1. Li Z, Yi CX, Katiraei S, Kooijman S, Zhou E, Chung CK, Gao Y, van den Heuvel JK, Meijer OC, Berbée JF, Heijink M, Giera M, Willems van Dijk K, Groen AK, Rensen PCN, Wang Y. Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit. Gut 2018 Jul; 67(7): 1269-1279 .
  • Highly cited paper according to Web of Science; top 1% of academic field.
  • Received a research highlight editorial: Fluitman KS, Wijdeveld M, Nieuwdorp M, IJzerman RG. Potential of butyrate to influence food intake in mice and men. Gut 2018 Jul; 67(7): 1203-1204.
  • Won the 2018 NASO (Netherlands Association for the Study of Obesity) Best Publication Prize.
 
  1. Zhou E, Li Z, Nakashima H, Liu C, Ying Z, Foks AC, Berbee JFP, van Dijk KW, Rensen PCN, Wang Y. Hepatic Scavenger Receptor Class B Type 1 Knockdown Reduces Atherosclerosis and Enhances the Antiatherosclerotic Effect of Brown Fat Activation in APOE*3-Leiden.CETP Mice. Arterioscler Thromb Vasc Biol 2021 Apr;41(4): 1474-1486.
 
  1. Zhou E, Li Z, Nakashima H, Choukoud A, Kooijman S, Berbee JFP, Rensen PCN, Wang Y. Beneficial effects of brown fat activation on top of PCSK9 inhibition with alirocumab on dyslipidemia and atherosclerosis development in APOE*3-Leiden.CETP mice. Pharmacol Res 2021 Mar 2;167: 105524.
 
  1. Zhou E, Hoeke G, Li Z, Eibergen AC, Schonk AW, Koehorst M, Boverhof R, Havinga R, Kuipers F, Coskun T, Boon MR, Groen AK, Rensen PCN, Berbée JFP, Wang Y. Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidemia and atherosclerosis development. Cardiovasc Res 2020 Aug 1;116(10): 1710-1720. 
 
  1. Van der Tuin S, Li Z, Berbée JF, Verkouter I, Ringnalda LE, Neele AE, van Klinken JB, Rensen SS, Fu J, de Winther MPJ, Groen AK, Rensen PCN, Willems van Dijk K, Wang Y.  Lipopolysaccharide lowers cholesteryl ester transfer protein by activating F4/80+Clec4f+Vsig4+Ly6C- Kupffer cell subsets. J Am Heart Assoc 2018 Mar;10: 7(6). 
 
  1. Van der Tuin SJ, Kühnast S, Berbée JF, Verschuren L, Pieterman EJ, Havekes LM, van der Hoorn JW, Rensen PC, Jukema JW, Princen HM, Willems van Dijk, Wang Y.  Anacetrapib reduces (V) LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9. J Lipid Res 2015 Nov; 56: 2085-2093. 
  • Received a research highlight commentary: Barter PJ, Tabet F, Rye KA. Reduction in PCSK9 levels induced by anacetrapib: an off-target effect? J Lipid Res 2015;56:2045-2047. 
 
  1. Wang Y, van der Tuin S, Tjeerdema N, van Dam AD, Rensen SS, Hendrikx T, Berbée JF, Atanasovska B, Fu J, Hoekstra M, Bekkering S, Riksen NP, Buurman WA, Greve JW, Hofker MH, Shiri-Sverdlov R, Meijer OC, Smit JW, Havekes LM, van Dijk KW, Rensen PC. Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells. Hepatology 2015 Dec; 62: 1710-1722. 
  • This article has been recommended by Faculty of 1000 Prime as being of special significance in its field.
  • Featured on cover and received a research highlight editorial: Haas JT, Staels B. Cholesteryl-ester transfer protein (CETP): A Kupffer cell marker linking hepatic inflammation with atherogenic dyslipidemia? Hepatology 2015; 62: 1659-1661.
 
  1. Herrera Moro Chao D*, Wang Y*, Foppen E, Ottenhoff R, van Roomen C, Parlevliet ET, van Eijk M, Verhoek M, Boot R, Marques AR, Scheij S, Mirzaian M, Kooijman S, Jansen K, Wang D, Mergen C, Seeley RJ, Tschöp MH, Overkleeft H, Rensen PCN, Kalsbeek A, Aerts JMFG, Yi CX.  . Diabetes 2019 Dec; 68(12): 2223-2234. [*Contributed equally] .
 
  1. Kooijman S*, Wang Y*, Parlevliet ET*, Boon MR, Edelschaap D, Snaterse G, Pijl H, Romijn JA, Rensen PC. Central GLP-1 receptor signalling accelerates plasma clearance of triacylglycerol and glucose by activating brown adipose tissue in mice. Diabetologia 2015 Nov; 58: 2637-2646 [*Contributed equally]. 
 
