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  • 教师姓名： 李燕
  • 性别： 女
  • 职称： 教授
  • 博士生导师： 是
  • 硕士生导师： 是
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  • 所在单位： 第一附属医院
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  • 学科： 临床医学

学术及科研成果、专利、论文

当前位置： 中文主页 > Yan Li > 学术及科研成果、专利、论文

  1.  Wang F#, Sun H#, Chen M#, Feng B, Lu Y, Lyu M, Cui D, Zhai Y, Zhang Y, Zhu Y, Wang C, Wu H, Ma X, Zhu F, Wang Q, Li Y*. The thalamic reticular nucleus orchestrates social memory. Neuron. 2024 May 1:S0896-6273(24)00274-5. (IF: 15.0; 通讯作者)

  2. Dongqi Cui #, Xiaodan Wang#, Ruosong Ai#, Feng Gao#, Huan Sun, Ying Zhang, Yixuan Lyu Zhijie Zhang, Wen Li, Yuhang Qin1 Yuxi Guo, Yinxia Liu, Ningxia Zhao, Juan Wang, Shen Li, Ying Wu, Siyuan Zhang, Changhe Wang*, Feidi Wang*, Yan Li*. Dyscoordination of thalamic reticular spindles is associated with social memory deficits in mice and humans with autism spectrum disorder.Nature Communications, 2026. (IF: 18.1，In press, 通讯作者)

  3. Feidi Wang#, Mingyue Chen#, Mi Lyu#, Ying Zhang#, Huan Sun, YuLu, Dongqi Cui, Wenting Xu, Yixuan Lyu, Yifang Zhai, Jiao Han, Jun Li,Han Xu, Wenting Wang, Li Chen, Xiancang Ma*, Yan Li*. Parallel anterior cingulate cortex pathways underlie dissociable social andattentional outputs.Science Advances, 2026.doi:10.1126/sciadv.aec8032. (IF: 13.9，通讯作者)

  4. Yifang Zhai#, Li Ma#, Lixia Zhuo#, Feidi Wang, Linjuan Zhang, Jiao Han, Yuhang Qin,Peiyu Luo, Xiaodan Wang, Gengyao Zhou, Yixuan Lyu, Dongqi Cui, Ying Zhang, JingWang, Ning Sun, Xiancang Ma*, Rongrong Yang*, Yan Li*. Enterochromaffin cells drive anxiety-like behaviors in sleep-deprived mice. Biological Psychiatry, 2026. doi: 10.1016/j.biopsych.2026.06.014. (IF: 10.3，通讯作者)

  5. Peiyu Luo#, Wei Wu#, Huan Peng#, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma,Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen,Erfei Zhang, Wei Wang*, Xiancang Ma*, Yan Li*. RPLP2 Mediates the Beneficial Effects of Exercise on StressResistance Through Muscle–Brain Communication. Advanced Science, 2026. doi:10.1002/advs.76479. (IF: 14.1，通讯作者)

  6. Li Y#,*, Yin A#, Sun X#, Zhang M#, Zhang J, Wang P, Xie R, Li W, Fan Z, Zhu Y, Wang H, Dong H, Wu S, Xiong L*. Deficiency of tumor suppressor NDRG2 leads to attention deficit and hyperactive behavior. J Clin Invest. 2017, 127(12):4270-4284. (IF: 13.25; F1000推荐文章) 

  7. Li Y#,*, Sun H#, Huang Y#, Yin A#, Zhang L, Han J, Lyu Y, Xu X, Zhai Y, Sun H, Wang P, Zhao J, Sun S, Dong H, Zhu F, Wang Q, Augusto Rohde L, Xie X, Sun X*, Xiong L*. Gut metagenomic characteristics of ADHD reveal low Bacteroides ovatus-associated host cognitive impairment. Gut Microbes. 2022, 14: 2125747. (IF: 12.2; 第一和共同通讯作者)

