Research Fields

 复杂性疾病易感基因的定位与克隆；

 慢性炎症性疾病的分子发病机理；

 动物模型的构建和评价。

Customization(Multiple times)

 国家自然科学基金重点项目2项、国家自然科学基金项目6项

PNEC-ILC2细胞单元的代谢重编程介导支气管哮喘的机制研究；

关节免疫炎症时特异SLC38A调节巨噬细胞活化的分子机制；

围孕期微营养素干预对先天性心脏病发生的一级预防作用及其机制；（重点项目）

肺固有细胞中组蛋白修饰酶对哮喘气道重塑的作用机制研究；

蛋白质精氨酸甲基转移酶在哮喘中的作用机制研究；

PIA 模型大鼠Toll 样受体基因表达增高的分子机制研究；

大骨节病病因及发病机制研究；（重点项目）

用NOCIA大鼠模型筛选和鉴定类风湿关节炎的易感基因

 

 博士点基金项目1项、春晖计划项目2项、“留学回国人员科研启动基金”1项、陕西省国际科技合作重点项目1项

降植烷诱导自噬参与免疫调节的分子机制研究；

先天性免疫细胞和分子及其在炎症中作用的分子机理；

Annexin I对NOCIA大鼠的影响及其影响机制的研究；

用大鼠模型鉴定类风湿关节炎的易感基因

以慢性免疫性疾病为对象，开展“疾病－基因－药物”的研究

Customization(Multiple times)

①创建了支气管哮喘的动物模型—AIPI，检测了肺脏和脾脏的PRMTs 表达谱，确定了PRMT1是调控AIPI 发生发展的一种关键表观遗传修饰酶，IL-4可通过诱导PRMT1 表达升高及其下游趋化因子的表达和分泌参与AIPI的发病机制；

 

②通过对降植烷诱导的关节炎（PIA）的TLR筛选，及进一步的TLR 配体刺激、RNAi 等动物实验及细胞实验确定巨噬细胞和滑膜成纤维细胞中高表达的TLR3对PIA 发生发展具有重要调控作用，其表达可受到 miRNA26a的负调控；

 

③通过近交系E3大鼠构建了高脂饮食诱导的胰岛素抵抗（HFD-IR）模型，发现其肝脏中HDAC3表达显著上调，上调的HDAC3可与sumo 化的C/EBPα结合负性调控LXRα表达；发现了一条新lnc-RNA，命名为lnc-HC，参与胆固醇的代谢；

 

④通过Solexa 方法获得大鼠骨软骨发育microRNA 表达谱，发现23种miRNA 显著高调，6 种miRNA 显著低调，及86 个新miRNA 的基因座位、序列和表达谱；进一步研究显示miR-337通过靶基因TGFBR2 作用于TGF-β 通路，从而参与调节软骨的生成及发育。

Customization(Multiple times)

