教授、博导
国家领军人才
西安交通大学基础医学院院长
中国西部科技创新港转化医学研究院院长
中组部青年人才、陕西省领军人才
省科技创新团队负责人
省高校青年创新团队负责人
市免疫相关疾病基础与转化重点实验室主任
"王宽诚育才奖"获得者
西安交通大学"青年拔尖人才支持计划(A)"
西安交通大学首届"青年优秀导师"
个人信息 - 张 保军
研究方向：
主要研究T细胞发育分化调控机制，筛选和研发抗肿瘤抗感染及自身免疫性疾病的治疗靶点与药物。
E-mail: bj.zhang@mail.xjtu.edu.cn
2019年4月 － 至今：西安交通大学基础医学院院长
中国西部科技创新港转化医学研究院院长
2016年9月 － 至今：教授、博导，西安交通大学
2015年9月 － 2016年9月：Research Scientist，免疫学，美国杜克大学
2014年2月 － 2015年8月：Research Associate，免疫学，美国杜克大学
2009年2月 － 2014年1月：博士后，免疫学，美国杜克大学
2004年9月 － 2009年1月：博士，移植免疫学，中国科学院
主要业绩：
创建T细胞生物学（TCB）团队，主要研究T细胞发育分化的调控机制，筛选和研发抗肿瘤抗感染及自身免疫性疾病的治疗靶点与药物。以第一或通讯作者在Immunity、J Clin Invest、PNAS、Sci Adv、Cell Mol Immunol、Signal Transduct Target Ther、J Immunother Cancer、J Adv Res、Elife、J Immunol等杂志发表论文60余篇。担任中国免疫学会理事、陕西省抗癌协会和细胞生物学学会副理事长；人卫版免疫学教材副主编，BMC Immunology杂志Senior Editorial Board Member。荣获省级教学成果一等奖、王宽诚育才奖、优秀共产党员、学科发展先进个人、研究生优秀导师等荣誉称号。
主持基金项目：
- 国家重点研发计划项目课题（2021）
- 国家自然科学基金国际（地区）合作与交流重点项目（2018）
- 国家自然科学基金面上项目（2021、2017）
- 陕西省高校联合重点项目（2022）
- 陕西省科技创新团队项目（2021）
| 论文标题 | 作者 | 发表/完成日期 | 期刊名称 |
|---|---|---|---|
| Targeting A Disintegrin and Metalloprotease (ADAM) 17-CD122 axis enhances CD8+ T cell effector differentiation and anti-tumor immunity (Accepted) | Lina Sun#, Anjun Jiao#, Haiyan Liu#, ..., Chenming, Sun*, Aijun Zhang*, Lianjun Zhang*, Baojun Zhang* | 2024-05-17 | Signal Transduct Target Ther |
| The Transcription Factor Zfp335 Promotes Differentiation and Survival of Effector Th1 Cells by Directly Regulating Lmna Expression | Haiyan Liu#, Zhao Feng#, Anjun Jiao#, Linbo Lan#, ..., Xiaofeng Yang*, Lianjun Zhang*, Lina Sun*, Baojun Zhang* | 2024-04-10 | J Immunol |
| Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation | Xin Wang#, Lina Sun#, Biao Yang#, Wenhua Li#, Cangang Zhang#, ..., Lei Lei*, WanJun Chen*, Baojun Zhang* | 2023-08-15 | J Clin Invest |
| SEL1L preserves CD8(+) T-cell survival and homeostasis by fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1 axis | Yafeng Gao#, Wenhui Li#, Zhenghao Wang#, Cangang Zhang#, ..., Jinping Zhang*, Baojun Zhang*, Lianjun Zhang* | 2023-08-03 | Cell Mol Immunol |
| T cells in health and disease | Lina Sun#, Yanhong Su#, Anjun Jiao#, Xin Wang#, Baojun Zhang* | 2023-06-19 | Signal Transduct Target Ther |
| Single-cell sequencing reveals the evolution of immune molecules across multiple vertebrate species | Anjun Jiao#, Cangang Zhang#, Xin Wang#, Lina Sun#, Haiyan Liu, Yanhong Su, Lei Lei, Wenhua Li, Renyi Ding, Chenguang Ding, Meng Dou, Puxun Tian, Chenming Sun, Xiaofeng Yang*, Lianjun Zhang*, Baojun Zhang* | 2023-03-04 | J Adv Res |
| Med1 controls effector CD8+ T cell differentiation and survival through C/EBPβ-mediated transcriptional control of T-bet Running title: Med1 controls effector CD8+ T cell fate | Anjun Jiao#, Haiyan Liu#, Renyi Ding#, Huiqiang Zheng, Cangang Zhang, Zhao Feng, Lei Lei1, Xin Wang,Yanhong Su, Xiaofeng Yang,Chenming Sun, Lianjun Zhang, Liang Bai*, Lina Sun*, Baojun Zhang* | 2022-07-01 | J Immunol |
