王然  (研究员)

博士生导师 硕士生导师

电子邮箱：

所在单位：生命科学与技术学院

学历：硕博连读

办公地点：

性别：男

联系方式：

学位：博士

毕业院校：剑桥大学

学科：生物学

   
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    特聘研究员

    博士生导师

    青年拔尖人才

    交大一附院特聘教授



  • 联系地址：创新港18号楼3095办公室

    联系方式：ran.wang@xjtu.edu.cn



  • 2007 – 2011: 西北大学，生命科学学院，生命科学与技术基地班，学士；

    2011 – 2017: 中国科学院，上海生物化学与细胞生物学研究所，博士；

    2012 – 2013: 中国科学院—马普学会计算生物学伙伴研究所，联合培养。



  • 2017 – 2018: 欧洲生物信息学研究所，联合博士后；

    2018 – 2019: 剑桥大学，癌症研究所，联合博士后；

    2019 – 2023: 中国科学院，上海生物化学与细胞生物学研究所，副研究员。

    2024 – 今 :   西安交通大学，生命科学与技术学院，研究员。



  • 单细胞和空间多组学研究，生物信息学算法开发，小鼠早期胚胎发育。

    本课题组利用数理统计学、几何拓扑学、数学建模等技术手段，研发生物信息学新算法，应用于细胞生物学和发育生物学研究中。近年来的科研工作中，通过结合单细胞测序技术与空间转录组技术，建立数学模型，在时间和空间四维层面上研究早期胚胎发育及相关疾病的分子调控机制。作为第一和通讯作者（含共同），研究成果发表于Cell Research, Nature Communications, Genomics Proteomics & Bioinformatics, Cell Reports, iScience, Stem Cell Reports, Journal of Molecular Cell Biology, Journal of Biological Chemistry等国际学术期刊；在Nature, Nature Cell Biology, Developmental Cell等发表共同作者论文十余篇。主持国家级科研项目4项。



  • 第一/通讯作者文章（含共同，按发表时间顺序）:

    1. Ran Wang *, Xianfa Yang #, Chengfei Lian #, Jianjie Wang, Jiehui Chen, Yun Qian, Yaochen Xu, Liantang Wang, John C. Marioni, Patrick P.L. Tam *, Naihe Jing *. Constructing the spatiotemporal atlas of single-cell lineage trajectories in stereotypic biological structures. iScience 2026, 29(1): 114307.

    1. Ran Wang #, Xianfa Yang #, Jiehui Chen #, Lin Zhang #, Jonathan A. Griffiths, Guizhong Cui, Yingying Chen, Yun Qian, Guangdun Peng, Jinsong Li, Liantang Wang, John C. Marioni, Patrick P.L. Tam *, Naihe Jing *. Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation. Nature Communications 2023, 14(1): 5675.

    1. Ran Wang, Guangdun Peng, Patrick P L Tam, Naihe Jing *. Integration of Computational Analysis and Spatial Transcriptomics in Single-cell Study. Genomics, Proteomics & Bioinformatics 2023, 21(1): 13-23.

    1. Zhiping Rao #, Ran Wang # (co-first author), Sanlan Li #, Yuhan Shi, Licun Mo, Su'e Han, Jiacheng Yuan, Naihe Jing *, Leping Cheng *. Molecular Mechanisms Underlying Ascl1-Mediated Astrocyte-to-Neuron Conversion. Stem Cell Reports 2021, 16(3): 534-547.

    1. Wenqian Song #, Ran Wang # (co-first author), Weimin Jiang, Qi Yin, Guangdun Peng, Ruikai Yang, Qing Cissy Yu, Jianfeng Chen, Jingsong Li, Tom H Cheung, Naihe Jing, Yi Arial Zeng *. Hormones induce the formation of luminal-derived basal cells in the mammary gland. Cell Research 2019, 29(4): 206-220.

    1. Guang Yang #, Changyang Zhou #, Ran Wang # (co-first author), Shisheng Huang, Yu Wei, Xianfa Yang, Yajing Liu, Jianan Li, Zongyang Lu, Wenqin Ying, Xiajun Li, Naihe Jing, Xingxu Huang *, Hui Yang *, Yunbo Qiao *. Base-Editing-Mediated R17H Substitution in Histone H3 Reveals Methylation-Dependent Regulation of Yap Signaling and Early Mouse Embryo Development. Cell Reports 2019, 26(2): 302-312.