  1. Xu J, Jiang C, Cai Y, Guo Y, Wang X, Zhang J, Xu J, Xu K, Zhu W, Wang S, Zhang F, Geng M, Han Y, Ning Q, Xu P, Meng L, Lu S. Intervening upregulated. SLC7A5 could mitigate inflammatory mediator by mTOR-P70S6K signal in rheumatoid arthritis synoviocytes. Arthritis Res Ther. 2020 Aug 31;22(1):200. doi: 10.1186/s13075-020-02296-8. PMID: 32867828.
  2. Geng M, Xu K, Meng L, Xu J, Jiang C, Guo Y, Ren X, Li X, Peng Y, Wang S, Huang F, Zhang J, Wang X, Zhu W, Lu S. Up-regulated DERL3 in fibroblast-like synoviocytes exacerbates inflammation of rheumatoid arthritis. Clin Immunol. 2020 Aug 28:108579. doi: 10.1016/j.clim.2020.108579. Epub ahead of print. PMID: 32866644.
  3. Wang B, Han D, Li F, Hou W, Wang L, Meng L, Mou K, Lu S, Zhu W, Zhou Y. Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax. Apoptosis. 2020 Jul 6. doi: 10.1007/s10495-020-01623-3. Epub ahead of print. PMID: 32632545.
  4. Xu J, Jiang C, Wang X, Geng M, Peng Y, Guo Y, Wang S, Li X, Tao P, Zhang F, Han Y, Ning Q, Zhu W, Meng L, Lu S. Upregulated PKM2 in Macrophages Exacerbates Experimental Arthritis via STAT1 Signaling. J Immunol. 2020 Jul 1;205(1):181-192. doi: 10.4049/jimmunol.1901021. Epub 2020 Jun 5. PMID: 32503893.
  5. Liang D, Osoro EK, Tan S, Lan X, Zhu W, Wu L, Du X, Li D, Lu S. Effects and Mechanisms of Autophagy Induced by Solubilized-Cholesterol in Hepatocytes: A Comparative Study Among Solvents. Cell Biochem Biophys. 2020 Sep;78(3):357-366. doi: 10.1007/s12013-020-00917-2. Epub 2020 May 21. PMID: 32441028.
  6. Lan X, Wu N, Wu L, Qu K, Osoro EK, Guan D, Du X, Wang B, Chen S, Miao J, Ren J, Liu L, Li H, Ning Q, Li D, Lu S. The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p. Mol Ther Nucleic Acids. 2020 Jun 5;20:468-479. doi: 10.1016/j.omtn.2020.03.008. Epub 2020 Mar 20. PMID: 32278306; PMCID: PMC7150434.
  7. Wu L, Sun J, Liu L, Du X, Liu Y, Yan X, Kombo Osoro E, Zhang F, Feng L, Liang D, Li Y, Chen Q, Sun S, Zhang L, Lan X, Li D, Lu S. Anti-toll-like receptor 2 antibody ameliorates hepatic injury, inflammation, fibrosis and steatosis in obesity-related metabolic disorder rats via regulating MAPK and NF-κB pathways. Int Immunopharmacol. 2020 Mar 6;82:106368. doi: 10.1016/j.intimp.2020.106368. Epub ahead of print. PMID: 32151955.
  8. Li X, Geng M, Peng Y, Meng L, Lu S. Molecular immune pathogenesis and diagnosis of COVID-19. J Pharm Anal. 2020 Apr;10(2):102-108. doi: 10.1016/j.jpha.2020.03.001. Epub 2020 Mar 5. PMID: 32282863; PMCID: PMC7104082.
  9. Gao D, Hu S, Zheng X, Lin W, Gao J, Chang K, Zhao D, Wang X, Zhou J, Lu S, Griffiths HR, Liu J. SOD3 Is Secreted by Adipocytes and Mitigates High-Fat Diet- Induced Obesity, Inflammation, and Insulin Resistance. Antioxid Redox Signal. 2020 Jan 20;32(3):193-212. doi: 10.1089/ars.2018.7628. PMID: 31680537.
  10. Liang D, Wang HY, Fan S, Wang J, Shen Y, Gao CY, Wu ML, Lu SM, Zhang SQ, Han W. W941, a new PI3K inhibitor, exhibits preferable anti-proliferative activities against nonsmall cell lung cancer with autophagy inhibitors. Invest New Drugs. 2019 Dec 10. doi: 10.1007/s10637-019-00886-1. Epub ahead of print. PMID: 31823159.
  11. Wu X, Cai Y, Lu S, Xu K, Shi X, Yang L, Huang Z, Xu P. Intra-articular Injection of Chloramphenicol Reduces Articular Cartilage Degeneration in a Rabbit Model of Osteoarthritis. Clin Orthop Relat Res. 2019 Dec;477(12):2785-2797. doi: 10.1097/CORR.0000000000001016. PMID: 31764352; PMCID: PMC6907289.
  12. Sun Q, Fang L, Roth M, Tang X, Papakonstantinou E, Zhai W, Louis R, Heinen V, Schleich FN, Lu S, Savic S, Tamm M, Stolz D. Bronchial thermoplasty decreases airway remodelling by blocking epithelium-derived heat shock protein-60 secretion and protein arginine methyltransferase-1 in fibroblasts. Eur Respir J. 2019 Dec 4;54(6):1900300. doi: 10.1183/13993003.00300-2019. PMID: 31467116.
  13. Huang F, Guo Y, Wang L, Jing L, Chen Z, Lu S, Fu R, Tian L. High glucose and TGF-β1 reduce expression of endoplasmic reticulum-resident selenoprotein S and selenoprotein N in human mesangial cells. Ren Fail. 2019 Nov;41(1):762-769. doi: 10.1080/0886022X.2019.1641413. PMID: 31880214; PMCID: PMC6735353.
  14. Lan X, Wu L, Wu N, Chen Q, Li Y, Du X, Wei C, Feng L, Li Y, Osoro EK, Sun M, Ning Q, Yan X, Yang X, Li D, Lu S. Long Noncoding RNA lnc-HC Regulates PPARγ- Mediated Hepatic Lipid Metabolism through miR-130b-3p. Mol Ther Nucleic Acids. 2019 Dec 6;18:954-965. doi: 10.1016/j.omtn.2019.10.018. Epub 2019 Oct 25. PMID: 31770672; PMCID: PMC6881655.
