个人简历

 

                             曹东元简历

男，1969年生，博士，研究员，博士生导师。

工作、学习经历：

1988年7月～1996年8月     西安医科大学脑和神经研究室工作

1996年9月～1999年7月     西安医科大学生理教研室攻读硕士学位

1999年7月～2004年11月    西安交通大学医学院生理教研室工作

2000年9月～2003年12月    西安交通大学医学院生理教研室攻读博士学位

2004年11月～2006年9月    美国纽约州立大学石溪分校医学院生物医学系, 博士后 (Department of Biomedicine, School of Medicine, State University of New York at Stony Brook, New York)

2006年10月～2010年5月    美国帕默整脊医学院研究中心，博士后

   (Palmer Center for Chiropractic Research, Palmer College of Chiropractic, Davenport, Iowa)

2010年6月～2015年3月  美国马里兰大学牙医学院神经和疼痛学系，Research Associate

  (Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, Maryland)

2015年4月至今  西安交通大学口腔医院研究中心，研究员，博士生导师

获奖情况：

1．  2009年北美互补和整合医学研究大会新人奖（Trainee Travel Award, North American Research Conference on Complementary & Integrative Medicine, Minneapolis, Minnesota, USA）

2．  陕西省科学技术三等奖（2005-82）：糖尿病性痛觉过敏外周神经机制的研究 （第三名）

3．  陕西省高等学校科技进步一等奖 (2005-05J03)： 糖尿病性痛觉过敏外周神经机制的研究 （第三名）

4．  教育部提名国家自然科学技术二等奖（2002-101）：初级感觉神经元的传入、会聚及其传出效应（第三名）  

5．  2002年陕西省高等学校科技进步二等奖：初级感觉神经元的传入、会聚及其传出效应（第二名）

 

学术任职：

中国神经科学会神经内稳态和内分泌分会委员，西安交通大学医学部学术委员会委员。

SCI杂志“国际生物医学研究(BioMed Research International)”编委，曾任SCI杂志“替代和互补医学杂志(Journal of Alternative and Complementary Medicine)”编委（2009-2016年）。神经精神药理学（Neuropsychopharmacology）、脑，行为和免疫（Brain Behavior and Immunity）、神经科学通报 (Neuroscience Bulletin)、生命科学（Life Sciences）、神经科学前沿（Frontiers in Neuroscience）、药理学(Pharmacology)、脑研究(Brain Research)、欧洲药理学杂志(European Journal of Pharmacology)、临床和实验生理学和药理学(Clinical and Experimental Physiology and Pharmacology)、实证互补和替代医学(Evidence Based Complementary and Alternative Medicine)、神经科学简讯 (Neuroscience Letters) 、针灸医学 (Acupuncture in Medicine) 等SCI杂志审稿人。

国际疼痛研究学会会员（International Association for the Study of Pain），美国神经科学会会员（Society for Neuroscience, USA）。

主持和参与的科研课题：

1.       国家自然科学基金面上项目(81971049)：5-HT3和5-HT2C受体介导颌面部炎症合并应激引起躯体和内脏痛敏化．55万元，2020-2023，负责人

2.       国家自然科学基金面上项目(81671097)：表观遗传学调控脊髓和杏仁中央核神经元组蛋白乙酰化对应激诱发内脏痛的抑制作用．52万元，2017-2020，负责人

3.       陕西省社会发展领域研究项目(2020SF-018)：丙戊酸钠调控颞下颌关节紊乱病与纤维肌痛综合征共病的表观遗传学机制．8.0万元，2020-2021，负责人

4.       医学神经生物学国家重点实验室开放课题：颌面部炎性痛合并应激刺激引起躯体痛敏化的机制研究．5.0万元，2019-2020，负责人

5.       陕西省自然科学基础研究计划面上项目(2016JM3015)：组蛋白去乙酰化酶抑制剂通过调节谷氨酸GluN1受体调节内脏痛．3.0万元，2016-2017，负责人

6.       The Organized Research Center on Persistent Pain grant, University of Maryland: The role of neurochemical markers in TMD-IBS comorbidity. Principal Investigator（PI, 主持人）. Oct 2011-Oct 2012, $10,000.

