Basic Information

西安交通大学二级教授，金属材料强度全国重点实验室副主任（2002年起任），国际生物材料科学与工程学会联合会Fellow。2001年入选教育部“跨世纪优秀人才计划”，2007 年受聘国务院特殊津贴专家，2011年入选陕西省“三五”人才，2012年受聘陕西省“三秦”人才。兼任中国生物材料学会常务理事（自第一届起）、科技成果评价工作委员会主任委员、医用金属材料分会主任委员、生物材料表界面工程分会常务委员，中国机械工程学会表面分会常务理事等。主要从事医用金属材料表面成骨活化、软组织密封和抗菌改性的相关机理，以及3D打印医用金属研究。作为负责人主持国家973计划项目课题1项、863计划项目2项、国家自然科学基金重点项目1项及面上项目7项、国家重点研发计划项目专题1项等。以第一获奖人获陕西省科学技术一等奖1项、陕西省科学技术二等奖1项，发表SCI收录论文240余篇，授权发明专利20余件。

Work Experience

2001-06 至 今, 西安交通大学, 材料学院, 教授

2001-01 至 2001-12, 韩国首尔大学, 材料系, 研究员

1998-03 至 2001-05, 西安交通大学, 材料学院, 副教授

1997-09 至 1997-12, 法国特鲁瓦技术大学, 机械系

Research Projects

国家重点研发计划，2023YFC2412600，结构功能一体化金属植入体用高品质原材料研发，2023/10-2027/10，180万元（专题），主持

国家自然科学基金重点项目，51631007，基于免疫调变和力学完整设计的钛合金表层结构及其生物功能提升机制，2017/01-2021/12，300万元，主持

国家自然科学基金面上项目，XXXXXXXX，XXXXXXX，2020/01-2023/12，60万元，主持

国家自然科学基金面上项目，51371137，基于降解与骨组织生长协同的镁合金生物改性机制研究，2014/01-2017/12，80万元，主持

国家自然科学基金面上项目，51071120，多孔钽孔壁的仿骨基质结构设计与关键技术，2011/01-2013/12，38万元，主持

国家自然科学基金面上项目，50671078，基于微弧放电的碳氨化钛厚膜形成机理及其力学行为多孔效应，2007/01-2009/12，31万元，主持

国家自然科学基金面上项目，50571079，含锶双相磷酸钙/钛”骨诱导涂层结构设计与力学相容性，2006/01-2008/12，33万元，主持

国家自然科学基金面上项目，50001009，抑制生物涂层结合强度退化的预应力理论及关键技术研究，2001/01-2003/12，20万元，主持

国家自然科学基金面上项目，50002008，碳-碳材料生物活化的钛酸钠诱导膜设计与关键技术研究，2001/01-2003/12，19万元，主持

国家973计划项目课题，2012CB619103，医用金属材料类骨表面功能化构建及生物适配机制研究，2012/01-2016/12，528万元（课题），主持

国家863计划项目，2006AA03Z0447，高性能人工关节的氧化锆基涂层结构优化与关键技术开发，2007/01-2009/12，90万元，主持

国家863计划项目，2002AA326070，与硬组织生物力学相容的新型钛合金及生物涂层技术开发，2002/09-2005/09，250万元，主持

教育部“跨世纪优秀人才培养计划”基金，纳米磷灰石复合生物材料的温合成技术研究，2002/01-2004/01，30万元，主持

Representative Publications (2020-2025)