  15. Hei YY, Guo YX, Jiang CS, Wang S, Lu SM, Zhang SQ. The dual luciferase reporter system and RT-qPCR strategies for screening of MicroRNA-21 small- molecule inhibitors. Biotechnol Appl Biochem. 2019 Sep;66(5):755-762. doi: 10.1002/bab.1756. Epub 2019 Aug 7. PMID: 31021480.
  16. Wang S, Zhu W, Xu J, Guo Y, Yan J, Meng L, Jiang C, Lu S. Interpreting the MicroRNA-15/107 family: interaction identification by combining network based and experiment supported approach. BMC Med Genet. 2019 May 31;20(1):96. doi: 10.1186/s12881-019-0824-9. PMID: 31151434; PMCID: PMC6544937.
  17. Jiang C, Xu J, Zhu W, Cai Y, Wang S, Guo Y, Xu K, Geng M, Hussain N, Han Y, Zhang F, Ning Q, Meng L, Lu S. Abnormal Expression of DICER1 Leads to Dysregulation of Inflammatory Effectors in Human Synoviocytes. Mediators Inflamm. 2019 May 28;2019:6768504. doi: 10.1155/2019/6768504. PMID: 31275058; PMCID: PMC6558604.
  18. Jiang C, Guo Y, Yu H, Lu S, Meng L. Pleiotropic microRNA-21 in pulmonary remodeling: novel insights for molecular mechanism and present advancements. Allergy Asthma Clin Immunol. 2019 May 20;15:33. doi: 10.1186/s13223-019-0345-2. PMID: 31139230; PMCID: PMC6528201.
  19. Jin A, Bao R, Roth M, Liu L, Yang X, Tang X, Yang X, Sun Q, Lu S. microRNA-23a contributes to asthma by targeting BCL2 in airway epithelial cells and CXCL12 in fibroblasts. J Cell Physiol. 2019 Nov;234(11):21153-21165. doi: 10.1002/jcp.28718. Epub 2019 Apr 24. PMID: 31020662.
  20. Zhang J, Yang S, Xu B, Wang T, Zheng Y, Liu F, Ren F, Jiang J, Shi H, Zou B, Lu X, Lu S, Dong L. p62 functions as an oncogene in colorectal cancer through inhibiting apoptosis and promoting cell proliferation by interacting with the vitamin D receptor. Cell Prolif. 2019 May;52(3):e12585. doi: 10.1111/cpr.12585. Epub 2019 Feb 22. PMID: 30793399; PMCID: PMC6536406.
  21. Sun, M., et al., Maintenance of SOX9 stability and ECM homeostasis by selenium-sensitive PRMT5 in cartilage. Osteoarthritis Cartilage, 2019.
  22. Sun, Q., et al., TGF-beta Upregulated Mitochondria Mass through the SMAD2/3-->C/EBPbeta-->PRMT1 Signal Pathway in Primary Human Lung Fibroblasts. J Immunol, 2019. 202(1): p. 37-47.
  23. Zhang, J., et al., p62 functions as an oncogene in colorectal cancer through inhibiting apoptosis and promoting cell proliferation by interacting with the vitamin D receptor. Cell Prolif, 2019: p. e12585.
  24. Yao, Y., et al., Rosmarinic acid inhibits nicotine-induced C-reactive protein generation by inhibiting NLRP3 inflammasome activation in smooth muscle cells. J Cell Physiol, 2019. 234(2): p. 1758-1767.
  25. Wang, X., et al., Proinflammatory macrophages impair skeletal muscle differentiation in obesity through secretion of tumor necrosis factor-alpha via sustained activation of p38 mitogen-activated protein kinase. J Cell Physiol, 2019. 234(3): p. 2566-2580.
  26. Sun, J., et al., T-2 Toxin Induces Epiphyseal Plate Lesions via Decreased SECISBP2-Mediated Selenoprotein Expression in DA Rats, Exacerbated by Selenium Deficiency. Cartilage, 2018: p. 1947603518809406.
  27. Zhu, J., et al., Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagydependent pathway in human synovial sarcoma cells. Oncol Rep, 2018. 40(4): p. 1927-1936.
  28. Zhang, R., et al., miR-497 Is Implicated in the Process of Chondrogenesis and Inhibits IHH Gene Expression in Human Chondrocytes. Cartilage, 2018: p. 1947603518796126.
  29. Min, Z., et al., Selenium-sensitive miRNA-181a-5p targeting SBP2 regulates selenoproteins expression in cartilage. J Cell Mol Med, 2018. 22(12): p. 5888-5898.
  30. Jiang, C., et al., Signaling network between the dysregulated expression of microRNAs and mRNAs in propofol-induced developmental neurotoxicity in mice. Sci Rep, 2018. 8(1): p. 14172.
  31. Hussain, S., et al., Down-regulated in OA cartilage, SFMBT2 contributes to NF-kappaB-mediated ECM degradation. J Cell Mol Med, 2018. 22(11): p. 5753-5758.
  32. Hussain, S., et al., SFMBT2 positively regulates SOX9 and chondrocyte proliferation. Int J Mol Med, 2018. 42(6): p. 3503-3512.
  33. Guo, Y., et al., Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis. Cell Death Dis, 2018. 9(6): p. 699.
  34. Yang, L., et al., Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in vitro. Molecular Medicine Reports, 2018. 17(5): p. 6560-6568.
