- Xinxin Zhang, Yu Zhang, Yuting Guo, Peiyun Xue, Yan Zhang, Hong Zhang, Yoichiro Ito, Jianwei Dou, Zengjun Guo. Research progress of diosgenin extraction from Dioscorea zingiberensis C. H. Wright: Inspiration of novel method with environmental protection and efficient characteristics. Steroids, 2023, 192: 109181.
- Xinxin Zhang, Zhaowei Xue, Shangjun Zhu, Yuting Guo, Yan Zhang, Jianwei Dou, Jiye Zhang, Yoichiro Ito, Zengjun Guo. Diosgenin revealed potential effect against cerebral ischemia reperfusion through HIKESHI/HSP70/NF-κB anti-inflammatory axis. Phytomedicine, 2022, 153991.
- Zhaowei Xue, Zhen Cao, Ming Jin, Xinxin Zhang*, Xinrui Wang, Jianwei Dou, Yuhong Zhu, Yoichiro Ito, Zengjun Guo. New bitter substances from medicine food homologous Dioscorea zingiberensis yam and their potential functions. Food & Function, 2021, 12(18), 8314-8325.
- Xinxin Zhang, Xingbin Wang, Zhaowei Xue, Guanqun Zhan, Yoichiro Ito, Zengjun Guo. Prevention properties on cerebral ischemia reperfusion of medicine food homologous Dioscorea yam-derived diosgenin based on mediation of potential targets. Food Chemistry, 2021, 345: 128672-128684.
- Muhammad Khurm, Xingbin Wang, Hui Zhang, Sajid Nawaz Hussain, Muhammad Naeem Qaisar, Khezar Hayat, Fatima Saqib, Xinxin Zhang*, Guanqun Zhan, Zengjun Guo. The genus Cassia L.: Ethnopharmacological and phytochemical overview. Phytotherapy Research, 2020, 1-50.
- Xinxin Zhang, Xingbin Wang, Muhammad Khurm, Guanqun Zhan, Hui Zhang, Yoichiro Ito, Zengjun Guo. Alterations of brain quantitative proteomics profiling revealed the molecular mechanisms of diosgenin against cerebral ischemia reperfusion effects. Journal of Proteome Research, 2020, 19(3): 1154-1168.
- Xinxin Zhang, Ming Jin, Nigatu Tadesse, Guanqun Zhan, Hui Zhang, Jun Dang, Sicen Wang, Zengjun Guo, Yoichiro Ito. Methods to treat the industrial wastewater in diosgenin enterprises produced from Diosorea zingiberensis C. H. Wright. Journal of Cleaner Production. 2018, 186: 34-44.
- Xinxin Zhang, Guanqun Zhan, Ming Jin, Hui Zhang, Jun Dang, Yan Zhang, Zengjun Guo, Yoichiro Ito. Botany, traditional use, phytochemistry, pharmacology, quality control, and authentication of Radix Gentianae Macrophyllae-A traditional medicine: A review. Phytomedicine, 2018, 46: 142-163.
- Xinxin Zhang, Ming Jin, Nigatu Tadesse, Jun Dang, Tao Zhou, Hui Zhang, Sicen Wang, Zengjun Guo, Yoichiro Ito. Dioscorea zingiberensis C. H. Wright: An overview on its Traditional Use, Phytochemistry, Pharmacology, Clinical Applications, Quality Control, and Toxicity. Journal of Ethnopharmacology, 2018, 220: 283-293.
- Xinxin Zhang, Ming Jin, Nigatu Tadesse, Liang Xian, Hui Zhang, Sicen Wang, Jun Dang, Yan Zhang, Zengjun Guo, Yoichiro Ito. Safety investigation on total steroid saponins extracts from Dioscorea zingiberensis C.H. Wright: Sub-acute and chronic toxicity studies on dogs. Regulatory Toxicology and Pharmacology, 2017, 91: 58-67.