7.       National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH) (No. 1R21DE022235-01A1): Mechanisms underlying TMD-IBS comorbidity. Main participator（主要执行者）. September 2012-present. PI: Richard J. Traub, $23万

8.       National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH) (No. 5R01NS037424-09): Neurochemical mechanism of visceral pain. Main participator（主要执行者）. June 2010-present. PI: Richard J. Traub, $160万

9.       National Center for Complementary and Alternative Medicine, National Institutes of Health (NIH) (No. 3U19AT004137): Developmental Center to Study Mechanisms and Effects of Chiropractic Manipulation. Main participator（主要执行者）. July 2007-Jun 2010, PI: Joel G. Pickar, $380万

10.    National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH) (No. 5R01NS046818): Vertebral Position alters muscle spindle sensitivity. Main participator（主要执行者）. Nov 2004-Sept 2008, PI: Joel G. Pickar, $140万

11.    National Center for Complementary and Alternative Medicine, National Institutes of Health (NIH) (No. 3U19AT002006): Mechanisms and effects of chiropractic manipulation. Main participator（主要执行者）. Nov 2004-Sept 2007, PI: William C. Meeker, $164万

12.    国家自然科学基金青年项目（30400131）：感觉神经末梢间兴奋传递参与痛觉外周敏化形成的机理． 21 万元，主持人

13.    陕西省自然科学基金(2004C225)：外周痛敏化和中枢痛敏化的机理研究．1.5万元，主持人

14.    西安交通大学在职博士基金(2004)：跨节段信息传递与痛觉外周敏化机理研究．1.0 万元，  主持人

15.    西安交通大学科研基金（2003）：NMDA受体和D2受体间信号转导在吗啡戒断形成的作用．1.5 万元，主持人

16.    西安交通大学医学院科研基金（2001-7）：局部效应器激活的离子机制．1.0 万元，主持人

17.    国家自然科学基金青年项目（81200604/H0713）：谷氨酸在糖尿病大鼠外周痛敏化中的作用及其机制．23万元，第三申请人

18.    国家自然科学基金青年项目（81072911/H2901）：右归丸和六味地黄丸对老年大鼠脑皮质胆碱能系统抗衰老作用的比较．24万元，参加

19.    国家自然科学基金青年项目（30700278/H0903）：P2X3受体介导外周伤害性信息传入的机制．17万元，第三申请人

20.    国家自然科学基金青年项目（30600219）：DA和DA.1u大鼠疼痛敏感性差异的分子基础及MHC位点上与疼痛相关的基因鉴定．21 万元，第二申请人

 

发表论文：

1.       Li JH, Yang JL, Wei SQ, Li ZL, Collins AA, Zou M, Wei F, Cao DY. Contribution of central sensitization to stress-induced spreading hyperalgesia in rats with orofacial inflammation. Mol Brain, 2020;13(1):106 (IF 4.686) (通讯作者).

2.       Xue Y, Wei SQ, Wang PX, Wang WY, Liu EQ, Traub RJ, Cao DY. Down-regulation of spinal 5-HT2A and 5-HT2C receptors contributes to somatic hyperalgesia induced by orofacial inflammation combined with stress. Neuroscience, 2020;440:196-209 (IF 3.056) (通讯作者).

3.       Xu GZ*, Xue Y*, Wei SQ, Li JH, Traub RJ, Wang MD, Cao DY. Valproate reverses stress-induced somatic hyperalgesia and visceral hypersensitivity by up-regulating spinal 5-HT2C receptor expression in female rats. Neuropharmacology, 2020;165:107926 (IF 4.367) (通讯作者).

4.       Li YX, An H, Wen Z, Tao ZY, Cao DY. Can oxytocin inhibit stress-induced hyperalgesia? Neuropeptides, 2020;79:101996 (IF 2.407) (通讯作者).

5.       Tao ZY, Wang PX, Wei SQ, Traub RJ, Li JF, Cao DY. The role of descending pain modulation in chronic primary pain: potential application of drugs targeting serotonergic system. Neural Plast, 2019:1389296 (IF 3.591) (通讯作者).

6.       Li ZL, Xue Y, Tao ZY, Du WZ, Jiang YG, Cao DY. Spinal 5-HT3 Receptor Contributes to Somatic Hyperalgesia Induced by Sub-chronic Stress. Mol Pain, 2019: 1744806919859723. doi: 10.1177/1744806919859723 [PubMed: 31184246](IF 2.746)(通讯作者).

7.       Li JH, He PY, Fan DN, Alemujiang D, Huo FQ, Zhao Y, Cao DY. Peripheral ionotropic glutamate receptors contribute to Fos expression increase in the spinal cord through antidromic electrical stimulation of sensory nerves. Neurosci Lett. 2018; 678:1-7. [PubMed 29705538] (IF 2.173) (通讯作者).