    1. Xianfa Yang #, Ran Wang # (co-first author), Xiongjun Wang #, Guoqing Cai, Yun Qian, Su Feng, Fangzhi Tan, Kun Chen, Ke Tang, Xingxu Huang *, Naihe Jing *, Yunbo Qiao *. TGFbeta signaling hyperactivation-induced tumorigenicity during the derivation of neural progenitors from mouse ESCs. Journal of Molecular Cell Biology 2018, 10(3): 216-228.

    1. Yuanyuan Li #, Ran Wang # (co-first author), Nan Qiao, Guangdun Peng, Ke Zhang, Ke Tang, Jing-Dong J Han *, Naihe Jing *. Transcriptome analysis reveals determinant stages controlling human embryonic stem cell commitment to neuronal cells. Journal of Biological Chemistry 2017, 292(48): 19590-19604.

    1. Yunbo Qiao #, Ran Wang # (co-first author), Xianfa Yang, Ke Tang, Naihe Jing *. Dual roles of histone H3 lysine 9 acetylation in human embryonic stem cell pluripotency and neural differentiation. Journal of Biological Chemistry 2015, 290(4): 2508-2520.

    共同作者文章:

    1. Yingying Chen, Fengxiang Tan, Qing Fang, Lin Zhang, Jiaoyang Liao, Penglei Shen, Yun Qian, Mingzhu Wen, Rui Song, Yonggao Fu, He Jax Xu, Ran Wang, Cheng Li *, Zhen Shao *, Jinsong Li *, Naihe Jing *, Xianfa Yang *. Gastrula-Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross-Talk with TGF-β Signaling Pathway. Advanced Science 2025, 12(36): e00895.

    1. V. Pragathi Masamsetti, Nazmus Salehin, Hani Jieun Kim, Nicole Santucci, Megan Weatherstone, Riley McMahon, Lee L. Marshall, Hilary Knowles, Jane Sun, Josh B. Studdert, Nader Aryamanesh, Ran Wang, Naihe Jing, Pengyi Yang, Pierre Osteil, Patrick P. L. Tam *. Lineage contribution of the mesendoderm progenitors in the gastrulating mouse embryo. Developmental Cell 2025, 60(14): 1-16.

    1. Adiyant Lamba #, Meng Zhu #, Maciej Meglicki, Sylwia Czukiewska, Lakshmi Balasubramaniam, Ron Hadas Nina Weishaupt, Ekta M Patel, Yu Hua Kavanagh, Ran Wang, Naihe Jing, Magdalena Zernicka-Goetz *. Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification. Elife 2024, 13: RP101140

    1. Xiaoxiao Wang #, Yunlong Xiang #, Yang Yu #, Ran Wang, Yu Zhang, Qianhua Xu, Hao Sun, Zhen-Ao Zhao, Xiangxiang Jiang, Xiaoqing Wang, Xukun Lu, Dandan Qin, Yujun Quan, Jiaqi Zhang, Ng Shyh-Chang, Hongmei Wang, Naihe Jing, Wei Xie *, Lei Li *. Formative pluripotent stem cells show features of epiblast cells poised for gastrulation. Cell Research 2021, 31(5): 526-541.

    1. Ke Zhang #, Fang Yu #, Jian Zhu #, Sue Han #, Jiehui Chen #, Xuanyuan Wu #, Yingying Chen, Tingyu Shen, Jiaoyang Liao, Wenke Guo, Xianfa Yang, Ran Wang, Yun Qian, Jiaxin Yang, Leping Cheng, Yun Zhao, Chi-Chung Hui, Jinsong Li, Guangdun Peng, Shuijin He *, Naihe Jing *, Ke Tang *. Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation. Cell Reports 2020, 31(3): 107521.

    1. Guangdun Peng #, Shengbao Suo #, Guizhong Cui #, Fang Yu #, Ran Wang, Jun Chen, Shirui Chen, Zhiwen Liu, Guoyu Chen, Yun Qian, Patrick P L Tam, Jing-Dong J Han *, Naihe Jing *. Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature 2019, 572(7770): 528-532.