  35. Yao, Y., et al., Tumor necrosis factor-alpha and diabetic retinopathy: Review and meta-analysis. Clin Chim Acta, 2018. 485: p. 210-217.
  36. Hussain, N., et al., Down-regulation of miR-10a-5p in synoviocytes contributes to TBX5-controlled joint inflammation. Journal Of Cellular And Molecular Medicine, 2018. 22(1): p. 241-250.
  37. Hussain, N., et al., Down-regulation of miR-10a-5p promotes proliferation and restricts apoptosis via targeting T-box transcription factor 5 in inflamed synoviocytes. Bioscience Reports, 2018. 38.
  38. Wang, X., et al., Bioinformatics analysis of genetic variants of endoplasmic reticulum aminopeptidase 1 in ankylosing spondylitis. Mol Med Rep, 2017. 16(5): p. 6532-6543.
  39. Cui, H., et al., Preparation of monoclonal antibody against human KIAA0100 protein and Northern blot analysis of human KIAA0100 gene. Journal Of Pharmaceutical Analysis, 2017. 7(3): p. 190-195.
  40. Cui, H., et al., Bioinformatic prediction and functional characterization of human KIAA0100 gene. Journal Of Pharmaceutical Analysis, 2017. 7(1): p. 10-18.
  41. Wang, B., et al., Increased expression of Th17 cytokines and interleukin-22 correlates with disease activity in pristane-induced arthritis in rats. Plos One, 2017. 12(11).
  42. Wang, K., et al., A microfluidic immunoassay system on a centrifugal platform. Sensors And Actuators B-Chemical, 2017. 251: p. 242-249.
  43. Li, Y., et al., Identification and application of anti-inflammatory compounds screening system based on RAW264.7 cells stably expressing NF-kappa B-dependent SEAP reporter gene. Bmc Pharmacology & Toxicology, 2017. 18.
  44. Xu, J., et al., Construction of Conveniently Screening pLKO.1-TRC Vector Tagged with TurboGFP. Applied Biochemistry And Biotechnology, 2017. 181(2): p. 699-709.
  45. Yan, J.D., et al., GPx1 knockdown suppresses chondrogenic differentiation of ATDC5 cells through induction of reductive stress. Acta Biochimica Et Biophysica Sinica, 2017. 49(2): p. 110-118.
  46. Zhu, W.H., et al., Pristane induces autophagy in macrophages, promoting a STAT1-IRF1-TLR3 pathway and arthritis. Clinical Immunology, 2017. 175: p. 56-68.
  47. Hou, W.K., et al., IL-22 expression is increased variedly in the initial phase, onset and chronic phase of a pristane-induced arthritis rat model. Molecular Medicine Reports, 2017. 16(2): p. 1109-1116.
  48. Sun, Q.Z., et al., Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling. Journal Of Allergy And Clinical Immunology, 2017. 140(2): p. 510-+.
  49. Jiang, C.S., et al., Neutrophil-Lymphocyte Ratio in Children with Recurrent Wheezing. Pediatric Allergy Immunology And Pulmonology, 2017. 30(4): p. 227-231.
  50. Zhang, Z., et al., A simple rhodamine hydrazide-based turn-on fluorescent probe for HOCl detection. Luminescence, 2016. 31(4): p. 997-1004.
  51. Klionsky, D.J., et al., Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 2016. 12(1): p. 1-222.
  52. Li, Y.-b., et al., Methotrexate affects HMGB1 expression in rheumatoid arthritis, and the downregulation of HMGB1 prevents rheumatoid arthritis progression. Molecular And Cellular Biochemistry, 2016. 420(1-2): p. 161-170.
  53. Tuncel, J., et al., Animal Models of Rheumatoid Arthritis (I): Pristane-Induced Arthritis in the Rat. Plos One, 2016. 11(5).
  54. Wei, L., et al., Activation of alpha 1 adrenoceptors in ventrolateral orbital cortex attenuates allodynia induced by spared nerve injury in rats. Neurochemistry International, 2016. 99: p. 85-93.
  55. Yan, J., et al., TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species. Experimental Cell Research, 2016. 344(1): p. 67-75.
  56. Zheng, F., et al., Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies. Scientific Reports, 2016. 6.
  57. Jiang, C.S., et al., A simplified and optimal RT-qPCR strategy for extracellular miRNA profiling. International Journal Of Clinical And Experimental Medicine, 2016. 9(2): p. 2112-2120.
  58. Liu, L., et al., Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation. Scientific Reports, 2016. 6.
  59. Sun, Q.Z., et al., PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts. Cellular Signalling, 2016. 28(4): p. 307-315.
  60. Jiang, C.S., et al., Extracellular microRNA-21 and microRNA-26a increase in body fluids from rats with antigen induced pulmonary inflammation and children with recurrent wheezing. Bmc Pulmonary Medicine, 2016. 16.
