002/advs.202502395. Epub ahead of print. PMID: 40999918.
（3）Yan Zhang, Yingxue Liang, Wenjuan Li, Lulu Zang, Xi Chen, Xiaofan Xiong, Siyu Zhang, Yuhao Gu, Shuaijie Zhong, Yingnan Li, Jing Geng*, Yanlong Xin*, Tea seed-derived leucoside attenuates sepsis via inhibition of TLR4-MD2 complex formation,Biochemical Pharmacology,Volume 243, Part 1,2025

（4）Song D, Zhao X, Zhang Y, Wang M, Tang H, Fang J, Song Z, Ma Q, Geng J. The amelioration effect of sesamoside on inflammatory response in septic shock. BMC Immunol. 2025 Mar 6;26(1):15.
（5）Zhang S, Xin Y, Yang Y, Zhang Y, Geng J. The Polarization of Macrophages Regulated by KCNG3 via the Activation of ASK1 Mediated by Potassium Ion Efflux. Cell Biol Int. 2025 Jul;49(7):810-823
（6）Dong W, Li Y, Fei Q, Li S, He X, Chai Y, Zhou J, Zong Y, Geng J*, Li Z*. Targeted spleen modulation: a novel strategy for next-generation disease immunotherapy. Theranostics. 2025 Mar 18;15(10):4416-4445. doi: 10.7150/thno.111116. PMID: 40225564; PMCID: PMC11984396.
（7）Chen X, Fang K, Li B, Li Y, Ke Y, Ke W, Tian T, Zhao Y, Wang L, Geng J, Leake MC, Bai F. Macrophage-derived reactive oxygen species promote Salmonella aggresome formation contributing to bacterial antibiotic persistence. Imeta. 2025 Jun 22;4(4):e70059.
（8）Jin Sun; Yingnan Li; Mengjiao Shi; Hongwei Tian; Jun Li; Kai Zhu; Ying Guo; Yanhua Mu; Jing Geng*; Zongfang Li* ; A Positive Feedback Loop of lncRNA HOXD-AS2 and SMYD3 Facilitates Hepatocellular Carcinoma Progression via the MEK/ERK Pathway, Journal of Hepatocellular Carcinoma, 2023, 2023:10 : 1237-1256
（9）Shaoying Zhang; Dan Wan; Mengchen Zhu; Guihu Wang; Xurui Zhang; Na Huang; Jian Zhang; Chongyu Zhang; Qi Shang; Chen Zhang; Xi Liu; Fanfan Liang; Chunyan Zhang; Guangyao Kong; Jing Geng; Libo Yao; Shemin Lu*; Yongyan Chen*; Zongfang Li*; CD11b+ CD43hi Ly6Clo splenocyte-derived macrophages exacerbate liver fibrosis via spleen-liver axis., Hepatology, 2022, 0(0)  
（10）Liu, Qingxu#; Li, Jiaxin#; Zhang, Weiji#; Xiao, Chen#; Zhang, Shihao#; Nian, Cheng; Li, Junhong; Su, Dongxue; Chen, Lihong; Zhao, Qian; Shao, Hui; Zhao, Hao; Chen, Qinghua; Li, Yuxi; Geng, Jing; Hong, Lixin; Lin, Shuhai; Wu, Qiao; Deng, Xianming; Ke, Rongqin; Ding, Jin; Johnson, Randy L.; Liu, Xiaolong; Chen, Lanfen*; Zhou, Dawang*; Glycogen accumulation and phase separation drives liver tumor initiation, Cell, 2021, 184(22): 5559-5576
（11）Geng, Jing#; Shi, Yiran#; Zhang, Jinjia#; Yang, Bingying; Wang, Ping; Yuan, Weihong; Zhao, Hao; Li, Junhong; Qin, Funiu; Hong, Lixin; Xie, Changchuan; Deng, Xianming; Sun, Yujie; Wu, Congying; Chen, Lanfen*; Zhou, Dawang*; TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection, Nature Communications, 2021, 2021(3519): 0-3519   
（12）Wang, Ping#; Geng, Jing#; Gao, Jiahui; Zhao, Hao; Li, Junhong; Shi, Yiran; Yang, Bingying; Xiao, Chen; Linghu, Yueyue; Sun, Xiufeng; Chen, Xin; Hong, Lixin; Qin, Funiu; Li, Xun; Yu, Jau Song; You, Han; Yuan, Zengqiang; Zhou, Dawang; Johnson, Randy L; Chen, Lanfen*; Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis, Nature Communications, 2019, 10(755)
（13）Ji, Suyuan#; Liu, Qingxu#; Zhang, Shihao#; Chen, Qinghua#; Wang, Cong; Zhang, Weiji; Xiao, Chen; Li, Yuxi; Nian, Cheng; Li, Jiaxin; Li, Junhong; Geng, Jing; Hong, Lixin; Xie, Changchuan; He, Ying; Chen, Xing; Li, Xun; Yin, Zhen Yu; You, Han; Lin, Kwang Huei; Wu, Qiao; Yu, Chundong; Johnson, Randy L; Wang, Li; Chen, Lanfen; Wang, Fen; Zhou, Dawang*; FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis, Developmental Cell, 2019, 48(4): 460-474
（14）Hong, Lixin; Li, Xun; Zhou, Dawang; Geng, Jing; Chen, Lanfen*; Role of Hippo signaling in regulating immunity, Cellular and Molecular Immunology, 2018, 15(12): 1003-109
（15）Geng, Jing#; Yu, Shujuan#; Zhao, Hao#; Sun, Xiufeng#; Li, Xun; Wang, Ping; Xiong, Xiaolin; Hong, Lixin; Xie, Changchuan; Gao, Jiahui; Shi, Yiran; Peng, Jiaqi; Johnson Randy L; Xiao, Nengming; Lu, Linrong; Han, Jiahuai; Zhou, Dawang*; Chen, Lanfen*; The transcriptional coactivator TAZ regulates reciprocal differentiation of T(H)17 cells and T-reg cells, Nature Immunology, 2017, 18(7): 800-812
（16）Zhang, Shihao#; Chen, Qinghua#; Liu, Qingxu#; Li, Yuxi; Sun, Xiufeng; Hong, Lixin; Ji, Suyuan; Liu, Chengyan; Geng, Jing; Zhang, Weiji; Lu, Zhonglei; Yin, Zhen Yu; Zeng, Yuanyuan; Lin Kwang Huei; Wu, Qiao; Li, Qiyuan; Nakayama Keiko; Nakayama Keiich I; Deng, Xianming; Johnson Randy L; Zhu, Liang; Gao, Daming; Chen, Lanfen*; Zhou, Dawang*; Hippo signaling suppresses cell ploidy and tumorigenesis through Skp2, Cancer Cell, 2017, 31(5): 669-684     
（17）Fan, Fuqin#; He, Zhixiang#; Kong, Lu Lu#; Chen, Qinghua#; Yuan, Quan#; Zhang, Shihao; Ye, Jinjin; Liu, Hao; Sun, Xiufeng; Geng, Jing; Yuan, Lunzhi; Hong, Lixin; Xiao, Chen; Zhang, Weiji; Sun, Xihuan; Li, Yunzhan; Wang, Ping; Huang, Lihong; Wu, Xinrui; Ji, Zhiliang; Wu, Qiao; Xia, Ning Shao; Gray Nathanael S; Chen, Lanfen; Yun, Cai Hong*; Deng, Xianming*; Zhou, Dawang*; Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration, Science Translational Medicine, 2016, 8(352)

