2020-2025年

[33] Feng Chen*, et. al. ABC-seq expands small RNAs content with randomized adapter pools operation. Angewandte Chemie International Edition, under revision.

[32] Xiaowen Cao, Yuheng Zhu, Siyue Fan, Feng Chen* and Yongxi Zhao*. Accurate counting of RNA in tissues with highly denoising amplified imaging. Chinese Chemical Letters, 2025, accepted, , .

[31] Siyue Fan^#, Xinyin Li^#, Huan Liu, Mengying Ye, Yan He, Wenhao Fu, Feng Chen* and Yongxi Zhao*. Molecule Differentiation Encoding Microscopy to Dissect Dense Biomolecules in Cellular Nanoenvironments Below Spatial Resolution. Angewandte Chemie International Edition, 2025, , , accepted. 

[30] Xiaowen Cao, Wenhao Fu, Xinyin Li, Feng Chen* and Yongxi Zhao*. DNA-encoded fluorescence signals for imaging analysis. Small Methods, 2025, accepted.

[29] Ying Sun*, Yuchuan Liu, Daqian Song, Feng Chen*. DNA-assisted separation of nanoparticles. Small Methods, 2025, , . https://doi.org/10.1002/smtd.202401389. 

[28] Feng Chen, Xinyin Li, Min Bai, and Yongxi Zhao*. Visualizing epigenetic modifications and their spatial proximities in single cells using three DNA-encoded amplifying FISH imaging strategies: BEA-FISH, PPDA-FISH and Cell-TALKING. Nature Protocols, 2025, 20, 220-247.

[27] Xiaowen Cao, Feng Chen*, Jing Xue, Yue Zhao, Min Bai and Yongxi Zhao*. Hierarchical DNA branch assembly-encoded fluorescent nanoladders for single-cell transcripts imaging. Nucleic Acids Research, 2023, 51, 3, e13. DOI: https://doi.org/10.1093/nar/gkac1138.

[26] Jing Xue, Youlan Fu, Siyue Fan, Xiaowen Cao, Wei Huang, Jin Zhang, Yongxi Zhao and Feng Chen*. Branched immunochip-integrated pairwise barcoding amplification exploring the spatial proximity of two post-translational modifications in distinct cell subpopulations. Chemical Communications, 2022, 58, 10020-10023. 

[25] Feng Chen#, Jing Xue#, Min Bai, Chunhai Fan and Yongxi Zhao*. Lighting up Nucleic Acid Modifications in Single Cells with DNA-Encoded Amplification. Accounts of Chemical Research, 2022, 55, 2248-2259. 

[24] Fengjiao Zhao^#, FengChen^#, Huahang Yu, Siyue Fan, Min Bai, Jing Xue, Yue Zhao, Xiaolei Zuo, Chunhai Fan and Yongxi Zhao*. CRISPR/Cas system-guided plasmid mutagenesis without sequence restriction. Fundamental Research, DOI: https://doi.org/10.1016/j.fmre.2022.06.017 

[23] Li Su^#, Feng Chen^#, Huahang Yu, Hao Yan, Fengjiao Zhao, Chunhai Fan, and  Yongxi Zhao*. Addition–Elimination Mechanism-Activated Nucleotide Transition Sequencing for RNA Dynamics Profiling. Analytical Chemistry, 2021, 93, 13974-13980.

[22]  Feng Chen^#, Min Bai^#, Xiaowen Cao, Jing Xue, Yue Zhao, Na Wu, Lei Zhang, Dexin Zhang, and Yongxi Zhao*. Cellular macromolecules-tethered DNA walking indexing to explore nanoenvironments of chromatin modifications. Nature Communications, 2021, 12, 1965. 

Selected as Research Highlight by Nature Methods. Walking through chromatin modifications. Nature Methods, 2021, 18: 446.

[21] Jing Xue^#, Feng Chen^#, Li Su^#, Xiaowen Cao, Min Bai, Yue Zhao, Chunhai Fan, and Yongxi Zhao*. Pairwise Proximity-differentiated Visualization of Single-cell DNA Epigenetic Marks. Angewandte Chemie International Edition, 2021, 60, 7, 3428-3432. 10.1002/anie.202011172.

[20]  Xiaowen Cao, Huahang Yu, Jing Xue, Min Bai, Yue Zhao, Youjun Li, Yongxi Zhao and  Feng Chen*. RNA-primed Amplification for Noise-suppressed Visualization of Single-cell Splice Variants. Analytical Chemistry, 2020, 92, 13, 9356-9361. 

[19] Min Bai^#, Feng Chen^#, Xiaowen Cao, Yue Zhao, Jing Xue, Xu Yu, Chunhai Fan, and Yongxi Zhao*. Intracellular Entropy-driven Multi-bit DNA Computing for Tumor Progression Discrimination. Angewandte Chemie International Edition, 2020, 59, 32, 13267-13272. DOI: 10.1002/anie.202001598.

Highlighted by 国家自然科学基金委员会,http://www.nsfc.gov.cn/csc/20340/20343/53227/index.html

[18] Feng Chen#, Jing Xue#, Jin Zhang, Min Bai, Xu Yu, Chunhai Fan and Yongxi Zhao*. Differentiated Visualization of Single-Cell 5-Hydroxymethylpyrimidines with Microfluidic Hydrogel Encoding. Journal of the American Chemical Society, 2020, 142, 6, 2889-2896. 