8.       Tao ZY, Xue Y, Li JF, Traub TJ, Cao DY. Do microRNAs modulate visceral pain? BioMed Res Intern, 2018: 5406973 (IF 2.583) (通讯作者)

9.       Xu GZ, Jia J, Jin L, Li JH, Wang ZY, Cao DY. Low-level laser therapy for temporomandibular disorders: a systematic review with meta-analysis. Pain Res Manag. 2018: 4230583 [PMID 29861802] (IF 1.701) (通讯作者)

10.    Zhao YJ, Li JH, Hu B, Wang Y, Chang XF, Traub RJ, Cao DY. Extracellular signal-regulated kinase activation in the spinal cord contributes to visceral hypersensitivity induced by craniofacial injury followed by stress. Neurogastroenterol Motil. 2018; 30(2). doi: 10.1111/nmo. 13161. [PubMed 28730748] (IF 3.842) (通讯作者).

11.    Xu GZ, Li YF, Wang MD, Cao DY. Complementary and alternative interventions for fatigue management after traumatic brain injury: a systematic review. Ther Adv Neurol Disord. 2017; 10(5):229-239. [PubMed 28529544] (IF 4.192) (通讯作者).

12.    Cao DY, Bai G, Ji Y, Karpowicz J, Traub RJ. Histone hyperacetylation modulates spinal type II metabotropic glutamate receptor alleviating stress-induced visceral hypersensitivity in female rats. Mol Pain, 2016; 12 [PubMed: 27385724] (IF 3.533).

13.    Cao DY, Bai G, Ji Y, Traub RJ. Epigenetic upregulation of metabotropic glutamate receptor 2 in the spinal cord attenuates oestrogen-induced visceral hypersensitivity. Gut, 2015; 64 (12): 1913-20 [PubMed 25378524] (IF 16.658).

14.    Cao DY, Pickar JG. Effect of spinal manipulation on the development of history-dependent responsiveness of lumbar paraspinal muscle spindles in the cat. J. Can. Chiropr. Assoc., 2014, 58(2):149-59 [PubMed 24932019].

15.    Cao DY, Reed W, Long CR, Kawchuk GN, Pickar JG. Effects of thrust amplitude and duration of high-velocity, low-amplitude spinal manipulation on lumbar muscle spindle responses to vertebral position and movement. J. Manipulative. Physiol. Ther., 2013;36(2):68-77 [PubMed 23499141] (IF 1.592).

16.    Reed W*, Cao DY*, Long CR, Kawchuk GN, Pickar JG. Relationship between biomechanical characteristics of spinal manipulation and neural responses in an animal model: effect of linear control of thrust displacement versus force, thrust amplitude, thrust duration, and thrust rate. Evid. Based Complement. Alternat. Med., 2013, 492039. *co-first author（共同第一作者）[PubMed 23401713] (IF 2.175).

17.    Cao DY, Ji Y, Tang B, Traub RJ. Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat. J. Pain, 2012, 13(7): 685-694 [PubMed 22698981] (IF 4.519).

18.    Cao DY, Pickar JG. Lengthening but not shortening history of paraspinal muscle spindles in the low back alters their dynamic sensitivity. J. Neurophysiol. 2011;105(1):434-41 [PubMed 21047939] (IF 3.041).

19.    Ge W*, Cao DY*, Long CR, Pickar JG. Plane of vertebral movement eliciting muscle lengthening history in the low back influences the decrease in muscle spindle responsiveness of the cat. J. Appl. Physiol., 2011;111(6):1735-1743 [PubMed 21960662]  *co-first author（共同第一作者）(IF 3.434).

20.    Cao DY, Pickar JG, Ge W, Ianuzzi A, Khalsa PS. Position sensitivity of feline paraspinal muscle spindles to vertebral movement in the lumbar spine. J. Neurophysiol., 2009; 101(4): 1722-1729 [PubMed 19164108] (IF 3.041).

21.    Cao DY, Khalsa PS, Pickar JG. Dynamic responsiveness of lumbar paraspinal muscle spindles during vertebral movement in the cat. Exp. Brain Res., 2009; 197(4): 369-377 [PubMed 19590861] (IF 2.168).

22.    Cao DY, Pickar JG. Thoracolumbar fascia does not influence proprioceptive signaling from lumbar paraspinal muscle spindles in the cat. J. Anat., 2009; 215(4):417-424 [PubMed 19627391] (IF 2.227).

23.    Cao DY, You HJ, Zhao Y, Guo Y, Wang HS, Arendt-Nielsen L, Wang HL, Zhang Q. Involvement of peripheral ionotropic glutamate receptors in activation of cutaneous branches of spinal dorsal rami following antidromic electrical stimulation of adjacent afferent nerves in rats. Brain Res. Bull., 2007; 72 (1): 10-17 [PubMed 17303502] (IF 2.974).

24.    Cao DY, Zhao Y, Niu HZ. Release of substance P induced by electrical stimulation of acupoint “zusanli”. International Journal of Clinical Acupuncture, 2006; 17(1): 35-43.