  61. Yan, J.D., et al., TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species. Experimental Cell Research, 2016. 344(1): p. 67-75.
  62. Lan, X., et al., A Novel Long Noncoding RNA Lnc-HC Binds hnRNPA2B1 to Regulate Expressions of Cyp7a1 and Abca1 in Hepatocytic Cholesterol Metabolism. Hepatology, 2016. 64(1): p. 58-72.
  63. Yan, J.D., et al., Selenoprotein O deficiencies suppress chondrogenic differentiation of ATDC5 cells. Cell Biology International, 2016. 40(10): p. 1033-1040.
  64. Zhang, Z., et al., A rhodamine hydrazide-based fluorescent probe for sensitive and selective detection of hypochlorous acid and its application in living cells. Analytical Methods, 2015. 7(1): p. 107-114.
  65. Jiang, C.-s., et al., Discovery of 4-benzoylamino-N-(prop-2-yn-1-yl)benzamides as novel microRNA-21 inhibitors. Bioorganic & Medicinal Chemistry, 2015. 23(19): p. 6510-6519.
  66. Wang, X., et al., Upregulation of miR-497 induces hepatic insulin resistance in E3 rats with HFD-MetS by targeting insulin receptor. Molecular And Cellular Endocrinology, 2015. 416(C): p. 57-69.
  67. Wang, X.-M., et al., Synthesis and antitumor activities evaluation of m-(4-morpholinoquinazolin-2-yl)benzamides in vitro and in vivo. European Journal Of Medicinal Chemistry, 2015. 96: p. 382-395.
  68. Wang, X.-M., et al., Design, synthesis and antiproliferative activity evaluation of m-(4-morpholinyl-1,3,5-triazin-2-yl)benzamides in vitro. Bioorganic & Medicinal Chemistry Letters, 2015. 25(8): p. 1730-1735.
  69. Xie, X.-X., et al., Synthesis and anticancer effects evaluation of 1-alkyl-3-(6-(2-methoxy-3-sulfonylaminopyridin-5-yl) benzo d thiazol-2-yl) urea as anticancer agents with low toxicity. Bioorganic & Medicinal Chemistry, 2015. 23(19): p. 6477-6485.
  70. Xu, J., et al., NOD2 pathway via RIPK2 and TBK1 is involved in the aberrant catabolism induced by T-2 toxin in chondrocytes. Osteoarthritis And Cartilage, 2015. 23(9): p. 1575-1585.
  71. Xu, K., et al., Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast-like synovial cells through high mobility group box chromosomal protein 1. Arthritis Research & Therapy, 2015. 17.
  72. Zhang, H., et al., Synthesis and antitumor activity evaluation of PI3K inhibitors containing 3-substituted quinazolin-4(3H)-one moiety. Bioorganic & Medicinal Chemistry, 2015. 23(24): p. 7765-7776.
  73. Zhang, R., et al., A comprehensive meta-analysis of association between genetic variants of GDF5 and osteoarthritis of the knee, hip and hand. Inflammation Research, 2015. 64(6): p. 405-414.
  74. Zhou, Y., et al., The elevated expression of Th17-related cytokines and receptors is associated with skin lesion severity in early systemic sclerosis. Human Immunology, 2015. 76(1): p. 22-29.
  75. Min, Z.X., et al., MicroRNAs associated with osteoarthritis differently expressed in bone matrix gelatin (BMG) rat model. International Journal Of Clinical And Experimental Medicine, 2015. 8(1): p. 1009-1017.
  76. Lan, X., et al., Identification of differentially expressed genes related to metabolic syndrome induced with high-fat diet in E3 rats. Experimental Biology And Medicine, 2015. 240(2): p. 235-241.
  77. Zhu, W.H., et al., Pristane primed rat T cells enhance TLR3 expression of fibroblast-like synoviocytes via TNF-alpha initiated p38 MAPK and NF-kappa B pathways. Clinical Immunology, 2015. 156(2): p. 141-153.
  78. Li, D., et al., Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats. Molecular And Cellular Endocrinology, 2015. 402(C): p. 1-12.
  79. Yang, W.Y., et al., MiR-223 targeting MAFB suppresses proliferation and migration of nasopharyngeal carcinoma cells. Bmc Cancer, 2015. 15.
  80. Sun, Q.Z., et al., PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation. Journal Of Immunology, 2015. 195(1): p. 298-306.
  81. Min, Z.X., et al., Abnormality of epiphyseal plate induced by selenium deficiency diet in two generation DA rats. Apmis, 2015. 123(8): p. 697-705.
  82. Huang, R., Y. Han, and S. Lu, Enhanced osteoblast functions and bactericidal effect of Ca and Ag dual-ion implanted surface layers on nanograined titanium alloys. Journal Of Materials Chemistry B, 2014. 2(28): p. 4531-4543.