  1. Y. Xue , L. Zhang*, J. Chen, D.Y Ma, Y.G Zhang, Y. Han*. An “all-in-one” therapeutic platform for programmed antibiosis, immunoregulation and neuroangiogenesis to accelerate diabetic wound healing. Biomaterials (2025) 123293.
  2. Y.L Shan, F. Cao, X. Zhao*, J. Luo, H. Mei, L. Zhang, Y. Huang, Y. Yang, L. Yan, Y. Huang, L.R.J Yan, Y.Y Huang, Y. Han*, B.L Guo*. Procoagulant, antibacterial and antioxidant high-strength porous hydrogel adhesives in situ formed via self-gelling hemostatic microsheets for emergency hemostasis and wound repair. Biomaterials 315 (2025) 122936.
  3. H.H Xie, L. Zhang*, J. Chen, C. Wang, Y.X Yan, S.L Deng, K. Liu, D.S Li, M. Yang, J.C Ren, S.L Wu, Y. Han*. A Dual-catalysis mode for ROS regulation to accelerate biointegration of implants in infected diabetic wound. Advanced Functional Materials (2025) 2423015.
  4. M. Yu, Y. Guo, S.W Zhou, Y.H Li, Z.X Deng*, X. Zhao*, Y. Han*. Spreadable thermosensitive nanocomposite hydrogel dressing with ultrasound-responsive bactericidal/repair-promoting regulation and cascade antioxidantion for infected burn wound repair. Journal of Materials Science & Technology 219 (2025) 189-204.
  5. X.M Cai#, B. Li#, *, Y.G Zhang, J.H Han, Y. Han*. Piezopotential and vacancies co-enhanced sonodynamic response of a ZnO-TiO2-x heterojunction array for osteointegration in MRSA-infected osteomyelitis. Chemical Engineering Journal 479 (2024) 47804.
  6. X.M Cai#, M. Yu#, *, B. Li, Y.G Zhang, Y. Han*. Cobalt ions-derived nanoenzyme array for endosseous neural network reconstruction and osseointegration. Bioactive Materials 42 (2024) 1-17.
  7. Y. Xue, L. Zhang*, J.H Zhou, J. Chen, Y.W Ma, Y. Han*. Low-dose Cu ions assisted by mild thermal stimulus inducing bacterial cuproptosis-like death for antibiosis and biointegration. Advanced Functional Materials 34 (2024) 2308197.
  8. S.W Zhuo#, Z. Deng#, Z.Y Wu, Y. Guo, Y.B Wu, X. Zhao*, Y. Han*, B.L Guo*. Janus gels for biomedical applications: progress and future prospective. Progress in Polymer Science (2024) 101856.
  9. S.W Zhuo, Y.P Liang, Z.Y Wu, X. Zhao*, Y. Han*, B.L Guo*. Supramolecular hydrogels for wound repair and hemostasis. Materials Horizons 11 (2024) 37-101.
  10. S.M Chen, F.W Liu, H. Xin, D. Wen, Y.G Zhang, B. Li*, Y. Han*. Boosting MRSA infectious osteoporosis treatment: Mg-doped nanofilm on vacancy-enriched TiO2 coating for providing in situ sonodynamic bacteria-killing and osteogenic alkaline microenvironment. Advanced Functional Materials 34 (2024) 2311965.
  11. T.X Ding, Y. Li, F.W Liu, J. Chen, Y.C Chen, L. Kong, Y. Han*, L. Zhang*. Electron spin polarization engineering in ferromagnetic bioheterojunction for sonotherapy of osteomyelitis.  Advanced Functional Materials 34 (2024) 2401795.
  12. T.X Ding, L. Zhang*, J. Han, J.H Zhou, Y. Han*. Photo-Responded antibacterial therapy of reinfection in percutaneous implants by nanostructured bio-heterojunction. Small 19 (2023) 2206265.
  13. J.L Luo, X. Zhao*, B.L Guo*, Y. Han*. Preparation, thermal response mechanisms and biomedical applications of thermosensitive hydrogels for drug delivery. Expert Opinion on Drug Delivery 20 (2023) 641-672.
  14. Y. Xue, L. Zhang*, F.W Liu, F. Dai, L. Kong, D.Y Ma, Y. Han*. Alkaline “nanoswords”  coordinate ferroptosis-like bacterial death for antibiosis and osseointegration. ACS Nano 17 (2023) 2711-2724.
  15. Y. Xue, L. Zhang*, F.W Liu, L. Kong, D.Y Ma, Y. Han*. Fluoride releasing photothermal responsive TiO2 matrices for antibiosis, biosealing and bone regeneration. Journal of Controlled Release 363 (2023) 657-669.
  16. M. Yu#, H.W Yang#, B. Li, R. Wang, Y. Han*. Molecular mechanisms of interrod spacing-mediated osseointegration via modulating inflammatory response and osteogenic differentiation. Chemical Engineering Journal 454 (2023) 140141.
  17. X. Zhao, J.L Luo, Y. Huang, L. Mu, J.Y Chen, Z. Liang, Z.H Yin, D.K Chu, Y. Han*, B.L Guo*. Injectable antiswelling and high-strength bioactive hydrogels with a wet adhesion and rapid gelling process to promote sutureless wound closure and scar-free repair of infectious wounds.  ACS Nano 17 (2023) 22015-22034.
