Research Fields

Our group current research interests are the development of new synthetic methodologies, strategies and transition-metal catalyzed tandem processes for the rapid construction of biologically active heterocycles.

 

(1) Transition-metal Catalyzed Decarboxylative Cross-coupling Reaction

Transition-metal catalyzed decarboxylative cross-coupling reactions using simple carboxylic acids as coupling partners have emerged as a new type of C-C bond formation reaction. In these reactions, using readily available and stable carboxylic acids instead of organometallic reagents enabled the decarboxylative cross-coupling reactions to proceed with good selectivities and tolerance of functional groups (Scheme 1).

 

Scheme 1Decarboxylative Cross-Coupling Reactions

 

 

 

(2) Synthesis of Heterocycles 

Heterocycles represent a larger group of organic compounds and play a significant role in life processed and in all aspects of pure and applied chemistry. Nitrogen-containing heterocycles are an component of not only some of the most interesting and biologically important natural products, such as alkaloids, carbohydrates, nucleic acids, and antibiotics but include numerous potent pharmaceutical drugs and a large amount of synthetic organic compounds (Scheme 2).

  

Scheme 2. Application of Heterocycles 

                                                                                                                                                                         

Science Project

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Project number Project name Project origin Start time Roles Project kind
xtr072022003 光电介导的惰性化学键活化及应用重大创新团队 西安交通大学 2022-06~2024-12 Leader Other
20220685 乙二醇制备乳酸的催化转化工艺研究 陕西榆能集团能源化工研究院有限公司 2022-03~2023-03 Leader horizontal project
22171220 自由基接力扩环构建含季碳中心环骨架的方法研究 国家自然科学基金项目 2022-01~2025-12 Leader Vertical project
20210457 京博农化科技有限公司与西安交通大学共建京博-西交大双链融合创新平台合作协议 京博农化科技有限公司 2021-03~2022-03 Leader horizontal project
2021JM-003 惰性烷基碳氢键官能团化反应研究 陕西省科学技术厅 2021-01~2022-12 Leader Vertical project
20200560 高效环保型螯合剂的研发与技术服务 山东远联化工股份有限公司 2020-05~2025-06 Leader horizontal project