  83. Li, H., et al., Combination of 2-methoxy-3-phenylsulfonylaminobenzamide and 2-aminobenzothiazole to discover novel anticancer agents. Bioorganic & Medicinal Chemistry, 2014. 22(14): p. 3739-3748.
  84. Zhou, J., Y. Han, and S. Lu, Direct role of interrod spacing in mediating cell adhesion on Sr-HA nanorod-patterned coatings. International Journal Of Nanomedicine, 2014. 9: p. 1243-1260.
  85. Jiang, C.S., et al., MicroRNA-26a negatively regulates toll-like receptor 3 expression of rat macrophages and ameliorates pristane induced arthritis in rats. Arthritis Research & Therapy, 2014. 16(1).
  86. Zhong, B., et al., Pdcd4 modulates markers of macrophage alternative activation and airway remodeling in antigen-induced pulmonary inflammation. Journal Of Leukocyte Biology, 2014. 96(6): p. 1065-1075.
  87. Han, Y., et al., Enhanced osteoblast functions of narrow interligand spaced Sr-HA nano-fibers/rods grown on microporous titania coatings. Rsc Advances, 2013. 3(28): p. 11169-11184.
  88. Huang, R., S. Lu, and Y. Han, Role of grain size in the regulation of osteoblast response to Ti-25Nb-3Mo-3Zr-2Sn alloy. Colloids And Surfaces B-Biointerfaces, 2013. 111: p. 232-241.
  89. Kang, B.-R., et al., Discovery of 2-aryl-8-hydroxy (or methoxy)-isoquinolin-1(2H)-ones as novel EGFR inhibitor by scaffold hopping. Bioorganic & Medicinal Chemistry, 2013. 21(22): p. 6956-6964.
  90. Wang, X.-M., et al., Synthesis and anticancer activity evaluation of a series of 1,2,4 triazolo 1,5-a pyridinylpyridines in vitro and in vivo. European Journal Of Medicinal Chemistry, 2013. 67: p. 243-251.
  91. Wu, D.-L., et al., Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B. Human Immunology, 2013. 74(5): p. 514-521.
  92. Xie, M., et al., Levels of HTNV-specific CD8(+) T lymphocytes in PBMC from the patients with hemorrhagic fever with renal syndrome. Internal And Emergency Medicine, 2013. 8(6): p. 503-508.
  93. Xu, K., et al., Reduced apoptosis correlates with enhanced autophagy in synovial tissues of rheumatoid arthritis. Inflammation Research, 2013. 62(2): p. 229-237.
  94. Zhou, J., et al., Regulation of Osteoblast Proliferation and Differentiation by Interrod Spacing of Sr-HA Nanorods on Microporous Titania Coatings. Acs Applied Materials & Interfaces, 2013. 5(11): p. 5358-5365.
  95. Yan, J.D., et al., Selenium effect on selenoprotein transcriptome in chondrocytes. Biometals, 2013. 26(2): p. 285-296.
  96. Ren, J., et al., HDAC3 interacts with sumoylated C/EBP alpha to negatively regulate the LXR alpha expression in rat hepatocytes. Molecular And Cellular Endocrinology, 2013. 374(1-2): p. 35-45.
  97. Jiang, X.G., et al., Transcription factor AP1 binds the functional region of the promoter and regulates gene expression of human PPARdelta in LoVo cell. Tumor Biology, 2013. 34(6): p. 3619-3625.
  98. Tuncel, J., et al., Class II major histocompatibility complex-associated response to type XI collagen regulates the development of chronic arthritis in rats. Arthritis And Rheumatism, 2012. 64(8): p. 2537-2547.
  99. Wu, D.-L., et al., Age versus clinical virological characteristics in chronic hepatitis B virus infection: a case series study in China. European Journal Of Gastroenterology & Hepatology, 2012. 24(4): p. 406-413.
  100. Zhang, G., et al., The Effects of Rosiglitazone on Fatty Liver of High Fat and Cholesterol-Fed Rabbits. Journal Of Animal And Veterinary Advances, 2012. 11(14): p. 2564-2569.
  101. Zhang, R., et al., Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706. Schizophrenia Research, 2012. 141(1): p. 40-47.
  102. Zhong, N., et al., MicroRNA-337 is associated with chondrogenesis through regulating TGFBR2 expression. Osteoarthritis And Cartilage, 2012. 20(6): p. 593-602.
  103. Zhu, W., et al., Induction of toll-like receptor 2 positive antigen-presenting cells in spleen of pristane-induced arthritis in rats. Molecular Biology Reports, 2012. 39(4): p. 3667-3673.
  104. Zhu, W., et al., Overexpression of Toll-Like Receptor 3 in Spleen is Associated with Experimental Arthritis in Rats. Scandinavian Journal Of Immunology, 2012. 76(3): p. 263-270.
  105. Zuo, M., et al., Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC-EGFR dual inhibitors. Bioorganic & Medicinal Chemistry, 2012. 20(14): p. 4405-4412.
  106. Zhang, R., et al., Genetic Evidence for the Association between the Early Growth Response 3 (EGR3) Gene and Schizophrenia. Plos One, 2012. 7(1).
