公共主页 - 李 源
2014 - 2017 美国佛罗里达大学 化学工程博士
2011 - 2013 美国佛罗里达大学 化学工程硕士
2006 - 2010 南昌大学 化学学士
2020 - 至今 西安交通大学仿生工程与生物力学中心 助理教授
2018 - 2020 美国迈阿密大学米勒医学院西尔维斯特综合癌症研究中心 博士后研究员
2022 - 至今 陕西省抗癌协会转化医学专委会委员 委员
2021 - 至今 西安市侨联青委会第二届委员会 委员
期刊审稿人:International Journal of Molecular Sciences, Journal of Cellular and Molecular Medicine ,International Journal of Biological Sciences,PeerJ,Cytoskeleton,International Journal of Cell Biology
本人主要研究方向聚焦癌症背景下的细胞生物力学与力生物学,通过研究和探索人体组织以及细胞的力学行为,特征以及周围微环境,融合力学,工程学以及生物医学等学科领域的知识解答基础科学问题,同时拓展与应用到癌症的研究与治疗。
Project number | Project name | Project origin | Start time | Roles | Project kind |
---|---|---|---|---|---|
2022ZDLSF04-03 | 力学调控促进创面无瘢痕愈合的新策略及新型创面生物敷料的研发 | 陕西省重点研发计划 | 2024-12~2022-01 | 骨干成员 | Vertical project |
82173277 | Amot-p130通过PTEN/Cdc42轴影响细胞外基质重构抑制乳腺癌侵袭转移的机制研究 | 国家自然科学基金项目 | 2022-01~2025-12 | 骨干成员 | Vertical project |
52175547 | 柔性模具毛细折叠技术制备三维微凝胶生物支架的成形机理研究 | 国家自然科学基金项目 | 2022-01~2025-12 | 骨干成员 | Vertical project |
2022-MS-1 | 肿瘤物理微环境调控癌细胞化疗耐药性的机制研究 | 陕西省感染与免疫疾病重点实验室开放课题 | 2022-01~2024-12 | 负责人 | Vertical project |
12102334 | 基质刚度介导核纤层蛋白B1增强DNA损伤修复影响癌细胞耐药行为的力学生物学机制研究 | 国家自然科学基金项目 | 2022-01~2024-12 | 负责人 | Vertical project |
Paper Name | Author | Publication/Completion Time | Magazine Name |
---|---|---|---|
Mechanotherapy in oncology: targeting nuclear mechanics and mechanotransduction | Liu S. *, Li Y. *, Hong Y., Wang M., Zhang H., Ma J., Qu K., Huang G.Y. #, Lu T.J.# | 2023-02-02 | Advanced Drug Delivery Reviews |
Targeting tumor physical microenvironment for improved radiotherapy | Wang J. *, HanY. L.*, Li Y., Zhang F.P., Cai M.J., Zhang X.Y., Chen J., Ji C., Ma J.L. Xu F.# | 2022-09-18 | Small Methods |
The effects of serum albumin pre-adsorption of nanoparticles on protein corona and membrane interaction: A molecular simulation study | Li L.X., Yang Y.Y., Wang L., Xu F., Li Y. #, He X. # | 2022-08-02 | Journal of Molecular Biology |
Torsional and translational vibrations of a eukaryotic nucleus, and the prospect of vibrational mechanotransduction and therapy | Liu S.;Yang H.; Wang M.; Tian J., Hong Y.; Li Y.; Genin G.M., Lu T.J. #, Xu F.# | 2021-07-15 | Journal of the Mechanics and Physics of Solids |
MT1-MMP-dependent ECM processing regulates laminB1 stability and mediates replication fork restart | Thakur V.; J Tiburcio de Freitas; Li Y.; Zhang K.; Savadelis A.; Bedogni, B.# | 2021-05-27 | PLoS ONE |
Nuclear deformation in mechanotransduction: A new role for heterogeneity | Hong Y.; Li Y.; Xu F.# | 2021-04-20 | Biophysical Journal |
Targeting extracellular matrix remodeling restores BRAF inhibitor sensitivity in BRAFi-resistant melanoma | Marusak, C., Thakur, V., Li, Y., Freitas, J.T., Zmina, P.M., Thakur, V.S., Chang, M., Gao, M., Tan, J.F., Xiao, M., Lu, Y.L., Mills, G.B., Flaherty, K., Frederick, D.T., Miao, B.C., Sullivan, R.J., Moll, T., Boland, G.M., Herlyn, M., Zhang, G., Bedogni, | 2020-08-20 | Clinical Cancer Research |
Nuclear size changes caused by local motion of cell boundaries unfold the nuclear lamina and dilate chromatin and intranuclear bodies | Katiyar, A.*, Tocco, V.J.*, Li, Y., Aggarwal, V., Tamashunas, A., Dickinson, R.B., Lele, T.P.# | 2019-10-23 | Soft Matter |
Apical cell protrusions cause vertical deformation of the soft cancer nucleus | 5 Kent, I., Zhang, Q., Katiyar, A., Li, Y., Pathak, S., Dickinson, R.B., Lele, T.P. # | 2019-03-21 | Journal of Cellular Physiology |
The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells | Tocco, V.J.*, Li, Y.*, Christopher, K.G., Matthews, J.H., Aggarwal, V., Paschall, L, Luesch, H., Licht, J.D., Dickinson, R.B., and Lele, T.P.# | 2017-05-24 | Journal of Cellular Physiology |
The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity | 2016Alam, S., Zhang, Q., Prasad, N., Li, Y., Chamala, S., Kuchibhotla, R., KC, B., Aggarwal, V., Shrestha, S., Jones, A., Levy, S., Roux, K., Nickerson, J., and Lele, T.P.# | 2016-12-01 | Scientific Reports |
Moving cell boundary drives nuclear flattening during cell spreading | Li, Y., Lovett, D.B., Zhang, Q., Kuchibhotla, R. A., Neelam, S., Zhu, R., Gundersen, G.G., Lele, T.P.#, Dickinson, R.B. # | 2015-07-07 | Biophysical Journal |
Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell | Neelam, S., Chancellor, T.J., Li, Y., Nickerson, J., Roux, K., Dickinson, R.B., and Lele, T.P.# | 2015-03-31 | Proceedings of the National Academy of Sciences |