教育经历:
1. 1999-09 至 2002-11, 西安交通大学, 内科学, 博士
2. 1996-09 至 1999-07, 西安交通大学, 内科学, 硕士
3. 1989-09 至 1994-07, 西安交通大学, 临床医学, 学士
博士后工作经历:
1. 2012-05 至 2012-12, Case Western Reserve University
科研与学术工作经历(博士后工作经历除外):
1. 2019-01 至 今, 西安交通大学, 第一附属医院, 主任医师
2. 2008-07 至 2018-12, 西安交通大学, 第一附属医院, 副主任医师
3. 2010-10 至 2012-04, Cleveland state university, USA, 访问学者
4. 2001-06 至 2008-07, 西安交通大学, 第一附属医院, 主治医师
5. 1994-07 至 2001-06, 西安交通大学, 第一附属医院, 住院医师
主持的科研项目:
1. 国家自然科学基金,30400520,蛋白酶体在砷剂诱导白血病细胞分化调亡中的作用机制研究,已结题
2. 国家自然科学基金,81541026,TLR/MyD88信号通路在诱导急性髓系白血病缓解的机制研究,已结题
3. 西安交通大学第一附属医院,AI辅助体内构建功能增强型CAR-NK细胞治疗急性髓系白血病, 2026-01 至 2028-01, 15万元, 在研
4. 西安交通大学第一附属医院,重大新技术项目,NK细胞治疗复发/难治急性髓系白血病,2024-07至2027-06,93万元,在研
5. 陕西省自然科学基金, NKG2D CAR-NK细胞在治疗急性髓系白血病中的应用研究
6. 西安交通大学第一附属医院, 临床研究, 脐血输注在老年急性髓系白血病巩固治疗中的应用研究, 2021-01 至 2023-12
7. 陕西省自然科学基金,MDMX抑制剂治疗CBFB-MYH11阳性AML的机制研究,已结题
8. 北京希斯科临床肿瘤学研究基金会,CD19/CD22双靶点非病毒TIM-3定点整合CAR-T细胞治疗复发/难治非霍奇金淋巴瘤的转化研究,25万元,在研
专利
一种靶向降解 CD26 的多肽降解剂及其制备方法与应用,申请号:202511155159.5
饲养细胞及利用饲养细胞体外扩增 NK 细胞的方法,申请号:202311336091.1
靶向肿瘤的嵌合抗原受体、细胞及其制备方法和应用,申请号:202610104253.6
调控 CD226 和 TIGIT 受体的免疫细胞及其制备方法和应用,申请号:202510730808.3
发表文章
1. Wang Lu;...;Wang Huaiyu. Armored CD33 CAR-NK cells secreting anti-CD73 scFv overcome adenosine-mediated immunosuppression and enhance anti-AML efficacy.The Journal for ImmunoTherapy of Cancer. 2026,14(9)e014825 (影响因子11.7)
2. HuaiyuWang; Xiaohui Wang; Ting Shi;SuhuaWei;XinLi;YunLeng;YinWu;MeiSun; Pengcheng He ; Hong-Hu Zhu. Granulocyte colony-stimulating factor plus venetoclax and azacitidinein newly diagnosed acute myeloid leukemia:a multicenterphase2trial,BloodCancerJournal,2025,15(1)184(影响因子13.8)
3. Gong, Sha; Mei, Nan; Wang, Jun;Zhu,Junsheng; Wang,Lu;Lu,Xiaohong;He,Pengcheng;Chen, Weiwei; Xi, Lei; Bao, Yingying; Wald, David N.; Fan,Xiaohu; Wang,Huaiyu.Anovelfeeder cell based on 4-1BBL and membrane-bound IL-21/IL-15 induce highly expansion and anti-tumor effect of natural killer cells,BMCBiotechnology, 2025, 25(1)89
4. Chang X, Wang H, Chen X. Tumor Diagnosis and Treatment Based on Stimuli-Responsive Aggregation of Gold Nanoparticles. Exploration (Beijing), 2025;5(3):270006.(共同通讯作者)(影响因子30.4)
5. Zhao,Yan; Wang,Huaiyu; Artificial intelligence-driven circRNAvaccinedevelopment: multimodal collaborative optimization and a new paradigm for biomedical applications,BriefingsInBioinformatics, 2025, 26(3):bbaf263(影响因子7.3)
