Basic Information

梁玲利博士，西安交通大学医学部基础医学院生理学与病理生理学系教授，转化医学研究院脑科学研究所PI，博士生导师。基础医学院青年委员会委员兼秘书，中国神经科学学会神经内稳态和内分泌分会委员，中国神经科学学会感觉和运动分会，中国药物滥用防治协会成瘾与脑科学分会委员，陕西省生理科学会理事。

2002年在郑州大学医学院获得预防和全科医学学士学位，2005年在上海中医药大学获得中西医结合基础生物硕士学位，2010年在复旦大学获得神经生物学专业博士学位，2010-2013年，在美国约翰霍普金斯大学从事博士后研究工作，2013-2017年在美国新泽西罗格斯大学任Research associate从事科学研究。

本人主要研究方向是慢性痛的分子神经生物学机制。主持国家自然科学基金3项，陕西省自然科学基金面上项目1项，中国博士后基金1项，高校基本科研业务费2项，另参与国家自然科学基金项目1项。目前单独以及合作指导研究生共6名，指导大学生创新实验若干项并获得腾飞杯奖状。

在国内外杂志发表论文40余篇，发表杂志包括Nature communication、Anesthesiology、The Journal of Pain、Neuropharmacology等，其中一半已发表论文以第一或通讯作者发表。

主持项目：

    1. 国家自然科学基金（面上项目），2023.1-2026.12，项目号82271253，¥520,000，项目负责人

    2. 国家自然科学基金（面上项目），2019.1-2022.12，项目号31871065，¥600,000，项目负责人

    3. 国家自然科学基金（青年项目），2018.1-2020.12，项目号81701112，¥200,000，项目负责人

    4. 陕西省自然科学基础研究计划一般项目（面上）， 2019.1.1-2020.12.31，项目号：2019JM-128，¥30,000，项目负责人

    5. 中国博士后科学基金第63批面上资助，2018.7.1-2020.6.30， 项目号：2018M633527，¥50,000，项目负责人

    6. 2021年四川省科技厅联合项目，2022.1-2024.1，项目号：22SYSX0173

    7. 北京大学神经科学重点实验室开放基金，2022.1.1-2023.12.31

    6. 西安交通大学“ 新教师科研支持计划”，2017.9.1-2020.12.31，¥150,000，项目负责人

    7. 西安交通大学基本科研业务费自由探索，2019.1.1-2021.12.31 ，项目号sxzy012019144，¥150,000，项目负责人

    8. 2017-2018年度“中外本科生基础医学开放性创新实验项目” 2017BKKF-Int.20，¥8000，指导教师

    9. 指导2018-2022年本科生大创项目9项

 

I am Lingli Liang, Ph.D., Professor in the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center. I am member and secretary of youth committee of School of Basic Medical Sciences and member of Neurohomeostasis and Endocrinology branch of Chinese society of neuroscience.

I got my Bachelor Degree in Preventive Medicine/General Medicine from Zhengzhou University in 2002, a Master Degree in Cooperation of Chinese and Western medicine (Biology) from Shanghai University of Traditional Chinese Medicine in 2005, and a PhD Degree in Neurobiology from Fudan University in 2010. From 2010 to 2013, I worked as a postdoctoral researcher at Johns Hopkins University and then as a Research associate in New Jersey Medical School, Rutgers University. In 2017, I was recruited in Xi’an Jiaotong University as an Associate Professor.