    1. Ting Zhang #, Wei Ke #, Xuan Zhou #, Yun Qian, Su Feng, Ran Wang, Guizhong Cui, Ran Tao, Wenke Guo, Yanhong Duan, Xiaobing Zhang, Xiaohua Cao, Yousheng Shu, Chunmei Yue *, Naihe Jing *. Human Neural Stem Cells Reinforce Hippocampal Synaptic Network and Rescue Cognitive Deficits in a Mouse Model of Alzheimer's Disease. Stem Cell Reports 2019, 13(6): 1022-1037.

    1. Xianfa Yang #, Boqiang Hu #, Jiaoyang Liao #, Yunbo Qiao #, Yingying Chen, Yun Qian, Su Feng, Fang Yu, Ji Dong, Yu Hou, He Xu, Ran Wang, Guangdun Peng, Jinsong Li *, Fuchou Tang *, Naihe Jing *. Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development. Cell Research 2019, 29(11): 911-926.

    1. Berna Sozen #, Gianluca Amadei #, Andy Cox, Ran Wang, Ellen Na, Sylwia Czukiewska, Lia Chappell, Thierry Voet, Geert Michel, Naihe Jing, David M Glover, Magdalena Zernicka-Goetz *. Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures. Nature Cell Biology 2018, 20(8): 979-989.

    1. Neophytos Christodoulou #, Christos Kyprianou #, Antonia Weberling, Ran Wang, Guizhong Cui, Guangdun Peng, Naihe Jing, Magdalena Zernicka-Goetz *. Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation. Nature Cell Biology 2018, 20(11): 1278-1289.

    1. Xianfa Yang #, Boqiang Hu #, Yu Hou #, Yunbo Qiao #, Ran Wang, Yingying Chen, Yun Qian, Su Feng, Jun Chen, Chang Liu, Guangdun Peng, Fuchou Tang *, Naihe Jing *. Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages. Cell Research 2018, 28(5): 593-596.

    1. Chang Liu, Ran Wang, Zhisong He, Pierre Osteil, Emilie Wilkie, Xianfa Yang, Jun Chen, Guizhong Cui, Wenke Guo, Yingying Chen, Guangdun Peng, Patrick P L Tam, Naihe Jing *. Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells. Stem Cell Reports 2018, 11(1): 43-57.

    1. Guizhong Cui #, Shengbao Suo #, Ran Wang, Yun Qian, Jing-Dong J Han *, Guangdun Peng *, Patrick P L Tam *, Naihe Jing *. Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning. Development, Growth & Differentiation 2018, 60(8): 463-472.

    1. Xue Han #, Sai Luo #, Guangdun Peng #, J Yuyang Lu, Guizhong Cui, Lichao Liu, Pixi Yan, Yafei Yin, Wei Liu, Ran Wang, Jiejie Zhang, Shanshan Ai, Zai Chang, Jie Na, Aibin He, Naihe Jing *, Xiaohua Shen *. Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development. Journal of Molecular Cell Biology 2018, 10(2): 175-178.

    1. Su Feng #, Can Xing #, Tingyu Shen #, Yunbo Qiao, Ran Wang, Jun Chen, Jiaoyang Liao, Zhuo Lu, Xiong Yang, Saber Mohamed Abd-Allah, Jinsong Li, Naihe Jing *, Ke Tang *. Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII. Scientific Reports 2017, 7(1): 5282

    1. Guangdun Peng #, Shengbao Suo #, Jun Chen #, Weiyang Chen, Chang Liu, Fang Yu, Ran Wang, Shirui Chen, Na Sun, Guizhong Cui, Lu Song, Patrick P L Tam, Jing-Dong J Han *, Naihe Jing *. Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo. Developmental Cell 2016, 36(6): 681-697.

    1. Yunbo Qiao #, Xiongjun Wang #, Ran Wang, Yuanyuan Li, Fang Yu, Xianfa Yang, Lu Song, Guoliang Xu, Y Eugene Chin *, Naihe Jing *. AF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation. Cell Discovery 2015, 1: 15017.

    1. Lingyu Li #, Lu Song #, Chang Liu, Jun Chen, Guangdun Peng, Ran Wang, Pingyu Liu, Ke Tang, Janet Rossant, Naihe Jing *. Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling. Journal of Molecular Cell Biology 2015, 7(5): 455-465.