  8. Yang R#, Ma L#, Peng H#, Zhai Y, Zhou G, Zhang L, Zhuo L, Wu W, Guo Y, Han J, Jing L, Zhou X, Ma X*, Li Y*. Microalgae-based bacteria for oral treatment of ASD through enhanced intestinal colonization and homeostasis. Theranostics. 2025; 15(6):2139-2158. (IF: 12.4; 通讯作者)

  9. Xu X#, Zhuo L#, Zhang L#, Peng H, Lyu Y, Sun H, Zhai Y, Luo D, Wang X, Li X, Li L, Zhang Y, Ma X, Wang Q, Li Y*. Dexmedetomidine alleviates host ADHD-like behaviors by reshaping the gut microbiota and reducing gut-brain inflammation. Psychiatry Res. 2023 May;323:115172. (IF: 4.2; 通讯作者)

  10.  Zhuo L#, Zhao X#, Zhai Y#, Zhao B, Tian L, Zhang Y, Wang X, Zhang T, Gan X, Yang C, Wang W, Gao W, Wang Q, Rohde LA, Zhang J*, Li Y*. Transcutaneous Electrical Acupoint Stimulation for Children with Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial. Transl Psychiatry. 2022 Apr 21;12(1):165. (IF: 6.8; 通讯作者)

  11.  Yin A#, Guo H#, Tao L, Cai G, Wang Y, Yao L, Xiong L, Zhang J*, Li Y*. NDRG2 Protects the Brain from Excitotoxicity by Facilitating Interstitial Glutamate Uptake. Transl Stroke Res. 2020,11(2):214-227. (IF: 8.27; 通讯作者)

  12. Han J#, Zhang L#, Lyu Y, Zhai Y, Wu W, Qin Y, Ma L, Zhuo L, Guo Y, Wang X, Wang F, Jing L, Wang J*, Li Y*, Yang R*. Indole-3-acetic acid exerts protective effects on sleep deprivation-induced cognitive impairment. Neuropharmacology. 2026 Feb 1;283:110747.  (IF: 4.7, 通讯作者)

  13. Wang X#, Zhuo L#, Wu W#, Cui D, Sun H, Wang F, Luo P, Lyu Y, Zhai Y, Han J, Li Y, Shen X, Xiao Y, Ai R. Anterior cingulate cortex dysfunction underlies anxiety-like behaviors in MT2-deficient mice. Neuropharmacology. 2025 Nov 15;279:110652.  (IF: 4.7, 通讯作者)

  14. Li X#, Sun H#, Zhu Y#, Wang F, Wang X, Han L, Cui D, Luo D, Zhai Y, Zhuo L, Xu X, Yang J*, Li Y*. Dysregulation of prefrontal parvalbumin interneurons leads to adult aggression induced by social isolation stress during adolescence. Front. Mol. Neurosci. 2022 Oct 4;15:1010152. (IF: 4.8; 通讯作者)

  15. Tao L#, Zhu Y#, Wang R#, Han J, Ma Y, Guo H, Tang W, Zhuo L, Fan Z, Yin A, Hou W, Li Y*. N-myc downstream-regulated gene 2 deficiency aggravates memory impairment in Alzheimer's disease. Behav Brain Res. 2020, 3;379:112384. (IF: 3.33; 通讯作者)

  16. Li Y#, Liu C#, Hou W#, Li Y, Ma J, Lin K, Situ Z, Xiong L, Li S* and Yao L*. Retrograde Ductal Administration of the Adenovirus-mediated NDRG2 Gene Leads to Improved Sialaden Hypofunction in Estrogen-deficient Rats. Mol Ther. 2014 May;22(5):908-18. (IF: 11.45 第一作者)

  17. Ma J#, Liu W#, Guo H#, Li S, Cao W, Du X, Lei S, Hou W, Xiong L, Yao L, Li N* and Li Y*. N-myc downstream-regulated gene 2 expression is associated with glucose transport and correlated with prognosis in breast carcinoma. Breast Cancer Res. 2014 Mar 18;16(2):R27 (IF: 5.87; 通讯作者，封面文章)