- Xinxin Zhang, Dandan Li, Xuanji Xue, Yan Zhang, Jie Zhang, Chen Huang, Zengjun Guo, Nigatu Tadesse. First total synthesis of a novel amide alkaloid derived from Aconitum taipeicum and its anticancer activity. Natural Product Research, 2017, (9): 1-5.
- Xinxin Zhang, Xuanji Xue, Jing Zhao, Zengjun Guo, Yoichiro Ito, Wenji Sun. Quantitative determination of gracillin by HPLC-MS/MS after oral administration and its application to a pharmacokinetic study. Steroids, 2016, 113: 78-86.
- Xinxin Zhang, Xuanji Xue, Liang Xian, Zengjun Guo, Yoichiro Ito, Wenji Sun. Potential neuroprotection of protodioscin against cerebral
- ischemia-reperfusion injury in rats through intervening inflammation and apoptosis. Steroids, 2016, 113: 52-63.
- Xinxin Zhang, Zengjun Guo, Jing Li, Yoichiro Ito, Wenji Sun. A new quantitation method of protodioscin by HPLC-ESI-MS/MS in rat plasma and its application to the pharmacokinetic study. Steroids, 2016, 106: 62-69.
- Xinxin Zhang, Xuanji Xue, Jing Zhao, Chunxiang Qian, Zengjun Guo, Yoichiro Ito, Wenji Sun. Diosgenin attenuates the brain injury induced by transient focal cerebral ischemia-reperfusion in rats. Steroids, 2016, 113: 103-112.
- Xinxin Zhang, Jing Li, Yoichiro Ito, Wenji Sun. Simultaneous quantification of five steroid saponins from Dioscorea zingiberensis C. H. Wright in rat plasma by HPLC-MS/MS and its application to the pharmacokinetic studies. Steroids, 2015, 93, 16-24.
- Xinxin Zhang, Jinru Liang, Jianli Liu, Ye Zhao, Juan Gao, Wenji Sun, Yoichiro Ito. Quality control and identification of steroid saponins from Dioscorea zingiberensis C.H.Wright by fingerprint with HPLC-ELSD and HPLC-ESI-Quadrupole/Time-of-fight tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2014, 91: 46-59.
- Xinxin Zhang, Yoichiro Ito, Jinru Liang, Jianli Liu, Jiao He, Wenji Sun. Therapeutic effects of total steroid saponin extracts from the rhizome of Dioscorea zingiberensis C.H.Wright in Freund’s complete adjuvant induced arthritis in rats. International Immunopharmacology, 2014, 23, 407-416.
- Xinxin Zhang, Lin Chen, Xuan Dang, Jianli Liu, Yoichiro Ito, Wenji Sun. Neuroprotective effects of total steroid saponins on cerebral ischemia injuries in an animal model of focal ischemia/reperfusion. Planta Medica, 2014, 80: 637-644.
- Xinxin Zhang, Lin Chen, Jianli Liu, Yoichiro Ito, Jiao He, Wenji Sun. Neuroprotection of total steroid saponins from Dioscorea zingiberensis against transient focal cerebral ischemia-reperfusion injury in rats via its anti-inflammatory and anti-apoptotic effects. Planta Medica, 2014, 80, 1597-1604.
- Xinxin Zhang, Yoichiro Ito, Jinru Liang, Qi Su, Yongmin Zhang, Jianli Liu, Wenji Sun. Preparative isolation and purification of five steroid saponins from Dioscorea zingiberensis C. H. Wright by counter-current chromatography coupled with evaporative light scattering detector. Journal of Pharmaceutical and Biomedical Analysis, 2013, 84: 117-123.
- Xinxin Zhang, Jianli Liu, Wenji Sun, Yoichiro Ito. Comparative Studies on Performance of CCC and Preparative RP-HPLC in Separation and Purification of Steroid Saponins from Dioscorea Zingiberensis C. H. Wright. Journal of Steroids & Hormonal Science, 2015, 6(1): 1-9.