25.    Cao DY, Guo Y, Zhang Q, Tian YL, Wang HS, Zhao Y. Effects of glutamate on the afferent discharges of dorsal cutaneous sensory nerves in rats. Neurosci. Bull., 2005; 21(2): 111-116.

26.    Wang J, Guo Y, Cao DY*, Luo R, Ma SJ, Wang HS, Pickar JG, Zhao Y. Tonic inhibition of somatostatin on C and A delta afferent fibers in rat dorsal skin in vivo. Brain Res., 2009; 1288: 50-59 [PubMed 19590861]. * Co-corresponding author（共同通讯作者）(IF 2.828).

27.    Tan YY, Fang L, Yao FR, Cao DY, Zhang Q. Orexin receptor-1 in the rostral ventrolateral medulla mediates the antihypertensive effects of electroacupuncture. Front Neurosci. 2019; 13:282. doi: 10.3389/fnins.2019.00282 [PMID: 30971886] (IF 3.648)

28.    Wang Y, Yang Q, Cao DY, Seminowicz DA, Remeniuk B, Gao L, Zhang M. Correlation between nerve atrophy, brain grey matter volume and pain se verity in patients with primary trigeminal neuralgia. Cephalalgia. 2018: 333102418793643 [PMID:30086682] (IF 3.882).

29.    Zhang Q, Tan YY, Liu XH, Yao FR, Cao DY. Electroacupuncture improves baroreflex and γ-aminobutyric acid type B receptor-mediated responses in the nucleus tractus solitarii of hypertensive rats. Neural Plast. 2018: 8919347. [PMID:30363902] (IF 3.591)

30.    Liao X, Mao C, Wang Y, Zhang Q, Cao DY, Seminowicz DA, Zhang M, Yang X. Brain gray matter alterations in Chinese patients with chronic knee osteoarthritis pain based on voxel-based morphometry. Medicine. 2018;97(12):e0145. doi: 10.1097/MD.0000000000010145. [PubMed: 29561420] (IF 2.028).

31.    Wang Y, Cao DY, Remeniuk B, Krimmel S, Seminowicz DA, Zhang M. Altered brain structure and function associated with sensory and affective components of classic trigeminal neuralgia. Pain. 2017;158(8):1561-1570 [PubMed:28520647](IF 5.445).

32.    Guo Y, Cao DY, Zhang ZJ, Yao FR, Wang HS, Zhao Y. Electrical signal propagated across acupoints along Foot Taiyang Bladder Meridian in rats. Chin. J. Integr. Med., 2016; 22 (7): 537-544 [PubMed 26631142]. (IF 1.217).

33.    Guo Y, Yao FR, Cao DY, Li L, Wang HS, Xie W, Zhao Y. The major histocompatibility complex genes impact pain response in DA and DA.1U rats. Physiol. Behav., 2015;147:30-37 [PubMed 25861730]. (IF 2.967).

34.    Ji Y, Bai G, Cao DY, Traub RJ. Estradiol modulates visceral hyperalgesia by increasing thoracolumbar spinal GluN2B subunit activity in female rats. Neurogastroenter. Motility., 2015;27(6):775-86 [PubMed 25810326] (IF 3.587).

35.    Traub RJ, Cao DY, Karpowicz J, Pandya S, Ji Y, Dorsey S, Dessem D. A clinically relevant animal model of temporomandibular disorder and irritable bowel syndrome comorbidity. J. Pain, 2014; 15(9): 955-966 [PubMed 24981128] (IF 4.216).

36.    Li L, Luo R, Guo Y, Yao F, Cao D, Ma S, Wang J, Wang H, Zhao Y. The inhibitory effect of somatostatin receptor activation on bee venom-evoked nociceptive behavior and pCREB expression in rats. Biomed. Res. Int., 2014;2014:251785 [PubMed 24895558] (IF 2.706).

37.    Reed W, Cao DY, Ge W, Pickar JG. Using vertebral movement and intact paraspinal muscles to determine the distribution of intrafusal fiber innervation of muscle spindle afferents in the anesthetized cat. Exp. Brain Res., 2013;225(2): 205-215 [PubMed 23229776] (IF 2.168).

38.    Ji Y, Tang B, Cao DY, Wang G, Traub RJ. Sex differences in spinal processing of transient and inflammatory colorectal stimuli in the rat. Pain, 2012; 153(9):1965-1973. [PubMed 22819535] (IF 5.836).