  18. B. Li, F.L Liu, J. Ye, X.M Cai, R.L Qian, K.W Zhang, Y.F Zheng, S.L Wu, Y. Han*. Regulation of macrophage polarization through periodic photo‐thermal treatment to facilitate osteogenesis. Small 18 (2022) 2202691.
  19. X. Zhao#, Z.Y Zhang#, J.L Luo, Z.Y Wu, Z.F Yang, S.W Zhou, Y.P Tu, Y. Huang, Y. Han*, B.L Guo*. Biomimetic, highly elastic conductive and hemostatic gelatin/rGO-based nanocomposite cryogel to improve 3D myogenic differentiation and guide in vivo skeletal muscle regeneration. Applied Materials Today 26 (2022) 101365.
  20. D.M. Yu#, S. Guo#, M. Yu#, W.W. Liu, X.K. Li, D.F. Chen, B. Li**, Z. Guo***, Y. Han*. Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content. Bioactive Materials 10 (2022) 323-334.
  21. J. Ye#, B. Li#**, M. Li, Y.F. Zheng, S.L. Wu, Y. Han*. Formation of a ZnO nanorods-patterned coating with strong bactericidal capability and quantitative evaluation of the contribution of nanorods-derived puncture and ROS-derived killing. Bioactive Materials 11 (2022) 181-191.
  22. Y. Xue, J. Chen, T.X. Ding, M.T. Mao, S.B. Zhu, J.H. Zhou, L. Zhang*, Y. Han**. Building biointegration of Fe2O3-FeOOH coated titanium implant by regulating NIR irradiation in an infected model. Bioactive Materials 8 (2022) 1-11. 
  23. J. Ye#, B. Li#, M. Li, Y.F. Zheng, S.L. Wu, D.F. Chen, Y. Han*. Eco-friendly bacteria-killing by nanorods through mechano-puncture with top selectivity. Bioactive Materials 15 (2022) 173-184.
  24. D.M. Yu#, B. Li#, M. Yu#, S. Guo, Z. Guo**, Y. Han*. Cubic multi-ions-doped Na2TiO3 nanorod-like coatings: structure-stable, highly efficient platform for ions-exchanged release to immunomodulatory promotion on vascularized bone apposition. Bioactive Materials 18 (2022) 72-90.
  25. R. Huang, L. Liu, B. Li, L. Qin, L. Huang, K.W.K. Yeung*, Y. Han*. Nanograins on Ti-25Nb-3Mo-2Sn-3Zr alloy facilitate fabricating biological surface through dual-ion implantation to concurrently modulate the osteogenic functions of mesenchymal stem cells and kill bacteria. Journal of Materials Science & Technology 73 (2021) 31-44.  
  26. D.M. Yu#, S. Guo#, D. Yang#, B. Li*, Z. Guo*, Y. Han*. Interrod spacing dependent angiogenesis and osseointegration of Na2TiO3 nanorods-patterned arrays via immunoregulation. Chemical Engineering Journal 426 (2021) 131187. 
  27. K. Li, J. Chen, Y. Xue, T.X. Ding, S.B. Zhu, M.T. Mao, L. Zhang*, Y. Han*. Polymer brush grafted antimicrobial peptide on hydroxyapatite nanorods for highly effective antibacterial performance. Chemical Engineering Journal 423 (2021) 130133. 
  28. Y. Xue, J. Chen, L. Zhang*, Y. Han*. BSA-lysozyme coated NaCa2HSi3O9 nanorods on titanium for cytocompatibility and antibacterial activity. Journal of Materials Science & Technology 88 (2021) 240-249. 
  29. H.W. Yang#, M. Yu#, R. Wang, B. Li, X. Zhao, Y.L. Hao, Z. Guo, Y. Han*. Hydrothermally grown TiO2-nanorods on surface mechanical attrition treated Ti: Improved corrosion fatigue and osteogenesis. Acta Biomaterialia 116 (2020) 400-414. 
  30. J. Ye#, B. Li#, M. Li, Y.F. Zheng, S.L. Wu, Y. Han*. ROS induced bactericidal activity of amorphous Zn-doped titanium oxide coatings and enhanced osseointegration in bacteria-infected rat tibias. Acta Biomaterialia 107 (2020) 313-324.
  31. B. Li#, R. Huang#, J. Ye#, L. Liu, L. Qin, J.H. Zhou, Y.F. Zheng, S.L. Wu, Y. Han*. A self-healing coating containing curcumin for osteoimmunomodulation to ameliorate osseointegration. Chemical Engineering Journal 403 (2020) 126323. 
  32. X. Zhao#, Y.P. Liang#, B.L. Guo*, Z.H. Yin, D. Zhu, Y. Han*. Injectable dry cryogels with excellent blood-sucking expansion and blood clotting to cease hemorrhage for lethal deep-wounds, coagulopathy and tissue regeneration. Chemical Engineering Journal 403 (2020) 126329. 
  33. K. Li, Y. Xue, T. Yan, L. Zhang*, Y. Han*. Si substituted hydroxyapatite nanorods on Ti for percutaneous implants. Bioactive Materials 5 (2020) 116-123. 

Enrollment Information

招收材料、化学、生物、医学相关知识背景的博士后。

 

招收材料、化学、生物、医学相关专业的学术型博士生、学术型/专业型硕士生，欢迎推免生和统考生报考。

Contact Information

Email：yonghan@mail.xjtu.edu.cn