Hippo信号通路激活所致心肌病的代谢调控机制

钙激活钾离子通道在心脏纤维化中的作用及调控机制

2017/03-2020/04，西安交通大学，病理学与病理生理学，博士，导师：邓秀玲教授

2015/09-2017/01，西安交通大学，病理学与病理生理学，硕士，导师：邓秀玲教授

2011/09-2015/07，天津医科大学，运动康复与健康，学士

2024/01至今，西安交通大学，生理学与病理生理学系，副教授

2020/06-2020/12，西安交通大学，生理学与病理生理学系，助理教授，合作导师：杜晓军教授

2019/02-2020/02，Monash University，药学与药理学系，访学研究生

1. She G, Du JC, Wu W, Pu TT, Zhang Y, Bai RY, Zhang Y, Pang ZD, Wang HF, Ren YJ, Sadoshima J, Deng XL, Du XJ. Hippo pathway activation mediates chemotherapy-induced anti-cancer effect and cardiomyopathy through causing mitochondrial damage and dysfunction. Theranostics 2023;13:560-577. (IF=12.4)
2. She G, Hou MC, Zhang Y, Zhang Y, Wang Y, Wang HF, Lai BC, Zhao WB, Du XJ, Deng XL. Gal-3 (Galectin-3) and KCa3.1 Mediate Heterogeneous Cell Coupling and Myocardial Fibrogenesis Driven by betaAR (beta-Adrenoceptor) Activation. Hypertension 2020;75:393-404. (IF=10.2)
3. She G, Ren YJ, Wang Y, Hou MC, Wang HF, Gou W, Lai BC, Lei T, Du XJ, Deng XL. KCa3.1 Channels Promote Cardiac Fibrosis Through Mediating Inflammation and Differentiation of Monocytes Into Myofibroblasts in Angiotensin II -Treated Rats. J Am Heart Assoc 2019;8:e010418. (IF=5)
4. Zhang Y, Li JJ, Xu R, Wang XP, Zhao XY, Fang Y, Chen YP, Ma S, Di XH, Wu W, She G, Pang ZD, Wang YD, Zhang X, Xie W, Deng XL, Du XJ, Zhang Y. Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts. Redox Biol 2023;68:102944. (IF=10.7)
5. Ma S, Bai L, Liu P, She G, Deng XL, Song AQ, Du XJ, Lu Q. Pathogenetic Link of Cardiac Rupture and Left Ventricular Thrombus Following Acute Myocardial Infarction: A Joint Preclinical and Clinical Study. Front Cardiovasc Med 2022;9:858720.
6. Wu W ZM, Huynh K, She G, Pang ZD, Zhang Y, Duong T, Kiriazis H, Pu TT, Bai RY, Li JJ, Zhang Y, Chen MX, Sadoshima J, Deng XL, Meikle PJ, Du XJ. Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice. Theranostics 2021;11. (IF=12.4)
7. Pang ZD, Wang Y, Song Z, She G, Ma XZ, Sun X, Wu W, Lai BC, Zhang J, Zhang Y, Du XJ, Shyy JYJ, Deng XL. AMPK upregulates KCa2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice. Biochem Pharmacol 2021;183:114337.
8. Zhang Y, Hou MC, Li JJ, Qi Y, Zhang Y, She G, Ren YJ, Wu W, Pang ZD, Xie W, Deng XL, Du XJ. Cardiac beta-adrenergic receptor activation mediates distinct and cell type-dependent changes in the expression and distribution of connexin 43. J Cell Mol Med 2020;24:8505-8517.
9. Pang ZD, Wang Y, Wang XJ, She G, Ma XZ, Song Z, Zhao LM, Wang HF, Lai BC, Gou W, Du XJ, Deng XL. K(Ca)3.1 channel mediates inflammatory signaling of pancreatic beta cells and progression of type 2 diabetes mellitus. FASEB J 2019;33:14760-14771.
10. Wang Y, Wang XJ, Zhao LM, Pang ZD, She G, Song Z, Cheng X, Du XJ, Deng XL. Oxidative stress induced by palmitic acid modulates K(Ca)2.3 channels in vascular endothelium. Exp Cell Res 2019;383:111552.
11. Wang Y, Sun HY, Liu YG, Song Z, She G, Xiao GS, Wang Y, Li GR, Deng XL. Tyrphostin AG556 increases the activity of large conductance Ca(2+) -activated K(+) channels by inhibiting epidermal growth factor receptor tyrosine kinase. J Cell Mol Med 2017;21:1826-1834.
12. 任雨洁, 佘刚, 侯梦晨，邓秀玲，赵丽梅. 成年大鼠心房成纤维细胞分离与培养方法的建立[J]. 西安交通大学学报(医学版),2018,5:747-751.

1. 2023年陕西高等学校科学技术研究优秀成果奖一等奖（邓秀玲等），钙激活钾离子通道（K_Ca）在心血管重塑中的作用与潜在治疗靶点。
2. 2024年陕西省科学技术奖自然科学奖二等奖（邓秀玲等），钙激活钾离子通道（K_Ca）在心血管重塑中的作用与潜在治疗靶点。