  1. Rozendaal YJW*, Wang Y*, Paalvast Y, Tambyrajah LL, Li Z, Willems van Dijk K, Rensen PCN, Kuivenhoven JA, Groen AK, Hilbers PAJ, van Riel NAW. In vivo and in silico dynamics of the development of Metabolic Syndrome. PLoS Comput Biol 2018 Jun; 14(6): e1006145. [*Contributed equally]. 
  • A press release by PLOS, entitled “New computational tool predicts progression of metabolic syndrome in mice”. AAAS and EurekAlert. Public release on 7-June-2018  
 
  1. Wang Y, Parlevliet ET, Geerling JJ, Tuin SJL, Zhang H, Bieghs V, Jawad AHM, Shiri-Sverdlov R, Bot I, de Jager SC, Havekes LM, Romijn JA, Willems van Dijk K, Rensen PC. Exendin-4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration. Br J Pharmacol 2014 Feb; 171: 723-734. 
 
  1. Wang Y, Snel M, Jonker JT, Hammer S, Lamb HJ, de Roos A, Meinders AE, Pijl H, Romijn JA, Smit JW, Jazet IM, Rensen PC. Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases plasma CETP and increases apolipoprotein AI levels without improving the cholesterol efflux properties of HDL. Diabetes Care 2011 Dec; 34: 2576-2580. 
 
  1. Wang Y, Berbée JF, Stroes ES, Smit JW, Havekes LM, Romijn JA, Rensen PC. CETP expression reverses the reconstituted HDL-induced increase in VLDL. J Lipid Res 2011 Aug; 52: 1533-1541. 
 
  1. Auvinen HE*, Wang Y*, Princen H, Romijn JA, Havekes LM, Smit JW, Meijer OC, Biermasz NR, Rensen PC, Pereira AM. Both transient and continuous corticosterone excess inhibit atherosclerotic plaque formation in APOE* 3-Leiden. CETP mice. PLoS One 2013 Sep; 8: e63882 [*Contributed equally]. 
 
  1. Geerling JJ*, Wang Y*, Havekes LM, Romijn JA, Rensen PC. Acute central neuropeptide Y administration increases food intake but does not affect hepatic very low-density lipoprotein (VLDL) production in mice. PLoS One 2013 May; 8: e55217 [*Contributed equally]. 
 
  1. Parlevliet ET*, Wang Y*, Geerling JJ, Schröder-Van der Elst JP, Picha K, O'Neil K, Stojanovic-Susulic V, Ort T, Havekes LM, Romijn JA, Pijl H, Rensen PC. GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE* 3-Leiden mice. PLoS One 2012; 7: e49152 [*Contributed equally]. 
 
  1. Trinder M, Wang Y, Madsen CM, Ponomarev T, Bohunek L, Daisely BA, Julia Kong H, Blauw LL, Nordestgaard BG, Tybjærg-Hansen A, Wurfel MM, Russell JA, Walley KR, Rensen PCN, Boyd JH, Brunham LR. Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis. Circulation. 2021 Mar 2;143(9):921-934.
 
  1. Liu C, Schonke M, Zhou E, Li Z, Kooijman S, Boon MR, Larsson M, Wallenius K, Dekker N, Barlind L, Peng XR, Wang Y, Rensen PCN. Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis. Cardiovasc Res 2021 Mar 8;cvab076. (Online ahead of print.)
 
  1. Zhang X, Paalvast Y, Wang Y, Rensen PCN and Groen AK. A hierarchical dynamic model used for investigating feed efficiency and its relationship with hepatic gene expression in APOE*3-Leiden.CETP mice. Physiol Rep 2021;9:e14832.
 
  1. van Eenige R, Ying Z, Tambyrajah L, Pronk ACM, Blomberg N, Giera M, Wang Y, Coskun T, van der Stelt M, Rensen PCN and Kooijman S. Cannabinoid type 1 receptor inverse agonism attenuates dyslipidemia and atherosclerosis in APOE *3-Leiden.CETP mice. J Lipid Res 2021;62:100070.
 
  1. Blauw LL, Wang Y, Willems van Dijk K, Rensen PCN. A Novel Role for CETP as Immunological Gatekeeper: Raising HDL to Cure Sepsis? Trends Endocrinol Metab 2020 May;31(5):334-343.
 
  1. Li Z, de Jonge WJ, Wang Y, Rensen PCN, Kooijman S. Electrical Neurostimulation Promotes Brown Adipose Tissue Thermogenesis. Front Endocrinol (Lausanne) 2020 Sep 30;11:567545.
 