39.    Wang J, Cao DY, Guo Y, Ma SJ, Luo R, Pickar JG, Zhao Y. Octreotide inhibits capsaicin-induced activation of C and Aδ afferent fibres in rat hairy skin in vivo. Clin. Exp. Pharmacol. Physiol., 2011;38(8):521-7 [PubMed 21595740] (IF 2.405).

40.    Luo R, Guo Y, Cao DY, Pickar JG, Li L, Wang J, Zhao Y. Local effects of octreotide on glutamate-evoked activation of adelta and c afferent fibers in rat hairy skin. Brain Res., 2010, 1322: 50-58 [PubMed 20117102] (IF 2.828).

41.    Guo Y, Yao FR, Lu SM, Cao DY, Reed W, Zhao Y. The major histocompatibility complex genes are associated with basal pain sensitivity differences between dark-agouti and novel congenic da.1u rats. Life Sci., 2010, 86: 972-978 [PubMed 20471989] (IF 2.296).

42.    Guo Y, Yao FR, Cao DY, Pickar JG, Zhang Q, Wang HS, Zhao Y. Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent thoracic segment in the rat. Brain Res., 2008; 1229(1):61-71 [PubMed 18640104] (IF 2.828).

43.    Zhang SH, Sun QX, Seltzer Z, Cao DY, Wang HS, Chen Z, Zhao Y. Paracrine-like excitation of low-threshold mechanoceptive c-fibers innervating rat hairy skin is mediated by substance p via nk-1 receptors. Brain Res. Bull., 2008; 75(1): 238-245 [PubMed 18158108] (IF 2.974).

44.    You HJ, Cao DY, Yuan B, Arendt-Nielsen L. Sex differences in the responses of spinal wide-dynamic range neurons to subcutaneous formalin and in the effects of different frequencies of conditioning electrical stimulation. Neuroscience, 2006; 138(4): 1299-1307 [PubMed 16426769] (IF 3.327).

45.    Zhang Q, Zhao Y, Guo Y, Cao DY, Tang XD, Tian YL, Yao FR, Wang HS. Activation and sensitization of c and a delta afferent fibers mediated by p2x receptors in rat dorsal skin. Brain Res., 2006; 1102(1): 78-85 [PubMed 16784725] (IF 2.828).

46.    Zhang Q, Zhao Y, Guo Y, Cao DY, Tian YL, Yao FR, Wang HS. Electrophysiological evidence for the interaction of substance p and glutamate on A-delta and C afferent fibers in rat hairy skin. Clin. Exp. Pharmacol. Physiol., 2006; 33(12): 1128–1133 [PubMed 17184490] (IF 2.405).

47.    Xiang XH, Wang HL, Wu WR, Guo Y, Cao DY, Wang HS, Zhao Y. Ethological analysis of scopolamine treatment or pretreatment in morphine dependent rats. Physiol Behav., 2006; 88(1,2): 183-190 [PubMed 16690091] (IF 3.033).

48.    Tian YL, Guo Y, Cao DY, Zhang Q, Wang HS, Zhao Y. Local application of morphine suppresses glutamate-evoked activities of c and adelta afferent fibers in rat hairy skin. Brain Res., 2005; 1059(1):28-34 [PubMed 16168967] (IF 2.828).

49.    Wang HL, Xiang XH, Guo Y, Wu WR, Cao DY, Wang HS, Zhao Y. Ionotropic glutamatergic neurotransmission in the ventral tegmental area modulates deltafosb expression in the nucleus accumbens and abstinence syndrome in morphine withdrawal rats. Eur. J. Pharmacol., 2005; 527(1-3): 94-104 [PubMed 16303124] (IF 2.684).

50.    曹东元，赵晏，郭媛，等．谷氨酸钠对大鼠初级感觉神经传入放电的影响，中国科技论文在线，2004：6.

51.    曹东元，牛汉璋，唐向东，李强．电刺激大鼠腓肠神经引起Aδ、C类传入神经纤维的背根反射电位．生理学报，2003；55（1）：35-40 [PubMed 12598945].

52.    曹东元，赵晏．谷氨酸在初级感觉传入中的作用．生理科学进展，2003；34（4）：361-364 [PubMed 14992025].

53.    曹东元，牛汉璋，赵晏，等．穴位电刺激引起皮肤的神经源性炎症反应．上海针灸杂志，2003；22（1）：7-10.

54.    曹东元，牛汉璋，赵晏，等．穴位刺激经初级传入反射引起SP释放．中国针灸，2001；21（10）：623-625.

55.    曹东元，牛汉璋，赵晏，等．穴位刺激引起内脏的神经源性炎症反应．中国针灸，2001；21（11）：662-664.

56.    曹东元，牛汉璋．初级传入反射引起躯体和内脏的神经源性炎症反应．西安医科大学学报，2000，21（1）：87-89.