6. Shu Chen; Weiwei Qin; XiaohongLu;LiLiu;YinsuoZheng;XinhuaLu;XiaohuiWang;Xiaojuan Zhang; Sha Gong; Suhua Wei; HuiyunZhang;HanruDing;RanjbarhaSeifollah;JingLi;Haitao Zhang; Di Wu; Olubukola Abiona; Pengcheng He; RongZhang;DavidWald; HuaiyuWang;Arsenic trioxide versus Realgar-Indigo naturalis formula in non-high-risk acute promyelocytic leukemia:amulticenter, randomized trial. Haematologica, 2025,110(3):621-628(影响因子8.2)
7. Mei, Nan; Gong, Sha; Wang, Lizhao; Wang,Lu; Wang,Jincheng;Li,Jianpeng;Bao,Yingying; Zhang, Huanming ; Wang,Huaiyu ; Identification of a Prognostic Model Basedon NKCell-Related Genes in Multiple Myeloma Using Single-Cell and Transcriptomic Data Analysis. Blood and Lymphatic Cancer: Targets and Therapy. 2024,14:31-48
8. Mei N, Su H, ..., Wang H. High CX3CR1 expression predicts poor prognosis in paediatric acute myeloid leukaemia undergoing hyperleukocytosis. Int J Lab Hematol. 2023;45(1):53-63.
9. 赵晨阳,张欣欣,王怀宇. 砷剂治疗急性早幼粒细胞白血病诱发带状疱疹再激活的研究. 中国实验血液学杂志2022,30(1)72
10. Wang HY, Gong S, Li GH, et al. An effective and chemotherapy-free strategy of all-trans retinoic acid and arsenic trioxide for acute promyelocytic leukemia in all risk groups (APL15 trial). Blood Cancer J. 2022;12(11):158. (影响因子12.8)
11. Gong S, Wang H, Zhang H, Liu W, Zhang X, Zhao C. Real-world data on the dose-related effect of arsenic trioxide in the relapse of acute promyelocytic leukemia. Mol Clin Oncol. 2020;13(6):91.
12. Wang H, Yang G, Zhao J, Wang M. Association between mean corpuscular volume and severity of coronary artery disease in the Northern Chinese population: a cross-sectional study. J Int Med Res. 2020;48(3):300060519896713.
13. Zhang X, Liu L, ...,Wang H. Treatment of non-high-risk acute promyelocytic leukemia with realgar-indigo naturalis formula (RIF) and all-trans retinoid acid (ATRA): study protocol for a randomized controlled trial. Trials. 2020;21(1):7.
14. Zhang X, Zhang H, ..., Wang H. Arsenic trioxide and all-trans retinoic acid (ATRA) treatment for acute promyelocytic leukemia in all risk groups: study protocol for a randomized controlled trial. Trials. 2018;19(1):476.
15. 王怀宇,张欣欣,张慧云. 急性早幼粒细胞白血病患者外周血白细胞计数与早期死亡率关系. 中国实验血液学杂志 2017; 25(3)718-722.
16. James Ignatz-Hoover, Huaiyu Wang,...,David Wald. The role of TLR8 signaling in acute myeloid leukemia differentiation. Leukemia 2015;29(4):918-926 (共同第一)(影响因子12.104)
17. Wang HY, Liu SX, Zhang M. Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol Sin. 2003 Jul;24(7):646-50.
18. Wang HY, Liu SX, Lu XH. Gene expression profile changes in NB4 cells induced by realgar. Chinese Medical Journal 2003.116(7):107421077