  18. Li Y#,*, Li S#, Qin X#, Hou W, Dong H, Yao L and Xiong L*. The pleiotropic roles of sphingolipid signaling in autophagy. Cell Death and Disease. 2014 May 22;5:e1245 (IF: 5.18; 第一作者)

  19. Li Y#, Yang J#, Li S#, Zhang J, Zheng J, Hou W, Zhao H, Guo Y, Liu X, Dou K, Situ Z* and Yao L*. N-Myc downstream-regulated gene 2, a novel estrogen-targeted gene is involved in the regulation of NA+/K+-ATPase. J Biol Chem. 2011, 286(37):32289-32299 (IF: 5.33; 第一作者)

  20. Tang W#, Li Y,# He S, Jiang T, Wang N, Du M, Cheng B, Gao W, Li Y*, Wang Q*. Caveolin-1 alleviates diabetes-associated cognitive dysfunction through modulating neuronal ferroptosis-mediated mitochondrial homeostasis. Antioxid Redox Signal. 2022 Nov;37(13-15):867-886. (IF: 6.6; 共同通讯作者)

  21. Tang W#, Li Y,# Li Y*, Wang Q*. Caveolin-1, a novel player in cognitive decline. Neuroscience and Biobehavioral Reviews. 2021, 129: 95-106. (IF: 8.99; 共同通讯作者)

  22. Zhu Y#, Wang R#, Fan Z#, Luo D, Cai G, Li X, Han J, Zhuo L, Zhang L, Zhang H, Li Y*, Wu S*. Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss. Cell Mol Neurobiol. 2023 Mar;43(2):827-840.  (IF: 4.0; 共同通讯作者)

  23. Guo H#, Yin A#, Ma Y#, Fan Z, Tao L, Tang W, Ma Y, Hou W, Cai G, Zhuo L, Zhang J, Li Y*, Xiong L*. Astroglial N-myc downstream-regulated gene 2 protects the brain from cerebral edema induced by stroke. Glia. 2021, 69(2):281-295. (IF: 7.45; 共同通讯作者)

  24. Cai Y#, Guo H#, Fan Z#, Zhang X#, Wu D, Tang W, Gu T, Wang S, Yin A, Tao L, Ji X, Dong H, Li Y*, Xiong L*. iScience. 2020, 6;23(5):101136. (IF: 5.24;共同通讯作者)

  25. Fan Z#, Zhang Z#, Zhao S#, Zhu Y, Guo D, Yang B, Zhuo L, Han J, Wang R, Fang Z, Dong H, Li Y*, and Xiong L*. Dynamic Variations in Brain Glycogen are Involved in Modulating Isoflurane Anesthesia in Mice. Neuroscience Bulletin. 2020 Dec;36(12). (IF: 5.20; 共同通讯作者)

  26. Zhu Y#, Fan Z#, Zhao Q, Li J, Cai G, Wang R, Liang Y, Lu N, Kang J, Luo D, Tao H, Li Y*, Huang J*, Wu S*. Brain-Type Glycogen Phosphorylase Is Crucial for Astrocytic Glycogen Accumulation in Chronic Social Defeat Stress-Induced Depression in Mice. Front Mol Neurosci. 2022 Jan 24;14:819440. (IF: 4.8; 共同通讯作者)

  27. Zhu Y#, Fan Z#, Wang R#, Xie R, Guo H, Zhang M, Guo B, Sun T, Zhang H, Zhuo L, Li Y*, Wu S*. Single-Cell Analysis for Glycogen Localization and Metabolism in Cultured Astrocytes. Cell Mol Neurobiol. 2020, 40(5):801-812. (IF: 5.05; 共同通讯作者)

  28. Lei S#, Yang J#, Chen C#, Sun J, Yang L, Tang H, Yang T, Chen A, Zhao H, Li Y*, Du X*. FLIPL is critical for aerobic glycolysis in hepatocellular carcinoma. J Exp Clin Cancer Res. 2016 May 13;35(1):79. (IF: 11.16; 共同通讯作者)