57.    曹东元．植物神经系统药理学概论．基础与临床药理学，张殿增主译．西安，世界图书出版西安公司，2000：84-102.

58.    王军，曹东元，郭媛，马少杰，赵晏. 局部应用奥曲肽对大鼠背部皮神经跨节段交互兴奋的抑制效应. 生理学报，2013; 65(6):593-599 [PubMed 24343716]. （共同通讯作者）

59.    眭明红，Sherrie Lessans，燕铁斌，曹东元，劳力行，Susan G. Dorsey．电针“足三里”治疗化疗所致周围神经痛的效应机制研究．中国针灸，2016; 36(5): 512-516

60.    姚繁荣，曹东元，赵晏．cAMP反应元件结合蛋白与痛觉调制．生理科学进展, 2006; 37(2):125-128. [PubMed 16850616].

61.    张琪，赵晏，田雨灵，郭媛，曹东元，王会生．局部注射αβme-ATP对大鼠背部皮肤初级传入纤维的兴奋作用．第一军医大学学报，2005;25(10):1256-1260 [PubMed 16234102].

62.    展淑琴，赵晏，郭新奎，王会生，曹东元．电针对大鼠脑内前速激肽原A mRNA表达的影响．中国临床康复，2004；8（16）：3204-3205.

63.    向晓辉，赵晏，王惠玲，王会生，曹东元．东莨宕碱对吗啡依赖大鼠摄食、饮水和尿量的影响．第四军医大学学报，2004；25（7）：615.

64.    刘健，张巧俊，郭北川，曹东元，王克模．α2-肾上腺素能受体影响糖尿病痛过敏大鼠尾神经中C和Aδ单位的传入活动．中国神经科学杂志，2003；19(1)：27-31.

65.    贾红，杜剑青，曹东元，等．“整肤治疗”对皮肤温度、痛阈、心率和外周神经传导速度的影响．西安医科大学学报，2002；23(3)：274-276.

66.    刘健，张巧俊，郭北川，曹东元，王克模．前列腺素抑制剂消炎痛抑制糖尿病痛过敏大鼠隐神经中Aδ和C单位的传入活动．生理学报，2002；54(5)：379-384 [PubMed 12399816].

67.    赵晏，孙启新，张世红，贾军，曹东元，郭媛．多种神经递质参与外周跨节段信息传递．针刺研究，2002；27（4）：298-302.

68.    展淑琴，赵晏，王会生，曹东元，等．电针对大鼠脑内P物质表达的影响．针刺研究，2002；27（1）：33-35.

69.    刘健，王克模，张巧俊，曹东元．糖尿病性痛过敏大鼠尾神经中的传入单位对交感传出的反应．生理学报，2001；53(6)：456-460 [PubMed 11930225].

70.    刘健，王克模，曹东元，何丽珍．糖尿病性神经病患者桡神经浅支中传入单位的反应特性．生理学报，1996; 48(4)：355-360 [PubMed 9389204].

71.    刘健，王克模，曹东元，何丽珍．链尿佐菌素糖尿病大鼠尾神经中传入单位的反映特性．生理学报，1996；48(4): 395-400 [PubMed 9389204].

72.    刘健，王克模，何丽珍，曹东元．交感传出在大鼠糖尿病性痛过敏中的作用．生理学报，1996；48(6)：536-542 [PubMed 9389151].

73.    刘健，王克模，曹东元，何丽珍．大鼠糖尿病痛过敏模型的建立．西安医科大学学报，1996；17(2)：136-139.

74.    刘健，王克模，曹东元，何丽珍．化学性交感神经切断术在大鼠糖尿病痛过敏中的作用．西安医科大学学报，1996；17(3): 288-291.

75.    刘健，王克模，曹东元，何丽珍．前列腺素在大鼠糖尿病痛过敏中的作用．西安医科大学学报, 1996；17(4)：418-421.

76.    王克模，曹东元．100例正常人Ｈ反射潜伏期与生理变量间的关系．西安医科大学学报，1994；15(4)：362-364.

77.    刘健，王克模，曹东元，何丽珍．人体桡神经浅支中Aδ和C纤维的生理学特性．生理学报，1993；45(3): 223-230 [PubMed 8235722].

78.    刘健，王克模，曹东元，何丽珍．人体桡神经浅支中支配机械感受性单位的生理学特性．西安医科大学学报，1993；14(1)：25-29.

79.    王克模，刘健，曹东元．胫神经支配穴位的外周装置及其针感的研究．针刺研究，1991，16(3-4)：211-212.