My major research interest is to elucidate the epigenetic mechanism of chronic pain. I have obtained multiple grants to support my research. The grants are listing here:

1. 2023.1-2026.12, National Natural Science Foundation of China (82271253)

2. 2019.1-2022.12, National Natural Science Foundation of China (31871065)

3. 2018.1-2020.12, National Natural Science Foundation of China (81701112) 

4. 2019.1.1-2020.12.31, Natural Science Foundation of Shaanxi Province (2019JM-128)

5. 2018.7.1-2020.6.30, China Postdoctoral Science Foundation (2018M633527)

6. 2017.9.1-2020.12.31, Basic Science Foundation from Xi’an Jiaotong University

7. 2019.1.1-2021.12.31, Basic Science Foundation from Xi’an Jiaotong University (sxzy012019144)

So far I have published more than 40 papers in domestic and foreign journals, half of them which I contributes as the first or corresponding author in Internationally renowned journals including Nature communication, Pain, Science signaling, Anesthesiology and other international journals. Currently, I am supervising 6 graduate students and some undergraduate students. Several students whom I directed in innovative experiments have got “Teng-Fei Cup” Prize.

Research areas: Molecular mechanisms of chronic pain.

Current interests: 1. Epigenetic regulation in neuropathic pain. 2. Central mechanisms of chemotherapy-induced neuropathic pain. 

 

 

Contact Information

地址：陕西省西安市雁塔西路76号科教楼807室，邮编：710061

Mail address: 76 Yanta Road W., Kejiao building, Room 807, Xi'an, Shaanxi 710061, PR China

E-mail: llliang@126.com; ll2017@xjtu.edu.cn

Homepage：http://gr.xjtu.edu.cn/web/ll2017/home

Researchgate：https://www.researchgate.net/profile/Lingli_Liang

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Research Fields

慢性痛病因多样，目前治疗不能满足患者需求。我们实验室通过应用各种慢性痛动物模型，研究慢性痛发生的分子神经生物学机制，主要研究发现包括：1. 背根神经节卫星胶质细胞载脂蛋白E参与调控神经病理性疼痛；2. 背根神经节EGFR、AXL等受体接受细胞外信号参与调控神经病理性疼痛；3. 背根神经节组蛋白甲基转移酶LSD1、G9a或SUV39H1通过调控钾通道和阿片受体基因表达参与神经病理痛的外周机制；4. 背根神经节DNA甲基转移酶DNMT3A通过调控钾通道和阿片受体基因表达参与神经病理痛的外周机制；5. 背根神经节Nrcam基因可变剪接调控神经病理性疼痛。