（18）Geng, Jing#; Sun, Xiufeng#; Wang, Ping; Zhang, Shihao; Wang, Xiaozhen; Wu, Hongtan; Hong, Lixin; Xie, Changchuan; Li, Xun; Zhao, Hao; Liu, Qingxu; Jiang, Mingting; Chen, Qinghua; Zhang, Jinjia; Li, Yang; Song, Siyang; Wang, Hong-Rui; Zhou, Rongbin; Johnson, Randy L; Chien, Kun-Yi; Lin, Sheng-Cai; Han, Jiahuai; Avruch, Joseph; Chen, Lanfen*; Zhou, Dawang*; Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity, Nature Immunology, 2015, 16(11): 1142-1152

（19）Wu, Hongtan#; Wei, Luyao#; Fan, Fuqin; Ji, Suyuan; Zhang, Shihao; Geng, Jing; Hong, Lixin; Fan, Xin; Chen, Qinghua; Tian, Jing; Jiang, Mingting; Sun, Xiufeng; Jin, Changnan; Yin, Zhen-Yu; Liu, Qingxu; Zhang, Jinjia; Qin, Funiu; Lin, Kwang-Huei; Yu, Jau-Song; Deng, Xianming; Wang, Hong-Rui; Zhao, Bin; Johnson, Randy L; Chen, Lanfen*; Zhou, Dawang*; Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis., Nature Communications, 2015, 6(6239)  

（20）Wu, Hongtan#; Xiao, Yubo#; Zhang, Shihao#; Ji, Suyuan; Wei, Luyao; Fan, Fuqin; Geng, Jing; Tian, Jing; Sun, Xiufeng; Qin, Funiu; Jin, Changnan; Lin, Jianjun; Yin, Zhen-Yu; Zhang, Ting; Luo, Lianzhong; Li, Yang; Song, Siyang; Lin, Sheng-Cai; Deng, Xianming; Camargo, Fernando; Avruch, Joseph; Chen, Lanfen*; Zhou, Dawang*; The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense, Cell Reports, 2013, 3(5): 1663-1677
（21）Geng, Jing; Xiao, Shuyan; Zheng, Zhonghui; Song, Siyang; Zhang, Lianru*; Gambogic acid protects from endotoxin shock by suppressing pro-inflammatory factors in vivo and in vitro, Inflammation Research, 2012, 62(2): 165-172