参与编写中英文专业书籍章节：

1.       Cao DY. How stress affects your health? (Book Chapter). In: The IHarbour Lectures Medicine and Health Series. Lv SM (Ed). Xi’an Jiaotong University Press, 2020

2.       Wei SQ, Xue Y, Tao ZY, Cao DY. Peripheral sensitization (Book Chapter). In: Peripheral Nerves-injuries, Disorders and Treatment. Turker H (Ed). IntechOpen, 2019 （通讯作者）

3.       Tao ZY, Traub RJ, Cao DY. Epigenetic modulation of visceral Pain (Book Chapter). In: Epigenetics of Chronic Pain. Bai G & Ren K (Eds). Elsevier, 2018, 141-156 （通讯作者）

4.       Cao DY, Zhao Y, Guo Y, Pickar JG. Glutamate receptors involved in interaction between peripheral nerve terminals (Book Chapter). In: Amino Acid Receptor Research, Paley BF & Warfield TE (Eds). NOVA Press, 2008, 309-327

5.       曹东元, 闫剑群. 氨基酸类递质. 神经生物学概论. 闫剑群，赵晏主编, 西安交通大学出版社，2007: 73-92页

6.       曹东元, 赵晏. 速激肽. 神经生物学概论. 闫剑群，赵晏主编, 西安交通大学出版社，2007: 116-123页

7.       曹东元, 赵晏. 神经递质在痛觉调制中的作用. 神经生物学概论. 闫剑群，赵晏主编, 西安交通大学出版社，2007: 252-258页

国际学术会议摘要

1.       Xue Y, Wei SQ, Wang PX, Li JH, Liu EQ, Traub RJ, Cao DY. Orofacial inflammation with stress induces hyperalgesia through down-regulation of 5-HT2 receptors. Society of Neuroscience 49th Annual Meeting, Chicago, IL, No. 2019-S-4571, 2019

2.       Xu GZ, Xue Y, Wei SQ, Li JH, Traub RJ, Wang MD, Cao DY. Valproate inhibits stress-induced somatic and visceral pain through up-regulation of 5-HT2C receptor. Society of Neuroscience 49th Annual Meeting, Chicago, IL, No. 2019-S-4576, 2019

3.       Li JH, Li ZL, Tao ZY, Xue Y, Cao DY. NMDA receptor in the spinal cord contributes to somatic hyperalgesia induced by craniofacial inflammatory pain combined with repeated forced swim stress. The 17th World Congress on Pain, Boston, MA, USA. Sept., 2018 (通讯作者)

4.       Cao DY, Bai G, Ji Y, Traub RJ. Stress epigenetically regulates spinal NMDA and mGluR3 expression modulating visceral sensitivity in female rats. Society of Neuroscience 45th Annual Meeting, Chicago, IL, No. 238.04, 2015

5.       Li A, Cao DY, Guo Y, Zhao Y. Peripheral glutamate receptors contribute to Fos expression in the spinal dorsal horn through interaction between peripheral nerve terminals. Society of Neuroscience 45th Annual Meeting, Chicago, IL, No. 704.08, 2015 (通讯作者)

6.       Cao DY, Bai G, Ji Y, Traub RJ. Stress-induced visceral hypersensitivity involves epigenetic modulation of spinal NMDA and mGluR2/3 expression modulating viseral sensitivity. The 6th Asian Pain Symposium, Suzhou, China, 2015

7.       Cao DY, Bai G, Karpowicz J, Ji Y, Traub RJ. Epigenetic modulation on stress-induced visceral hypersensitivity. Society of Neuroscience 44th Annual Meeting, Washington, DC, No. 628.07, 2014

8.       Ji Y, Karpowicz J, Pandya S, Cao DY, Traub RJ. Estrogen receptor alpha and beta differentially mediate MAPK signaling pathway activation in the female rat spinal cord. Society of Neuroscience 44thAnnual Meeting, Washington, DC, No. 628.17, 2014.

9.       Cao DY, Guang B, Ji Y, Traub RJ. Epigenetic modulation of estrogen-induced facilitation of visceral pain. Society for Neuroscience 43rd Annual Meeting, San Diego, CA, No. 643.04, November 2013.

10.    Traub RJ, Cao DY, Dorsey S, Dessem D. Stress and estrogen induce persistent visceral hypersensitivity following masseter muscle inflammation: A new model of overlapping pain conditions. Society for Neuroscience 43rd Annual Meeting, San Diego, CA, No. 369.02, November 2013.

11.    Cao DY, Ji Y, Tang B, Traub RJ. Activation of estrogen receptor beta inhibits visceral pain. The 14th World Congress on Pain, Milan, Italy. No.107935, August 2012.