| The transcription factor Zfp335 promotes differentiation and persistence of memory CD8+ T cells by regulating TCF-1 Running title: Zfp335 regulates memory CD8+ T cells through TCF-1 | Haiyan Liu#, Xin Wang#, Renyi Ding#, Anjun Jiao#, Huiqiang Zheng, Cangang Zhang, Zhao Feng, Yanhong Su, Xiaofeng Yang, Lei Lei1, Lina Sun, Lianjun Zhang, Chenming Sun* , Baojun Zhang* | 2022-06-24 | J Immunol |
| Cytosolic Nuclear Sensor Dhx9 Controls Medullary Thymic Epithelial Cell Differentiation by p53-Mediated Pathways | Xue Dong*, Jiayu Zhang*, Qian Zhang*, Zhanfeng Liang*, Yanan Xu, Yong Zhao#, Baojun Zhang# | 2022-06-03 | Front Immunol |
| Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases. | Liu J＃, Zhang H＃, Su Y, Zhang B | 2022-05-26 | Cell Biosci |
| Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8+ T cell exhaustion | Kaili Ma#, Lina Sun#, Mingjing Shen#, ..., Feng Guo*, Baojun Zhang*, Lianjun Zhang* | 2022-05-04 | iScience |
| DExD/H-box helicase 9 intrinsically controls CD8+ T cell-mediated antiviral response through noncanonical mechanisms. | Jiao A＃, Sun C＃, Wang X＃, Lei L＃, Liu H＃, Li W, Yang X, Zheng H, Ding R, Zhu K, Su Y, Zhang C, Zhang L*, Zhang B* | 2022-02-11 | Sci Adv |
| Zinc finger protein Zfp335 controls early T-cell development and survival through β-selection-dependent and -independent mechanisms. | Wang X＃, Jiao A＃, Sun L＃, Li W＃, Yang B, Su Y, Ding R, Zhang C, Liu H, Yang X, Sun C, Zhang B* | 2022-02-03 | Elife |
| Arid1a promotes thymocyte development through β-selection-dependent and β-selection-independent mechanisms. | Yang X, Wang X, Lei L, Su Y, Zou Y, Liu H, Jiao A, Zhang C, Liu J, Li W, Ding R, Zhou X, Shi L, Zhang D, Sun C, Zhang B* | 2021-11-18 | Immunology |
| Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice. | Zhang C＃, Lei L＃, Yang X＃, Ma K, Zheng H, Su Y, Jiao A, Wang X, Liu H, Zou Y, Shi L, Zhou X, Sun C, Hou Y, Xiao Z, Zhang L, Zhang B* | 2021-10-09 | J Immunother Cancer |
| Lineage Tracking the Generation of T Regulatory Cells From Microbial Activated T Effector Cells in Naïve Mice | Kun Zhu#, Chenfeng He#, ..., Baojun Zhang* | 2020-01-17 | Front Immunol |
| Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity. | Zhang B*, Jiao A, Dai M, Wiest DL, Zhuang Y | 2018-09-01 | J Immunol |
| Glimpse of natural selection of long-lived T-cell clones in healthy life. | Zhang B, Jia Q, Bock C, Chen G, Yu H, Ni Q, Wan Y*, Li Q*, Zhuang Y* | 2016-08-30 | Proc Natl Acad Sci U S A |
| MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium. | Zhang B, Liu SQ, Li C, Lykken E, Jiang S, Wong E, Gong Z, Tao Z, Zhu B, Wan Y, Li QJ* | 2016-03-15 | Immunity |
| Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells | Zhang B, Wu J, Jiao Y, Bock C, Dai M, Chen B, Chao N, Zhang W, Zhuang Y* | 2015-11-01 | J Immunol |