  1. Schilperoort M, van den Berg R, Coomans CP, Khedoe PPSJ, Ramkisoensing A, Boekestijn S, Wang Y, Berbée JFP, Meijer JH, Biermasz NR, Rensen PCN, Kooijman S. Continuous Light Does Not Affect Atherosclerosis in APOE*3-Leiden.CETP Mice. J Biol Rhythms 2020 Dec;35(6):598-611.
 
  1. Körner A, Zhou E, Müller C, Mohammed Y, Herceg S, Bracher F, Rensen PCN, Wang Y, Mirakaj V, Giera M. Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution. Proc Natl Acad Sci U S A 2019 Oct; 116(41): 20623-20634
 
  1. Florijn BW, Duijs JMGJ, Levels JH, Dallinga-Thie GM, Wang Y, Boing AN, Yuana Y, Stam W, Limpens RWAL, Au YW, Nieuwland R, Rabelink TJ, Reinders MEJ, van Zonneveld AJ, Bijkerk R. Diabetic Nephropathy Alters the Distribution of Circulating Angiogenic MicroRNAs Among Extracellular Vesicles, HDL, and Ago-2. Diabetes 2019 Dec; 68(12): 2287-2300.
 
  1. van Eyk HJ, Blauw LL, Bizino MB, Wang Y, van Dijk KW, de Mutsert R, Smit JWA, Lamb HJ, Jazet IM, Rensen PCN. Hepatic triglyceride content does not affect circulating CETP: lessons from a liraglutide intervention trial and a population-based cohort. Sci Rep 2019 Jul; 9(1): 9996
 
  1. Blauw LL, Noordam R, Soidinsalo S, Blauw CA, Li-Gao R, de Mutsert R, Berbée JFP, Wang Y, van Heemst D, Rosendaal FR, Jukema JW, Mook-Kanamori DO, Würtz P, Willems van Dijk K, Rensen PCN. Mendelian randomization reveals unexpected effects of CETP on the lipoprotein profile. Eur J Hum Genet 2019 Mar; 27(3): 422-431.
 
  1. Trinder M, Genga KR, Kong HJ, Blauw LL, Lo C, Li X, Cirstea M, Wang Y, Rensen PCN, Russell JA, Walley KR, Boyd JH, Brunham LR. Cholesteryl Ester Transfer Protein Influences High-Density Lipoprotein Levels and Survival in Sepsis. Am J Respir Crit Care Med 2019 Apr; 199(7): 854-862.
 
  1. Rozendaal YJW, Wang Y, Hilbers PAJ, van Riel NAW. Computational modelling of energy balance in individuals with Metabolic Syndrome. BMC Syst Biol 2019 Feb 26;13(1):24.
 
  1. Blauw LL, Li Z, Rensen SS, Greve JW, Verhoeven A, Derks RJ, Giera M, Wang Y, Rensen PCN. Metabolic liver inflammation in obesity does not robustly decrease hepatic and circulating CETP.  Atherosclerosis 2018 Aug; 275: 149-155.
 
  1. Tahapary DL, de Ruiter K, Kurniawan F, Djuardi Y, Wang Y, Nurdin SME, Iskandar E, Minggu D, Yunir E, Guigas B, Supali T, Rensen PCN, Sartono E, Soewondo P, Harbuwono DS, Smit JWA, Yazdanbakhsh M. Impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet. Sci Rep 2018 May; 8(1): 8149.
 
  1. Blauw LL, Li-Gao R, Noordam R, de Mutsert R, Trompet S, Berbée JFP, Wang Y, van Klinken JB, Christen T, van Heemst D, Mook-Kanamori DO, Rosendaal FR, Jukema JW, Rensen PCN, Willems van Dijk K. CETP (Cholesteryl Ester Transfer Protein) Concentration: A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease. Circ Genom Precis Med 2018 May; 11(5): e002034.
 
  1. Hoeke G, Wang Y, van Dam AD, Mol IM, Gart E, Klop HG, van den Berg SM, Pieterman EH, Princen HMG, Groen AK, Rensen PCN, Berbée JFP, Boon MR. Atorvastatin accelerates clearance of lipoprotein remnants generated by activated brown fat to further reduce hypercholesterolemia and atherosclerosis. Atherosclerosis 2017 Dec; 267: 116-126.
 
  1. Paalvast Y, Gerding A, Wang Y, Bloks VW, van Dijk TH, Havinga R, Willems van Dijk K, Rensen PCN, Bakker BM, Kuivenhoven JA, Groen AK. Male apoE*3-Leiden.CETP mice on high-fat high-cholesterol diet exhibit a biphasic dyslipidemic response, mimicking the changes in plasma lipids observed through life in men. Physiol Rep 2017 Oct; 5 (19).
 