12.    Ji Y, Cao DY, Guang B, Traub RJ. Estrogen modulation of spinal GluN2B subunit in a visceral pain model in the rat. Society for Neuroscience 42nd Annual Meeting, New Orleans, LA. No. 473.22, October 2012.

13.    Cao DY, Ji Y, Tang B, Traub RJ. Effect of estrogen receptor beta activation on the response of dorsal horn neurons to colorectal distention. Society for Neuroscience 41st Annual Meeting, Washington DC, No. 494.04, November 2011.

14.    Cao DY, Reed WR, Kawchuk GN, Pickar JG. Effects of thrust displacement simulating a spinal manipulation on the response of lumbar paraspinal muscle spindles to ramp and hold movement. Society for Neuroscience 40th Annual Meeting, San Diego, CA, No. 182.1, November 2010.

15.    Reed WR, Cao DY, Kawchuk GN, Pickar JG. Effects of spinal manipulation's mechanical characteristics (magnitude and duration) on paraspinal muscle spindle discharge. Society for Neuroscience 40th Annual Meeting, San Diego, CA, No. 182.17, November 2010.

16.    Cao DY, Pickar JG. The effect of muscle history on the velocity sensitivity of lumbar paraspinal muscle spindles. Society for Neuroscience 39th Annual Meeting, Chicago, IL, No. 80.4, October 2009.

17.    Cao DY, Pickar JG. Lumbodorsal fascia does not affect passive signaling properties of lumbar paraspinal muscle spindles. The 2nd International Fascia Research Congress, Amsterdam, The Netherlands, October 2009.

18.    Cao DY, Pickar JG. The effect of spinal manipulative thrusts on the development of muscle history-dependent responsiveness of lumbar paraspinal muscle spindles. Oral Presentation at 2nd North American Research Conference on Complementary & Integrative Medicine, No. 2869, Minneapolis, MN, May 2009. Also published as abstract in Altern. Ther. Health Med. 2009; 15: S81.

19.    Reed WR, Cao DY, Pickar JG. An in vivo spinal joint hypo- and hypermobility model for investigating paraspinal afferent feedback. Society for Neuroscience 39th Annual Meeting, Chicago, IL, No. 80.3, October 2009.

20.    Cao DY, Pickar JG. Removing lumbodorsal fascia does not affect the development of muscle history-dependent responsiveness in lumbar paraspinal muscle spindles. Society for Neuroscience 38th Annual Meeting, No. 181.10, Washington DC, November 2008.

21.    Pickar JG, Cao DY, Ge W. The responsiveness of lumbar paraspinal muscle spindles is affected by the history of vertebral position along 3 orthogonal axes of vertebral motion. Society for Neuroscience 38th Annual Meeting, No. 181.11, Washington DC, November 2008.

22.    Cao DY, Pickar JG, Ge W, Ianuzzi A, Khalsa PS. Sensitivity of paraspinal muscle spindles to intervertebral movement in the cat lumbar spine. Society for Neuroscience 37th Annual Meeting, No. 410.10, San Diego, November 2007.

23.    Ge W, Cao DY, Pickar JG. Resting discharge of paraspinal muscle spindles is stable under deep anesthesia using sodium pentobarbital. Society for Neuroscience 37th Annual Meeting, No. 410.12, San Diego, November 2007.

24.    Pickar JG, Cao DY, Ge W, Ianuzzi A, Khalsa PS. Sensitivity of paraspinal muscle spindles to intervertebral position in the cat lumbar spine. Society for Neuroscience 37th Annual Meeting, No. 410.11, San Diego, CA, November 2007.

25.    Cao DY, Pickar JG, Ge W, Ianuzzi A, Khalsa PS. Changes in lumbar facet joint capsule strain and paraspinal muscle spindle discharge during vertebral movement in the anesthetized cat. Society for Neuroscience 36th Annual Meeting, No. 650.1, Atlanta, GA, October 2006.

26.    Ge W, Cao DY, Pickar JG. Very small changes in vertebral position evoke muscle history dependent changes in paraspinal muscle spindle discharge of the anesthetized cat. Society for Neuroscience 36th Annual Meeting, No. 650.2, Atlanta, GA, October 2006.

27.    Cao DY, Zhao Y, Guo Y, Wang HS. Antidromic electrical stimulation of sensory nerve sensitizes adjacent primary afferent terminal: the role of glutamate ionotropic receptors. Oral Presentation at Society for Neuroscience 35th Annual Meeting, No. 364.10, Washington DC, November 2005.

 

联系方式:

              曹东元

西安交通大学口腔医院研究中心

陕西省西安市新城区西五路98号

电话: 18291885396   

E-mail: Dongyuan_cao@hotmail.com,  caody1@ xjtu.edu.cn