  107. Sun, Q.Z., et al., Upregulated Protein Arginine Methyltransferase 1 by IL-4 Increases Eotaxin-1 Expression in Airway Epithelial Cells and Participates in Antigen-Induced Pulmonary Inflammation in Rats. Journal Of Immunology, 2012. 188(7): p. 3506-3512.
  108. Lei, L., et al., Mitogen-Activated Protein Kinase Pathways are Involved in the Upregulation of Calcitonin Gene-Related Peptide of Rat Trigeminal Ganglion After Organ Culture. Journal Of Molecular Neuroscience, 2012. 48(1): p. 53-65.
  109. Tian, J., et al., T-2 toxin enhances catabolic activity of hypertrophic chondrocytes through ROS-NF-kappa B-HIF-2 alpha pathway. Toxicology In Vitro, 2012. 26(7): p. 1106-1113.
  110. Yan, J.D., et al., Selenium promotes proliferation of chondrogenic cell ATDC5 by increment of intracellular ATP content under serum deprivation. Cell Biochemistry And Function, 2012. 30(8): p. 657-663.
  111. Zhang, R., et al., Population-based and family-based association studies of ZNF804A locus and schizophrenia. Molecular Psychiatry, 2011. 16(4): p. 360-361.
  112. Cai, Y., et al., Infliximab alleviates inflammation and ex vivo airway hyperreactivity in asthmatic E3 rats. International Immunology, 2011. 23(7): p. 443-451.
  113. Hou, W.-k., et al., Methotrexate ameliorates pristane-induced arthritis by decreasing IFN-gamma and IL-17A expressions. Journal Of Zhejiang University-Science B, 2011. 12(1): p. 40-46.
  114. Liu, S.-z., et al., Analysis of correlation between blood biochemical indicators and bone mineral density of post-menopausal women. Molecular Biology Reports, 2011. 38(2): p. 939-948.
  115. Sun, J., et al., MicroRNAs of rat articular cartilage at different developmental stages identified by Solexa sequencing. Osteoarthritis And Cartilage, 2011. 19(10): p. 1237-1245.
  116. Xie, M., et al., Expression of VLA-4 molecule in PBMC from patients with hemorrhagic fever with renal syndrome. Inflammation Research, 2011. 60(7): p. 613-617.
  117. Zhang, R., et al., Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis. Schizophrenia Research, 2011. 133(1-3): p. 159-164.
  118. Zhao, S., et al., Interferon plus Chinese herbs are associated with higher sustained virological response than interferon alone in chronic Hepatitis C: A meta-analysis of randomised trials. Antiviral Research, 2011. 89(2): p. 156-164.
  119. Zhong, N., et al., A novel replicated association between FXYD6 gene and schizophrenia. Biochemical And Biophysical Research Communications, 2011. 405(1): p. 118-121.
  120. Zhu, W.H., et al., Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts. Arthritis Research & Therapy, 2011. 13(3).
  121. Meng, L.S., et al., TLR3 and TLR7 Modulate IgE Production in Antigen Induced Pulmonary Inflammation via Influencing IL-4 Expression in Immune Organs. Plos One, 2011. 6(2).
  122. Sun, Q.Z., et al., Different challenge terms determine disease patterns of antigen-induced pulmonary inflammation in E3 rats. Apmis, 2011. 119(4-5): p. 229-238.
  123. Li, D.M., et al., High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-gamma and LXR-alpha-pathways in E3 rats. Molecular And Cellular Endocrinology, 2011. 344(1-2): p. 69-80.
  124. Tian, L.F., et al., Autoimmune and inflammatory responses in Kashin-Beck disease compared with rheumatoid arthritis and osteoarthritis. Human Immunology, 2011. 72(10): p. 812-816.
  125. Sun, J., Q.Z. Sun, and S.M. Lu, From selenoprotein to endochondral ossification: A novel mechanism with microRNAs potential in bone related diseases? Medical Hypotheses, 2011. 77(5): p. 807-811.
  126. Wang, W., et al., Down-regulated HS6ST2 in osteoarthritis and Kashin-Beck disease inhibits cell viability and influences expression of the genes relevant to aggrecan metabolism of human chondrocytes. Rheumatology, 2011. 50(12): p. 2176-2186.
  127. Guo, Y., et al., The major histocompatibility complex genes are associated with basal pain sensitivity differences between Dark-Agouti and novel congenic DA.1U rats. Life Sciences, 2010. 86(25-26): p. 972-978.
  128. Yu, H.-b., et al., Treatment with peginterferon versus interferon in Chinese patients with hepatitis B. Biomedicine & Pharmacotherapy, 2010. 64(8): p. 559-564.
  129. Zhang, R., et al., Is the EFNB2 locus associated with schizophrenia? Single nucleotide polymorphisms and haplotypes analysis. Psychiatry Research, 2010. 180(1): p. 5-9.