  1. Blauw LL, de Mutsert R, Lamb HJ, de Roos A, Rosendaal FR, Jukema JW, Wang Y, van Dijk KW, Rensen PC. Serum CETP concentration is not associated with measures of body fat: The NEO study. Atherosclerosis 2016 Mar; 246: 267-273.
 
  1. Boon MR, Bakker LE, Haks MC, Quinten E, Schaart G, Van Beek L, Wang Y, Van Schinkel L, van Harmelen V, Meinders AE, Ottenhoff TH, Van Dijk KW, Guigas B, Jazet IM, Rensen PC. Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects. Clin Sci (Lond) 2015 Jan; 128: 143-151.
 
  1. Klop B, van der Pol P, van Bruggen R, Wang Y, de Vries MA, van Santen S, O'Flynn J, van de Geijn GJ, Njo TL, Janssen HW, de Man P, Jukema JW, Rabelink TJ, Rensen PC, van Kooten C, Cabezas MC. Differential Complement Activation Pathways Promote C3b Deposition on Native and Acetylated LDL thereby Inducing Lipoprotein Binding to the Complement Receptor 1. J Biol Chem 2014 Dec; 289: 35421-35430.
 
  1. Boon MR, van den Berg SA, Wang Y, van den Bossche J, Karkampouna S, Bauwens M, De Saint-Hubert M, van der Horst G, Vukicevic S, de Winther MP, Havekes LM, Jukema JW, Tamsma JT, van der Pluijm G, van Dijk KW, Rensen PC. BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality. PLoS One 2013; 8: e74083.
 
  1. Berbée JF, Wong MC, Wang Y, van der Hoorn JW, Khedoe PP, van Klinken JB, Mol IM, Hiemstra PS, Tsikas D, Romijn JA, Havekes LM, Princen HM, Rensen PC. Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden. CETP mice. J Nutr Biochem 2013 Aug; 24: 1423-1430.
 
  1. Georgiadi A, Wang Y, Stienstra R, Tjeerdema N, Janssen A, Stalenhoef A, van der Vliet JA, de Roos A, Tamsma JT, Smit JW, Tan NS, Müller M, Rensen PC, Kersten S. Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development. Arterioscler Thromb Vasc Biol 2013 Jul; 33: 1529-1537.
 
  1. Li Z, Wang Y, van der Sluis RJ, van der Hoorn JW, Princen HM, Van Eck M, Van Berkel TJ, Rensen PC, Hoekstra M. Niacin reduces plasma CETP levels by diminishing liver macrophage content in CETP transgenic mice. Biochem Pharmacol 2012 Sep; 84: 821-829.
 
  1. Petropoulou PA, Gantz DL, Wang Y, Rensen PC, Kypreos KE. The aminoterminal 1-185 domain of human apolipoprotein E suffices for the de novo biogenesis of apoE-containing HDL-like particles in apoA-I deficient mice. Atherosclerosis 2011 Nov; 219: 116-123.
 
  1. Jonker JT, Wang Y, De Haan W, Diamant M, Rijzewijk LJ, Van Der Meer RW, Lamb HJ, Tamsma JT, de Roos A, Romijn JA, Rensen PC, Smit JW. Pioglitazone decreases plasma cholesteryl ester transfer protein mass, associated with a decrease in hepatic triglyceride content, in patients with type 2 diabetes. Diabetes Care 2010 Jul; 33: 1625-1628.
 
  1. den Boer MA, Westerterp M, de Vries-van der Weij J, Wang Y, Hu L, Santo SME, Kooistra T, Reiss P, Romijn JA, Havekes LM, Rensen PC. Ritonavir protects against the development of atherosclerosis in APOE* 3-Leiden mice. Atherosclerosis 2010 Jun; 210: 381-387. 
 
  1. Out R, Hoekstra M, Habets K, Meurs I, De Waard V, Hildebrand RB, Wang Y, Chimini G, Kuiper J, Van Berkel TJ, Van Eck M. Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels. Arterioscler Thromb Vasc Biol 2008; 28: 258-264.
 
  1. Xian X, Ding Y, Zhang L, Wang Y, McNutt MA, Ross C, Hayden MR, Deng X, Liu G. Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice. Biochem Biophys Res Commun 2009; 385: 563-569.
 
  1. Huang W, Bi N, Zhang X, Wang Y, Chen B, Liu G. Overexpression of apolipoprotein AV in the liver reduces plasma triglyceride and cholesterol but not HDL in ApoE deficient mice. Biochem Biophys Res Commun 2006; 346: 14-18.