Highlighted by 科技日报http://digitalpaper.stdaily.com/http_www.kjrb.com/kjrb/html/2020-03/16/content_441516.htm?div=-1

2019年以前

[17] Feng Chen^#, Min Bai^#, Xiaowen Cao, Yue Zhao, Jing Xue, and Yongxi Zhao*. Click-encoded rolling FISH for visualizing single-cell RNA polyadenylation and structures. Nucleic Acids Research, 2019, 47, 22, e145. 

[16] Jing Xue^#, Feng Chen^#, Min Bai, Xiaowen Cao, Ping Huang,  and Yongxi Zhao*. All-in-one Synchronized DNA Nanodevices Facilitating Multiplexed Cell Imaging. Analytical Chemistry, 2019, 91, 7, 4696-4701. 

[15] Feng Chen^#, Jing Xue^#, Min Bai, Jing Qin,  and Yongxi Zhao*. Programming in situ accelerated DNA walkers in diffusion-limited microenvironments. Chemical Science, 2019, 10，3103-3109. 

[14] Jing Wei^#, Gen Wang^#, Feng Chen^#, Min Bai, Yan Liang, Huanting Wang, Dongyuan Zhao,  Yongxi Zhao*. Sol-gel Synthesis of Metal-Phenolic Coordination Spheres and Their Derived Carbon Composites. Angewandte Chemie International Edition, 2018, 57, 9838 –9843.

[13] Feng Chen^#, Min Bai^#, Yue Zhao, Ke Cao, Xiaowen Cao and Yongxi Zhao*. MnO₂-Nanosheet-Powered Protective Janus DNA Nanomachines Supporting Robust RNA Imaging. Analytical Chemistry, 2018, DOI: 10.1021/acs.analchem.7b04634.

[12] Feng Chen^#, Min Bai^#, Ke Cao, Yue Zhao, Xiaowen Cao, Jing Wei, Na Wu, Jiang Li, Lihua Wang, Chunhai Fan, and Yongxi Zhao* .Programming Enzyme-Initiated Autonomous DNAzyme Nanodevices in Living Cells. ACS Nano, 2017, 11: 11908-11914. 

[11] Feng Chen, Min Bai, Ke Cao, Yue Zhao, Jing Wei, Yongxi Zhao*. Fabricating MnO₂ Nanozymes as Intracellular Catalytic DNA Circuit Generators for Versatile Imaging of  Base-Excision Repair in Living Cell.Advanced Functional Materials, 2017, 27, 1702748.

[10] Feng Chen^#, Xuyao Wang^#, Xiaowen Cao , Yongxi Zhao*.  Accurate Electrochemistry Analysis of Circulation Methylated DNA from Clinical Plasma Based on Paired-End Tagging and Amplifications. Analytical Chemistry, 2017, 89: 10468-10473. 

[9] Xuyao Wang^#, Feng Chen^#, Dexin Zhang, Yue Zhao, Jing Wei, Lihua Wang, Shiping Song, Chunhai Fan, Yongxi Zhao*. Single copy-sensitive electrochemical assay for circulating methylated DNA in clinical samples with ultrahigh specificity based on a sequential discrimination-amplification strategy. Chemical Science, 2017, 8: 4764-4770. (Outside Back Cover, RSC优秀论文) 

[8] Feng Chen^#, Manli Lin^#, Yue Zhao, Yongxi Zhao*. Catalase-functionalized SiO₂ nanoparticles mediate growth of gold nanoparticles for plasmonic biosensing of attomolar microRNA with the naked eye. RSC Advances, 2016, 6: 15709-15715. 

[7] Feng Chen, Dexin Zhang, Qing Zhang, Xiaolei Zuo, Chunhai Fan, Yongxi Zhao*. Zero-background helicase-dependent amplification and its application to reliable assay of telomerase activity in cancer cell by eliminating primer-dimer artifacts. ChemBioChem, 2016, 17: 1171-1176. 

[6] Yongxi Zhao*, Feng Chen, Qian Li, Lihua Wang, Chunhai Fan*.Isothermal amplification of nucleic acids.Chemical Reviews, 2015 , 115: 12491-12545. (ESI高被引论文)

[5] Feng Chen, Chunhai Fan,Yongxi Zhaoo*. Inhibitory impact of 3′-terminal 2′-O-methylated small silencing RNA on target-primed polymerization and unbiased amplified quantification of the RNA in arabidopsis thaliana. Analytical Chemistry, 2015, 87: 8758-8764.

[4] Feng Chen,Yue Zhao,Chunhai Fan,Yongxi Zhao*. Mismatch extension of DNA polymerases and high-accuracy single nucleotide polymorphism diagnostics by gold nanoparticle-improved isothermal amplification. Analytical Chemistry, 2015, 87: 8718-8723.

[3] Qing Zhang^#, Feng Chen^#, Feng Xu, Yongxi Zhao*, Chunhai Fan. Target-triggered three-way junction structure and polymerase/nicking enzyme synergetic isothermal quadratic DNA machine for highly specific, one-step, and rapid microRNA detection at attomolar level. Analytical Chemistry,2014, 86 (16):8098-8105.

[2] Feng Chen, Yongxi Zhao*, Lin Qi, Chunhai Fan. One-step highly sensitive florescence detection of T4 polynucleotide kinase activity and biological small molecules by ligation-nicking coupled reaction-mediated signal amplification. Biosensors and Bioelectronics, 2013,47:218-224.

[1] Feng Chen, Yongxi Zhao*. Methylation-blocked enzymatic recycling amplification for highly sensitive fluorescence sensing of DNA methyltransferase activity. Analyst,2013,138:284-289.