  130. Zhao, S., et al., A Comparison of Peginterferon alpha-2a and alpha-2b for Treatment-Naive Patients With Chronic Hepatitis C Virus: A Meta-Analysis of Randomized Trials. Clinical Therapeutics, 2010. 32(9): p. 1565-1577.
  131. Meng, L.S., et al., Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats. Arthritis Research & Therapy, 2010. 12(3).
  132. Yang, X.D., et al., Nitric Oxide in Both Bronchoalveolar Lavage Fluid and Serum Is Associated With Pathogenesis and Severity of Antigen-Induced Pulmonary Inflammation in Rats. Journal Of Asthma, 2010. 47(2): p. 135-144.
  133. Hou, W., et al., A systematic comparison between collagen-induced arthritis and pristane-induced arthritis in Dark Agouti rats. Clinical And Experimental Rheumatology, 2010. 28(4): p. 532-538.
  134. Yang, W.Y., et al., Up-regulation of Tiam1 and Rac1 Correlates with Poor Prognosis in Hepatocellular Carcinoma. Japanese Journal Of Clinical Oncology, 2010. 40(11): p. 1053-1059.
  135. Long, J.-w., et al., Alteration of airway responsiveness mediated by receptors in ovalbumin-induced asthmatic E3 rats. Acta Pharmacologica Sinica, 2009. 30(7): p. 965-972.
  136. Shahzad, M., et al., Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats. Pulmonary Pharmacology & Therapeutics, 2009. 22(1): p. 37-43.
  137. Liu, S.Z., et al., Relationships between endothelial nitric oxide synthase gene polymorphisms and osteoporosis in postmenopausal women. Journal Of Zhejiang University-Science B, 2009. 10(8): p. 609-618.
  138. Li, D.M., et al., A Modified Method using TRIzol(A (R)) Reagent and Liquid Nitrogen Produces High-Quality RNA from Rat Pancreas. Applied Biochemistry And Biotechnology, 2009. 158(2): p. 253-261.
  139. Jiang, C.S., et al., Housekeeping gene stability in pristane-induced arthritis and antigen-induced pulmonary inflammation of rats. Inflammation Research, 2009. 58(9): p. 601-609.
  140. Liu, S.Z., et al., Correlation Analysis Between Bone Mineral Density and Serum Element Contents of Postmenopausal Women in Xi'an Urban Area. Biological Trace Element Research, 2009. 131(3): p. 205-214.
  141. Yao, F., et al., Mechanical hyperalgesia is attenuated by local administration of octreotide in pristane-induced arthritis in Dark-Agouti rats. Life Sciences, 2008. 83(21-22): p. 732-738.
  142. Holmberg, J., et al., Pristane, a non-antigenic adjuvant, induces MHC class II-restricted, arthritogenic T cells in the rat. Journal Of Immunology, 2006. 176(2): p. 1172-1179.
  143. Dzhambazov, B., et al., The major T cell epitope on type II collagen is glycosylated in normal cartilage but modified by arthritis in both rats and humans. European Journal Of Immunology, 2005. 35(2): p. 357-366.
  144. Olofsson, P., et al., Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1. Genomics, 2004. 83(5): p. 765-771.
  145. Olofsson, P., et al., Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nature Genetics, 2003. 33(1): p. 25-32.
  146. Olofsson, P., et al., A comparative genetic analysis between collagen-induced arthritis and pristane-induced arthritis. Arthritis And Rheumatism, 2003. 48(8): p. 2332-2342.
  147. Hansson, A.S., S. Lu, and R. Holmdahl, Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models. Clinical And Experimental Immunology, 2002. 127(1): p. 37-42.
  148. Lu, S.M., et al., Immunization of rats with homologous type XI collagen leads to chronic and relapsing arthritis with different genetics and joint pathology than arthritis induced with homologous type II collagen. Journal Of Autoimmunity, 2002. 18(3): p. 199-211.
  149. Lu, S.M., et al., Both common and unique susceptibility genes in different rat strains with pristane-induced arthritis. European Journal Of Human Genetics, 2002. 10(8): p. 475-483.
  150. Holmdahl, R., et al., Arthritis induced in rats with non-immunogenic adjuvants as models for rheumatoid arthritis. Immunological Reviews, 2001. 184: p. 184-202.
  151. Lu, S.M. and R. Holmdahl, Different therapeutic and bystander effects by intranasal administration of homologous type II and type IX collagens on the collagen-induced arthritis and pristane-induced arthritis in rats. Clinical Immunology, 1999. 90(1): p. 119-127.
  152. Bai, X.W., S. Lu, and C. Bai, Advances in the study of cartilaginous type X collagen. Progress In Biochemistry And Biophysics, 1995. 22(6): p. 521-525.