Basic Information

  

 

侯玉柱，博士，教授，博士生导师

2011年毕业于中国科学院动物研究所，获理学博士学位；2011-2017年分别于中国科学院动物研究所和芝加哥大学Ludwig肿瘤研究中心从事博士后工作；2018-2019任芝加哥大学肿瘤放疗系讲师；2020年1月至今任西安交通大学基础医学院教授，入选“青年拔尖人才支持计划（A类）”；2023年起担任感染与免疫研究所副所长。

研究领域为肿瘤免疫学。致力于从分子、细胞及机体整体水平上，研究肿瘤发生、发展及治疗过程中的免疫反应机制，包括：（1）研究肿瘤发生、发展及转移过程中的免疫监视与免疫逃逸机制；（2）研究放疗与免疫治疗过程中肿瘤免疫微环境变化以及系统性免疫反应；等。在 Immunity、Science Translational Medicine、Science Immunology、Protein Cell、Journal of Immunology等学术期刊公开发表SCI论文30篇，被引用1800余次。目前担任中国抗癌协会生物治疗专委会委员、中国免疫学会肿瘤免疫与生物治疗分会委员、中国肿瘤放射治疗联盟放射免疫委员会常委、陕西省抗癌协会转化医学专委会副主委、陕西省抗癌协会整合肿瘤免疫分会常委等学术兼职。

Contact Information

通信地址： 西安交通大学基础医学院 

                     陕西省西安市雁塔西路76号微免楼225室

                     西咸新区中国西部科技创新港

                     21号楼4-4148室
邮        编： 710049

联系电话： +8618301198037
电子邮箱： houyuzhu@xjtu.edu.cn

站点计数器

Research Fields

1. 肿瘤放疗的免疫学机制；

2. 肿瘤发生和转移的免疫学机制；

3. 肿瘤免疫治疗。

Publications

  1. Yuzhu Hou, Kaiting Yang, Liangliang Wang, Jiaai Wang, Xiaona Huang, András Piffkó, Sean Z Luo, Xinshuang Yu, Enyu Rao, Carlos Martinez, Jason Bugno, Matthias Mack, Everett E Vokes, Sean P Pitroda, Steven J Chmura, Ralph R Weichselbaum*, Hua Laura Liang*. Radiotherapy Enhances Metastasis Through Immune Suppression by inducing PD-L1 and MDSC in distal sites. Clinical Cancer Research, 2024; 30(9): 1945-1958 (IF: 11.1)
  2. Yuanyuan Zhang, Yujie Zhang, Yonghong Li, Yuhan Fu, Yuanru Zhao, Wei Zhao, Runqing Li, Yao Xian, Kangsheng Tu, Feng Wu, Cheng Li*, Yuzhu Hou*, Mingzhen Zhang*. Harnessing Ag2S quantum dots with immune adjuvant for NIR-II fluorescence imaging-guided sonodynamic immunotherapy of colon cancer. Chemical Engineering Journal, 2023; 474. doi: 10.1016/j.cej.2023.145685 (IF: 15.1)
  3. Liangliang Xu, Chang Zou, Shanshan Zhang, Timothy Shun Man Chu, Yan Zhang, Weiwei Chen, Caining Zhao, Li Yang, Zhiyuan Xu, Shaowei Dong, Hao Yu, Bo Li, Xinyuan Guan, Yuzhu Hou*, Feng-Ming Kong*. Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors. Journal of Hematology and Oncology, 2022; 15(1):87. doi: 10.1186/s13045- 022-01307-2 (IF: 23.1)
  4. Yuzhu Hou#*, Hua L Liang#, Xinshuang Yu, Zhida Liu, Xuezhi Cao, Enyu Rao, Xiaona Huang, Liangliang Wang, Lei Li, Jason Bugno, Yanbin Fu, Steven J Chmura, Wenjun Wu, Sean Z Luo, Wenxin Zheng, Ainhoa Arina, Jessica Jutzy, Anne R McCall, Everett E Vokes, Sean P Pitroda, Yang-Xin Fu*, Ralph R Weichselbaum*. Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity. Science Translational Medicine, 2021; 13(528):eabb0130. doi: 10.1126/scitranslmed.abb0130 (IF: 19.3)
  5. Enyu Rao#, Yuzhu Hou#, Xiaona Huang, Liangliang Wang, Jiaai Wang, Wenxin Zheng, Hengjin Yang, Xinshuang Yu, Kaiting Yang, Jason Bugno, Xingchen Ding, Everett Vokes, Yang-Xin Fu, Ralph R Weichselbaum*, Hua L Liang*. All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages. Science Immunology, 2021; 6(60):eaba8426. doi: 10.1126/sciimmunol.aba8426 (IF: 30.6)
  6. Yuzhu Hou, Hua Liang, Enyu Rao, Wenxin Zheng, Xiaona Huang, Liufu Deng, Yuan Zhang, Xinshuang Yu, Meng Xu, Helena Mauceri, Ainhoa Arina, Ralph R Weichselbaum*, Yang-Xin Fu*. Non-canonical NF-κB antagonizes STING sensor-mediated DNA sensing in radiotherapy. Immunity, 2018; 49(3): 490-503. (IF: 22.5)
  7. Yuzhu Hou#, Linnan Zhu#, Hongling Tian#, Haixi Sun, Lianfeng Zhang, Ruoyu Wang, Yong Zhao*. IL-23-induced macrophage polarization and its pathological roles in mice withimiquimod-induced psoriasis. Protein Cell. 2018; doi: 10.1007/s13238-018-0505-z (IF: 10.1)
  8. Yuzhu Hou#, Haijiang Lin#, Linnan Zhu#, Zhaoting Liu, Fanlei Hu, Jianfeng Shi, Tao Yang, Xiaoyun Shi, Huifang Guo, Lianfeng Zhang, Qiang Wang, Zhanguo Li, Yong Zhao*. The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis. Journal of Immunology, 2014;193(1):130-8 (IF: 4.8)
  9. Yuzhu Hou#, Haijiang Lin#, Linnan Zhu, Zhaoting Liu, Fanlei Hu, Jianfeng Shi, Tao Yang, Xiaoyun Shi, Mingzhao Zhu, Bernard F Godley, Qiang Wang, Zhanguo Li, Yong Zhao*. LPS increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA1 expression. Arthritis & Rheumatism. 2013; 65(11): 2835-46. (IF: 9.5)