(1.)Basic Information

            

                  Zhengda Pang 

Dr. Zhengda Pang is the associate professor in department of Physiology and Pathophysiology, Basic Medicine School, Xi’an Jiaotong University. In 2017, Dr. Pang was awarded the National Postdoctoral Program for International Exchange project. Dr. Pang has hosted the National Natural Science Foundation of China youth Project, China Postdoctoral Science Foundation project, Shaanxi Natural Science Foundation project, etc., In recent years, as the first author he has published original papers in high-impact journals such as PNAS, FASEB J, etc., The research direction is cardiovascular pathophysiology, and the main research direction is the role and mechanism of calcium-activated potassium channel in the regulation of diabetes mellitus and vascular endothelial function.

Contact Information

E-mail: pangzd@mail.xjtu.edu.cn

陕西省西安市西咸新区西交大创新港21号4136

Work Experience

  1. Pang ZD, Sun X, Bai RY, Han MZ, Zhang YJ, Wu W, Zhang Y, Lai BC, Zhang Y, Wang Y, Du XJ, Deng XL. YAP-galectin-3 signaling mediates endothelial dysfunction in angiotensin II-induced hypertension in mice. Cell Mol Life Sci. 2023 Jan 11;80(2):38.
  2. ​​​​​​​Wu W, Ziemann M, Huynh K, She G, Pang ZD, Zhang Y, Duong T, Kiriazis H, Pu TT, Bai RY, Li JJ, Zhang Y, Chen MX, Sadoshima J, Deng XL, Meikle PJ, Du XJ. Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice. Theranostics. 2021 Aug 21;11(18):8993-9008.
  3. Pang ZD, Wang Y, Song Z, She G, Ma XZ, Sun X, Wu W, Lai BC, Zhang J, Zhang Y, Du XJ, Shyy JYJ, Deng XL. AMPK upregulates KCa2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice. Biochem Pharmacol. 2021 Jan;183:114337.  
  4. Zhang Y, Hou MC, Li JJ, Qi Y, Zhang Y, She G, Ren YJ, Wu W, Pang ZD, Xie W, Deng XL, Du XJ. Cardiac β-adrenergic receptor activation mediates distinct and cell type-dependent changes in the expression and distribution of connexin 43. J Cell Mol Med. 2020 Aug;24(15):8505-8517.
  5. Pang ZD, Wang Y, Wang XJ, She G, Ma XZ, Song Z, Zhao LM, Wang HF, Lai BC, Gou W, Du XJ, Deng XL. KCa3.1 channel mediates inflammatory signaling of pancreatic β cells and progression of type 2 diabetes mellitus. FASEB J. 2019 Dec;33(12):14760-14771.
  6. Wang Y, Wang XJ, Zhao LM, Pang ZD, She G, Song Z, Cheng X, Du XJ, Deng XL. Oxidative stress induced by palmitic acid modulates KCa2.3 channels in vascular endothelium. Exp Cell Res. 2019 Oct 15;383(2):111552.
  7. Ma XZ, Pang ZD, Wang JH, Song Z, Zhao LM, Du XJ, Deng XL. The role and mechanism of KCa3.1 channels in human monocyte migration induced by palmitic acid. Exp Cell Res. 2018 Aug 15;369(2):208-217.
  8. Pang Z, Kushiyama A, Sun J, Kikuchi T, Yamazaki H, Iwamoto Y, Koriyama H, Yoshida S, Shimamura M, Higuchi M, Kawano T, Takami Y, Rakugi H, Morishita R, Nakagami H. Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes. FASEB J. 2017 Sep;31(9):4053-4063.
  9. Pang Z, Higuchi M, Koriyama H, Yoshida S, Kurinami H, Shimamura M, Takami Y, Rakugi H, Morishita R, Nakagami H. Evaluating the potential of the GFAP-KLH immune-tolerizing vaccine for type 1 diabetes in mice. FEBS Lett. 2017 Jan;591(1):129-136.
  10. Nakagami H, Pang Z, Shimosato T, Moritani T, Kurinami H, Koriyama H, Tenma A, Shimamura M, Morishita R. The dipeptidyl peptidase-4 inhibitor teneligliptin improved endothelial dysfunction and insulin resistance in the SHR/NDmcr-cp rat model of metabolic syndrome. Hypertens Res. 2014 Jul;37(7):629-35.
  11. Shimamura M, Nakagami H, Osako MK, Kurinami H, Koriyama H, Zhengda P, Tomioka H, Tenma A, Wakayama K, Morishita R. OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8191-6.
  12. Pang Z, Nakagami H, Osako MK, Koriyama H, Nakagami F, Tomioka H, Shimamura M, Kurinami H, Takami Y, Morishita R, Rakugi H. Therapeutic vaccine against DPP4 improves glucose metabolism in mice. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1256-63.
  13. Kyutoku M, Nakagami H, Koriyama H, Tomioka H, Nakagami F, Shimamura M, Kurinami H, Zhengda P, Jo DH, Kim JH, Takakura N, Morishita R. Development of novel DNA vaccine for VEGF in murine cancer model. Sci Rep. 2013 Nov 29;3:3380.