研究方向：慢性痛的分子神经生物学机制研究

Research area: Molecular Neurobiology mechanisms of chronic pain

Major publications：

  1. Liu S#, Yang S, Zhou X, Zhu X, Xu L, Li X, Gao Z, Sun T, Wei J, Tian L, Cheng H, Wei G, Huo FQ, Liang L*. Nerve injury-induced upregulation of apolipoprotein E in dorsal root ganglion participates in neuropathic pain in male mice. Neuropharmacology. 2023 Feb 15;224:109372. IF(2021): 5.273
  2. Wei J#, Chang S#, Liu S, Tian L, Zhu X, Wang S, Zhou X, Wang Y, Xu L, Huo FQ, Liang L*. Lysine-specific demethylase 1 in primary sensory neurons participates in chronic compression of dorsal root ganglion-induced neuropathic pain. Brain Res Bull. 2022 Dec;191:30-39.
  3. Mao Q#, Tian L, Wei J, Zhou X, Cheng H, Zhu X, Li X, Gao Z, Zhang X, Liang L*. Transcriptome analysis of microRNAs, circRNAs, and mRNAs in the dorsal root ganglia of paclitaxel-induced mice with neuropathic pain. Front Mol Neurosci. 2022 Aug 31;15:990260.
  4. Lixia Tian#, Yu Chen, Shuyang Chang, Linping Xu, Xiaoqiong Zhou, Qingxiang Mao, Lingli Liang*. Antisense oligonucleotides targeting alternative splicing of Nrcam exon 10 suppress neurite outgrowth of ganglion sensory neurons in vitro. Neuroreport. 2021 May 5;32(7):548-554.
  5. Siqi Wei#, Shuyang Chang, Yue Dong, Linping Xu, Xiaocui Yuan, Hong Jia, Jun Zhang#, Lingli Liang*. Electro-acupuncture suppresses AXL expression in dorsal root ganglion neurons and enhances analgesic effect of axl inhibitor in spinal nerve ligation induced-neuropathic pain in rats. Neurochem Res. 2021 Mar;46(3):504-512.
  6. Liang L#, Wu S, Lin C, Chang YJ, Tao YX*. Alternative splicing of Nrcam gene in dorsal root ganglion contributes to neuropathic pain. J Pain. 2020 Jan 6. pii: S1526-5900(19)30881-8. IF: 5.38
  7. Liang L*#, Wei J, Tian L, Padma Nagendra BV, Gao F, Zhang J, Xu L, Wang H, Huo FQ. Paclitaxel Induces Sex-biased Behavioral Deficits and Changes in Gene Expression in Mouse Prefrontal Cortex. Neuroscience. 2020 Feb 1;426:168-178.
  8. Liang L*#, Zhang J#, Tian L, Wang S, Xu L, Wang Y, Guo-Shuai Q, Dong Y, Chen Y, Jia H, Yang X, Yuan C. AXL signaling in primary sensory neurons contributes to chronic compression of dorsal root ganglion-induced neuropathic pain in rats. Mol Pain. 2020 Jan-Dec;16:1744806919900814.
  9. Shuo Wang#, Siyi Liu#, Linping Xu#, Xuan Zhu, Wanyuan Liu, Lixia Tian, Yu Chen, Yuying Wang, Borra. V. Padma Nagendra, Shushan Jia,, Lingli Liang*, Fu-Quan Huo**. The upregulation of EGFR in the dorsal root ganglion contributes to chronic compression of dorsal root ganglions-induced neuropathic pain in rats. Molecular Pain. 2019 Jan-Dec;15:1744806919857297. doi: 10.1177/1744806919857297. IF: 3.44.
  10.  Lingli Liang#*, Yuan-Xiang Tao. Expression of acetyl-histone H3 and acetyl-histone H4 in dorsal root ganglion and spinal dorsal horn in rat chronic pain models. Life sciences. 2018; 211:182-188. IF: 3.234.
  11.  Lingli Liang#, Xiyao Gu#, Jian-Yuan Zhao#, Shaogen Wu, Xuerong Miao, Kai Mo, Brianna Marie Lutz, Alex Bekker, Yuan-Xiang Tao*. G9a participates in nerve injury-induced Kcna2 downregulation in primary sensory neurons. Scientific Reports. 2016; 6: 37704. IF: 4.259. 
  12. Lingli Liang#, Jian-Yuan Zhao, Xiyao Gu, Shaogen Wu, Kai Mo, Ming Xiong, Alex Bekker, Yuan-Xiang Tao*. G9a inhibits CREB-triggered expression of mu opioid receptor in primary sensory neurons following peripheral nerve injury. Molecular pain. 2016;12: 1744806916682242. IF: 3.070. 
