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Peer-reviewed Publications:

 

  1. Jiwoon Park#, Yuanyuan Zhao#, Fan Zhang#, Shaoyan Zhang#, Andrew C. Kwong#, Yujie Zhang, Hans-Heinrich Hoffmann, Leila Bushweller, Xin Wu, Alison W. Ashbrook, Branko Stefanovic, Shuyang Chen, Andrea D. Branch, Christopher E. Mason, Jae U. Jung, Charles M. Rice*, and Xianfang Wu*. The IL6/STAT3 axis dictates the PNPLA3-mediated susceptibility to nonalcoholic fatty liver disease. Journal of Hepatology, 2023 Jan;78(1):45-56. PMID: 36049612 (# co-first author)
  • Media Report on the website of Ministry of Science and Technology of the People’s Republic of China.

  1. Yuanyuan Zhao#, Di Hu#, Rihua Wang#, Xiaoyan Sun, Zita Hubler, Kathleen Lundberg, Ernest R. Chan, Quanqiu Wang, Drew Adams, Rong Xu and Xin Qi*. ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models. Nature Communications, 2022 Mar 2;13(1):1121. PMID: 35236834 (# Co-first author)
  • Media Reports: Study identifies therapeutic target for Alzheimer’s disease, revealing strategy for preventing or slowing disease progression.--- Science Daily, EurekAlert!/AAAS, NewsWise, NewsMedical, MDlinx, Medical Xpress, UK Today News, MIRAGE News, etc.

  1. Yuanyuan Zhao, Xiaoyan Sun, Di Hu, Domenick A. Prosdocimo, Mukesh K. Jain, Charles Hoppel, Rajesh Ramachandran and Xin Qi. ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects. Nature Communications. 2019 Mar 26;10(1):1371. PMID: 30914652.
  • A provisional patent on the application of DA1 was granted in 2018.

  1. Yuanyuan Zhao, Xiaoyan Sun, Xin Qi*. Inhibition of Drp1 hyperactivation reduces neuropathology and behavioral deficits in zQ175 knock-in mouse model of Huntington’s disease. Biochem Biophys Res Commun. 2018 Dec 9; 507(1-4): 319–323. PMID: 30449600
  • Drp1 peptide inhibitor P110 used here is licensed to Mitoconix.

  1. Xiaofeng Sun#, Liwei Sun#, Yuanyuan Zhao#, Ying Li, Wei Lin, Dahua Chen, Qinmiao Sun*. MAVS maintains mitochondrial homeostasis via autophagy. Cell Discovery. 2016. 2: 16024. PMID: 27551434 (# Co-first author)

  1. Yuanyuan Zhao#, Xiaofeng Sun#, Xuanli Nie, Liwei Sun, Tie-shan Tang, Dahua Chen, Qinmiao Sun*. COX5B Regulates MAVS-mediated Antiviral Signaling through Interaction with ATG5 and Repressing ROS Production. PLoS Pathogens 2012 Dec;8(12):e1003086. PMID: 23308066 (# Co-first author) 

  1. Leila Bushweller, Yuanyuan Zhao, Fan Zhang and Xianfang Wu*. Generation of Human Pluripotent Stem Cell-derived Polarized Hepatocytes. Current Protocols, 2022 Jan;2(1): e345. PMID: 35007406.

  1. Xuemei Fang#, Shanshan Zou#, Yuanyuan Zhao, Ruina Cui, Wei Zhang, Jiayue Hu, Jiayin Dai*. Kupffer cells suppress perfluorononanoic acid-induced hepatic peroxisome proliferator-activated receptor α expression by releasing cytokines. Archives of Toxicology 2012 Oct;86(10):1515-25. PMID: 22648072.