科研成果 - 肖 正涛
Emmanuel, N., He, Q., Kang, Y., Zhang, D., Gao, M., Wang, M., Fan, K., Xiong, J., Wu, S., and Fa, B. (2025). Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration. FEBS Open Bio.
Liu, H., Huang, C., Liu, Z., Li, Y., Zhu, Y., Gao, M., Chen, J., Zhang, H., Xiao, Z., and Zhao, W. (2025). Systematic drug screening and target analysis identify digitoxin as a potential therapy for uveal melanoma. Br. J. Pharmacol. 182, 1275-1291.
Mao, X., Xiong, J., Cai, M., Wang, C., He, Q., Wang, B., Chen, J., Xiao, Z., Wang, B., and Han, S. (2025). SCARB1 links cholesterol metabolism-mediated ferroptosis inhibition to radioresistance in tumor cells. Journal of Advanced Research.
Wang, B., Huang, C., Liu, X., Liu, Z., Zhang, Y., Zhao, W., Xu, Q., Ho, P.-C., and Xiao, Z. (2025). iMetAct: An integrated systematic inference of metabolic activity for dissecting tumor metabolic preference and tumor-immune microenvironment. Cell Rep. 44.
Bevilacqua, A., Franco, F., Lu, Y.-T., Rahiman, N., Kao, K.-C., Chuang, Y.-M., Zhu, Y., Held, W., Xie, X., and Gunsalus, K.C. (2024). PPARβ/δ-orchestrated metabolic reprogramming supports the formation and maintenance of memory CD8+ T cells. Science immunology 9, eadn2717.
Gong, W., Liu, Z., Wang, Y., Huang, W., Yang, K., Gao, Z., Guo, K., Xiao, Z., and Zhao, W. (2024). Reprogramming of Treg cell-derived small extracellular vesicles effectively prevents intestinal inflammation from PANoptosis by blocking mitochondrial oxidative stress. Trends Biotechnol.
Li, S., Meng, C., Hao, Q., Zhou, R., Dai, L., Guo, Y., Zhao, S., Zhou, X., Lou, C., and Xu, J. (2024). “On/off”-switchable crosslinked PTX-nanoformulation with improved precise delivery for NSCLC brain metastases and restrained adverse reaction over nab-PTX. Biomaterials, 122537.
Mo, H., Li, R., Yang, N., Han, J., Xiao, X., Zhang, Y., Xiao, Z., Jiao, L., Xu, Q., and Tu, K. (2024). USP40 promotes hepatocellular carcinoma progression through a YAP/USP40 positive feedback loop. Cancer Lett. 589, 216832.
Wang, J., Wang, M., Wu, S., Zhu, Y., Fan, K., Chen, Y., Xiao, Z., Chen, J., Tu, K., and Huang, D. (2024). Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels. Oncogenesis 13, 31.
Chang, L., Cui, H., Ren, X., Dai, L., Zhai, Z., Xiao, Z., Wu, H., Kang, H., and Ma, X. (2023). Purine and pyrimidine metabolism regulatory gene signature predicts prognosis and immunotherapy efficiency in breast cancer.
Chen, T., Wang, L., Chen, C., Li, R., Zhu, N., Liu, R., Niu, Y., Xiao, Z., Liu, H., and Liu, Q. (2023). HIF-1α-activated TMEM237 promotes hepatocellular carcinoma progression via the NPHP1/Pyk2/ERK pathway. Cell. Mol. Life Sci. 80, 120.
Cui, H., Ren, X., Zhao, X., Dai, L., Liu, D., Bao, Y., Hu, L., Xiao, Z., Ma, X., and Kang, H. (2023). Prognostic value and mode selection of locoregional treatment in Stage-IV breast cancer patients. J. Cancer Res. Clin. Oncol. 149, 13591-13605.
Sun, R., Yang, Y., Lü, W., Yang, Y., Li, Y., Liu, Z., Diao, D., Wang, Y., Chang, S.e., and Lu, M. (2023). Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression. Cell & Bioscience 13, 62.
Xu, Y., Peng, J.-J., Chuang, Y.-M., Akrami, M., Roychoudhuri, R., Zippelius, A., Xiao, Z., and Ho, P.-C. (2023a). 933 Heme-mediated reprogramming guides CD8+ T cell exhaustion in response to mitochondrial dysfunction. (BMJ Specialist Journals).
Wang, J., Sun, X., Jiao, L., Xiao, Z., Riaz, F., Zhang, Y., Xu, P., Liu, R., Tang, T., and Liu, M. (2022). Clinical characteristics and variant analyses of transient infantile hypertriglyceridemia related to GPD1 gene. Frontiers in Genetics 13, 916672.
Zhu, Y., Li, F., Yang, X., and Xiao, Z. (2022). De novo identification of actively translated open reading frames with ribosome profiling data. Journal of Visualized Experiments (JoVE), e63366.
Chen, Y., Long, W., Yang, L., Zhao, Y., Wu, X., Li, M., Du, F., Chen, Y., Yang, Z., and Wen, Q. (2021). Functional peptides encoded by long non-coding RNAs in gastrointestinal cancer. Frontiers in Oncology 11, 777374.
Di Conza, G., Tsai, C.-H., Gallart-Ayala, H., Yu, Y.-R., Franco, F., Zaffalon, L., Xie, X., Li, X., Xiao, Z., and Raines, L.N. (2021). Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity. Nat. Immunol. 22, 1403-1415.
Reid, M.A., Bose, S., Pladna, K.M., Anderson, R., Mikhael, P.G., Xiao, Z., Dai, Z., Liu, S., Liu, J., and Pardee, T.S. (2021). Predictive targeting of mitochondrial metabolism in Acute Myeloid Leukemia patients with a lipoic acid analog. medRxiv, 2021.2006. 2003.21257935.
Wang, X., Hu, X., Song, W., Xu, H., Xiao, Z., Huang, R., Bai, Q., Zhang, F., Chen, Y., and Liu, Y. (2021). Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation. Cell Res. 31, 664-683.
Xiao, Z., and Locasale, J.W. (2021). Epigenomic links from metabolism—methionine and chromatin architecture. Curr. Opin. Chem. Biol. 63, 11-18.
Zhang, C., Lei, L., Yang, X., Ma, K., Zheng, H., Su, Y., Jiao, A., Wang, X., Liu, H., and Zou, Y. (2021a). Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice. Journal for immunotherapy of cancer 9, e002809.
Zhang, C., Lei, L., Yang, X., Zheng, H., Su, Y., Jiao, A., Wang, X., Liu, H., Zou, Y., and Shi, L. (2021b). Single-cell sequencing characterizes intratumoral profile of immune cells in old mice. bioRxiv, 2021.2002. 2023.432366.
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