  13. Jun Zhang#, Lingli Liang#, Xuerong Miao#, Shaogen Wu, Jing Cao, Bo Tao, Qingxiang Mao, Kai Mo, Brianna Marie Lutz, Alex Bekker, Yuan-Xiang Tao*. Contribution of the histone methyltransferase SUV39H1 in dorsal root ganglia and spinal cord dorsal horn to neuropathic pain. Anesthesiology. 2016; 125(4):765-78. IF: 5.66, Co-1st author.
  14. Jian-Yuan Zhao#, Lingli Liang#, Xiyao Gu#, Zhisong Li#, Shaogen Wu, Linlin Sun, Fidelis E. Atianjoh, Jian Feng, Kai Mo, Shushan Jia, Brianna Marie Lutz, Alex Bekker, Eric J. Nestler, Yuan-Xiang Tao*. DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nature Communications. 2017;8:14712. IF: 12.124. Co-1st author. 
  15. Linlin Sun#, Jian-Yuan Zhao#, Xiyao Gu#, Lingli Liang#, Shaogen Wu, Kai Mo, Jian Feng, Brianna Marie Lutz, Alex Bekker, Xinyu Zhao, Eric J Nestler, Yuan-Xiang Tao*. Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons. Pain. 2017 Jun;158(6):1153-1165. IF: 5.445. Co-1st author.
  16. Zhisong Li#, Yuanyuan Mao#, Lingli Liang#, Shaogen Wu, Jingjing Yuan, Kai Mo, Weihua Cai, Qingxiang Mao, Jing Cao, Alex Bekker, Wei Zhang, Yuanxiang Tao*. The transcription factor C/EBPβ in the dorsal root ganglion contributes to peripheral nerve trauma-induced nociceptive hypersensitivity. Science signaling. 2017;10(487). IF: 7.359. Co-1st author.
  17. Lingli Liang#, Brianna M. Lutz, Alex Bekker, Yuanxiang Tao*. Epigenetic regulation of chronic pain. Epigenomics. 2015;7(2):235-45. IF: 4.541. 
  18. Lian Cui#, Xuerong Miao#, Lingli Liang, Ishmail Abdus-Saboor, Michael S Fleming, William Olson, Minghong Ma, Yuan-Xiang Tao*, Wenqin Luo*. Identification of Early RET+ Deep Dorsal Spinal Cord Interneurons in Gating Pain. Neuron. 2016; 91(5): 1137–1153. IF: 15.054. 
  19. Lingli Liang#, Jiale Yang, Ning Lü, Xiyao Gu, Yuqiu Zhang, Zhiqi Zhao*. Synergetic analgesia of propentofylline and electroacupuncture by interrupting spinal glial function in rats. Neurochemical Research. 2010, 35(11):1780-6. IF: 2.593. 
  20. Lingli Liang#, Zhiyong Wang, Ning Lu, Jiale Yang, Yuqiu Zhang, Zhiqi Zhao*. Involvement of nerve injury and activation of peripheral glial cells in tetanic sciatic stimulation-induced persistent pain in rats. The Journal of Neuroscience Research. 2010; 88(13):2899-910. IF: 2.594. 
  21. Lingli Liang#, Longchang Fan, Bo Tao, Myron Yaster, Yuan-Xiang Tao*. Protein kinase B/Akt is required for complete Freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons. The Journal of Pain. 2013 Jun;14(6):638-47.
  22. Lingli Liang#, Bo Tao, Longchang Fan, Myron Yaster, Yi Zhang, Yuan-Xiang Tao*. mTOR and its downstream pathway are activated in the dorsal root ganglion and spinal cord after peripheral inflammation, but not after nerve injury. Brain Research. 2013 Jun 4;1513:17-25. IF: 2.746. 
  23. Ji-Tian Xu#, Xiuli Zhao#, Davinna Ligons#, Vinod Tiwari#, Fidelis E. Atianjoh#, Chun-Yi Lee, Jian-Yuan Zhao, Lingli Liang, Weidong Zang, Dolores Njoku, Srinivasa N. Raja, Myron Yaster, Yuan-Xiang Tao*. Morphine tolerance and hyperalgesia mediated through mu opioid receptor-triggered activation of the mammalian target of rapamycin complex 1 pathway in dorsal horn neurons. The Journal of Clinical Investigation. 2014 Feb;124(2):592-603. IF: 12.575. 
  24. Xiuli Zhao#, Zongxiang Tang#, Hongkang Zhang#, Fidelis E. Atianjoh#, Jianyuan Zhao#, Lingli Liang, Wei Wang, Xiaowei Guan, Sheng-Chin Kao, Vinod Tiwari, Yong-Jing Gao, Paul N. Hoffman, Hengmi Cui, Min Li, Xinzhong Dong, Yuan-Xiang Tao*. A native long noncoding RNA contributes to neuropathic pain by specifically silencing Kv1.2 in primary afferent neurons. Nature Neuroscience. 2013 Aug;16(8):1024-31. IF: 17.839.