ResearchGate: https://www.researchgate.net/profile/Wanglong-Gou

 代表论文（#共同第一作者）：

1.     Gou W,Zheng JS. Updating the evidence on ultra-processed foods and health. Nature Medicine. 2025; 31:2119–2120.

2.     Gou W, Wang H, Su Chang, Fu Y, Wang X, Gao C, Shuai M, Miao Z, Zhang J, Jia X, Du W, Zhang K, Zhang B, Zheng JS. The temporal dynamics of gut mycobiome and its association with cardiometabolic health in a nationwide cohort of 12,641 Chinese adults. Cell Reports Medicine. 2024;5(10):101775.

    基于自建的万人级、多地域肠道真菌数据库，刻画了中老年人群肠道真菌的构成、动态变化及其与心血管代谢健康的关联。该论文入选Cell Reports Medicine当月封面。

3.     Gou W, Ling CW, He Y, Jiang Z, Fu Y, Xu F, Miao Z, Sun TY, Lin JS, Zhu HL, Zhou H, Chen YM, Zheng JS. Interpretable Machine Learning Framework Reveals Robust Gut Microbiome Features Associated With Type 2 Diabetes. Diabetes Care. 2021;44(2):358-366.

    整合可解释机器学习框架提出一种新的2型糖尿病菌群风险评分算法，解析出14个与2型糖尿病发病相关的肠道菌群标记物，并通过动物实验验证了上述菌群标记物与2型糖尿病的因果关联。该成果入选中国营养学会独立评选 的全球“2021 年度营养原创研究 Top15”榜单，被Nature等杂志引用190余次（截止2026.6）。

4.     Gou W, Xiao C, Liang X, Miao Z, Shi M, Wu Y, Lu S, Wang X, Fu Y, Hu W, Zheng JS.Physical activity during pregnancy and preterm birth among women with gestational diabetes. JAMA Network Open. 2024;7(12):e2451799.

    基于可穿戴设备系统评估妊娠期糖尿病（GDM）孕妇孕早期体力活动模式与早产风险的关系，为GDM专病管理提供了重要的指南依据，该研究发表后受到广泛关注，Altmetric 73。

5.     Fu Y,Gou W#, Wu P, Lai Y, Liang X, Zhang K, Shuai M, Tang J, Chen J, Yuan J, Zhao B, Yang Y, Liu X, Hu Y, Pan A, Pan X, Zheng JS. Landscape of the gut mycobiome dynamics during pregnancy and its relationship with host metabolism and pregnancy health. Gut. 2024;73(8):1302-1312.

    系统刻画孕期肠道真菌的动态变化及其与出生结局的关联。

6.     Gou W, Miao Z, Deng K, Zheng J-S. Nutri-microbiome epidemiology, an emerging field to disentangle the interplay between nutrition and microbiome for human health.Protein & Cell 2023; 14 (11), 787-806.

     Protein & Cell与2023中国肠道大会微生物组专刊邀稿（1/9），详述“营养-菌群流行病”研究进展，并展望未来发展方向。

7.     Gou W, Wang H, Tang XY, He Y, Su C, Zhang J, Sun TY, Jiang Z, Miao Z, Fu Y, Zhao H, Chen YM, Zhang B, Zhou H, Zheng, JS. Early-life exposure to the Great Chinese Famine and gut microbiome disruption across adulthood for type 2 diabetes: three population-based cohort studies. BMC Medicine. 2023;21(1):414.

    首次从肠道微生态出发，解析生命早期营养不良影响2型糖尿病发病的潜在机制，为理解“健康和疾病的发育起源”学说提供了新的视角。该成果受到浙江日报采访及报道。

8.     Gou W, Yue L, Tang XY, Wu YY, Cai X, Shuai M, Miao Z, Fu Y, Chen H, Jiang Z, Wang J, Tian Y, Xiao C, Xiang N, Wu Z, Chen YM, Guo T, Zheng JS. Circulating proteome and progression of type 2 diabetes. J Clin Endocrinol Metab. 2022;20:dgac098.

    基于巢式病例设计，解析2型糖尿病的蛋白质标记物，并探究其与膳食交互对2型糖尿病发病风险的影响。

9.     Gou W,Fu Y, Yue L, Chen GD, Cai X, Shuai M, Xu F, Yi X, Chen H, Zhu Y, Xiao ML, Jiang Z, Miao Z, Xiao C, Shen B, Wu X, Zhao H, Ling W, Wang J, Chen YM, Guo T, Zheng JS. Gut microbiota, inflammation, and molecular signatures of host response to infection. Journal of Genetics and Genomics. 2021; 3:S1673-8527(21)00094-1.

    整合肠道微生物组、蛋白质组及代谢组“模拟”宿主对“新冠肺炎”的分子响应，研究受到广泛关注，被引150余次（含预印版）。

10. Wang H,Gou W#,Su C, Du W, Zhang J, Miao Z, Xiao C, Jiang Z, Wang Z, Fu Y, Jia X, Ouyang Y, Jiang H, Huang F, Li L, Zhang B, Zheng JS. Association of gut microbiota with glycaemic traits and incident type 2 diabetes, and modulation by habitual diet: a population-based longitudinal cohort study in Chinese adults. Diabetologia. 2022;65(7):1145-1156.

    揭示中国南北方人群肠道细菌的差异，解析肠道菌群-营养互作与2型糖尿病发病风险的纵向关联。

11.  Fu Y,Gou W#, Zhong H, Tian Y, Zhao H, Liang X, Shuai M, Zhuo LB, Jiang Z, Tang J, Ordovas JM, Chen YM, Zheng JS. Diet-gut microbiome interaction and its impact on host blood glucose homeostasis: a series of nutritional n-of-1 trials. EBioMedicine. 2025 Jan;111:105483.

    结合N of 1试验设计，揭示肠道菌群对宿主个性化膳食响应的影响。该论文入选EBioMedicine当月封面。

12. Fu Y,Gou W#, Hu W, Mao Y, Tian Y, Liang X, Guan Y, Huang T, Li K, Guo X, Liu H, Li D, Zheng JS. Integration of an interpretable machine learning algorithm to identify early life risk factors of childhood obesity among preterm infants: a prospective birth cohort.BMC Medicine. 2020;18(1):184.

    可解释机器学习揭示影响早产儿学龄前肥胖发病风险的主要风险因子。

13. Wu Y,Gou W#, Yan Y, Liu CY, Yang Y, Chen D, Xie K, Jiang Z, Fu, Y, Zhu H, Zheng JS, Chen Y M. Gut microbiota and acylcarnitine metabolites connect the beneficial association between equol and adiposity in adults: a prospective cohort study.The American Journal of Clinical Nutrition, 2022; 116(6):1831-1841.

    揭示雌马酚可能通过肠道菌群和酰基肉碱代谢物缓解肥胖风险。

  14. Xu J, Gou W#, Wang X, Ru D, Hu W, Chen J, Li BY, Xi Y, Zheng JS, Chen YM. Integrated serum proteomic and liver genomic analyses identify molecular signatures associated with metabolic dysfunction-associated steatotic liver disease: a multi-cohort study. BMC Medicine. 2026.