  29. Ma Y#, Qin P#, Li Y#, Shen L, Wang S, Dong H, Hou W* and Xiong L*. The effects of different doses of estradiol (E2) on cerebral ischemia in an in vitro model of oxygen and glucose deprivation and reperfusion and in a rat model of middle carotid artery occlusion. BMC Neurosci. 2013 Oct 9;14:118. (IF: 3.00; 共同第一作者)

  30. Yang J#, Zheng J#, Wu L#, Shi M#, Zhang H, Wang X, Xia N, Wang D, Liu X, Yao L, Li Y* and Dou K*. NDRG2 Ameliorates Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway and Altering the MMP2/TIMP2 Ratio in Rats. PLoS ONE. 2011, 6(11):e27710. (IF: 4.09; 共同通讯作者)

  31. Zheng J#, Li Y#, Yang JD#, Liu qiang#, Yao LB* and Liu WC*. NDRG2 inhibits hepatocellular carcinoma adhesion, migration and invasion by regulating CD24 expression. BMC Cancer. 2011;11:251 (IF: 3.01; 共同第一作者)

  32. Yang J#, Li Y#, Wu L#, Zhang Z, Han T, Guo H, Jiang N, Tao K, Ti Z, Liu X, Yao L* and Dou K*. NDRG2 in rat liver regeneration: Role in proliferation and apoptosis. Wound Repair Regen. 2010;18:524-531 (IF: 3.44; 共同第一作者)

  33. Hou W#, Hu J#, Li Y#, Zhao J, Li Z, Liu X, Yao L and Zhang Y*. Altered Expression of NDRG2 in the Testes of Experimental Rat Model of Cryptorchidism. Urology. 2010;75(4):985-991. (IF: 2.33; 共同第一作者)

  34.  Zheng J#, Liu Q#, Li Y#, Yang JD, Ma J, Yu F, Shi H, Ren Q, Zhang R, Zhang J, Xue Y, Tao YR, Jiang N, Guo H, Yao LB* and Liu WC*. NDRG2 Expression Regulates CD24 and Metastatic Potential of Breast Cancer Cells. Asian Pac J Cancer Prev. 2010;11(6):1817-21. (IF: 1.24; 共同第一作者)

  35.  Li Y#, Li S#, Han Y, Liu J, Zhang J, Li F, Wang Y, Liu X, Yao L*. Calebin-A Induces Apoptosis and Modulates MAPK family activity in drug-resistant human gastric cancer cells. Eur J Pharmacol. 2008;591:252-258. (IF: 4.43; 第一作者)

  36. Li Y#, Liu J, Liu X, Xing K, Wang Y, Li F, Yao L*. Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9. Appl Biochem Biotech. 2006,135(3):181-192. (IF: 2.93; 第一作者)

  37. Yin A#, Wang C#, Sun J#, Gao J, Tao L, Du X, Zhao H, Yang J*, Li Y*. Overexpression of NDRG2 Increases Iodine Uptake and Inhibits Thyroid Carcinoma Cell Growth In Situ and In Vivo. Oncol Res. 2016;23(1-2):43-51. (IF: 5.57; 通讯作者)

  38. Lin K#, Yin A, Yao L, Li Y*. N-myc downstream-regulated gene 2 in the nervous system: from expression pattern to function. Acta Biochim Biophys Sin. 2015,47(10):761-6. (IF: 2.12; 通讯作者)

  39. Li Y#, Yang J, Li S, Yao L*. National, regional, and worldwide estimates of stillbirth rates. The Lancet. 2011, 378(9794):873-874. (IF: 38.278; 第一作者) (Correspondence letter)

 

1. 《脑科学常用研究技术》                 科学出版社               2023 主编

2.《精编分子生物学实验技术》           世界图书出版社         2017 主编

3. 《分子生物学实用实验技术》          第四军医大学出版社  2011 主编

4. 《细胞与分子生物学常用实验技术》第四军医大学出版社  2009 主编

 

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